scholarly journals Transverse Sinus Stenosis in Venous Pulsatile Tinnitus Patients May Lead to Brain Perfusion and White Matter Changes

2021 ◽  
Vol 15 ◽  
Author(s):  
Xiaoshuai Li ◽  
Ning Xu ◽  
Xuxu Meng ◽  
Chihang Dai ◽  
Xiaoyu Qiu ◽  
...  
Keyword(s):  
White Matter ◽  
Brain Perfusion ◽  
Structural Mri ◽  
Transverse Sinus ◽  
Pulsatile Tinnitus ◽  
Low Degree ◽  
Significant Difference ◽  
Sinus Stenosis ◽  
Brain Changes ◽  
High Degree

Objective: Transverse sinus stenosis (TSS) is associated with various symptoms, but whether it can lead to pathological brain changes is unclear. This study aimed to investigate brain changes in venous pulsatile tinnitus (PT) patients with TSS.Materials and Methods: In this study, fifty-five consecutive venous PT patients and fifty age- and gender-matched healthy controls (HCs) were investigated. In CT venography, the combined conduit score (CCS) was used to assess the degree of TSS in venous PT patients. Magnetic resonance venography was used to assess TSS in HCs. All the participants had undergone arterial spin labeling and structural MRI scans.Results: Two patients without TSS and ten HCs with TSS were excluded. Fifty-three venous PT patients with TSS and 40 HCs without TSS were included in this study. All the patients had unilateral cases: 16 on the left and 37 on the right. Based on the CCS, the patients were divided into high-degree TSS (a score of 1–2) (n = 30) and low-degree TSS groups (a score of 3–4) (n = 23). In the whole brain and gray matter, the patients with high-degree TSS showed decreased cerebral blood flow (CBF) compared with patients with low-degree TSS as well as HCs (P < 0.05), and no significant difference in CBF was found in patients with low-degree TSS and HCs (P > 0.05). In white matter (WM) regions, the patients with high-degree TSS exhibited decreased CBF relative to the HCs (P < 0.05). The incidence of cloud-like WM hyperintensity was significantly higher in the above two patient groups than in the HC group (P < 0.05).Conclusion: TSS in venous PT patients may lead to decreased CBF and cloud-like WM hyperintensity. These neuroimaging findings may provide new insights into pathological TSS in venous PT.

scholarly journals TOLAK UKUR FUNGSI HATI BERDASARKAN DERAJAT FIBROSIS PENYAKIT HATI KRONIS (Liver Function Parameters based on Degree of Liver Fibrosis in Chronic Liver Disease)

2018 ◽  
Vol 21 (1) ◽  
pp. 57
Author(s):  
Rahmafitria Rahmafitria ◽  
Mutmainnah Mutmainnah ◽  
Ibrahim Abdul Samad
Keyword(s):  
Liver Disease ◽  
Liver Fibrosis ◽  
Liver Function ◽  
Chronic Liver Disease ◽  
Total Bilirubin ◽  
Chronic Liver ◽  
Low Degree ◽  
Significant Difference ◽  
The Mean ◽  
High Degree

Evaluating the degree of liver fibrosis degree is invasive as well as uncomfortable, therefore, non invasive examinations such as liverfunction tests and elastography (Fibro Scan) as a predictor‘s device of liver fibrosis degree are necessary. The aim of this study was toknow the differences of liver function parameters based on the fibrosis degree in patients with chronic liver disease. This study was a crosssectional design using data from chronic liver disease patients treated at the Dr. Wahidin Sudirohusodo Hospital. The elasticity of the liverwas measured using a fibro scan device during June 2010–July 2011. The analysis was carried out by ANOVA test on various parametersof liver function particularly on the fibrosis degree in chronic liver disease. In this study PT, albumin, total bilirubin and platelet countshowed a significant difference of 0.019, 0.009, 0.017 and 0.000 respectively. The mean values of PT and total bilirubin were significantlyhigher in the high degree of fibrosis compared to those with medium and low degree of fibrosis in the chronic liver disease patients. Basedon this study, the mean albumin levels and platelet count were significantly lower in the high degree of fibrosis compared with the mediumand low degree of fibrosis, however, no significant differences in AST, ALT, APTT and GGT were found.

Pattern and severity of transverse sinus stenosis in patients with pulsatile tinnitus associated with sigmoid sinus wall anomalies

2020 ◽  
Vol 130 (4) ◽  
pp. 1028-1033 ◽  
Author(s):  
Daniel Hewes ◽  
Robert Morales ◽  
Prashant Raghavan ◽  
David J. Eisenman
Keyword(s):  
Transverse Sinus ◽  
Sigmoid Sinus ◽  
Pulsatile Tinnitus ◽  
Sinus Wall ◽  
Sinus Stenosis

scholarly journals CT venography correlate of transverse sinus stenosis and venous transstenotic pressure gradient in unilateral pulsatile tinnitus patients with sigmoid sinus wall anomalies

2020 ◽  
Author(s):  
Pengfei Zhao ◽  
Heyu Ding ◽  
Han Lv ◽  
Xiaoshuai Li ◽  
Xiaoyu Qiu ◽  
...  
Keyword(s):  
Pressure Gradient ◽  
Transverse Sinus ◽  
Mean Value ◽  
Sigmoid Sinus ◽  
Pulsatile Tinnitus ◽  
Ct Venography ◽  
Sinus Wall ◽  
Key Points ◽  
Sinus Stenosis ◽  
Different Shapes

Abstract Objectives To investigate the correlation between transverse sinus stenosis (TSS) and transstenotic pressure gradient (TPG) in unilateral pulsatile tinnitus (PT) patients with sigmoid sinus wall anomalies (SSWA). Methods Fifty-seven patients with unilateral venous PT were retrospectively included. All of them underwent CT venography and catheter manometry, accompanied with SSWA. The degree, length, shape (intrinsic/extrinsic/dysplasia), location (proximal/middle/distal, referring to the relative position of TSS and the Labbé vein junction) of TSS, the types of SSWA (dehiscence/diverticulum), and the degree of transverse sinus outflow laterality were assessed, and the correlations with ipsilesional TPG were analyzed. Results The mean value of ipsilesional TPG was 7.61 ± 0.52 mmHg. The degree and length of ipsilesional TSS were positively correlated with TPG (p < 0.001, p’ < 0.001), respectively. TPG was significantly larger in patients with contralateral transverse sinus dysplasia than those without (p = 0.023) and significantly smaller in patients with ipsilesional sigmoid sinus diverticulum than those with isolated dehiscence (p = 0.001). No statistical difference in TPG was shown between ipsilesional TSSs of different shapes or locations (p > 0.05). No correlation was noted between the degree of ipsilesional transverse sinus outflow laterality and TPG (p = 0.051). Stepwise linear regression indicated that the degree (β = 9.207, 95% CI = 3.558–14.856), length (β = 0.122, 95% CI = 0.025–0.220) of ipsilesional TSS, and contralateral transverse sinus dysplasia (β = 1.875, 95% CI = 0.220–3.530) were significantly correlated with TPG (R2 = 0.471). Conclusions The degree, length of ipsilesional TSS, and contralateral transverse sinus dysplasia may be used to predict TPG in unilateral PT patients with SSWA. Key Points • CT venography may act as a screening tool to help low-probability unilateral pulsatile tinnitus (PT) patients with sigmoid sinus wall anomalies (SSWA) avoid invasive catheter manometry. • The degree and length of ipsilesional transverse sinus stenosis (TSS) are positively correlated with transtenotic pressure gradient (TPG) in unilateral PT patients with SSWA. • Ipsilesional TPG is larger in unilateral PT patients with contralateral transverse sinus dysplasia than those without and is smaller in unilateral PT patients with sigmoid sinus diverticulum than those with isolated dehiscence.

scholarly journals The Relationships Among Transverse Sinus Stenosis Measured by CT Venography, Venous Trans-stenotic Pressure Gradient and Intracranial Pressure in Patients With Unilateral Venous Pulsatile Tinnitus

2021 ◽  
Vol 15 ◽  
Author(s):  
Xiaoyu Qiu ◽  
Pengfei Zhao ◽  
Xiaoshuai Li ◽  
Heyu Ding ◽  
Han Lv ◽  
...  
Keyword(s):  
Intracranial Pressure ◽  
Pressure Gradient ◽  
Characteristic Curve ◽  
Transverse Sinus ◽  
Optimal Threshold ◽  
Pulsatile Tinnitus ◽  
Cross Sectional ◽  
Predictive Values ◽  
Non Invasive ◽  
Sinus Stenosis

ObjectivesTo assess a non-invasive means of predicting a venous trans-stenotic pressure gradient (TPG) and intracranial pressure (ICP) as opposed to invasive examinations in unilateral venous pulsatile tinnitus (PT) patients.MethodsThirty patients with unilateral venous PT who presented symptomatic-sided transverse sinus stenosis (TSS) on computed tomography venography (CTV), ipsilateral TPG measured by digital subtraction angiography (DSA) and cerebrospinal fluid (CSF) pressure measured by lumbar puncture were included. The ratio of TSS was calculated by dividing the cross-sectional areas of the maximal stenosed transverse sinus by that of the adjacent normal transverse sinus on CTV. The correlations among and predictive values of TSS, TPG, and ICP were analyzed.ResultsIn patients with unilateral venous PT, the symptomatic-sided and average bilateral TSS values were 78 ± 11 and 77 ± 9%; ICP, 230.50 ± 55.75 mmH2O; and the TPG, 9.51 ± 5.76 mmHg. The symptomatic-sided TSS was linearly and positively correlated with TPG (R2 = 0.400), and the symptomatic-sided and bilateral average TSS both showed weak correlations with ICP (R2 = 0.288, R′2 = 0.156). When the degree of TSS increased by 10%, the TPG and ICP increased by approximately 3.3 mmHg and 25.8 mmH2O, respectively. The receiver operating characteristic curve showed the optimal threshold of ipsilateral TSS for a positive TPG was 0.75, while TSS had no significant predictive value for ICP (p &gt; 0.05). TPG and ICP also exhibited a linear positive correlation (R2 = 0.552). When ICP increased by 10 mmH2O, the TPG increased by approximately 0.77 mmHg, and the optimal threshold of ICP for a positive TPG was 227.5.ConclusionTSS, TPG, and ICP are interrelated. TSS measured by CTV can predict TPG in patients with unilateral venous PT.

Study on the correlation between hemodynamic status of the transverse sinus-sigmoid sinus and the clinical efficacy of sigmoid sinus wall reconstruction

2021 ◽  
pp. 159101992110620
Author(s):  
Zhenfeng Li ◽  
Long Jin
Keyword(s):  
Blood Flow ◽  
Pressure Distribution ◽  
Flow Velocity ◽  
Clinical Efficacy ◽  
Blood Flow Velocity ◽  
Transverse Sinus ◽  
Sigmoid Sinus ◽  
Pulsatile Tinnitus ◽  
Sinus Wall ◽  
Sinus Stenosis

Background and Purpose For patients with pulsatile tinnitus who have both transverse sinus stenosis and sigmoid sinus wall anomalies, sigmoid sinus wall reconstruction surgery is the first-choice treatment when the trans-stenotic pressure gradient less than 10 mmHg. However, not all patients are cured by surgery. We hypothesized the abnormal hemodynamics caused by transverse sinus stenosis is associated with the clinical efficacy of surgery. Methods Eight pulsatile tinnitus patients treated with surgery were retrospectively reviewed (4 rehabilitated, 4 nonrehabilitated). All patients had radiologically diagnosed transverse sinus stenosis and sigmoid sinus wall anomalies. A numerical simulation of the hemodynamics of the transverse sinus-sigmoid sinus was performed using computational fluid dynamics technology. Changes in the blood flow patterns before and after surgery were observed. The blood flow velocity at the stenosis, vorticity of blood flow in the sigmoid sinus and wall pressure distribution in the sigmoid sinus wall anomalies area were compared. Results The blood flow velocity in the stenosis (preoperative P = 0.04, postoperative P = 0.004) and vorticity in the sigmoid sinus (preoperative P = 0.02, postoperative P = 0.007) pre- and post-surgery were significantly higher in the non-rehabilitation group than in the rehabilitation group. No significant difference was found in the wall pressure distribution in the sigmoid sinus wall anomalies area (preoperative P = 0.12, postoperative P = 0.24). Conclusions There is a clear correlation between the abnormal hemodynamic status caused by transverse sinus stenosis and the clinical efficacy of surgery. The blood flow velocity at the stenosis and vorticity of blood flow in the sigmoid sinus are factors influencing the clinical efficacy of surgery.

scholarly journals Individual deviations from normative models of brain structure in a large cross-sectional schizophrenia cohort

2020 ◽  
Author(s):  
Jinglei Lv ◽  
Maria Di Biase ◽  
Robin F. H. Cash ◽  
Luca Cocchi ◽  
Vanessa Cropley ◽  
...  
Keyword(s):  
White Matter ◽  
Brain Structure ◽  
Structural Mri ◽  
Healthy Individuals ◽  
Cross Sectional ◽  
White Matter Tracts ◽  
Schizophrenia Group ◽  
Brain Changes ◽  
Cortical Regions ◽  
Normative Models

AbstractBackgroundThe heterogeneity of schizophrenia has defied efforts to derive reproducible and definitive anatomical maps of structural brain changes associated with the disorder. We aimed to map deviations from normative ranges of brain structure for individual patients and evaluate whether the loci of individual deviations recapitulated group-average brain maps of schizophrenia pathology.MethodsFor each of 48 white matter tracts and 68 cortical regions, normative percentiles of variation in fractional anisotropy (FA) and cortical thickness (CT) were established using diffusion-weighted and structural MRI from healthy adults (n=195). Individuals with schizophrenia (n=322) were classified as either within the normative range for healthy individuals of the same age and sex (5-95% percentiles), infra-normal (<5% percentile) or supra-normal (>95% percentile). Repeating this classification for each tract and region yielded a deviation map for each individual.ResultsCompared to the healthy comparison group, the schizophrenia group showed widespread reductions in FA and CT, involving virtually all white matter tracts and cortical regions. Paradoxically, however, no more than 15-20% of patients deviated from the normative range for any single tract or region, whereas 79% of patients showed infra-normal deviations for at least one locus (healthy individuals: 59±2%, p<0.001). Higher polygenic risk for schizophrenia associated with a greater number of regions with infra-normal deviations in CT (r=-0.17, p=0.006).ConclusionsAnatomical loci of schizophrenia-related changes are highly heterogeneous across individuals to the extent that group-consensus pathological maps are not representative of most individual patients. Normative modeling can aid in parsing schizophrenia heterogeneity and guiding personalized interventions.

The traits of the behavior of sled dogs depending on their origin

2021 ◽  
pp. 43-51
Author(s):  
N. M. Kostomakhin ◽  
A. V. Dikov
Keyword(s):  
Average Degree ◽  
Lower Score ◽  
Defensive Reaction ◽  
Behavioral Trait ◽  
Sled Dogs ◽  
Low Degree ◽  
Significant Difference ◽  
Complex Relationships ◽  
High Degree ◽  
Sports Type

A dog is a unique animal, capable of complex relationships not only with its relatives, but also with a man. Impulsivity is a behavioral trait described as the inability to postpone behavior in the presence of significant signals. The purpose of the work was to study the traits of the behavior of sled dogs depending on their origin. The studies have been carried out on dogs of the breeds of Siberian and Alaskan husky. The animals have been divided into groups: the 1st group Siberian husky (show type); the 2nd group – Siberian husky (sports type); the 3rd group – Alaskan husky. It has been found that Siberian husky of the show type and the Siberian husky of the sports type were indifferent to the shot (4,6 points). Alaskan husky dogs received a significantly lower score of 3,5 points (P > 0,95). According to the degree of excitability, the ratio of animal ratings in the studied groups was distributed as follows; the dogs of the 3rd group had the high degree of excitability, which received 2,8±0,09 points out of 3 possible points. Significantly lower scores of 2,0 and 2,2 were awarded to individuals of the 1st and 2nd groups (Siberian husky of show and sports types) with the significant difference of P > 0,999 and P > 0,95, respectively, in relation to animals of the 3rd group (Alaskan husky). For the 1st and 2nd groups of dogs, the average degree of excitability was more characteristic. While in the 3rd group there were no dogs with the low degree of excitability. The dogs of Siberian husky show-type did not show fear and fright towards a man. In the dogs of Siberian husky show type, the passive-defensive reaction was not expressed.

Effect of eccentricity of overnight lenses on 2-year axial growth and visual quality

2021 ◽  
Vol 2 (4) ◽  
pp. 223-227
Author(s):  
Zi-Yang Chen ◽  
◽  
Ye Zhang ◽  
Yan-Hong Hu ◽  
◽  
...  
Keyword(s):  
Visual Quality ◽  
Lens Position ◽  
Low Degree ◽  
Significant Difference ◽  
Uncorrected Visual Acuity ◽  
Before And After ◽  
The Mean ◽  
The Difference ◽  
High Degree ◽  
Axial Growth

AIM: To explore the effect of eccentricity of overnight orthokeratology (OK) lenses on 2-year eye axial growth and visual quality. METHODS: Based on the degree of eccentricity of OK lenses, patients were divided into three groups: a low degree of eccentricity group (degree of eccentricity ≤0.5 mm), a group of moderate eccentricity (eccentric degree >0.5-1.0 mm) and a group with a high degree of eccentricity (eccentric degree >1-1.5 mm). The degree of eccentricity of the OK lens, spherical equivalent (SE), the uncorrected visual acuity (UCVA) after wearing OK lenses, axial length (AL) before and after wearing OK lenses, total higher-order aberrations (HOA), comas, and spherical aberrations (SA) for 3 mm pupils were analyzed. The difference among the three groups for all parameters was compared using the Kruskal-Wallis H Rank-Sum test. RESULTS: The study retrospectively analyzed 75 cases (139 eyes). In the low eccentricity group (53 eyes), the mean age was 11.4±2.4y, SE was -3.24±1.48 D, and AL was 24.85±1.01 mm. In the moderate eccentricity group (53 eyes), the mean age was 11.4±2.2y, SE was -3.22±1.29 D, and AL was 25.15±0.92 mm. In the high eccentricity group (31 eyes), the mean age was 11.5±1.9y, SE was -3.54±1.43 D, and AL was 24.95±0.84mm. After two years, there was no significant difference in the changes of the axis among the three groups (P=0.089). The HOA, SA, and coma in the high eccentric group were significantly higher than in the middle eccentric group (P<0.05). The HOA, SA, and coma in the high eccentric group were also significantly higher than those in the low eccentric group (P<0.05). CONCLUSION: For OK lenses, it is unnecessary to strictly require the absolute centralization of the lens position. An unnecessary change of the lenses may delay the eye-axis control. However, the balance between axial control and visual quality should be assessed.

scholarly journals Bone remodeling in sigmoid sinus diverticulum after stenting for transverse sinus stenosis in pulsatile tinnitus: A case report

2021 ◽  
Vol 9 (10) ◽  
pp. 2320-2325
Author(s):  
Xiao-Yu Qiu ◽  
Peng-Fei Zhao ◽  
He-Yu Ding ◽  
Xiao-Shuai Li ◽  
Han Lv ◽  
...  
Keyword(s):  
Case Report ◽  
Bone Remodeling ◽  
Transverse Sinus ◽  
Sigmoid Sinus ◽  
Pulsatile Tinnitus ◽  
Sinus Stenosis

scholarly journals Relation Between Degree of Anger and Gender - A Case Study

2019 ◽  
pp. 401-407
Author(s):  
Sankara Pitchaiah Podila
Keyword(s):  
Cognitive Control ◽  
Andhra Pradesh ◽  
Statistical Tools ◽  
Government Schools ◽  
Healthy Human ◽  
Low Degree ◽  
Significant Difference ◽  
And Gender ◽  
High Degree

Usually, anger is a normal, healthy human emotion. Anger, impairs one's ability to process information and to exert cognitive control over their behavior. The response was taken from 2743 students (male:1589) and female (1154) Government schools of Guntur, Andhra Pradesh, India. The students were asked to respond for a question “Are you getting anger frequently/sometimes/ never. Statistical tools were used to analyze the data. Under high degree anger the recorded highest percentage was 38.83 for males (SJRR school) and 28.64 for females (SK school). In the case of low degree the percentages are 18.75 and 18.06. The study found that there is a significant difference between the degree of anger and gender, i.e., high percent of males had high degree, compared to female. As the anger has Influence on health and career, parents shall arrange the counseling for their children to manage the anger.

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