scholarly journals Polarity-Specific Cortical Effects of Transcranial Direct Current Stimulation in Primary Somatosensory Cortex of Healthy Humans

2016 ◽  
Vol 10 ◽  
Author(s):  
Robert Rehmann ◽  
Matthias Sczesny-Kaiser ◽  
Melanie Lenz ◽  
Tomasz Gucia ◽  
Annika Schliesing ◽  
...  
Keyword(s):  
Somatosensory Cortex ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Primary Somatosensory Cortex ◽  
Direct Current Stimulation ◽  
Healthy Humans

scholarly journals Effects of transcranial direct current stimulation of primary somatosensory cortex on vibrotactile detection and discrimination

2016 ◽  
Vol 115 (4) ◽  
pp. 1978-1987 ◽  
Author(s):  
Sara Labbé ◽  
El-Mehdi Meftah ◽  
C. Elaine Chapman
Keyword(s):  
Somatosensory Cortex ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Middle Finger ◽  
Primary Somatosensory Cortex ◽  
Direct Current Stimulation ◽  
Stimulus Response ◽  
Neuronal Mechanisms ◽  
Vibrotactile Perception ◽  
Stimulation Of

Anodal transcranial direct current stimulation (a-tDCS) of primary somatosensory cortex (S1) has been shown to enhance tactile spatial acuity, but there is little information as to the underlying neuronal mechanisms. We examined vibrotactile perception on the distal phalanx of the middle finger before, during, and after contralateral S1 tDCS [a-, cathodal (c)-, and sham (s)-tDCS]. The experiments tested our shift-gain hypothesis, which predicted that a-tDCS would decrease vibrotactile detection and discrimination thresholds (leftward shift of the stimulus-response function with increased gain/slope) relative to s-tDCS, whereas c-tDCS would have the opposite effects (relative to s-tDCS). The results showed that weak a-tDCS (1 mA, 20 min) led to a reduction in both vibrotactile detection and discrimination thresholds to 73–76% of baseline during the application of the stimulation in subjects categorized as responders. These effects persisted after the end of a-tDCS but were absent 30 min later. Most, but not all, subjects showed a decrease in threshold (8/12 for detection; 9/12 for discrimination). Intersubject variability was explained by a ceiling effect in the discrimination task. c-tDCS had no significant effect on either detection or discrimination threshold. Taken together, our results supported our shift-gain hypothesis for a-tDCS but not c-tDCS.

scholarly journals Immediate and after effects of transcranial direct-current stimulation in the mouse primary somatosensory cortex

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Carlos A. Sánchez-León ◽  
Isabel Cordones ◽  
Claudia Ammann ◽  
José M. Ausín ◽  
María A. Gómez-Climent ◽  
...  
Keyword(s):  
Somatosensory Cortex ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Immunohistochemical Analysis ◽  
Gamma Oscillations ◽  
Primary Somatosensory Cortex ◽  
After Effects ◽  
Direct Current Stimulation ◽  
Sensory Evoked ◽  
Cathodal Stimulation

AbstractTranscranial direct-current stimulation (tDCS) is a non-invasive brain stimulation technique consisting in the application of weak electric currents on the scalp. Although previous studies have demonstrated the clinical value of tDCS for modulating sensory, motor, and cognitive functions, there are still huge gaps in the knowledge of the underlying physiological mechanisms. To define the immediate impact as well as the after effects of tDCS on sensory processing, we first performed electrophysiological recordings in primary somatosensory cortex (S1) of alert mice during and after administration of S1-tDCS, and followed up with immunohistochemical analysis of the stimulated brain regions. During the application of cathodal and anodal transcranial currents we observed polarity-specific bidirectional changes in the N1 component of the sensory-evoked potentials (SEPs) and associated gamma oscillations. On the other hand, 20 min of cathodal stimulation produced significant after-effects including a decreased SEP amplitude for up to 30 min, a power reduction in the 20–80 Hz range and a decrease in gamma event related synchronization (ERS). In contrast, no significant changes in SEP amplitude or power analysis were observed after anodal stimulation except for a significant increase in gamma ERS after tDCS cessation. The polarity-specific differences of these after effects were corroborated by immunohistochemical analysis, which revealed an unbalance of GAD 65–67 immunoreactivity between the stimulated versus non-stimulated S1 region only after cathodal tDCS. These results highlight the differences between immediate and after effects of tDCS, as well as the asymmetric after effects induced by anodal and cathodal stimulation.

Transcranial direct current stimulation applied over the somatosensory cortex – Differential effect on low and high frequency SEPs

2006 ◽  
Vol 117 (10) ◽  
pp. 2221-2227 ◽  
Author(s):  
Anne Dieckhöfer ◽  
Till Dino Waberski ◽  
Michael Nitsche ◽  
Walter Paulus ◽  
Helmut Buchner ◽  
...  
Keyword(s):  
Somatosensory Cortex ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
High Frequency ◽  
Differential Effect ◽  
Direct Current Stimulation
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