scholarly journals The Long Journey of Pontine Nuclei Neurons: From Rhombic Lip to Cortico-Ponto-Cerebellar Circuitry

2017 ◽  
Vol 11 ◽  
Author(s):  
Claudius F. Kratochwil ◽  
Upasana Maheshwari ◽  
Filippo M. Rijli
Keyword(s):  
Pontine Nuclei ◽  
Rhombic Lip

Role of Neph2 in pontine nuclei formation in the developing hindbrain

2011 ◽  
Vol 46 (3) ◽  
pp. 662-670 ◽  
Author(s):  
Kazuhiko Nishida ◽  
Kazuhide Nakayama ◽  
Saori Yoshimura ◽  
Fujio Murakami
Keyword(s):  
Pontine Nuclei

scholarly journals Syntaxin 1 is required for DCC/Netrin-1-dependent chemoattraction of migrating neurons from the lower rhombic lip

2013 ◽  
Vol 38 (2) ◽  
pp. 2338-2338
Author(s):  
Tiziana Cotrufo ◽  
Rosa María Andrés ◽  
Oriol Ros ◽  
Francesc Pérez-Brangulí ◽  
Ashraf Muhaisen ◽  
...  
Keyword(s):  
Rhombic Lip

Disequilibrium in patients with atherosclerosis

Neurology ◽  
1998 ◽  
Vol 51 (2) ◽  
pp. 570-573 ◽  
Author(s):  
Vincent I.H. Kwa ◽  
Laura H. Zaal ◽  
Bernard Verbeeten ◽  
Jan Stam ◽  
Keyword(s):  
Sickness Impact Profile ◽  
Statistical Significance ◽  
Structured Interview ◽  
The Body ◽  
Pontine Nuclei ◽  
Mri Findings ◽  
Initial Manifestation ◽  
Walking Test ◽  
Walking Tests ◽  
Body Care

Objective: To examine the clinical relevance of isolated pontine hyperintense lesions(PHLs) on MRI in patients with atherosclerosis.Methods: Seventeen atherosclerotic patients with isolated PHL on MRI were compared with 17 patients without PHL and were matched for age, sex, and initial manifestation of atherosclerosis. Subjects and observer were blinded to the MRI findings. We assessed symptoms, impairment, and disability with a structured interview and neurologic examination as well as disability scales.Results: On all items, patients with PHL scored worse that did their controls. We found the largest differences in frequencies of symptoms of disequilibrium, difficulties with speech or swallowing, the Timed Walking Test, and the body care and movement subscale of the Sickness Impact Profile. Except for disequilibrium (p = 0.04), these differences did not reach statistical significance. Abnormal tandem-walking tests were more frequent in patients than they were in controls. Pyramidal signs were equally distributed.Conclusions: We propose PHL as a cause of symptoms of disequilibrium in patients with atherosclerosis. Symptoms are probably elicited by dysfunction of the corticopontine fibers, the pontocerebellar fibers, or the pontine nuclei.

Role of Pax6 in development of the cerebellar system

Development ◽  
1999 ◽  
Vol 126 (16) ◽  
pp. 3585-3596 ◽  
Author(s):  
D. Engelkamp ◽  
P. Rashbass ◽  
A. Seawright ◽  
V. van Heyningen
Keyword(s):  
Cell Proliferation ◽  
Cell Migration ◽  
Granule Cell ◽  
Granule Cells ◽  
Cerebellar Granule Cells ◽  
Long Distance ◽  
Cerebellar Granule ◽  
Precerebellar Nuclei ◽  
Rhombic Lip

Post-mitotic neurons generated at the rhombic lip undertake long distance migration to widely dispersed destinations, giving rise to cerebellar granule cells and the precerebellar nuclei. Here we show that Pax6, a key regulator in CNS and eye development, is strongly expressed in rhombic lip and in cells migrating away from it. Development of some structures derived from these cells is severely affected in Pax6-null Small eye (Pax6(Sey)/Pax6(Sey)) embryos. Cell proliferation and initial differentiation seem unaffected, but cell migration and neurite extension are disrupted in mutant embryos. Three of the five precerebellar nuclei fail to form correctly. In the cerebellum the pre-migratory granule cell sub-layer and fissures are absent. Some granule cells are found in ectopic positions in the inferior colliculus which may result from the complete absence of Unc5h3 expression in Pax6(Sey)/Pax6(Sey) granule cells. Our results suggest that Pax6 plays a strong role during hindbrain migration processes and at least part of its activity is mediated through regulation of the netrin receptor Unc5h3.

The zebrafish cerebellar upper rhombic lip generates tegmental hindbrain nuclei by long-distance migration in an evolutionary conserved manner

2010 ◽  
pp. NA-NA ◽  
Author(s):  
Katrin Volkmann ◽  
Yi-Yen Chen ◽  
Matthew P. Harris ◽  
Mario F. Wullimann ◽  
Reinhard W. Köster
Keyword(s):  
Long Distance ◽  
Rhombic Lip
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