scholarly journals The Diverse Applications of Recombinant BCG-Based Vaccines to Target Infectious Diseases Other Than Tuberculosis: An Overview

2021 ◽  
Vol 12 ◽  
Author(s):  
Esma Mouhoub ◽  
Pilar Domenech ◽  
Momar Ndao ◽  
Michael B. Reed
Keyword(s):  
Young Children ◽  
Infectious Diseases ◽  
Parasitic Diseases ◽  
Bacillus Calmette Guerin ◽  
The Past ◽  
Heterologous Antigens ◽  
Recombinant Bcg

Live attenuated Bacillus Calmette-Guérin (BCG) is the world’s most widely used vaccine which is mainly administered for its protection against tuberculosis (TB), particularly in young children. However, since its initial use over 100years ago, it has also proven to offer a level of protection against various other pathogens, as a consequence of its non-specific immune enhancing effects. Thus, over the past few decades, recombinant BCG (rBCG) technology has been used as a vector to create rBCG vaccines expressing heterologous antigens that elicit immunity against a range of bacterial, viral, and parasitic diseases. Our goal with this mini-review is to provide an up-to-date survey of the various techniques, approaches, and applications of rBCG-based vaccines for targeting infectious diseases other than TB.

scholarly journals MicroRNAs: Biological Regulators in Pathogen–Host Interactions

Cells ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 113 ◽  
Author(s):  
Stephanie Maia Acuña ◽  
Lucile Maria Floeter-Winter ◽  
Sandra Marcia Muxel
Keyword(s):  
Immune Response ◽  
Infectious Diseases ◽  
Small Rnas ◽  
Immune Cell ◽  
Fine Tuning ◽  
Biological Processes ◽  
Host Interactions ◽  
The Past ◽  
Biological Aspects

An inflammatory response is essential for combating invading pathogens. Several effector components, as well as immune cell populations, are involved in mounting an immune response, thereby destroying pathogenic organisms such as bacteria, fungi, viruses, and parasites. In the past decade, microRNAs (miRNAs), a group of noncoding small RNAs, have emerged as functionally significant regulatory molecules with the significant capability of fine-tuning biological processes. The important role of miRNAs in inflammation and immune responses is highlighted by studies in which the regulation of miRNAs in the host was shown to be related to infectious diseases and associated with the eradication or susceptibility of the infection. Here, we review the biological aspects of microRNAs, focusing on their roles as regulators of gene expression during pathogen–host interactions and their implications in the immune response against Leishmania, Trypanosoma, Toxoplasma, and Plasmodium infectious diseases.

scholarly journals Epidemiology of childhood tuberculosis after ceasing universal Bacillus Calmette–Guérin vaccination

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sayori Kobayashi ◽  
Takashi Yoshiyama ◽  
Kazuhiro Uchimura ◽  
Yuko Hamaguchi ◽  
Seiya Kato
Keyword(s):  
Policy Change ◽  
Vaccine Coverage ◽  
Lessons Learned ◽  
Public Health Authority ◽  
Bacillus Calmette Guerin ◽  
Notification Rate ◽  
Bcg Vaccination ◽  
The Past ◽  
Childhood Tb ◽  
Selective Vaccination

AbstractUniversal Bacillus Calmette–Guérin (BCG) vaccination is recommended in countries with high tuberculosis (TB) burden. Nevertheless, several countries have ceased universal BCG vaccination over the past 40 years, with scarce comparative epidemiological analyses regarding childhood TB after the policy change. We analysed data on childhood TB in countries that ceased universal BCG vaccination. Data sources included national/international databases, published papers, annual TB reports, and public health authority websites. Childhood TB notification rate increased in one of seven countries with available data. Pulmonary TB and TB lymphadenitis were the main causes of increasing childhood cases, while changes in severe forms of TB cases were minor. Maintaining high vaccine coverage for the target group was a common challenge after shifting selective vaccination. In some countries showing no increase in childhood TB after a BCG policy change, the majority of childhood TB cases were patients from abroad or those with overseas parents; these countries had changed immigration policies during the same period. Heterogeneity in childhood TB epidemiology was observed after ceasing universal BCG vaccination; several factors might obscure the influence of vaccination policy change. Lessons learned from these countries may aid in the development of better BCG vaccination strategies.

scholarly journals Young children's selective trust in informants

2011 ◽  
Vol 366 (1567) ◽  
pp. 1179-1187 ◽  
Author(s):  
Paul L. Harris ◽  
Kathleen H. Corriveau
Keyword(s):  
Young Children ◽  
Reliable Information ◽  
The Past ◽  
Selective Trust ◽  
History Of ◽  
Scientific Conception

Young children readily act on information from adults, setting aside their own prior convictions and even continuing to trust informants who make claims that are manifestly false. Such credulity is consistent with a long-standing philosophical and scientific conception of young children as prone to indiscriminate trust. Against this conception, we argue that children trust some informants more than others. In particular, they use two major heuristics. First, they keep track of the history of potential informants. Faced with conflicting claims, they endorse claims made by someone who has provided reliable care or reliable information in the past. Second, they monitor the cultural standing of potential informants. Faced with conflicting claims, children endorse claims made by someone who belongs to a consensus and whose behaviour abides by, rather than deviating from, the norms of their group. The first heuristic is likely to promote receptivity to information offered by familiar caregivers, whereas the second heuristic is likely to promote a broader receptivity to informants from the same culture.

Nonossifying fibroma. Four cases and review of the literature

1997 ◽  
Vol 87 (2) ◽  
pp. 66-69 ◽  
Author(s):  
A Glockenberg ◽  
E Sobel ◽  
JF Noël
Keyword(s):  
Young Children ◽  
Lower Extremity ◽  
Children And Adolescents ◽  
Lytic Lesion ◽  
Long Bones ◽  
Review Of The Literature ◽  
The Past ◽  
Nonossifying Fibroma ◽  
Metaphyseal Region

Nonossifying fibroma is a benign, lytic lesion that occurs in young children and adolescents. Radiographically, the lesion is multilocular and sharply demarcated. It often occurs at the metaphyseal region of long bones of the lower extremity and is usually eccentrically located. Four cases of nonossifying fibroma occurring during the past 7 years are presented with a review of the literature.

Varicella and Cortisone

PEDIATRICS ◽  
1956 ◽  
Vol 18 (1) ◽  
pp. 160-162 ◽  
Author(s):  
ROBERT J. HAGGERTY ◽  
R. CANNON ELEY
Keyword(s):  
Infectious Diseases ◽  
Clinical Course ◽  
Medical Center ◽  
Post Mortem ◽  
The Past ◽  
Vesicle Fluid ◽  
Heart Blood ◽  
Cortisone Therapy ◽  
Relationship Of

In the past 2 years we have seen 2 patients at the Children's Medical Center, who, while receiving cortisone therapy, developed varicella and died following a state of shock within a few days after the appearance of the vesicles. Post-mortem examinations of these patients revealed hemorrhagic vesicles throughout all viscera. In 1 case the virus of varicella was grown from vesicle fluid, heart blood, and lung. Since fatalities from varicella in childhood are so rarely encountered, even by physicians with vast experience in the field of infectious diseases, and since the clinical course of the infection in these two patients was so fulminating, the possible relationship of cortisone administration was raised.

ANALYSIS OF THE REASONS FOR THE REFUSAL OF THE POPULATION FROM VACCINES

Vestnik ◽  
2021 ◽  
pp. 280-284
Author(s):  
Х. Б. Сарсенбай ◽  
А. Н. Турсынханова ◽  
Б. А. Конысов
Keyword(s):  
Preschool Children ◽  
Young Children ◽  
Disease Prevention ◽  
Infectious Diseases ◽  
Respiratory Infections ◽  
Epidemiological Studies ◽  
Recurrent Respiratory Infections ◽  
High Level ◽  
Mandatory Vaccination

Согласно данным ВОЗ, современные эпидемиологические исследования показали, что рецидивирующие респираторные инфекции у детей раннего и дошкольного возраста сохраняются на высоком уровне 10-50% в течение более 40 лет. Конец вакцинации может спровоцировать массовые инфекционные заболевания. Врачи бьют тревогу, что число отказников от обязательной вакцинации растет. Только в каждой поликлинике Алматы 30-40 родителей в год говорят о готовности к профилактике заболеваний. Среди тех, кто категорически отказывается трогать своих детей иголками, - те, кто идет по пути религии. Они считают, что прививка противоречит убеждениям. В последнее время список недовольных групп пополняют и простые жители, которые скептически относятся к квалификации белых. According to WHO, current epidemiological studies have shown that recurrent respiratory infections in young children and preschool children persist at a high level of 10-50% for more than 40 years. The end of vaccination can provoke mass infectious diseases. Doctors are sounding the alarm that the number of refusers from mandatory vaccination is growing. Only in every polyclinic in Almaty, 30-40 parents a year talk about their readiness for disease prevention. Among those who categorically refuse to touch their children with needles are those who follow the path of religion. They believe that vaccination is contrary to their beliefs. Recently, the list of discontented groups has been supplemented by ordinary residents who are skeptical about the qualifications of whites.

scholarly journals Dermoscopy revealing a case of Tinea Nigra*

2013 ◽  
Vol 88 (1) ◽  
pp. 128-129 ◽  
Author(s):  
Paulo Ricardo Criado ◽  
Lívia Delgado ◽  
Gustavo Alonso Pereira
Keyword(s):  
Infectious Diseases ◽  
Diagnostic Tool ◽  
Glabrous Skin ◽  
Daily Routine ◽  
Brown Patch ◽  
The Past ◽  
History Of ◽  
Tinea Nigra ◽  
Skin Conditions

Dermoscopy has being used over the past twenty years as a noninvasive aid in the diagnosis of innumerable skin conditions, including infectious diseases and infestations (Entodermoscopy).Tinea nigra is a superficial phaeohyfomycosis that affects mainly the glabrous skin of palms and soles. We describe a 14 year-old girl with a three-month history of an enlarging brown patch of her hand diagnosed as Tinea Nigra following clinical and dermoscopy examination.These images emphasize the importance of dermoscopy as a diagnostic tool in the daily routine of dermatologists.

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