Case Report: Multiple Sclerosis Relapses After Vaccination Against SARS-CoV2: A Series of Clinical Cases

Objective: To describe a temporal association between COVID-19 vaccine administration and multiple sclerosis (MS) relapses.Methods: This case series study was collected in four MS Centres in Central Italy, using data from 16 MS patients who received COVID-19 vaccination and presented both clinically and radiologically confirmed relapses between March and June 2021. We collected patients' relevant medical history, including demographics, MS clinical course, disease-modifying treatment (DMT) received (if applicable), and data from MRI scans obtained after the COVID-19 vaccination.Results: Three out of 16 patients received a diagnosis of MS with a first episode occurring after COVID-19 vaccination; 13 had already a diagnosis of MS and, among them, 9 were on treatment with DMTs. Ten patients received BNT162b2/Pfizer-BioNTech, 2 patients mRNA-1273/Moderna, and 4 patients ChAdOx1 nCoV-19/AstraZeneca. All MS relapses occurred from 3 days to 3 weeks after receiving the first dose of the COVID-19 vaccination or the booster. All patients had evidence of radiological activity on MRI.Discussion: Clinical and radiological findings in these cohort of MS patients confirmed disease re/activation and suggested a temporal association between disease activity and COVID-19 vaccination. The nature of this temporal association, whether causative or incidental, remains to be established.

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The use of Modified Rio score for determining treatment failure in patients with multiple sclerosis: retrospective descriptive case series study

Acta Neurologica Belgica ◽

10.1007/s13760-020-01476-2 ◽

2020 ◽

Author(s):

Mesude Tutuncu ◽

Ayse Altintas ◽

Burcu V. Dogan ◽

Ugur Uygunoglu ◽

Nilufer Kale Icen ◽

...

Keyword(s):

Multiple Sclerosis ◽

Treatment Failure ◽

Case Series ◽

Case Series Study ◽

Series Study

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Nordic walking for people with relapsing-remittent multiple sclerosis: A case series study.

Multiple Sclerosis and Related Disorders ◽

10.1016/j.msard.2020.102479 ◽

2020 ◽

Vol 46 ◽

pp. 102479

Author(s):

Iván Martínez-Lemos ◽

Daniel Martínez-Aldao ◽

Manuel Seijo-Martínez ◽

Carlos Ayán

Keyword(s):

Multiple Sclerosis ◽

Case Series ◽

Nordic Walking ◽

Case Series Study ◽

Series Study

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Cerebrovascular disorders in childhood: etiology, clinical presentation, and neuroimaging findings in a case series study

Arquivos de Neuro-Psiquiatria ◽

10.1590/s0004-282x2006000200002 ◽

2006 ◽

Vol 64 (2a) ◽

pp. 181-185 ◽

Cited By ~ 10

Author(s):

André P.C. Matta ◽

Keila R.F. Galvão ◽

Betânia S. Oliveira

Keyword(s):

Cerebrovascular Disorders ◽

Case Series ◽

First Episode ◽

Motor Deficits ◽

Left Middle Cerebral Artery ◽

Vascular Area ◽

Case Series Study ◽

Neuro Imaging ◽

Series Study ◽

Careful Investigation

OBJECTIVE: To describe the main etiologies, neurological manifestations and neuro-imaging findings among children with sequelae of cerebrovascular disorders. METHOD: Case series study of children whose diagnosis was stroke sequelae. Variables studied were age at the time of first episode, number of episodes, etiology, motor deficits, epilepsy, and effected vascular territory. RESULTS: Twenty three patients were studied. Average age at first episode was 6.91 (±2.08) years. Fourteen patients were female. The number of stroke events per patient ranged from one to five. The most frequent etiologies were heart disease and sickle cell anemia. The most frequent neurological deficit was right hemiparesis. Nine patients experienced seizures. The left middle cerebral artery was the most affected vascular area. CONCLUSION: Our findings are similar to those described in the literature. Despite a careful investigation, some causes of stroke remain unidentified.

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OP0267 INACTIVATED INFLUENZA VACCINATION DOES NOT ASSOCIATE WITH DISEASE FLARES IN AUTOIMMUNE RHEUMATIC DISEASES: A SELF-CONTROLLED CASE SERIES STUDY USING DATA FROM THE CLINICAL PRACTICE RESEARCH DATALINK

10.1136/annrheumdis-2019-eular.1597 ◽

2019 ◽

Author(s):

Georgina Nakafero ◽

Matthew Grainge ◽

Puja Myles ◽

Christian Mallen ◽

Weiya Zhang ◽

...

Keyword(s):

Clinical Practice ◽

Influenza Vaccination ◽

Rheumatic Diseases ◽

Case Series ◽

Practice Research ◽

Clinical Practice Research Datalink ◽

Autoimmune Rheumatic Diseases ◽

Case Series Study ◽

Using Data ◽

Series Study

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Aetiology of arthritis in hospitalised children: an observational study

Archives of Disease in Childhood ◽

10.1136/archdischild-2014-307490 ◽

2015 ◽

Vol 100 (8) ◽

pp. 742-747 ◽

Cited By ~ 15

Author(s):

Camille Aupiais ◽

Brice Ilharreborde ◽

Catherine Doit ◽

Audrey Blachier ◽

Marie Desmarest ◽

...

Keyword(s):

Septic Arthritis ◽

Tertiary Care ◽

Case Series ◽

First Episode ◽

Tertiary Care Centre ◽

Female Ratio ◽

Fluid Analysis ◽

Case Series Study ◽

Male Female Ratio ◽

Series Study

Background and objectiveArthritis in children has many causes and includes septic and viral arthritis, reactive arthritis and juvenile idiopathic arthritis (JIA). We aimed to describe the different types of arthritis among children hospitalised for a first episode of arthritis.DesignRetrospective, descriptive case series study.SettingA French tertiary care centre.PatientsChildren under 16 years of age hospitalised for an arthritis episode between 1 January 2008 and 31 December 2009.Main outcome measuresDemographic and clinical features were compared with χ2 or Fisher's exact tests and non-parametric tests.Results173 children were hospitalised for a first episode of arthritis during the study period, with a male/female ratio of 1.14. The most frequent cause of hospitalisation was septic arthritis (43.4% of cases, 69.3% of which were due to Kingella kingae and 10.7% to Staphylococcus aureus). JIA was responsible for 8.1% of cases and arthritis without any definitive diagnosis for 40.4%. Median age at diagnosis was 2.7 years (IQR 0.3–14.6) and was lower in the septic arthritis group (1.5 years; 1.1–3.4) than in the JIA group (4.7 years; 2.5–10.9) (p<0.01). Septic arthritis involved a single joint in 97.3% of cases, while JIA involved four joints in 14.3% of cases and two to four joints in 28.6% of cases (p<0.01).ConclusionsSeptic arthritis was the most frequent cause of arthritis in hospitalised children. Despite the increasing application of microbiological molecular methods to synovial fluid analysis, further measures are required to improve the diagnosis of arthritis of unknown cause.

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