Association of Prenatal Famine Exposure With Inflammatory Markers and Its Impact on Adulthood Liver Function Across Consecutive Generations

Although there has been increasing recognition that famine exposure in the fetal stage damages liver function in adulthood, this deteriorated effect could be extended to the next generation remains vague. This study aimed to explore whether famine exposure was associated with liver function in the two consecutive generations, and its association with the mediation role of inflammatory markers. We analyzed the data of 2,681 participants from Suihua rural area, Heilongjiang Province, China. According to the date of birth, the participants were classified as fetal exposed and nonexposed. The F2 subjects were classified as having no parents exposed to famine, maternal famine exposure, paternal famine exposure, or parental famine exposure. In the mixed-effect models, prenatal exposure to famine was associated with the elevation of Δ aspartate aminotransferase (ΔAST) (β: 0.22, 95% CI: 0.01, 0.43) and Δ alanine aminotransferase (ΔALT) (β: 0.42, 95% CI: 0.19, 0.66) levels in F1 adults. The mediation analysis showed that the inflammatory markers including serum C-reactive protein (CRP) and tumor necrosis factor-alpha (TNF-α) might mediate the famine-liver function association. This longitudinal data were consistent with the hypothesis that the inflammatory markers explained part of the influence of prenatal famine exposure on liver function injury, and the natal mechanism was needed to be elucidated in the future study.

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Effect of Clarithromycin on Inflammatory Markers in Patients with Atherosclerosis

Clinical and Diagnostic Laboratory Immunology ◽

10.1128/cdli.10.4.525-528.2003 ◽

2003 ◽

Vol 10 (4) ◽

pp. 525-528 ◽

Cited By ~ 8

Author(s):

Hans F. Berg ◽

Boulos Maraha ◽

Gert-Jan Scheffer ◽

Marcel F. Peeters ◽

Jan A. J. W. Kluytmans

Keyword(s):

Inflammatory Markers ◽

Interleukin 2 ◽

Patient Characteristics ◽

Double Blind Study ◽

Double Blind ◽

Necrosis Factor Alpha ◽

Treatment Groups ◽

Reactive Protein ◽

Factor Alpha ◽

Artery Disease

ABSTRACT Atherosclerosis can to a certain extent be regarded as an inflammatory disease. Also, inflammatory markers may provide information about cardiovascular risk. Whether macrolide antibiotics, especially clarithromycin, have an anti-inflammatory effect in patients with atherosclerosis is not exactly known. To study this phenomenon, a placebo-controlled, randomized, double-blind study was performed. A total of 231 patients with documented coronary artery disease received a daily dose of either 500 mg of slow-release clarithromycin or placebo until the day of surgery. Levels of inflammatory markers (C-reactive protein, interleukin-2 receptor [IL-2R], IL-6, IL-8, and tumor necrosis factor alpha) were assessed during the preoperative outpatient visit, on the day of surgery, and 8 weeks after surgery. Also, changes in the levels of inflammatory markers between visits were determined by delta calculations. Baseline patient characteristics were balanced between the two treatment groups: the average age was 66 years (standard deviation [SD] = 9.0), 79% of the patients were male, and the average number of tablets used was 16 (SD = 9.3). The inflammatory markers of the groups as well as the delta calculations were not significantly changed. Treatment with clarithromycin did not influence the inflammatory markers in patients with atherosclerosis.

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THE EFFECT OF ATORVASTATINUM IN THE TREATMENT OF PATIENTS WITH RHEUMATOID ARTHRITIS

Wiadomości Lekarskie ◽

10.36740/wlek202011117 ◽

2020 ◽

Vol 73 (11) ◽

pp. 2427-2430

Author(s):

Sergii V. Shevchuk ◽

Yuliia S. Seheda ◽

Inna P. Kuvikova ◽

Olena V. Shevchuk ◽

Olena Y. Galiutina

Keyword(s):

Inflammatory Process ◽

Necrosis Factor Alpha ◽

Traditional Treatment ◽

Reactive Protein ◽

Tnf Α ◽

Endothelium Function ◽

Factor Alpha ◽

Inflammatory Drugs ◽

Serum Paraoxonase ◽

Necrosis Factor

The aim: Was to evaluate the effect of 6-month pathogenetic treatment in combination with atorvastatinum on the endothelium function, lipid and adipokine levels, paroxonase activity and activity of inflammatory process in RA patients. Materials and methods: The study included 55 patients with RA, dividing into two groups depending on the intended therapy. The first group included 33 patients with “traditional” treatment by methotrexate, glucocorticoids, and non-steroid anti-inflammatory drugs. The second group included 22 patients with “traditional” treatment and additionally prescribed of atorvastatinum 20 mg/day. The lipid profile, leptin, adipokine, paroxonase activity. C-reactive protein (CRP) and tumor necrosis factor-alpha (TNF-α) levels, FMDBA and IMT of carotid artery were determined in all participants of the study. Control parameters were recorded before the start, after 1 and 6 months of treatment. Results: The FMDBA has increased by 32% in the second group, compared by only 10.9% in the first group. The dynamics of IMT in the first group was also twice lower than in group with the additional use of atorvastatinum. The leptin levels in the second group significantly decreased by 27% and adiponectin levels increased by 12.8%, than in the first group – by 12.8% and by 7% respectively. The appointment of statins over 6 months resulted in DAS28, TNF-α, ESR and CRP reduction by 15%, 31%, 25% and 21.5% respectively. In the first group the dynamics of indicate rates ranged from 7.8% to 22.5%, and was significantly lower than in the second group. Conclusions: As a result of the study, it was found that the appointment of atorvastatinum 20 mg/day during 6 months not only reduces dyslipidemia, but also significantly reduces the inflammatory process and adipokine dysregulation, normalizes serum paraoxonase activity and improves the endothelium function.

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Inflammation, nutritional status, PUFA profile and outcome in hemodialysis patients

Archives of Biological Sciences ◽

10.2298/abs1203173p ◽

2012 ◽

Vol 64 (3) ◽

pp. 1173-1180 ◽

Cited By ~ 3

Author(s):

Gordana Perunicic-Pekovic ◽

Zorica Rasic-Milutinovic ◽

Z. Gluvic ◽

Milena Lackovic ◽

Danijela Ristic-Medic ◽

...

Keyword(s):

Risk Factors ◽

Nutritional Status ◽

Inflammatory Markers ◽

Albumin Level ◽

Necrosis Factor Alpha ◽

Reactive Protein ◽

Cell Functions ◽

Factor Alpha ◽

Stage Renal Disease ◽

End Stage

Patients with end-stage renal disease (ESRD) include a significant percentage of malnourished patients with other risk factors: dyslipoproteinemia, insulin resistance, increased oxidative stress and inflammation that together impair endothelial function. Abnormal polyunsaturated fatty acids (PUFA) patterns are reported in patients with ESRD. The basic mechanisms of these disorders are connected with changes in cell functions at the membrane level. Vascular smooth muscle cell proliferation plays an important role in the pathogenesis of atherosclerosis. We have examined the association between atherosclerotic risk factors and nutritional status in hemodialysis (HD) patients. Mortality was followed for up to 18 month. Forty-three HD patients were examined (20 males, 23 females, ages 55?12 years). Nutritional and inflammatory markers, including serum concentrations of C-reactive protein (CRP), tumor necrosis factor alpha (TNF-alpha), and interleukin 6 (IL-6), were measured. There was significant positive correlation between the plasma albumin level and CRP. Significant correlation was found between plasma the cholesterol level and some PUFA. Increasing inflammation and endothelial dysfunction predict the development of vascular disease. We report on the relationship between inflammatory markers and nutritional parameter, indices of atherosclerosis and other cardiovascular risk factors in patients on hemodialysis.

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Delanzomib, a Novel Proteasome Inhibitor, Combined With Adalimumab Drastically Ameliorates Collagen-Induced Arthritis in Rats by Improving and Prolonging the Anti-TNF-α Effect of Adalimumab

Frontiers in Pharmacology ◽

10.3389/fphar.2021.782385 ◽

2021 ◽

Vol 12 ◽

Author(s):

Lei Wang ◽

Lixiong Liu ◽

Xiaoping Hong ◽

Dongzhou Liu ◽

Zeneng Cheng

Keyword(s):

Proteasome Inhibitor ◽

Proteasome Inhibitors ◽

Collagen Induced Arthritis ◽

Initial Finding ◽

Necrosis Factor Alpha ◽

Reactive Protein ◽

Tnf Α ◽

Factor Alpha ◽

Α Level

Delanzomib is a novel proteasome inhibitor initially developed for treating multiple myeloma. It was found to inhibit the expression of tumor necrosis factor alpha (TNF-α). This study aimed to investigate the ameliorating effect of delanzomib on collagen-induced arthritis (CIA) and to explore the pharmacodynamics and pharmacokinetics (PK) interactions between delanzomib and adalimumab. Rats with CIA were randomly assigned to receive the treatment with delanzomib, adalimumab, delanzomib combined with adalimumab, or placebo. Visual inspection and biochemical examinations including TNF-α, interleukin 6, and C-reactive protein were performed to assess arthritis severity during the treatment. The adalimumab concentration in rats was determined to evaluate the PK interaction between delanzomib and adalimumab. Also, the levels of neonatal Fc receptor (FcRn) and FcRn mRNA were measured to explore the role of FcRn in the PK interaction between delanzomib and adalimumab. As a result, delanzomib combined with adalimumab exhibited stronger anti-arthritis activity than a single drug because both drugs synergistically reduced TNF-α level in vivo. Delanzomib also decreased adalimumab elimination in rats by increasing the level of FcRn. The slower elimination of adalimumab in rats further prolonged the anti-TNF-α effect of adalimumab. Moreover, FcRn level was increased by delanzomib via suppressing FcRn degradation rather than promoting FcRn production. In conclusion, delanzomib combined with adalimumab may be a potential therapeutic approach for treating rheumatoid arthritis. The initial finding that the PK interaction occurred between delanzomib and adalimumab may have clinical relevance for patients who simultaneously take proteasome inhibitors and anti-TNF-α therapeutic proteins.

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Cardiorenal Syndrome in Hypertensive Rats: Microalbuminuria, Inflammation and Ventricular Hypertrophy

Physiological Research ◽

10.33549/physiolres.932146 ◽

2012 ◽

pp. 13-24 ◽

Cited By ~ 14

Author(s):

M. MOUBARAK ◽

H. JABBOUR ◽

V. SMAYRA ◽

E. CHOUERY ◽

Y. SALIBA ◽

...

Keyword(s):

Ventricular Hypertrophy ◽

Cardiorenal Syndrome ◽

Left Ventricular ◽

Low Grade ◽

Necrosis Factor Alpha ◽

Reactive Protein ◽

Tnf Α ◽

Male Wistar Rats ◽

Factor Alpha ◽

Low Grade Inflammation

The aim of our study was to evaluate a possible association between microalbuminuria (MA), several low-grade inflammation factors and left ventricular hypertrophy (LVH) by using a pharmacological approach. This may provide new insights into the pathophysiologic mechanisms of the cardiorenal syndrome (CRS) linking early renal impairment with elevated cardiovascular risk. Two kidney-one clip (2K-1C) renovascular hypertension was induced in 24 male Wistar rats (220-250 g). After the development of hypertension, rats were divided into four groups: 2K-1C (untreated), calcium channel blocker (amlodipine-treated), angiotensin receptor blocker (losartan-treated) and peripheral vasodilator (hydralazine-treated), which were treated for 10 weeks. Rats in the 2K-1C group had all developed hypertension, a significant increase in plasma levels of tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), brain natriuretic peptide (BNP) and C-reactive protein (CRP). Moreover MA and creatininaemia underwent a significant increase. Under treatment decreases were observed in systolic blood pressure (SBP), TNF-α, CRP, IL-6, BNP concentrations and creatininaemia. These results were related to the absence of MA which was significantly associated with reductions in cardiac mass and hypertrophy markers (BNP and β-MHC gene expression) as well as renal interstitial inflammation. In conclusion, our results suggest that the reduction of MA is correlated with the decrease of the inflammatory components and seems to play an important role in protecting against cardiac hypertrophy and renal injury.

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Curcumin Alleviates Potassium Bromate-Induced Hepatic Damage by Repressing CRP Induction through TNF-α and IL-1β and by Suppressing Oxidative Stress

Notulae Scientia Biologicae ◽

10.15835/nsb11410552 ◽

2019 ◽

Vol 11 (4) ◽

pp. 337-344 ◽

Cited By ~ 1

Author(s):

Omowumi O. ADEWALE ◽

Seun F. AKOMOLAFE ◽

Nnaemeka T. ASOGWA

Keyword(s):

Enzyme Linked Immunosorbent Assay ◽

Necrosis Factor Alpha ◽

Reactive Protein ◽

Tnf Α ◽

Serum Transaminases ◽

Factor Alpha ◽

Inflammatory Proteins ◽

Biochemical Mechanisms ◽

Molecular And Biochemical Mechanisms ◽

Necrosis Factor

This study evaluated the prospective molecular and biochemical mechanisms behind the hepatoprotective effects of curcumin in Wistar rats exposed to KBrO3. Techniques for assessment of hepatic oxidative injury and histological biomarkers were used. The concentrations of proteins connected with inflammation (e.g. tumor necrosis factor-alpha (TNF-α), interleukins 1β (IL-1β) and C-reactive protein (CRP)) were estimated by enzyme-linked immunosorbent assay (ELISA) techniques. Results showed that, curcumin administered orally at a dose of 20 mg/kg for 28 days significantly suppressed the activities of serum transaminases and alkaline induced by KBrO3 administration (20 mg/kg, twice weekly) and protected the integrity of the liver tissue. Also, curcumin at the tested dose abridged the KBrO3-induced increase in hepatic malondialdehyde (MDA) levels and reversed KBrO3 mediated reduction in activities of hepatic antioxidant molecules including reduced glutathione (GSH), total thiol (TSH), glutathione peroxidase (GPx), catalase and superoxide dismutase (SOD). In addition, curcumin significantly assuaged inflammatory response in KBrO3-lesioned liver as revealed by the decrease in inflammatory biomarkers. This study suggests that curcumin exhibits a protective effect via induction of hepatic detoxification proteins and inhibition of inflammatory proteins in addition to its antioxidative ability in KBrO3- induced hepatic injury in rats.

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The effects of peritoneal dialysis and hemodialysis on serum tumor necrosis factor-alpha, interleukin-6, interleukin-10 and C-reactive-protein levels

Mediators of Inflammation ◽

10.1080/09511920410001713493 ◽

2004 ◽

Vol 13 (3) ◽

pp. 201-204 ◽

Cited By ~ 29

Author(s):

Ali Borazan ◽

Hasan Ustün ◽

Yucel Ustundag ◽

Selim Aydemir ◽

Taner Bayraktaroglu ◽

...

Keyword(s):

Tumor Necrosis ◽

Serum Levels ◽

C Reactive Protein ◽

Necrosis Factor Alpha ◽

Reactive Protein ◽

The Third ◽

Tnf Α ◽

Factor Alpha ◽

Necrosis Factor ◽

Healthy Persons

BACKGROUND: Markers of an acute phase reaction, such as C-reactive protein (CRP) or tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-6, are predictive for cardiovascular morbidity and mortality in normal subjects and in chronic renal failure patients. In this study, we aimed to investigate serum TNF-α, IL-6, IL-10 and CRP levels in continuous ambulatory peritoneal dialysis (CAPD) and hemodialysis (HD) patients.Materials and methods: Serum levels of TNF-α, IL-6, IL-10 and CRP levels were measured in 30 patients who were just diagnosed with end-stage renal failure and treated, with 16 CAPD (nine female, seven male) and 14 HD (eight female, six male) patients, before CAPD or HD treatment and after 3 months from the beginning of CAPD or HD in patients with no clinical signs of infection. The control groups were 20 healthy persons of similar age and sex. Serum levels of TNF-α, IL-6, IL-10 and CRP were measured by enzyme-linked immunosorbent assay in stable CAPD and HD patients and in healthy persons.Results: The mean serum levels of TNF-α, IL-6, IL-10 and CRP showed no significant differences between the CAPD and HD patients for the beginning values and the third month of treatment. However, serum TNF-α, IL-6, IL-10 and CRP levels were higher than the control group in the CAPD and HD patients regarding the beginning values and the third month of treatment (p<0.001).Conclusions: CAPD and HD of the renal replacement therapy have no effects on serum CRP and cytokines.

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The Impact of a Plant-Based Diet on Gestational Diabetes: A Review

Antioxidants ◽

10.3390/antiox10040557 ◽

2021 ◽

Vol 10 (4) ◽

pp. 557

Author(s):

Antonio Schiattarella ◽

Mauro Lombardo ◽

Maddalena Morlando ◽

Gianluca Rizzo

Keyword(s):

Gestational Diabetes ◽

Antioxidant Compounds ◽

Intrauterine Death ◽

Necrosis Factor Alpha ◽

Endothelium Dysfunction ◽

Reactive Protein ◽

Tnf Α ◽

Factor Alpha ◽

Cesarean Delivery Rate ◽

The Impact

Gestational diabetes mellitus (GDM) represents a challenging pregnancy complication in which women present a state of glucose intolerance. GDM has been associated with various obstetric complications, such as polyhydramnios, preterm delivery, and increased cesarean delivery rate. Moreover, the fetus could suffer from congenital malformation, macrosomia, neonatal respiratory distress syndrome, and intrauterine death. It has been speculated that inflammatory markers such as tumor necrosis factor-alpha (TNF-α), interleukin (IL) 6, and C-reactive protein (CRP) impact on endothelium dysfunction and insulin resistance and contribute to the pathogenesis of GDM. Nutritional patterns enriched with plant-derived foods, such as a low glycemic or Mediterranean diet, might favorably impact on the incidence of GDM. A high intake of vegetables, fibers, and fruits seems to decrease inflammation by enhancing antioxidant compounds. This aspect contributes to improving insulin efficacy and metabolic control and could provide maternal and neonatal health benefits. Our review aims to deepen the understanding of the impact of a plant-based diet on oxidative stress in GDM.

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The Potential Role of Korean Mistletoe Extract as an Anti-Inflammatory Supplementation

Journal of Immunology Research ◽

10.1155/2021/2183427 ◽

2021 ◽

Vol 2021 ◽

pp. 1-10

Author(s):

Soo-Min Ha ◽

Ji-Hyeon Kim ◽

Jong-Won Kim ◽

Do-Yeon Kim ◽

Min-Seong Ha

Keyword(s):

High Strength ◽

Necrosis Factor Alpha ◽

Mistletoe Extract ◽

Korean Mistletoe ◽

Reactive Protein ◽

Tnf Α ◽

Cytokine Levels ◽

Factor Alpha ◽

Anti Inflammatory ◽

Exercise Induced

Korean mistletoe has anti-inflammatory and antioxidant functions and may be a useful training supplement. We investigated the effect of Korean mistletoe extract (KME) on inflammatory markers after high-intensity exercise by 20 university male rowers (KME group vs. CON group) consuming 110 mL KME/dose (2 times a day over 8 weeks). Blood samples were collected for measurement of serum cytokine levels at baseline, immediately after exercise, and following 30 minutes of recovery. Interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and C-reactive protein (CRP) were used as markers for inflammation. After supplementation, IL-6 and TNF-α levels were significantly lowered in the KME group than in the CON group at baseline, immediately after exercise, and following 30 minutes of recovery. KME can reduce high-strength exercise-induced increases in the levels of serum inflammatory cytokines in active individuals and improve anti-inflammatory functions.

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The use of inflammatory markers as a diagnostic and prognostic approach in neonatal calves with septicaemia

Acta Veterinaria Hungarica ◽

10.1556/004.2019.037 ◽

2019 ◽

Vol 67 (3) ◽

pp. 360-376

Author(s):

Akın Kirbas ◽

Fatih Mehmet Kandemir ◽

Demet Celebi ◽

Basak Hanedan ◽

Mehmet Ozkan Timurkan

Keyword(s):

Blood Cell ◽

Inflammatory Markers ◽

Necrosis Factor Alpha ◽

E Coli ◽

Diagnosis And Prognosis ◽

Tnf Α ◽

Faecal Samples ◽

Factor Alpha ◽

Neonatal Calves ◽

Biochemical Analyses

The objective of this study was to evaluate the usefulness of inflammatory markers as a diagnostic and prognostic approach in neonatal calves with septicaemia. The study material consisted of 13 neonatal calves with septicaemia (septicaemic calves, SC) and ten healthy neonatal calves (control calves, CC). Blood samples were collected for biochemical, haematological and microbiological analyses. In addition, faecal samples were collected for microbiological and virological analyses. Three of neonatal calves with septicaemia were positive for E. coli (E. coli O157 serotype) by microbiological examination, but all neonatal calves with septicaemia were negative for rota- and coronaviruses. By haematological examination, there were no significant differences between SC and CC for white blood cell (WBC) and neutrophil (NEU) counts (P > 0.05). NEU counts were higher on day 0 than on day 15 in SC (P < 0.05). Red blood cell (RBC) counts and packed cell volume (PCV) values were higher on day 0 in the SC than in the CC (P < 0.05). By biochemical analyses, tumour necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), procalcitonin (PCT), haptoglobin (Hp), and fibrinogen (Fb) concentrations were higher on day 0 in the SC than in the CC (P < 0.05). After treatment (on day 15), the serum IL-6, PCT, Hp, and Fb concentrations were significantly decreased in the SC compared to the CC (P < 0.05). The serum iron (Fe) concentrations were lower on day 0 in the SC than in the CC (P < 0.05), and were higher on day 15 than on day 0 in the SC (P < 0.05). The study revealed that inflammatory markers could be used for determining the diagnosis and prognosis in neonatal calves with septicaemia.

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