scholarly journals Zinc Finger Proteins in Neuro-Related Diseases Progression

2021 ◽  
Vol 15 ◽  
Author(s):  
Siyuan Bu ◽  
Yihan Lv ◽  
Yusheng Liu ◽  
Sen Qiao ◽  
Hongmei Wang
Keyword(s):  
Zinc Finger ◽  
Neurological Diseases ◽  
Zinc Finger Proteins ◽  
Regulate Gene Expression ◽  
Pathophysiological Role ◽  
Zinc Finger Domains ◽  
Eukaryotic Genomes ◽  
Regulate Gene

Zinc finger proteins (ZNF) are among the most abundant proteins in eukaryotic genomes. It contains several zinc finger domains that can selectively bind to certain DNA or RNA and associate with proteins, therefore, ZNF can regulate gene expression at the transcriptional and translational levels. In terms of neurological diseases, numerous studies have shown that many ZNF are associated with neurological diseases. The purpose of this review is to summarize the types and roles of ZNF in neuropsychiatric disorders. We will describe the structure and classification of ZNF, then focus on the pathophysiological role of ZNF in neuro-related diseases and summarize the mechanism of action of ZNF in neuro-related diseases.

scholarly journals Zinc Finger Proteins in the Human Fungal Pathogen Cryptococcus neoformans

2020 ◽  
Vol 21 (4) ◽  
pp. 1361
Author(s):  
Yuan-Hong Li ◽  
Tong-Bao Liu
Keyword(s):  
Cryptococcus Neoformans ◽  
Zinc Finger ◽  
Fungal Pathogen ◽  
Ion Homeostasis ◽  
Zinc Finger Proteins ◽  
Morphological Development ◽  
Human Fungal Pathogen ◽  
Essential Trace Elements

Zinc is one of the essential trace elements in eukaryotes and it is a critical structural component of a large number of proteins. Zinc finger proteins (ZNFs) are zinc-finger domain-containing proteins stabilized by bound zinc ions and they form the most abundant proteins, serving extraordinarily diverse biological functions. In recent years, many ZNFs have been identified and characterized in the human fungal pathogen Cryptococcus neoformans, a fungal pathogen causing fatal meningitis mainly in immunocompromised individuals. It has been shown that ZNFs play important roles in the morphological development, differentiation, and virulence of C. neoformans. In this review, we, first, briefly introduce the ZNFs and their classification. Then, we explain the identification and classification of the ZNFs in C. neoformans. Next, we focus on the biological role of the ZNFs functionally characterized so far in the sexual reproduction, virulence factor production, ion homeostasis, pathogenesis, and stress resistance in C. neoformans. We also discuss the perspectives on future function studies of ZNFs in C. neoformans.

scholarly journals Erratum: Proprietary science, open science and the role of patent disclosure: the case of zinc-finger proteins

2009 ◽  
Vol 27 (5) ◽  
pp. 485-485
Author(s):  
Subhashini Chandrasekharan ◽  
Sapna Kumar ◽  
Cory M Valley ◽  
Arti Rai
Keyword(s):  
Zinc Finger ◽  
Zinc Finger Proteins ◽  
Open Science

Biopsychosocial pathways to mental health and disease across the lifespan: The emerging role of epigenetics

2020 ◽  
pp. 190-206
Author(s):  
Charlotte A.M. Cecil
Keyword(s):  
Gene Expression ◽  
Mental Health ◽  
Dna Methylation ◽  
Mental Illness ◽  
Psychiatric Disorders ◽  
Regulate Gene Expression ◽  
Health And Disease ◽  
Regulate Gene ◽  
Epigenetic Processes

The biopsychosocial (BPS) model of psychiatry has had a major impact on our modern conceptualization of mental illness as a complex, multi-determined phenomenon. Yet, interdisciplinary BPS work remains the exception, rather than the rule in psychiatry. It has been suggested that this may stem in part from a failure of the BPS model to clearly delineate the mechanisms through which biological, psychological, and social factors co-act in the development of mental illness. This chapter discusses how epigenetic processes that regulate gene expression, such as DNA methylation, are fast emerging as a candidate mechanism for BPS interactions, with potentially widespread implications for the way that psychiatric disorders are understood, assessed, and, perhaps in future, even treated.

scholarly journals Polyamines regulate gene expression by stimulating translation of histone acetyltransferase mRNAs

2020 ◽  
Vol 295 (26) ◽  
pp. 8736-8745 ◽  
Author(s):  
Akihiko Sakamoto ◽  
Yusuke Terui ◽  
Takeshi Uemura ◽  
Kazuei Igarashi ◽  
Keiko Kashiwagi
Keyword(s):  
Gene Expression ◽  
Regulation Of Gene Expression ◽  
Histone Acetyltransferases ◽  
Regulate Gene Expression ◽  
Double Stranded Rna ◽  
Protein Levels ◽  
Lysine Residues ◽  
Regulate Gene ◽  
Stimulation Of

Polyamines regulate gene expression in Escherichia coli by translationally stimulating mRNAs encoding global transcription factors. In this study, we focused on histone acetylation, one of the mechanisms of epigenetic regulation of gene expression, to attempt to clarify the role of polyamines in the regulation of gene expression in eukaryotes. We found that activities of histone acetyltransferases in both the nucleus and cytoplasm decreased significantly in polyamine-reduced mouse mammary carcinoma FM3A cells. Although protein levels of histones H3 and H4 did not change in control and polyamine-reduced cells, acetylation of histones H3 and H4 was greatly decreased in the polyamine-reduced cells. Next, we used control and polyamine-reduced cells to identify histone acetyltransferases whose synthesis is stimulated by polyamines. We found that polyamines stimulate the translation of histone acetyltransferases GCN5 and HAT1. Accordingly, GCN5- and HAT1-catalyzed acetylation of specific lysine residues on histones H3 and H4 was stimulated by polyamines. Consistent with these findings, transcription of genes required for cell proliferation was enhanced by polyamines. These results indicate that polyamines regulate gene expression by enhancing the expression of the histone acetyltransferases GCN5 and HAT1 at the level of translation. Mechanistically, polyamines enhanced the interaction of microRNA-7648-5p (miR-7648-5p) with the 5′-UTR of GCN5 mRNA, resulting in stimulation of translation due to the destabilization of the double-stranded RNA (dsRNA) between the 5′-UTR and the ORF of GCN5 mRNA. Because HAT1 mRNA has a short 5′-UTR, polyamines may enhance initiation complex formation directly on this mRNA.

Abscisic acid and stress regulate gene expression during germination of chick-pea seeds. Possible role of calcium

1994 ◽  
Vol 91 (3) ◽  
pp. 461-467 ◽  
Author(s):  
Pilar Colorado ◽  
Antonio Rodriguez ◽  
Gregorio Nicolas ◽  
Dolores Rodriguez
Keyword(s):  
Gene Expression ◽  
Abscisic Acid ◽  
Regulate Gene Expression ◽  
Chick Pea ◽  
Pea Seeds ◽  
Regulate Gene

scholarly journals Activation of a Mitogen-Activated Protein Kinase Hog1 by DNA Damaging Agent Methyl Methanesulfonate in Yeast

2020 ◽  
Vol 7 ◽  
Author(s):  
Shan Huang ◽  
David Zhang ◽  
Fangli Weng ◽  
Yuqi Wang
Keyword(s):  
Protein Kinase ◽  
Cellular Responses ◽  
Mitogen Activated Protein Kinase ◽  
Yeast Cells ◽  
Methyl Methanesulfonate ◽  
Regulate Gene Expression ◽  
Dna Damaging Agents ◽  
Mitogen Activated Protein ◽  
Regulate Gene

Hog1 is a mitogen-activated protein kinase in yeast that primarily regulates cellular responses to hyperosmolarity stress. In this study, we have examined the potential involvement of Hog1 in mediating cellular responses to DNA damaging agents. We find that treatment of yeast cells with DNA damaging agent methyl methanesulfonate (MMS) induces a marked and prolonged Hog1 activation. Distinct from stressors such as arsenite that activates Hog1 via inhibiting its phosphatases, activation of Hog1 by MMS is phosphatase-independent. Instead, MMS impairs a critical phosphor-relay process that normally keeps Hog1 in an inactive state. Functionally, MMS-activated Hog1 is not translocated to the nucleus to regulate gene expression but rather stays in the cytoplasm and regulates MMS-induced autophagy and cell adaptation to MMS stress. These findings reveal a new role of Hog1 in regulating MMS-induced cellular stress.

scholarly journals The role of ZFP57 and additional KRAB-zinc finger proteins in the maintenance of human imprinted methylation and multi-locus imprinting disturbances

2020 ◽  
Vol 48 (20) ◽  
pp. 11394-11407
Author(s):  
Ana Monteagudo-Sánchez ◽  
Jose Ramon Hernandez Mora ◽  
Carlos Simon ◽  
Adam Burton ◽  
Jair Tenorio ◽  
...  
Keyword(s):  
Zinc Finger ◽  
Expression Profiling ◽  
Zinc Finger Proteins ◽  
Early Embryogenesis ◽  
Mouse Embryos ◽  
Parental Origin ◽  
Embryonic Genome ◽  
Repressor Complex ◽  
Genome Activation

Abstract Genomic imprinting is an epigenetic process regulated by germline-derived DNA methylation that is resistant to embryonic reprogramming, resulting in parental origin-specific monoallelic gene expression. A subset of individuals affected by imprinting disorders (IDs) displays multi-locus imprinting disturbances (MLID), which may result from aberrant establishment of imprinted differentially methylated regions (DMRs) in gametes or their maintenance in early embryogenesis. Here we investigated the extent of MLID in a family harbouring a ZFP57 truncating variant and characterize the interactions between human ZFP57 and the KAP1 co-repressor complex. By ectopically targeting ZFP57 to reprogrammed loci in mouse embryos using a dCas9 approach, we confirm that ZFP57 recruitment is sufficient to protect oocyte-derived methylation from reprogramming. Expression profiling in human pre-implantation embryos and oocytes reveals that unlike in mice, ZFP57 is only expressed following embryonic-genome activation, implying that other KRAB-zinc finger proteins (KZNFs) recruit KAP1 prior to blastocyst formation. Furthermore, we uncover ZNF202 and ZNF445 as additional KZNFs likely to recruit KAP1 to imprinted loci during reprogramming in the absence of ZFP57. Together, these data confirm the perplexing link between KZFPs and imprint maintenance and highlight the differences between mouse and humans in this respect.

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