scholarly journals Case Report: Recurrence of Testicular Myofibroblastic Tumor After Surgery

2022 ◽  
Vol 11 ◽  
Author(s):  
Jiayi Liu ◽  
Zhijie Bai ◽  
Shuaiqi Li ◽  
Sheng Zeng ◽  
Chuang Li ◽  
...  
Keyword(s):  
Rare Case ◽  
Plasma Cells ◽  
Therapeutic Approaches ◽  
Inflammatory Pseudotumour ◽  
Alk Rearrangement ◽  
Rare Tumour ◽  
Inflammatory Infiltration ◽  
Factors Associated ◽  
Spindle Cells ◽  
Children And Young Adults

Inflammatory myofibroblastic tumour (IMT), also known as plasma cell granuloma (PCG) or inflammatory pseudotumour (IPT), is a distinctive, rarely metastasizing neoplasm composed of myofibroblastic and fibroblastic spindle cells accompanied by inflammatory infiltration of plasma cells, lymphocytes and/or eosinophils. IMT predominantly affects children and young adults, and the age at presentation ranges from 3 to 89 years. We present a very rare case of recurrent testicular IMT without ALK rearrangement. This case highlights the clinical characteristics and diagnostic factors associated with primary and recurrent foci of this rare tumour, along with key therapeutic approaches.

scholarly journals Tail in the duodenum

2018 ◽  
Vol 5 (7) ◽  
pp. 2676
Author(s):  
Sruthi Ranganathan ◽  
T. Mohanapriya ◽  
K. Balaji Singh
Keyword(s):  
Plasma Cells ◽  
Abdominal Cavity ◽  
Complete Resection ◽  
Soft Tissue Tumour ◽  
Inflammatory Myofibroblastic Tumour ◽  
Radiological Imaging ◽  
Spindle Cells ◽  
Tissue Tumour ◽  
Children And Young Adults ◽  
Locally Recurrent

Inflammatory myofibroblastic tumour, commonly called as pseudotumor is a soft tissue tumour, commonly occurring in children and young adults and very rarely in elderly. Lungs are the most commonly affected site but sometimes it can occur in retroperitoneum and abdominal cavity. It contains spindle cells, myofibroblasts, lymphoctyes, plasma cells, and histiocytes. It is a non-encapsulated lesion. The pathogenesis of IMT remains unclear, although various allergic, immunogenic infectious mechanisms have been postulated. They are locally recurrent (15-37%) and rarely metastasize (<5%).  IMT features mimcs malignancy on UGIscopy and radiological imaging and hence surgical exploration and complete resection is required for diagnosis and treatment. The worldwide incidence of IMT is 0.04- 0.7%. Here is a case of inflammatory myofibroblastic tumour in duodenum presented with complaints of vomiting and melena.

Chitosan oligosaccharide attenuates endoplasmic reticulum stress- associated intestinal apoptosis via Akt/mTOR pathway

2021 ◽  
Author(s):  
Tingting Fang ◽  
Ying Yao ◽  
Gang Tian ◽  
Daiwen Chen ◽  
Aimin Wu ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Disease Activity ◽  
Mtor Pathway ◽  
Chitosan Oligosaccharide ◽  
Therapeutic Approaches ◽  
Factors Associated ◽  
Control Disease

Endoplasmic reticulum stress (ERS) and apoptosis are widely considered as essential factors associated with intestinal disorders, whereas nutritional therapeutic approaches target for ERS may control disease activity. Thus, we focus...

scholarly journals Osteosarcoma: a review of current and future therapeutic approaches

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Xin Zhao ◽  
Qirui Wu ◽  
Xiuqing Gong ◽  
Jinfeng Liu ◽  
Yujie Ma
Keyword(s):  
Bimodal Distribution ◽  
Therapeutic Approaches ◽  
Rapid Disease Progression ◽  
New Ideas ◽  
Degree Of Malignancy ◽  
Primary Bone ◽  
Children And Young Adults ◽  
High Degree ◽  
Single Lesion ◽  
Tubular Bones

AbstractOsteosarcoma (OS) is the most common primary bone malignancy that affects children and young adults. OS is characterized by a high degree of malignancy, strong invasiveness, rapid disease progression, and extremely high mortality rate; it is considered as a serious threat to the human health globally. The incidence of OS is common in the metaphysis of long tubular bones, but rare in the spine, pelvis, and sacrum areas; moreover, majority of the OS patients present with only a single lesion. OS has a bimodal distribution pattern, that is, its incidence peaks in the second decade of life and in late adulthood. We examine historical and current literature to present a succinct review of OS. In this review, we have discussed the types, clinical diagnosis, and modern and future treatment methods of OS. The purpose of this article is to inspire new ideas to develop more effective therapeutic options.

scholarly journals Systemic congenital lymphangiomatosis

1996 ◽  
Vol 114 (5) ◽  
pp. 1278-1281 ◽  
Author(s):  
Ligia Maria Suppo de Souza ◽  
Maria Regina Bentlin ◽  
Eliana Souto de Abreu ◽  
Carlos Eduardo Bacchi
Keyword(s):  
Young Adults ◽  
Respiratory Failure ◽  
Rare Disease ◽  
Poor Prognosis ◽  
Rare Case ◽  
Soft Tissues ◽  
Lymphatic Channel ◽  
Autopsy Findings ◽  
Children And Young Adults ◽  
Cervical Area

Systemic lymphangiomatosis is a rare disease characterized by the exageration of lymphatic channel proliferation, occurring in children and young adults. We describe an extremely rare case of congenital systemic lymphangiomatosis in a newborn who had ascitis and respiratory failure develop immediately after delivery. Death occurred during the first hour of life. Autopsy findings showed numerous cysts in soft tissues of the cervical area, mediastinum and diaphragm, and several other organs including the liver, spleen, thyroid and kidneys. The severe and diffuse involvement with cysts in both lungs by lymphangiomatosis was associated with poor prognosis and death in our case.

scholarly journals A Rare Case of Primary Anterior Mediastinal Yolk Sac Tumor in an Elderly Adult Male

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Sammy G. Nakhla ◽  
Srinath Sundararajan
Keyword(s):  
Germ Cell ◽  
Rare Case ◽  
Germ Cell Tumors ◽  
Anterior Mediastinum ◽  
Yolk Sac ◽  
Yolk Sac Tumor ◽  
Elderly Adult ◽  
Children And Young Adults ◽  
Extragonadal Germ Cell Tumors ◽  
Mediastinal Germ Cell Tumors

Mediastinal germ cell tumors are extragonadal germ cell tumors (EGGCTs) commonly seen in children and young adults. They are more common in men. Clinically they are classified as teratomas, seminomas, and nonseminomatous germ cell tumors. Primary mediastinal yolk sac neoplasm is an extremely rare tumor. We present here a very rare case of primary yolk sac tumor of the anterior mediastinum in a 73-year-old male. Mediastinal germ cell tumors have a worse prognosis than gonadal germ cell tumors. Chemotherapy followed by adjuvant surgery improves overall response in EGGCTs. However, comorbidities can render treatment with chemotherapy and surgery challenging in elderly patients.

Rare case of biphasic tumor of the breast with prominent CD34-positive spindle cells

2001 ◽  
Vol 51 (9) ◽  
pp. 713-717
Author(s):  
Masahiro Hayashi ◽  
Gen Tamura ◽  
Osamu Matsumoto ◽  
Teiichi Motoyama
Keyword(s):  
Rare Case ◽  
Spindle Cells ◽  
Biphasic Tumor

scholarly journals Therapeutic Approaches Targeting PAX3-FOXO1 and Its Regulatory and Transcriptional Pathways in Rhabdomyosarcoma

Molecules ◽  
2018 ◽  
Vol 23 (11) ◽  
pp. 2798 ◽  
Author(s):  
Thanh Hung Nguyen ◽  
Frederic G. Barr
Keyword(s):  
Skeletal Muscle ◽  
Transcription Factor ◽  
Young Adults ◽  
Soft Tissue ◽  
Chromosomal Translocation ◽  
Murine Models ◽  
Therapeutic Approaches ◽  
Recent Developments ◽  
Children And Young Adults ◽  
Oncogenic Transcription Factor

Rhabdomyosarcoma (RMS) is a family of soft tissue cancers that are related to the skeletal muscle lineage and predominantly occur in children and young adults. A specific chromosomal translocation t(2;13)(q35;q14) that gives rise to the chimeric oncogenic transcription factor PAX3-FOXO1 has been identified as a hallmark of the aggressive alveolar subtype of RMS. PAX3-FOXO1 cooperates with additional molecular changes to promote oncogenic transformation and tumorigenesis in various human and murine models. Its expression is generally restricted to RMS tumor cells, thus providing a very specific target for therapeutic approaches for these RMS tumors. In this article, we review the recent understanding of PAX3-FOXO1 as a transcription factor in the pathogenesis of this cancer and discuss recent developments to target this oncoprotein for treatment of RMS.

scholarly journals Aggressive Monophasic Sarcomatoid Carcinoma of Small Intestine - A Rare Case Report With Review of Literature

2012 ◽  
Vol 02 (01) ◽  
pp. 45-47
Author(s):  
Shetty K. Padma ◽  
Harish S. Permi ◽  
C.N. Patil ◽  
Michelle Mathias
Keyword(s):  
Small Intestine ◽  
Rare Case ◽  
Spindle Cell ◽  
Correct Diagnosis ◽  
Sarcomatoid Carcinoma ◽  
Intestinal Wall ◽  
Cell Tumor ◽  
Review Of Literature ◽  
Spindle Cells ◽  
Rare Case Report

AbstractSarcomatoid carcinoma occurring in the small intestine is very rare. They can be monophasic or biphasic. We report a rare case of monophasic Sarcomatoid carcinoma of the small intestine in a 60 year old male patient. The tumor was an ulceronodular mass involving the ileum circumferentially. The tumor infiltrated the full thickness of the intestinal wall and the serosa of an adjacent loop of ileum. Microscopically, the tumor was composed of sheets of malignant spindle cells. The carcinomatous nature of the tumor was evident only after Immunohistochemistry. The diagnosis of sarcomatoid carcinoma should be considered in the differential diagnosis of malignant spindle cell tumor of small intestine and immunohistochemical stains are required for the correct diagnosis.

scholarly journals Diffuse neurofibroma - an uncommon cause of alopecia

2013 ◽  
Vol 88 (6 suppl 1) ◽  
pp. 166-169 ◽  
Author(s):  
Vasco Coelho Macias ◽  
Margarida Rafael ◽  
Cândida Fernandes ◽  
Joaninha Costa Rosa
Keyword(s):  
Young Adults ◽  
Subcutaneous Tissue ◽  
Neurofibromatosis Type ◽  
Benign Tumors ◽  
Nerve Sheath ◽  
Spindle Cells ◽  
Children And Young Adults ◽  
Low Incidence ◽  
Infiltrative Tumor

Although infrequent, alopecia can be caused by benign cutaneous tumours. Neurofibromas are common benign tumors that originate in the peripheral nerve sheath. Diffuse neurofibroma is a rare variant of neurofibroma that is thought to occur mainly in the head and neck of children and young adults. Histology generally shows an infiltrative tumor, composed of spindle cells in the dermis and subcutaneous tissue. Despite being rare, malignant transformation has been reported. The association between diffuse neurofibromas and neurofibromatosis type 1 still remains to be determined since some authors question the low incidence usually described. We report the case of a 42-year-old man who had a diffuse neurofibroma on the scalp presenting as alopecic plaques.

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