scholarly journals Similar Profile and Magnitude of Cognitive Impairments in Focal and Generalized Epilepsy: A Pilot Study

2022 ◽  
Vol 12 ◽  
Author(s):  
Helena Gauffin ◽  
Anne-Marie Landtblom ◽  
Patrick Vigren ◽  
Andreas Frick ◽  
Maria Engström ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cognitive Function ◽  
Focal Epilepsy ◽  
Cognitive Impairments ◽  
Self Esteem ◽  
Long Term Memory ◽  
Term Memory ◽  
Generalized Epilepsy

Introduction: Cognitive impairments in epilepsy are not well-understood. In addition, long-term emotional, interpersonal, and social consequences of the underlying disturbances are important to evaluate.Purpose: To compare cognitive function including language in young adults with focal or generalized epilepsy. In addition, quality of life and self-esteem were investigated.Patients and Methods: Young adults with no primary intellectual disability, 17 with focal epilepsy and 11 with generalized epilepsy participated and were compared to 28 healthy controls. Groups were matched on age (mean = 26 years), sex, and education. Participants were administered a battery of neuropsychological tasks and carried out self-ratings of quality of life, self-esteem, and psychological problems.Results: Similar impairments regarding cognitive function were noted in focal and generalized epilepsy. The cognitive domains tested were episodic long-term memory, executive functions, attention, working memory, visuospatial functions, and language. Both epilepsy groups had lower results compared to controls (effect sizes 0.24–1.07). The total number of convulsive seizures was predictive of episodic long-term memory function. Participants with focal epilepsy reported lower quality of life than participants with generalized epilepsy. Lowered self-esteem values were seen in both epilepsy groups and particularly in those with focal epilepsy. Along with measures of cognitive speed and depression, the total number of seizures explained more than 50% of variation in quality of life.Conclusion: Interestingly, similarities rather than differences characterized the widespread cognitive deficits that were seen in focal and generalized epilepsy, ranging from mild to moderate. These similarities were modified by quality of life and self-esteem. This study confirms the notion that epilepsy is a network disorder.

scholarly journals Cognitive profile of patients with facioscapulohumeral muscular dystrophy

2021 ◽  
Vol 15 (4) ◽  
pp. 541-547
Author(s):  
Vanessa Brzoskowski dos Santos ◽  
Jonas Alex Morales Saute ◽  
Laís Alves Jacinto-Scudeiro ◽  
Annelise Ayres ◽  
Rafaela Soares Rech ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Muscular Dystrophy ◽  
Verbal Fluency ◽  
Facioscapulohumeral Muscular Dystrophy ◽  
Cognitive Profile ◽  
Life Assessment ◽  
Long Term Memory ◽  
Term Memory

ABSTRACT Although it is predominantly a muscular disease, impairments in the central nervous system in patients with facioscapulohumeral muscular dystrophy (FSHD) have been described in the literature. Objective: To describe the cognitive profile of patients with FSHD and to correlate the impairments found with clinical variables and quality of life. Methods: Cross-sectional and case–control study that evaluated FSHD patients using a series of cognitive assessments (Mini-Mental State Examination — MMSE, Montreal Cognitive Assessment — MoCA, verbal fluency with phonological restriction — FAS, categorical verbal fluency — FAS-cat, trail-making test — TMT, and Rey’s Verbal Auditory Learning Test); a neurological severity scale (Gardner–Medwin–Walton — GMWS); and a quality of life measurement tool (Medical Outcomes Study 36-Item Short-Form Health Survey). Results: Individuals with FSHD (13) and healthy controls (26) were paired by gender and age. Significant differences between case and control groups were found in MMSE, TMT A, and A7 (p≤0.05) and MOCA (p≤0.001) performances. A positive correlation was verified in long-term memory impairments and the age in which symptoms appear (r=-0.593, p=0.033). Regarding quality of life assessment, the emotional domain correlated to MEEM (r=0.657, p=0.015), TMT A (r=-0.601, p=0.030), and A7 (r=0.617, p=0.025) performances. Conclusions: Individuals with FSHD presented mild impairments in the performance of tasks that involve attention, planning, and long-term memory functions. Those impairments were associated neither with the disease duration nor with its neurological severity.

Cognitive function in long-term lymphoma survivors: relationship between subjective reports and objective assessments and with quality of life

2020 ◽  
pp. 1-12
Author(s):  
Barbara Muzzatti ◽  
Nicoletta Cattaruzza ◽  
Marika Piccinin ◽  
Cristiana Flaiban ◽  
Giulia Agostinelli ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cognitive Function ◽  
Subjective Reports ◽  
Lymphoma Survivors

scholarly journals Nine-year prospective efficacy and safety of brain-responsive neurostimulation for focal epilepsy

Neurology ◽  
2020 ◽  
Vol 95 (9) ◽  
pp. e1244-e1256 ◽  
Author(s):  
Dileep R. Nair ◽  
Kenneth D. Laxer ◽  
Peter B. Weber ◽  
Anthony M. Murro ◽  
Yong D. Park ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Seizure Frequency ◽  
Focal Epilepsy ◽  
Responder Rate ◽  
Seizure Freedom ◽  
Open Label ◽  
Cognitive Domains ◽  
Signed Rank

ObjectiveTo prospectively evaluate safety and efficacy of brain-responsive neurostimulation in adults with medically intractable focal onset seizures (FOS) over 9 years.MethodsAdults treated with brain-responsive neurostimulation in 2-year feasibility or randomized controlled trials were enrolled in a long-term prospective open label trial (LTT) to assess safety, efficacy, and quality of life (QOL) over an additional 7 years. Safety was assessed as adverse events (AEs), efficacy as median percent change in seizure frequency and responder rate, and QOL with the Quality of Life in Epilepsy (QOLIE-89) inventory.ResultsOf 256 patients treated in the initial trials, 230 participated in the LTT. At 9 years, the median percent reduction in seizure frequency was 75% (p < 0.0001, Wilcoxon signed rank), responder rate was 73%, and 35% had a ≥90% reduction in seizure frequency. We found that 18.4% (47 of 256) experienced ≥1 year of seizure freedom, with 62% (29 of 47) seizure-free at the last follow-up and an average seizure-free period of 3.2 years (range 1.04–9.6 years). Overall QOL and epilepsy-targeted and cognitive domains of QOLIE-89 remained significantly improved (p < 0.05). There were no serious AEs related to stimulation, and the sudden unexplained death in epilepsy (SUDEP) rate was significantly lower than predefined comparators (p < 0.05, 1-tailed χ2).ConclusionsAdjunctive brain-responsive neurostimulation provides significant and sustained reductions in the frequency of FOS with improved QOL. Stimulation was well tolerated; implantation-related AEs were typical of other neurostimulation devices; and SUDEP rates were low.ClinicalTrials.gov identifierNCT00572195.Classification of evidenceThis study provides Class IV evidence that brain-responsive neurostimulation significantly reduces focal seizures with acceptable safety over 9 years.

scholarly journals MNGI-27. THE LONG-TERM DISEASE BURDEN OF MENINGIOMA PATIENTS: RESULTS ON HEALTH-RELATED QUALITY OF LIFE, COGNITIVE FUNCTION, ANXIETY AND DEPRESSION

2018 ◽  
Vol 20 (suppl_6) ◽  
pp. vi154-vi155
Author(s):  
Amir Zamanipoor Najafabadi ◽  
Pim van der Meer ◽  
Florien Boele ◽  
Rob Nabuurs ◽  
Johan Koekkoek ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cognitive Function ◽  
Disease Burden ◽  
Anxiety And Depression ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

Long-term study of the Quality of Life and Self-esteem in women submitted to immediate reconstruction after Breast Cancer

2019 ◽  
Vol 45 (2) ◽  
pp. e90-e91
Author(s):  
M.D.L.A. Gil-Olarte Marquez ◽  
G. Gines Moreno ◽  
P. Gil-Olarte Marquez ◽  
J. Garcia Schiever ◽  
A. Gil Rendo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Self Esteem ◽  
Term Study ◽  
Immediate Reconstruction ◽  
Long Term Study

scholarly journals Quality of Life and Self-Esteem of Long-Term Survivors of Invasive and Noninvasive Cervical Cancer

2009 ◽  
Vol 18 (5) ◽  
pp. 655-661 ◽  
Author(s):  
Monina G. Bartoces ◽  
Richard K. Severson ◽  
Barbara Ann Rusin ◽  
Kendra L. Schwartz ◽  
Julie Joanne Ruterbusch ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cervical Cancer ◽  
Self Esteem ◽  
Long Term Survivors

Long-term memory impairment in patients with focal epilepsy

Epilepsia ◽  
2007 ◽  
Vol 48 ◽  
pp. 26-29 ◽  
Author(s):  
Christian Hoppe ◽  
Christian E. Elger ◽  
Christoph Helmstaedter
Keyword(s):  
Memory Impairment ◽  
Focal Epilepsy ◽  
Long Term Memory ◽  
Term Memory

Progesterone to improve neurocognitive outcomes following cranial irradiation.

2016 ◽  
Vol 34 (3_suppl) ◽  
pp. 128-128
Author(s):  
Derick Okwan-Duodu ◽  
Fahim Atif ◽  
David S. Yu ◽  
Seema Yousuf ◽  
Deborah Bruner ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Memory Function ◽  
Cranial Irradiation ◽  
Long Term Memory ◽  
Group Effect ◽  
Significant Group Effect ◽  
Significant Group ◽  
Term Memory ◽  
Short And Long Term

128 Background: Neurocognitive functional decline is a common sequalae of cranial irradiation (CI) that significantly impacts quality of life. Preclinical studies and randomized clinical trials show that following traumatic brain injury and cerebrovascular accidents, premenopausal women demonstrate decreased mortality and improved neurocognitive function, with these benefits presumed to be derived from progesterone. We hypothesized that progesterone may serve similar role in neuroprotection following cranial irradiation. Methods: Adult non-tumor bearing wild type C57BL/6 male mice were treated with two separate fractionated radiation therapy regimen (9 Gy and 15 Gy) to the brain. Cohorts of these mice were administered progesterone (16mg/kg daily) as a pretreatment for 3 days and concurrent with the radiotherapy for a total of 14 days with tapering during the last two days. The animals were then tested using different behavioral measures for cognitive function including morris water maze (MWM) for assessing spatial and related forms of learning and memory, elevated plus maze (EPM), , and spontaneous locomotor activity (SLA) tests. Mice were tested for cognitive function on day 10 and after 30 days of treatment for short and long-term effects of (CI) on memory function. Results: All irradiated mice showed statistically significant decline in MWM, EPM, and SLA measures. There were no significant differences in the 9 Gy versus 15 Gy cohorts. Progesterone administration produced a statistically significant group effect (F (4, 25) = 8.553; P<0.001) in the improvement of long-term memory function over 5 days of learning process. Progesterone administration also demonstrated a significant group effect (F (4, 25) = 8.613; P<0.001) in the probe trial, and a significant beneficial effect (F (4, 25)= 7.993; P<0.001) in short-term memory functional latency to reach the platform. Conclusions: The preclinical data show that progesterone improves radiation-induced deficits in short-and long-term memory functions in adult mice. Further work is required to show if progesterone may show similar clinical benefit in neuroprotection for adults undergoing prophylactic CI or definitive CI for brain metastases or benign intracranial processes such as AVM.

scholarly journals Health-related quality of life of COVID-19 survivors at 6 months after hospital discharge: a cohort study

2021 ◽  
Author(s):  
MeiXuan Lin ◽  
Liqun Huang ◽  
Danwen Zheng ◽  
Linjie Zhang ◽  
Bing Feng ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Risk Factors ◽  
Cognitive Function ◽  
Health Related Quality ◽  
Sf 36 ◽  
Related Quality ◽  
Health Related

Abstract Background: COVID-19 is a multi-systemic disease that is highly contagious and pathogenic. The long-term consequences of it are not yet clear, as is whether society and life can return to a healthy state. Long-term assessment of their health-related quality of life (HRQoL) is essential. This study aimed to investigate HRQoL and its risk factors in COVID-19 survivors at a follow-up of 6-month. Methods: A multicenter cross-sectional survey was conducted among 192 COVID-19 patients with confirmed age ≥ 18 years who were discharged from various hospitals in Wuhan from January to April 2020. The demographic characteristics, clinical characteristics, and laboratory results of the study subjects were obtained from the hospital's medical records. Survivors' HRQoL was assessed using the Short Form 36 (SF-36), cognition was assessed using the ascertain dementia eight-item informant questionnaire (AD8), and survivors' pulmonary function were examined. All participants in this study completed the survey and testing at Hubei Provincial Hospital of Chinese and Western Medicine. SF-36 scores were compared with the Chinese norm, and logistic regression and multivariate analysis were used to investigate the factors affecting HRQoL in COVID-19 survivors. Results: SF-36 showed significant differences in HRQoL between COVID-19 survivors and the general Chinese population ( P< 0.05).Multiple linear regression demonstrated that age was negatively correlated with physical functioning (PF), role-physical limitation (RP) and social functioning (SF) ( P <0.05). Bodily pain (BP), vitality (VT), SF and role-emotional limitation (RE) were negatively correlated with females ( P <0.05). Length from discharge to follow‐up was positively correlated with PF and RP ( P <0.05). Abnormal cognitive function was negatively correlated with PF, RP, general health (GH), VT, SF, RE and mental health (MH) ( P <0.05). Abnormal Carbon Monoxide Diffusing Capacity (DLCO%<80%) was significantly negatively correlated with PF and SF ( P <0.05).In addition, there was a significant negative correlation between Coronary heart disease and RP, GH, VT and RE ( P <0.05).Logistic regression analysis demonstrated that age(OR 1.032) and AD8 scores (OR 1.203)were risk factors associated with a low physical component summary (PCS) score. Length from discharge to follow‐up (OR 0.971) was the protective factor for PCS score. Abnormal cognitive function (OR 1.543) was a significant determinant associated with a mental component summary (MCS)<50 in COVID-19 patients. Conclusions: The HRQoL of COVID-19 survivors remains to be improved at six-month follow-up. Future studies should track HRQoL in older adults, women, patients with abnormal DLCO, and abnormal cognitive function for a long time and provide them with rehabilitation advice and guidance.

Impact of Voice Pitch on Text Memory

2011 ◽  
Vol 70 (2) ◽  
pp. 85-93 ◽  
Author(s):  
Hede Helfrich ◽  
Philipp Weidenbecher
Keyword(s):  
Linear Correlation ◽  
Long Term Memory ◽  
Learning Material ◽  
Voice Pitch ◽  
Term Memory ◽  
Text Memory ◽  
Original Speech ◽  
Stimulus Materials

Previous research on communication has demonstrated that the quality of a speaker’s voice affects the attitude of the audience toward the speaker. The present study aimed to find out whether the pitch of a speaker’s voice affects the listener’s memory for the contents of the texts read. Stimulus materials consisted of three different texts spoken by different male speakers in different average pitches (measured as F0 in Hz). The original speech samples were digitally manipulated to produce predefined pitches. Both original and manipulated texts were then presented to participants as learning material. The results indicate a linear correlation between pitch and speaker rating in so far as low-pitched voices were rated more positively than high-pitched voices. Concerning the retention of content, it was shown that, in long-term memory, both high- and low-pitched voices led to better results than medium-pitched voices. This result was independent of whether the speech samples represented natural or manipulated voices.

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