scholarly journals Medium-Term Pulmonary Function Test After Thoracoscopic Lobectomy and Segmentectomy for Congenital Lung Malformation: A Comparative Study With Normal Control

2021 ◽  
Vol 9 ◽  
Author(s):  
Jin-Xi Huang ◽  
Song-Ming Hong ◽  
Jun-Jie Hong ◽  
Qiang Chen ◽  
Hua Cao

Purpose: This study aimed to compare the outcomes and pulmonary function test (PFT) of thoracoscopic segmentectomy and lobectomy in infants with congenital lung malformation and study the result of PFT on a medium-term basis.Methods: The clinical data of 19 infants with congenital lung malformation who underwent thoracoscopic surgery in our hospital from January 2018 to March 2019 were retrospectively studied; these infants were paired with another 19 infants who underwent thoracoscopic lobectomy during the same period using propensity score matching. Age-matched healthy individuals with similar body sizes were recruited for PFT as the control group. Patient characteristics, postoperative PFT, and outcomes were extracted for statistical analysis.Results: The average length of hospital stay did not significantly differ between segmentectomy and lobectomy groups. The segmentectomy group had more chest tube drainage than the lobectomy group. PFT 1 month after the operation showed that the tidal volume of the lobectomy group was lower than that of the segmentectomy group. Time to peak expiratory flow/time of expiration and peak flow/terminal airway velocity (V25%) indicated small airway dysfunction in the lobectomy group, and no obvious abnormalities were found in “time of inspiratory/time of expiration” in either group. Reexamination of pulmonary function 2 years after the operation showed that the small airway function of the segmentectomy group returned to normal, and no significant difference in pulmonary function was noted among the three groups.Conclusion: The short-term pulmonary function recovery was better after segmentectomy than after lobectomy. Patients who underwent thoracoscopic lobectomy and segmentectomy have normal lung function 2 years after the operation.

2013 ◽  
Vol 39 (6) ◽  
pp. 701-710 ◽  
Author(s):  
Helena Mocelin ◽  
Gilberto Bueno ◽  
Klaus Irion ◽  
Edson Marchiori ◽  
Edgar Sarria ◽  
...  

OBJECTIVE: To determine whether air trapping (expressed as the percentage of air trapping relative to total lung volume [AT%]) correlates with clinical and functional parameters in children with obliterative bronchiolitis (OB).METHODS: CT scans of 19 children with OB were post-processed for AT% quantification with the use of a fixed threshold of −950 HU (AT%950) and of thresholds selected with the aid of density masks (AT%DM). Patients were divided into three groups by AT% severity. We examined AT% correlations with oxygen saturation (SO2) at rest, six-minute walk distance (6MWD), minimum SO2 during the six-minute walk test (6MWT_SO2), FVC, FEV1, FEV1/FVC, and clinical parameters.RESULTS: The 6MWD was longer in the patients with larger normal lung volumes (r = 0.53). We found that AT%950 showed significant correlations (before and after the exclusion of outliers, respectively) with the clinical score (r = 0.72; 0.80), FVC (r = 0.24; 0.59), FEV1 (r = −0.58; −0.67), and FEV1/FVC (r = −0.53; r = −0.62), as did AT%DM with the clinical score (r = 0.58; r = 0.63), SO2 at rest (r = −0.40; r = −0.61), 6MWT_SO2 (r = −0.24; r = −0.55), FVC (r = −0.44; r = −0.80), FEV1 (r = −0.65; r = −0.71), and FEV1/FVC (r = −0.41; r = −0.52).CONCLUSIONS: Our results show that AT% correlates significantly with clinical scores and pulmonary function test results in children with OB.


2019 ◽  
Vol 6 (6) ◽  
pp. 1774
Author(s):  
Sivaranjani H. ◽  
Chaitra K. R.

Background: Hypothyroidism is a common disease with a prevalence rate of 11% in India. It affects all organ systems in the body. Patients with hypothyroidism frequently have symptoms of fatigue and exercise intolerance. These symptoms could arise from a reduced pulmonary reserve, cardiac reserve or decreased muscle strength or increased muscle fatigue. This study aims to study the pulmonary function test in patients with hypothyroidism.Methods: This is a cross sectional study conducted on 100 patients divided into 2 groups (a) newly detected hypothyroids (b) normal control group. Cases were matched with controls in having similar environment exposure and age group. All patients had routine symptom and clinical assessment. Laboratory investigations such as complete blood picture, pulmonary function test, chest x ray and thyroid function test were done. Data was entered and analysed.Results: In this study conducted on 100 patients, case group had symptoms of easy fatiguability (36%), breathlessness (20%), menstrual abnormality (20%), weight gain (7%) and generalised body aches (5%). Mean FEV1 levels between cases and controls were 1.34 and 1.72 (p value 0.00), mean FVC were 1.88 and 2.09 (p value 0.114), FEV1/FVC ratio of 70.56, 81.98 respectively (p value 0.00). The distribution of PFT pattern was 32% obstructive, 28% mixed pattern and 22% restrictive pattern.Conclusions: This study shows that hypothyroidism causes significant decrease in FEV1 and FEV1/FVC ratio, thereby suggesting obstructive patterns of lung involvement .Therefore PFT can be used routinely as a screening test for all hypothyroid patients to detect early respiratory dysfunction and thereby optimise treatment especially in obese patients and patients with pre-existing lung disease as hypothyroidism adds to their respiratory dysfunction.


2014 ◽  
Vol 32 (4_suppl) ◽  
pp. 530-530
Author(s):  
Kwon-Oh Park ◽  
Jae-Lyun Lee ◽  
Jin-Hee Ahn ◽  
In Gab Jeong ◽  
Cheryn Song ◽  
...  

530 Background: The aim of this study was to evaluate the changes of pulmonary function test (PFT) during everolimus treatment and to assess whether the change of PFT is associated with the development of non-infectious pneumonitis in patients with metastatic renal cell carcinoma. In addition, we tried to determine whether everolimus-associated pneumonitis could affect the efficacy of everolimus. Methods: Patients with mRCC who had received everolimus (10 mg dose once daily) after failure to VEGF-TKI treatment and underwent baseline PFT with regular PFT follow up were included in this study. The diffusing capacity divided by the alveolar volume (DLCO/VA) was used among various parameters of PFT. Repeated-measures ANOVA was used to describe changes of DLCO/VA. A Cox proportional hazard model with pneumonitis onset as a time-dependent covariate used to assess the prognostic role of pneumonitis. Results: This study included 36 patients. Nine patients (30%) developed everolimus-associated pneumonitis (pneumonitis group) and 27 were included in non-pneumonitis group. Five patients (14%) among pnemonitis group were symptomatic. The baseline DLCO/VA of patients was 90.0%. It decreased to 80.2%, 76.4%, 76.0%, and 72.1% after everolimus treatment of 6, 12, 18, and 24 weeks, respectively. DLCO/VA declined significantly as the treatment duration becomes longer (p < 0.001). There was no significant difference in change of DLCO/VA between patients with pneumonitis and those without pneumonitis (p =0.435). On time-variant Cox analysis, the decrease of DLCO/VA was not correlated with the efficacy of everolimus in terms of progression free survival (PFS, HR=1.0, p=0.94) and overall survival (OS, HR=0.98, p=0.18), while development of pneumonitis was associated with poor PFS (HR=4.60, p=0.005). Conclusions: Although the eveolimus treatment decreased DLCO/VA, the decline of DLCO/VA was not associated with the development of pneumonitis. Changes in DLCO/VA were not related with efficacy of everolimus, while the development of pneumonitis was a prognostic factor for PFS.


2019 ◽  
Vol 6 (1) ◽  
pp. 164
Author(s):  
Archana Toppo ◽  
Kulvant Singh Ajamani

Background: Diabetes mellitus (DM) is a group of metabolic disorders characterized by hyperglycemia and deranged metabolism of carbohydrates, lipids and protein that result from insensitivity to endogenous insulin. It is a substantial global health problem and markedly increases morbidity and mortality of the affected people.Methods: The present study was conducted in the Department of medicine Dr. B.R.A.M. Hospital, Raipur. Total 67 subjects with type II diabetes mellitus as per WHO criteria of diabetes mellitus, aged between 18-60years of both sexes were included in the study. Patients FBS, PPBS were analysed by glucose oxidase (GOD), peroxidase (POD) methods in ILAB 650 analyser and HbA1C was analysed using HPLC. Pulmonary function test was conducted in all the subjects using the spirometer which is the gold standard for accurate and repeatable measurement of lung function.Results: Majority of the subjects were male (36, 53.7%) and belonged to age group of 51-60years (n=34, 50.7%), Duration of DM </=10years (n=47, 70.1%), restrictive pulmonary function in 10 (14.9%) subjects. Correlation of age with a restrictive pattern of PFT (P=0.013*) and with duration of diabetes (P<0.0001**). Pulmonary function test parameters having mild downstream correlation with diabetes mellitus.Conclusions: Diabetes was more common in the sixth decade of life with slight male preponderance. The short-term indicators of glycaemic controls were not significantly associated with a restrictive pattern of PFT. Despite the best effort, there are limitations of this study, which includes small sample size, author have not taken general population, and lack of a control group. These limitations can be overcome in the future studies.


2018 ◽  
Vol 36 (7_suppl) ◽  
pp. 117-117 ◽  
Author(s):  
Mylene Bassal ◽  
Eden Story ◽  
Lynn Chang ◽  
Vimoj Nair ◽  
Joseph Reisman ◽  
...  

117 Background: As childhood cancer survival approaches 85%, it is increasingly recognized that childhood cancer survivors (CCS) are at risk for long-term therapy-related complications. Data suggest that pulmonary function test (PFT) abnormalities occur in as many as 84.1% of CCS. Our aim was to assess the prevalence and nature of respiratory abnormalities in adult CCS and to correlate these abnormalities with therapeutic exposures and health behaviors. Methods: Patients who received pulmonary toxic therapy routinely undergo PFTs at their first visit to the POGO AfterCare clinic in Ottawa, Canada. We conducted a retrospective review of all patients seen in clinic from August 2015 until December 2016. PFT results, treatment exposures and health habits were documented. We used NHANES-III prediction equations for PFT interpretation, with expiratory flows and lung volumes of ≥80% predicted as cutoffs for normal. Results: Of a total of 200 patients, 48 received pulmonary toxic therapy and 38 underwent PFTs. Mean age at the time of PFT was 28.8 years (18.5-57.5 years) and the mean time from diagnosis was 17.4 years (3.4-47.5 years). Although no patients reported respiratory symptoms, 42% (16/38) demonstrated a mild restrictive ventilatory defect, 11% (4/38) had mild airflow obstruction, 18% (7/38) had an isolated reduction in diffusion capacity and 1 patient had a moderate mixed obstructive/restrictive abnormality. Only 26% (10/38) had normal lung function. Of those with restrictive defects, all received radiation and 50% were also exposed to pulmonary toxic chemotherapy. All patients with obstructive defects received radiation therapy in combination with bleomycin. Tobacco or marijuana use was reported in 26% (10/38) of the cohort, and in 29% (8/28) of those with PFT abnormalities. Conclusions: PFT abnormalities are common among adult CCS who received pulmonary toxic therapy. Studies evaluating the change in pulmonary function abnormalities over time and their correlation to cardiopulmonary exercise testing and lung imaging are required to inform the health impact on these survivors.


2021 ◽  
Vol 6 (2) ◽  
pp. 75-79
Author(s):  
Jaykumari Choudhary ◽  
Suprova Chakraborty ◽  
Prasanta Kumar De

Tuberculosis is one of the most important communicable disease, which poses a global public health threat and remains the leading cause of death among infectious diseases, especially in undeveloped and developing countries.It was a prospective, observational, hospital based study conducted in the department of Respiratory Medicine, IPGMER SSKM Hospital, Kolkata from January 2020 to December 2020. Atotal of 80 cases, with history of adequately treated one episode of pulmonary tuberculosis, were included in this study.According to pulmonary function test results, 30(37.5%) patients had obstructive pattern and 11(13.8%) had restrictive pattern, in spirometry. Another 15(18.8%) patients had, mixed obstructive/restrictive pattern, while in rest 24 (30%) patients, spirometry test results were normal. The distribution of various pulmonary function test results among patients with obstructive pattern (N=30), ATT completion history was 7.57 ± 2.77 years back in average. Whereas average duration of symptoms in them was found to be 4.03 ± 1.96 years. For patients with restrictive pattern (N=11), these durations were 10.91 ± 2.51years and 7.59 ± 2.35 years respectively. Patients with mixed pattern (N=15), both durations were 11.33 ± 3.50 years and 7.33 ± 2.94 years respectively. Whereas among patients with normal lung function (N=24), ATT completion duration was 2.83 ± 2.21 years and symptom onset duration was 0.63 ± 0.34 years.There was emphatically found thatduration of anti-tubercular treatment, duration of symptoms and pulmonary function abnormalities. Hence clinical suspicion, early diagnosis and early treatment strategy are required to prevent further deterioration of pulmonary function in treated Pulmonary tuberculosis (PTB) patients. So, frequent or annual spirometry is required in these patients.


2017 ◽  
Vol 4 (1) ◽  
pp. 19-26
Author(s):  
Alok Dhungel ◽  
Tariq Wassem ◽  
Kshitiz Upadhyay-Dhungel

Background and Objectives: Type II diabetes mellitus (DM) is particularly common medical disorder and is leading cause of morbidity worldwide. The complication of DM is due to micro or macro vascular damage. The presence of an extensive microvascular circulation and abundant connective tissue in the lungs raises the possibility that lung tissue may be a target organ in diabetic patients and thus pulmonary function test can be affected by DM. This study was designed to compare pulmonary function test between Type II diabetic and non-diabetic individuals; and, with the duration of DM.Material and Methods: This cross sectional comparative study was conducted at King Edward Medical University, Lahore Pakistan. Total sample consist of 91 diabetic and 91 non-diabetic grouped as group A and group B. FEV1, FVC, FEV1/FVC ratio, and PEFR were compared within two groups and with the duration of DM.Results: Total 182 sample with mean age 53.1±5.90 years, with 91(50%) male and 91(50%) female. Group A and B had 91(50%) sample each. Mean value of FVC, FEV1 and PEFR showed statistically significant difference among the both group. Mean of FVC decreases significantly with the increasing duration of DM; although, is not significant with FEV1, FEV1/FVC ratio, and PEFR.Conclusion: Diabetic group showed significantly impaired pulmonary functions test as FEV1, FVC, and PEFR as compare to non-diabetic group.Janaki Medical College Journal of Medical Sciences (2016) Vol. 4 (1): 19-26


2018 ◽  
Vol 24 (3) ◽  
pp. 216-219 ◽  
Author(s):  
Adauto de Oliveira Nunes Júnior ◽  
Marina Andrade Donzeli ◽  
Suraya Gomes Novais Shimano ◽  
Nuno Miguel Lopes de Oliveira ◽  
Gualberto Ruas ◽  
...  

ABSTRACT Introduction: Rugby is a sport characterized by high and low intensity motor action. Therefore, the respiratory muscles need adequate work to maintain sustained effective breathing. Objective: To analyze the effects of high-intensity inspiratory muscle training (IMT) in amateur rugby players from the city of Uberaba, Minas Gerais, Brazil. Methods: This is a clinical study in which 20 amateur players underwent a pulmonary function test, respiratory muscle strength and physical capacity assessment. The participants were divided into two groups: 10 volunteers in the IMT group (G1) and 10 in the control group (G2). All the assessments were carried out before and after 12 weeks of IMT. Results: No significant changes were observed in the pulmonary function test. However, maximal voluntary ventilation, maximal inspiratory pressure, maximal expiratory pressure and distance increased significantly after IMT. Conclusion: IMT had beneficial effects on amateur rugby players. Level of evidence I; Therapeutic studies - Investigation of treatment results.


1997 ◽  
Vol 36 (2) ◽  
pp. 235
Author(s):  
Jung Hwa Hwang ◽  
Chull Hee Cha ◽  
Jai Soung Park ◽  
Young Beom Kim ◽  
Hae Kyung Lee ◽  
...  

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