scholarly journals Impact of SARS-CoV-2 Infection During Pregnancy on Infant Neurobehavioral Development: A Case-Control Study

2021 ◽  
Vol 9 ◽  
Author(s):  
Yao Cheng ◽  
Haoyue Teng ◽  
Yue Xiao ◽  
Mengxin Yao ◽  
Jieyun Yin ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Case Control Study ◽  
Statistical Significance ◽  
Case Control ◽  
Control Group ◽  
Neurobehavioral Development ◽  
Ages And Stages Questionnaires ◽  
Group 5 ◽  
Larger Sample ◽  
Control Study

Background: Previous studies on the pneumonia outbreak caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have focused on the general population and pregnant women, while little is known about the effects of SARS-CoV-2 on retardation during and after pregnancy. The purpose of this study was to evaluate the potential influence of SARS-CoV-2 on infant neurobehavioral development.Methods: A case-control study was conducted in Wuhan Maternal and Child Health Hospital, China. Nine pregnant women with SARS-CoV-2 infection and 9 controls matched by maternal age, parity, and status of chronic disease were included. Infantile neurobehavioral development was assessed through the Ages and Stages Questionnaires Edition 3 (ASQ-3).Results: The majority of pregnant women with SARS-CoV-2 experienced cesarean section (7 of 9), which was higher than the control group (5 of 9). The throat swabs of all newborn were negative. We found that compared with the control group, neonates of mothers with SARS-CoV-2 infection during pregnancy had lower scores in communication, gross movement, fine movement, problem solving, and personal-social domains; but only fine movement domain yielded statistical significance (P = 0.031).Conclusion: Infection with SARS-CoV-2 during pregnancy may have a certain impact on infant neurobehavioral development. Further studies with larger sample size are warranted for validation.

Pregnancy outcomes in adolescents: a case-control study in the West of Iran

2021 ◽  
Vol 17 ◽  
Author(s):  
Salman Khazaei ◽  
Saeid Bashirian ◽  
Akram Bathaei ◽  
Mohadese Sadri ◽  
Fateme Shirani ◽  
...  
Keyword(s):  
Prenatal Care ◽  
Pregnant Women ◽  
Adolescent Pregnancy ◽  
Case Control Study ◽  
Case Control ◽  
Control Group ◽  
Adult Women ◽  
The West ◽  
Adolescent Women ◽  
Control Study

Background: Adolescent pregnancy, pregnancy in women aged between 13-19 years, is considered a major health problem. Objective: This study was performed to determine the maternal, perinatal, and neonatal outcomes of adolescent pregnancies. Materials and Methods: The present hospital-based case-control study was performed on pregnant women who were referred to Fatemieh Hospital in Hamadan City for delivery. The case group was pregnant women whose gestational age was less than 19 years (adolescent pregnancy) and the control group included pregnant women whose gestational age was at 19-35 years (adult women pregnancy). Data were analyzed using Stata software version 14. The significant level was considered less than 0.05. Results: The unwanted pregnancy was significantly higher in adolescent women (45% vs. 28.5%, P=0.002). 18% of adolescent women had the experience of spouse violence compared to 4.25% in the control group (P<0.001). Accessing prenatal care and supplements were significantly higher in adult women (P<0.05). The adult mothers had significantly higher cesarean section delivery compared adolescent group (54.91% vs. 33%, P<0.001). Also, there was a significant association between postpartum hemorrhages and the study group (22% in cases compared to 13.75% in the control group, P=0.04). The Apgar score 1 minute was significantly higher in adult mothers (8.05±2.08 vs. 7.39±2.05, P<0.001). Conclusion: In conclusion, adolescent mothers in the west of Iran had a higher risk of inadequate prenatal care, low Apgar score and postpartum hemorrhage. Therefore, society should focus on public health policies that can improve the adequacy of prenatal care among adolescents.

scholarly journals Mode of Delivery in Drug-Dependent Pregnant Women: A Case Control Study

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Ana Raquel Neves ◽  
Fabiane Neves ◽  
Isabel Santos Silva ◽  
Maria do Céu Almeida ◽  
Pitorra Monteiro
Keyword(s):  
Pregnant Women ◽  
Vaginal Delivery ◽  
Case Control Study ◽  
Mode Of Delivery ◽  
Case Control ◽  
Control Group ◽  
Maternal Characteristics ◽  
Drug Dependent ◽  
Route Of Delivery ◽  
Control Study

Objective. To determine the contribution of drug use during pregnancy to the route of delivery.Methods. A case-control study was conducted at a hospital in Coimbra, Portugal, between 2001 and 2014. Drug-dependent pregnant women (n=236) were compared with a control group of low risk women (n=228) in terms of maternal characteristics, obstetric history, pregnancy complications, and labor details. Factors that influenced the mode of delivery were determined. Statistical analysis was performed with SPSS v. 23.0 (IBM Corp.).pvalues < 0.05 were considered statistically significant.Results. Drug-dependent women presented a lower rate of cesarean delivery (18.2 versus 28.9%,p=0.006). After adjusting for the factors that were significantly related to the mode of delivery, drug dependency influenced the rate of cesarean section (β=0.567; 95% CI = 0.328–0.980). Within the drug-dependent group, the mode of delivery was significantly related to previous cesarean or vaginal delivery (p=0.008andp<0.001, resp.) and fetal presentation (p<0.001), but not with the type of drug, route of administration, or substitution maintenance therapy.Conclusions. The drug-dependent group presented a significantly higher rate of vaginal delivery. However, this was not associated with the behavioral factors analyzed. We hypothesize that other social and psychological factors might explain this difference.

Association of Dyslipidemia with Uterine Fibroid: A Case Control Study

2020 ◽  
Vol 33 (2) ◽  
pp. 100-106
Author(s):  
Shahzadi Afruza ◽  
AKM Azad Hossain ◽  
Jesmin Jahan ◽  
Asma Sharmin ◽  
Halima Naznin ◽  
...  
Keyword(s):  
Uterine Fibroid ◽  
Case Control Study ◽  
Statistical Significance ◽  
Hormonal Treatment ◽  
Case Control ◽  
Atherogenic Index ◽  
Control Group ◽  
Case Group ◽  
Control Study ◽  
Inpatient Department

Background & objective: Uterine fibroid (UF) is the most common gynaecological neoplasm. Despite the major public health impact of UF, little is known about their association. Some studies focused on the similarities between the common biological mechanisms underlying the development of UF and atherosclerotic plaques. So, it is possible to hypothesize that same atherogenic risk factors, such as dyslipidemia may play a role in UF pathogenesis. This study was carried out to investigate the lipid profile in patients with UF and to analyze the association of dyslipidemia with UF. Materials & Methods: This case-control study was carried out in the outpatient and inpatient Department of Obstetrics & Gynaecology, BSMMU, Shahbag, Dhaka over a period of 12 months between March 2017 to February 2018. Participants were 100 in number and aged between 18 and 45 years. Cases consisted of 50 women with uterine fibroids diagnosed by ultrasonography attending the outpatient and inpatient department of obstetrics and gynaecology, BSMMU, having no previous hormonal treatment. A similar number of age matched women without UF visiting the same gynaecological outpatient clinic for routine reasons were recruited as controls. Women who were postmenopausal, pregnant, diagnosed cases of malignant diseases, diagnosed cases of hypertension, diabetes mellitus, thyroid disease, CLD and CKD and women undergoing hormonal therapy were excluded from the study. Fasting lipid profiles were determined in blood samples taken from each participant. Atherogenic index was also calculated. Chi-square test was used for testing statistical significance. Statistical significance was set at p < 0⋅05. Results: Women with UF were found to have significantly higher levels of serum TC, TG and significantly lower level of HDL-C compared to the controls (p<0.05). The mean atherogenic index was 4.30±1.41 in case group and 2.86±0.97 in control group. The difference was statistically significant (p<0.05) between two groups. Conclusion: There is an association between dyslipidemia and UF. Women with UF have higher atherogenic index compared to women without UF. TAJ 2020; 33(2): 100-106

scholarly journals Safety and Efficacy of Ferric Carboxymaltose in Anemic Pregnant Women: A Retrospective Case Control Study

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Anouk Pels ◽  
Wessel Ganzevoort
Keyword(s):  
Pregnant Women ◽  
Pregnancy Outcomes ◽  
Case Control Study ◽  
Case Control ◽  
Ferric Carboxymaltose ◽  
Control Group ◽  
Efficient Treatment ◽  
Safety And Efficacy ◽  
Anemia During Pregnancy ◽  
Control Study

Background. Anemia during pregnancy is commonly caused by iron deficiency and can have severe consequences for both the mother and the developing fetus. The aim of this retrospective study was to assess the safety and efficacy of intravenous ferric carboxymaltose (FCM) in pregnant women.Methods. All women treated with FCM for anemia during pregnancy between 2010 and 2012 at our institution were included. A matched control group was selected, including women who either were nonanemic or had anemia but were not considered for intravenous iron. Main outcome measures were maternal safety and pregnancy outcomes.Results. The study included 128 patients (FCM: 64; control: 64). Median FCM dose was 1000 mg and median gestational age at the time of first treatment was 34 weeks and 6 days. Median Hb increased from 8.4 g/dL (interquartile range 7.7; 8.9 g/dL) at the first FCM administration to 10.7 g/dL (9.8; 11.5 g/dL;n=46with available Hb at delivery) at the time of delivery, achieving levels similar to those in the control group (10.8 g/dL [9.8; 11.8 g/dL;n=48]). No treatment-related adverse events were reported and no statistically significant differences in pregnancy outcomes were observed between groups.Conclusions. Within the limitations of this case control study, FCM was a safe and efficient treatment of anemia during pregnancy.

Assessment of fetal Doppler parameters in pregnant women with COVID-19 infection: a prospective case-control study

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Sule Goncu Ayhan ◽  
Atakan Tanacan ◽  
Aysegul Atalay ◽  
Selcan Sinaci ◽  
Eda Ozden Tokalioglu ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Case Control Study ◽  
Case Control ◽  
Ductus Venosus ◽  
Control Group ◽  
City Hospital ◽  
Fetal Doppler ◽  
Control Study ◽  
Prospective Case Control Study ◽  
Demographic Features

Abstract Objectives To investigate the effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on fetal Doppler parameters. Methods This was a prospective case-control study conducted in Ankara City Hospital with confirmed SARS-CoV-2 infected pregnants between August 1, 2020 and October 1, 2020. There were 54 COVID-19 confirmed pregnant women and 97 age-matched pregnant women as a control group between 28 and 39 weeks. Infection was confirmed based on positive real-time polymerase-chain reaction results. Demographic features, uterine artery (right, left), umblical artery, middle cerebral artery, ductus venosus, cerebro-placental ratio, and cerebral-placental-uterine ratio Doppler parameters were investigated in both groups. Results Two groups were similar in terms of demographic features and no difference was found for fetal Doppler parameters. Conclusions COVID-19 seems to have no adverse effect on fetoplacental circulation in mild and moderate patients during the acute phase of the infection.

scholarly journals The lower methylation of RANK is associated with osteoporosis in male aged general population of Xinjiang: A Case-Control Study

2020 ◽  
Author(s):  
Junjing Shang ◽  
Hong xiang ◽  
Xue Bai ◽  
Buluhan Halan ◽  
Hongmei Wang
Keyword(s):  
Blood Pressure ◽  
General Population ◽  
Case Control Study ◽  
Statistical Significance ◽  
Multivariate Logistic Regression Analysis ◽  
Case Control ◽  
Control Group ◽  
Case Group ◽  
Methylation Rate ◽  
Control Study

Abstract Background RANK is a candidate gene for osteoporosis on both functional and genetic grounds. The study is to investigate the relationships between the methylation of RANK and osteoporosis in aged general population. Methods On the basis of an epidemiological investigation, we detect for methylation CpGs in promoter of RANK in 32 aged subjects (16 males and 16 females) firstly. Secondly, after considering the relationships among osteoporosis and the methylation rate of identified CpGs in male and female subjects, the selected representatives CpGs were detected in 90 male aged general subjects (43 controls and 47 cases) by bisulfite sequencing. Then a case-control study is conducted. Results Age and the prevalence of diabetes were significantly difference between the case patients and control individuals (P = 0. 025, P = 0. 005)., There was no statistical significance between the case group and the control group for the following values: systolic blood pressure, diastolic blood pressure, body mass index, 25-dihydroxyvitaminD3, folic acid, testosterone, creatinine, serum calcium concentration, and the prevalence of smoking, drinking and hypertension (P > 0.05). The methylation rate of RANK in control group was significant higher than that in osteoporosis group (P < 0.001). In addition, by covariance analysis to adjust age, prevalence of smoking, drinking, hypertension, and diabetes, the methylation rate of RANK in control group was significant higher than that in osteoporosis group in male aged general population of Xinjiang (P = 0.001). After adjusting for confounding factors (age, smoking, drinking, and diabetes), multivariate logistic regression analysis also showed that lower methylation of RNAK gene were significantly associated with osteoporosis (OR = 0.930, 95% CI = 0.886–0.976) Conclusions The lower methylation rate of RANK was associated with osteoporosis in male aged general population of Xinjiang. This confirms that lower methylation of RANK might be involved in the pathogenesis of osteoporosis

scholarly journals Dynamic Thiol Disulphide Homeostasis in Patients with Surfer’s Eye: A Case-Control Study

2021 ◽  
Author(s):  
Hanife Tuba Akcam ◽  
Ozcan Erel
Keyword(s):  
Negative Correlation ◽  
Case Control Study ◽  
Case Control ◽  
Control Group ◽  
Ocular Diseases ◽  
Total Thiol ◽  
Larger Sample ◽  
Shed Light ◽  
Control Study

Abstract Purpose The role of oxidative stress in the pathogenesis of pterygium is still unclear. However, abnormal thiol disulfide homeostasis levels are involved in the pathogenesis of various systemic or ocular diseases. We aim to analyze dynamic thiol disulphide homeostasis in patients suffering from conjunctival pterygium using a contemporary technique. Methods Thirty-eight subjects suffering from pterygium and 35 age-gender matched healthy volunteers were recruited for study. For each case, total thiol, disulfide and native thiol levels in blood were obtained. Additionally, ratio of disulfide over total thiol, native thiol over total thiol and disulfide over native thiol were computed. Results The level of median native thiol was lower in pterygium group (318.2 µmol /L vs 333.4 µmol /L) and median disulfide was slightly higher in pterygium group (24.3 µmol /L vs 22.8 µmol /L) compared to control group. Both disulfide over total thiol and disulfide over native thiol ratios were higher in pterygium group, ratio of native thiol over total thiol was found to be higher in control group. Nevertheless, none of those differences were statistically significant at 95% confidence level. Notably, correlation test pointed to a negative correlation both between pterygium grade and native thiol and between total thiol and pterygium grade in pterygium group (P = 0.03 and 0.02 respectively). Conclusion A negative correlation hinting that slightly weakened dynamic thiol disulphide homeostasis in subjects with pterygium, a local ocular disease. Further studies with larger sample sizes may shed light on this potential relationship and justify systemic antioxidant therapies in these cases.

A case–control study on effects of the ATM, RAD51 and TP73 genetic variants on colorectal cancer risk

2019 ◽  
Vol 44 (6) ◽  
pp. 778-786
Author(s):  
Merve Yazici ◽  
Umit Yilmaz ◽  
Nesibe Yilmaz ◽  
Faruk Celik ◽  
Ece Gizem Isikoren ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Patient Group ◽  
Case Control Study ◽  
Statistical Significance ◽  
Turkish Population ◽  
Case Control ◽  
Control Group ◽  
Clinical Parameters ◽  
Allele Distribution ◽  
Control Study

Abstract Aim ATM, RAD51 and TP73 are genes that take part in DNA repair pathways. The aim of this prospective case-control study was to determine the genotype and allele distributions of the ATM 5′-UTR G/A, RAD51 135 G/C and TP73 GC/AT polymorphisms and their relationship with clinical parameters in Turkish colorectal cancer (CRC) patients. Material and methods One hundred and four CRC patients and 113 healthy individuals were included in this study as control. The polymerase chain reaction-restriction fragment length polymorphism techniques were used. Results The ATM 5′-UTR G/A polymorphism GG (p = 0.001) and AA (p = 0.0001) genotypes were found higher in the patient group, while the GA genotype (p = 0.0001) and A allele (p = 0.001) were significantly higher in the control group. Moreover, the GG genotype (p = 0.042) was higher among patients with advanced-stage cancer and, while GA genotype (p = 0.047) was increased in patients without perineural invasion. The RAD51 135 G/C polymorphism GC genotype (p = 0.0001) and C allele (p = 0.0001) were significantly higher in the patient group, while CC genotype (p = 0.0001) was higher in the control group. No statistical significance was observed between the TP73 GC/AT polymorphism genotype and allele distribution and the clinical parameters. Conclusion In the Turkish population, the ATM 5′-UTR GG and AA genotypes, and the RAD51 135 G/C GC genotype and the C allele presence may be risk factors for CRC.

scholarly journals Pregnancy outcomes among SARS-CoV-2-infected pregnant women with and without underlying diseases: a case-control study

2021 ◽  
Vol 14 (4) ◽  
pp. 518-522
Author(s):  
Samereh Ghelichkhani ◽  
◽  
Ensiyeh Jenabi ◽  
Ebrahim Jalili ◽  
Azam Alishirzad ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Pregnancy Outcomes ◽  
Preterm Labor ◽  
Case Control Study ◽  
Risk Groups ◽  
Case Control ◽  
Control Group ◽  
Case Group ◽  
Underlying Diseases ◽  
Control Study

This study aimed to examine the pregnancy outcomes in women infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with and without underlying diseases in western Iran. This case-control study compared 49 pregnant women with Coronavirus disease (COVID-19) with underlying diseases (the case group) and 49 women with COVID-19 without underlying diseases (the control group). The groups were pregnant women with COVID-19 admitted to Hamadan hospitals for delivery. COVID-19 was diagnosed by using the reverse transcriptase-polymerase chain reaction (real-time RT-PCR). Data were evaluated using a checklist. Further, the Statistical Package for the Social Sciences (SPSS) version 16 was used for data analysis. A value of p<0.05 was considered statistically significant. The odds of preterm labor were five times higher in women with underlying diseases (OR=5.95, 95% CI (3.01, 7.15), p=0.034). Moreover, the odds of preeclampsia and eclampsia in women with underlying diseases was (OR=3.35, 95% CI (1.18, 4.93), p=0.048) and (OR=2.65, 95% CI (1.43, 3.54), p=0.035), respectively. The results revealed that preterm labor, preeclampsia, and eclampsia were significantly higher in women with COVID-19 and underlying diseases compared to those without underlying diseases. Thus, the need to identify and educate pregnant mothers on underlying diseases and attention to prenatal care, particularly in high-risk groups, is necessary for the COVID-19 pandemic.

scholarly journals Serum Calcium Level in Patients with Pre Eclampsia : A Case Control Study

2021 ◽  
Vol 20 (1) ◽  
pp. 33-36
Author(s):  
Rajasree Bhowmick ◽  
Juthi Bhowmik ◽  
Shiuly Chowdhury ◽  
Ayesha Najma Nur ◽  
Firoza Begum
Keyword(s):  
Pregnant Women ◽  
Serum Calcium ◽  
Calcium Level ◽  
Serum Calcium Level ◽  
Case Control Study ◽  
Calcium Supplementation ◽  
Case Control ◽  
Control Group ◽  
Group Data ◽  
Control Study

Background: To compare serum calcium level in pre-eclamptic women and normal pregnant women. Materials and methods: It was a case-control study carried out in patient Department of Fetomaternal Medicine unit in the Department of Obstetrics & Gynaecology of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka. From September 2010 to February 2011. Total 60 cases, among them 30 comprising control group and 30 were cases. This was a non interventional case control study that was carried out on total 60 women with age range 18 to 38 years of them 30 healthy gravid women as control group and 30 pregnancy with pre eclampsia as case. Serum calcium level of the groups were measured, and compare between this two group. Data were analyzed by computer with the help of SPSS (Statistical Package for Social Sciences) win 13 software package. Results: Serum calcium in pre-eclamptic women was significantly low [7.88±0.75mg/dl vs 9.9267±0.58 mg/dl] than in normal pregnant women. Conclusion: Serum calcium may be used for earlier detection of preeclampsia. Further studies are required to investigate whether calcium supplementation can be used as a preventable measure for the development of preeclampsia. Chatt Maa Shi Hosp Med Coll J; Vol.20 (1); January 2021; Page 33-36

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