scholarly journals Educational Setting and SARS-CoV-2 Transmission Among Children With Multisystem Inflammatory Syndrome: A French National Surveillance System

2021 ◽  
Vol 9 ◽  
Author(s):  
Celia Guenver ◽  
Mehdi Oualha ◽  
Corinne Levy ◽  
Denise Antona ◽  
Fouad Madhi ◽  
...  
Keyword(s):  
Public Health ◽  
Family Environment ◽  
School Attendance ◽  
Population Level ◽  
Severe Form ◽  
School Closure ◽  
Educational Setting ◽  
Educational Settings ◽  
Household Transmission ◽  
Inflammatory Syndrome

Background: Multisystem inflammatory syndrome in children (MIS-C) is the most severe form associated with SARS-CoV-2 infection in children. To reduce the spread of SARS-CoV-2 at the population level, educational setting closure have been implemented in many countries. However, the direct benefit of school closure on the MIS-C burden remains to be explored. We aimed to assess the role of educational settings in SARS-CoV-2 transmission among children with MIS-C.Methods: We conducted a French national prospective surveillance of MIS-C, coordinated by Public Health France, from April 2020 to March 2021. During this period, we included all children with MIS-C fulfilling the WHO definition who were reported to Public Health France. For each child, we traced the source of SARS-CoV-2 transmission. The main outcome was the proportion of children with MIS-C, with educational setting-related SARS-CoV-2 infection, during the period of school opening.Results: We included 142 children fulfilling WHO criteria for MIS-C: 104 (70%) cases occurred during school opening periods. In total, 62/104 children (60%, 95%CI [50; 69]) had been contaminated by a household contact and 5/104 in educational settings (5%, 95%CI [2; 11]). Among children with MIS-C occurring during school closure periods, the proportion of household transmission remained similar (66%, 25/38).Conclusion: Children with MIS-C were mainly infected by SARS-CoV-2 within their family environment, and the educational setting played a marginal role in this transmission. This suggests that mitigating school attendance may not reduce substantially the burden of MIS-C.

PENERAPAN CLUSTERING PADA PENDUDUK YANG MEMPUNYAI KELUHAN KESEHATAN DENGAN DATAMINING K-MEANS

2018 ◽  
Vol 2 (1) ◽  
Author(s):  
Nurul Rofiqo ◽  
Agus Perdana Windarto ◽  
Dedy Hartama
Keyword(s):  
Public Health ◽  
Data Mining ◽  
Population Level ◽  
Research Data ◽  
Health Complaints ◽  
Public Health Services ◽  
National Statistics ◽  
Central Java ◽  
Indonesian Population ◽  
The Government

This study aims to utilize Clushtering Algorithm in grouping the number of people who have health complaints with the K-means algorithm in Indonesia. The source of this research data was collected based on the documents of the provincial population which had health complaints produced by the National Statistics Agency. The data used in this study are data from 2013-2017 consisting of 34 provinces. The method used in this research is K-means Algorithm. Data will be processed by clushtering in 3 clushter, namely clusther high health complaints, clusther moderate and low health complaints. Centroid data for high population level clusters 37.48, Centroid data for moderate population level clusters 27.08, and Centroid data for low population level clusters 14.89. So that obtained an assessment based on the population index that has health complaints with 7 provinces of high health complaints, namely Central Java, Yogyakarta, Bali, West Nusa Tenggara, East Nusa Tenggara, South Kalimantan, Gorontalo, 18 provinces of moderate health complaints, and 9 other provinces including low health complaints. This can be an input to the government to give more attention to residents in each region who have high health complaints through improving public health services so that the Indonesian population becomes healthier without health complaints.Keywords: data mining, health complaints, clustering, K-means, Indonesian residents

Fidelity and Its Relationship to Implementation Effectiveness, Adaptation, and Dissemination

2017 ◽  
Author(s):  
Jennifer D. Allen ◽  
Rachel C. Shelton ◽  
Karen M. Emmons ◽  
Laura A. Linnan
Keyword(s):  
Public Health ◽  
Treatment Strategies ◽  
Implementation Fidelity ◽  
Population Level ◽  
The United States ◽  
Dissemination And Implementation ◽  
Evidence Based ◽  
Health Gains ◽  
Significant Public Health ◽  
Research Continuum

There is substantial variability in the implementation of evidence-based interventions across the United States, which leads to inconsistent access to evidence-based prevention and treatment strategies at a population level. Increased dissemination and implementation of evidence-based interventions could result in significant public health gains. While the availability of evidence-based interventions is increasing, study of implementation, adaptation, and dissemination has only recently gained attention in public health. To date, insufficient attention has been given to the issue of fidelity. Consideration of fidelity is necessary to balance the need for internal and external validity across the research continuum. There is also a need for a more robust literature to increase knowledge about factors that influence fidelity, strategies for maximizing fidelity, methods for measuring and analyzing fidelity, and examining sources of variability in implementation fidelity.

Tobacco as a Matter of Public Health: Ethical Issues

2019 ◽  
pp. 494-510
Author(s):  
Kristin Voigt
Keyword(s):  
Public Health ◽  
Tobacco Use ◽  
Ethical Issues ◽  
Population Level ◽  
Third Parties ◽  
Background Factors ◽  
Normative Issues

This chapter considers normative issues that tobacco raises at the population level, particularly with respect to the anti-smoking strategies policymakers might pursue and the reasons and justifications underlying these strategies. After setting out several background factors that shape the debate, the chapter discusses different grounds on which state and public health actors might seek to restrict tobacco use, considering in turn those justifications that focus on protecting smokers and those that seek to protect third parties. The chapter then considers normative problems arising in relation to specific anti-smoking strategies, such as restrictions on the sale, use, and marketing of cigarettes; taxation; incentives for cessation; and denormalization strategies. Issues of paternalism and the stigma associated with smoking are also discussed.

scholarly journals The Evolution of Gambling-Related Harm Measurement: Lessons from the Last Decade

2021 ◽  
Vol 18 (9) ◽  
pp. 4395
Author(s):  
Matthew Browne ◽  
Vijay Rawat ◽  
Catherine Tulloch ◽  
Cailem Murray-Boyle ◽  
Matthew Rockloff
Keyword(s):  
Public Health ◽  
Population Level ◽  
Health Utility ◽  
Health And Wellbeing ◽  
Recent Developments ◽  
Psychometric Evidence ◽  
Future Work ◽  
Utility Metrics ◽  
Gambling Harms ◽  
Related Harm

Jurisdictions around the world have a self-declared mandate to reduce gambling-related harm. However, historically, this concept has suffered from poor conceptualisation and operationalisation. However, recent years have seen swift advances in measuring gambling harm, based on the principle of it being a quantifiable decrement to the health and wellbeing of the gambler and those connected to them. This review takes stock of the background and recent developments in harm assessment and summarises recent research that has validated and applied the Short Gambling Harms Screen and related instruments. We recommend that future work builds upon the considerable psychometric evidence accumulated for the feasibility of direct elicitation of harmful consequences. We also advocate for grounding harms measures with respect to scalar changes to public health utility metrics. Such an approach will avoid misleading pseudo-clinical categorisations, provide accurate population-level summaries of where the burden of harm is carried, and serve to integrate gambling research with the broader field of public health.

scholarly journals Comprehensive and safe school strategy during COVID-19 pandemic

2021 ◽  
Vol 47 (1) ◽  
Author(s):  
Susanna Esposito ◽  
Nicola Cotugno ◽  
Nicola Principi
Keyword(s):  
School Attendance ◽  
Asymptomatic Infection ◽  
School Closure ◽  
Prevention Measures ◽  
Effective Measure ◽  
The Real ◽  
Definitive Answer ◽  
Mild Disease ◽  
Infectious Risk ◽  
Over Time

Abstract Background Although several studies have tried to evaluate the real efficacy of school closure for pandemic control over time, no definitive answer to this question has been given. Moreover, it has not been clarified whether children or teenagers could be considered a problem for SARS-CoV-2 diffusion or, on the contrary, whether parents and school workers play a greater role. The aims of this review are to discuss about children’s safety at school and the better strategies currently able to reduce the risk of SARS-CoV-2 infection at school. Main aim Compared to adults, very few cases of COVID-19 were diagnosed in children, who generally suffered from an asymptomatic infection or a mild disease. Moreover, school closure is systematically associated with the development of problems involving students, teachers and parents, particularly among populations with poor resources. Although several researches have tried to evaluate the real efficacy of school closure for pandemic control over time, no definitive answer to this question has been given. Available findings seem to confirm that to ensure adequate learning and to avoid social and economic problems, schools must remain open, provided that the adults who follow children at home and at school absolutely comply with recommendations for prevention measures and that school facilities can be optimized in order to significantly reduce the spread of infection. In this regard, the universal use of face masks in addition to hand hygiene and safe distancing in schools, at least starting from the age of 6 years, seems extremely useful. Moreover, since the beginning of the COVID-19 outbreak the use of telemedicine to manage suspected SARS-CoV-2-infected individuals in the community has appeared to be an easy and effective measure to solve many paediatric problems and could represent a further support to schools . Conclusions We think that schools must remain open, despite COVID-19 pandemic. However, several problems strictly related to school frequency and reduction of infectious risk must be solved before school attendance can be considered completely safe. A single more in-depth guideline agreed between countries with the same school problems could be very useful in eliminating doubts and fostering the compliance of students, teachers and non-teaching school staff reducing errors and misinterpretations.

Linkage of Public Health and All Payer Claims data for Population‐Level Opioid Research

2021 ◽  
Author(s):  
Sara E. Hallvik ◽  
Nazanin Dameshghi ◽  
Sanae El Ibrahimi ◽  
Michelle A. Hendricks ◽  
Christi Hildebran ◽  
...  
Keyword(s):  
Public Health ◽  
Claims Data ◽  
Population Level

scholarly journals Shared inflammatory pathways and therapeutic strategies in COVID-19 and cancer immunotherapy

2021 ◽  
Vol 9 (5) ◽  
pp. e002392
Author(s):  
Lorenzo Iovino ◽  
Laurel A Thur ◽  
Sacha Gnjatic ◽  
Aude Chapuis ◽  
Filippo Milano ◽  
...  
Keyword(s):  
Preliminary Evidence ◽  
Severe Form ◽  
Cell Transplant ◽  
T Cell Therapy ◽  
Cell Therapies ◽  
Novel Drugs ◽  
Prospective Trials ◽  
Systemic Manifestations ◽  
Anti Inflammatory ◽  
Inflammatory Syndrome

COVID-19, the syndrome caused by the infection with SARS-CoV-2 coronavirus, is characterized, in its severe form, by interstitial diffuse pneumonitis and acute respiratory distress syndrome (ARDS). ARDS and systemic manifestations of COVID-19 are mainly due to an exaggerated immune response triggered by the viral infection. Cytokine release syndrome (CRS), an inflammatory syndrome characterized by elevated levels of circulating cytokines, and endothelial dysfunction are systemic manifestations of COVID-19. CRS is also an adverse event of immunotherapy (IMTX), the treatment of diseases using drugs, cells, and antibodies to stimulate or suppress the immune system. Graft-versus-host disease complications after an allogeneic stem cell transplant, toxicity after the infusion of chimeric antigen receptor-T cell therapy and monoclonal antibodies can all lead to CRS. It is hypothesized that anti-inflammatory drugs used for treatment of CRS in IMTX may be useful in reducing the mortality in COVID-19, whereas IMTX itself may help in ameliorating effects of SARS-CoV-2 infection. In this paper, we focused on the potential shared mechanisms and differences between COVID-19 and IMTX-related toxicities. We performed a systematic review of the clinical trials testing anti-inflammatory therapies and of the data published from prospective trials. Preliminary evidence suggests there might be a benefit in targeting the cytokines involved in the pathogenesis of COVID-19, especially by inhibiting the interleukin-6 pathway. Many other approaches based on novel drugs and cell therapies are currently under investigation and may lead to a reduction in hospitalization and mortality due to COVID-19.

scholarly journals Evaluation of vaccines against enteric infections: a clinical and public health research agenda for developing countries

2011 ◽  
Vol 366 (1579) ◽  
pp. 2799-2805 ◽  
Author(s):  
John Clemens
Keyword(s):  
Public Health ◽  
Developing Countries ◽  
Age Groups ◽  
Population Level ◽  
Vaccine Safety ◽  
Public Health Research ◽  
Protective Effects ◽  
Vaccine Protection ◽  
Enteric Infections ◽  
Research Questions

Enteric infections are a major cause of morbidity and mortality in developing countries. To date, vaccines have played a limited role in public health efforts to control enteric infections. Licensed vaccines exist for cholera and typhoid, but these vaccines are used primarily for travellers; and there are two internationally licensed vaccines for rotavirus, but they are mainly used in affluent countries. The reasons that enteric vaccines are little used in developing countries are multiple, and certainly include financial and political constraints. Also important is the need for more cogent evidence on the performance of enteric vaccines in developing country populations. A partial inventory of research questions would include: (i) does the vaccine perform well in the most relevant settings? (ii) does the vaccine perform well in all epidemiologically relevant age groups? (iii) is there adequate evidence of vaccine safety once the vaccines have been deployed in developing countries? (iv) how effective is the vaccine when given in conjunction with non-vaccine cointerventions? (v) what is the level of vaccine protection against all relevant outcomes? and (vi) what is the expected population level of vaccine protection, including both direct and herd vaccine protective effects? Provision of evidence addressing these questions will help expand the use of enteric vaccines in developing countries.

The public health approach to suicide prevention in Ireland

2021 ◽  
pp. 1-6
Author(s):  
S. Rochford ◽  
P. Dodd ◽  
C. Austin
Keyword(s):  
Public Health ◽  
Suicide Prevention ◽  
Population Level ◽  
Prevention Strategy ◽  
Public Health Approach ◽  
National Strategy ◽  
Extended Phase ◽  
The Public ◽  
National Implementation

Abstract This article provides an overview of the public health approach to suicide in Ireland. The authors provide detail on the current suicide prevention strategy in Ireland, Connecting for Life, which is a whole-of-government, systemic, multicomponent national strategy. As the strategy enters its final extended phase of implementation over the period 2020–2024, the public health elements of Connecting for Life are presented, including the population level and more targeted approaches. The findings of an interim review of the strategy are discussed, in addition to the local and national implementation structures which are in place to assist implementation and monitoring of the strategy.

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