scholarly journals Study Protocol of the Exercise Study: Unraveling Limitations for Physical Activity in Children With Chronic Diseases Order to Target Them With Tailored Interventions—A Randomized Cross Over Trial

2022 ◽  
Vol 9 ◽  
Author(s):  
Linda E. Scheffers ◽  
Willem A. Helbing ◽  
Elisabeth M. W. J. Utens ◽  
Gwen C. Dieleman ◽  
Karolijn Dulfer ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Chronic Diseases ◽  
Exercise Capacity ◽  
Exercise Intervention ◽  
Fontan Circulation ◽  
Dietary Advice ◽  
Activity Levels ◽  
Physical Activity Levels

Introduction: Physical activity is associated with many physiological and psychological health benefits across the lifespan. Children with a chronic disease often have lower levels of daily physical activity, and a decreased exercise capacity compared to healthy peers. In order to learn more about limitations for physical activity, we investigate children with four different chronic diseases: children with a Fontan circulation, children with Broncho Pulmonary Dysplasia (BPD), Pompe disease and inflammatory bowel disease (IBD). Each of these diseases is likely to interfere with physical activity in a different way. Knowing the specific limitations for physical activity would make it possible to target these, and increase physical activity by a personalized intervention. The aim of this study is to first investigate limitations for physical activity in children with various chronic diseases. Secondly, to measure the effects of a tailored exercise intervention, possibly including a personalized dietary advice and/or psychological counseling, on exercise capacity, endurance, quality of life, fatigue, fear for exercise, safety, muscle strength, physical activity levels, energy balance, and body composition.Methods and Analysis: This randomized crossover trial will aim to include 72 children, aged 6–18 years, with one of the following diagnosis: a Fontan circulation, BPD, Pompe disease and IBD. Eligible patients will participate in the 12-week tailored exercise intervention and are either randomized to start with a control period or start with the intervention. The tailored 12-week exercise interventions, possibly including a personalized dietary advice and/or psychological counseling, will be designed based on the found limitations for physical activity in each disease group during baseline measurements by the Rotterdam Exercise Team. Effects of the tailored training interventions will be measured on the following endpoints: exercise capacity (measured by cardiopulmonary exercise test), endurance, physical activity levels, muscle strength, quality of life, fatigue, fear for exercise, disease activity, cardiac function (in children with a Fontan circulation), energy balance, and body composition.Ethics and Dissemination: Conducted according to the Declaration of Helsinki and Good Clinical Practice. Medical-ethical approval was obtained.Trial Registration Number: NL8181, https://www.trialregister.nl/trial/8181.

A randomized trial of exercise on quality of life in men with metastatic prostate cancer: The ExPeCT Trial.

2019 ◽  
Vol 37 (31_suppl) ◽  
pp. 97-97
Author(s):  
Grainne Sheill ◽  
Lauren Brady ◽  
Emer M. Guinan ◽  
Juliette M. Hussey ◽  
Brian Hayes ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Prostate Cancer ◽  
Aerobic Exercise ◽  
Metastatic Prostate Cancer ◽  
Exercise Intervention ◽  
Randomised Control Trial ◽  
Activity Levels ◽  
Physical Activity Levels

97 Background: All patients living with cancer, including those with metastatic cancer, are encouraged to be physically active. This paper examines the feasibility of an aerobic exercise intervention for men with metastatic prostate cancer. Methods: ExPeCT (Exercise, Prostate Cancer and Circulating Tumour Cells), was a multi-centre randomised control trial for men living with metastatic prostate cancer. Participants were randomized to either control or exercise arms. Participants in the exercise arm completed six- months of prescribed aerobic exercise. Quality of life assessments were completed at baseline, at 3 months and at 6 months using a standardised questionnaire derived from the Harvard Health Professionals Follow-up study. Physical activity was measured using a self-administered physical activity questionnaire. Exercise adherence data was collected via Polar heart rate monitors, worn by the patient for every exercise session undertaken. Results: A total of 61 patients were included (69.4±7.3 yr, Body Mass Index 29.2±5.8 kg/m2). The median time since diagnosis was 34 months (IQR 7-54). A total of 35 (55%) of participants had >1 region affected by metastatic disease. A total of 54 (81%) of participants completed the 3 month assessment and 52 (78%) of the participants completed the 6 month assessment. Adherence to the supervised sessions was 83% (329 out of 396 sessions attended). Participants were adherent to both the intensity (82%) and duration (83%) of the prescribed exercise programme during class sessions. No adverse events were reported by participants enrolled in this study. There was no significant difference in physical activity levels, sedentary time or quality of life between either group at baseline, 3 months or 6 months. Systolic blood pressure was significantly lower in the exercise group when compared to the control group at 3 months (p=.008) and 6 months (p=.011). Conclusions: The exercise intervention was tolerated well by a group of patients with a high burden of metastatic prostate cancer however did not lead to change in physical activity levels or quality of life. This trial provides proof of principle evidence for future exercise studies involving this patient group. Clinical trial information: NCT02453139.

scholarly journals Physical activity trajectories following gynecological cancer: results from a prospective, longitudinal cohort study

2020 ◽  
Vol 30 (11) ◽  
pp. 1784-1790
Author(s):  
Steven Fleming ◽  
Tamara Jones ◽  
Monika Janda ◽  
Dimitrios Vagenas ◽  
Leigh Ward ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Endometrial Cancer ◽  
Gynecological Cancer ◽  
Activity Levels ◽  
Physical Activity Levels ◽  
Low Levels ◽  
The Relationship ◽  
Over Time

BackgroundParticipating in physical activity after a diagnosis of cancer is associated with reduced morbidity and improved outcomes. However, declines in, and low levels of, physical activity are well documented in the broader cancer population, but with limited evidence following gynecological cancer.ObjectiveTo describe physical activity levels from before and up to 2 years after gynecological cancer surgery; to explore the relationship between physical activity patterns and quality of life; and to describe characteristics associated with physical activity trajectories post-gynecological cancer.MethodsWomen with gynecological cancer (n=408) participated in a prospective study that assessed physical activity and quality of life pre-surgery (baseline), at 6 weeks, and 3, 6, 9, 12, 15, 18 and 24 months post-surgery. Validated questionnaires were used to assess physical activity (Active Australia Survey) and quality of life outcomes (Functional Assessment of Cancer Therapy-General). Generalized estimating equation modeling, group-based trajectory analysis, and analysis of variance were used to identify physical activity levels over time, to categorize women into physical activity trajectory groups, and to assess the relationship between physical activity levels and quality of life, respectively.ResultsWomen had a mean±SD age of 60±11.4 years at diagnosis, with the majority diagnosed with endometrial cancer (n=235, 58%) or stage I disease (n=241, 59%). Most women (80%) started with and maintained low levels of physical activity (1–10 metabolic equivalent task hours per week), reported no physical activity throughout the follow-up period, or reduced physical activity levels over time. Only 19% of women maintained or doubled physical activity levels, so that by 24 months post-diagnosis they were engaging in sufficient levels of physical activity. Women with endometrial cancer (58% of the sample) were more likely to be overweight or obese and to report low levels of physical activity or none at all. Higher physical activity levels were associated with higher quality of life (p<0.05).ConclusionThe low baseline and surveillance levels of physical activity show that the vast majority of gynecological cancer survivors have the ability to improve their physical activity levels. Integration of physical activity advice and support into standard care could lead to gains in quality of life during gynecological cancer survivorship.

Objectively measured physical activity and its influence on physical capacity and clinical parameters in patients with primary Sjögren’s syndrome

Lupus ◽  
2016 ◽  
Vol 26 (7) ◽  
pp. 690-697 ◽  
Author(s):  
T Dassouki ◽  
F B Benatti ◽  
A J Pinto ◽  
H Roschel ◽  
F R Lima ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Physical Capacity ◽  
Activity Levels ◽  
Health Related Quality ◽  
Physical Activity Levels ◽  
Related Quality ◽  
Health Related ◽  
And Function

Objective The objectives of this paper are to objectively measure habitual physical activity levels in patients with primary Sjögren’s syndrome (pSS) with mild disease activity and to determine to which extent it may be associated with physical capacity and function and clinical features. Methods In this cross-sectional study, 29 women with pSS were objectively assessed for habitual physical activity levels (using accelerometry) and compared with 20 healthy women (CTRL) frequency-matched for physical activity levels, age, body mass index, and body fat percentage with regard to physical capacity and function, fatigue, depression, pain, and health-related quality of life. Results pSS showed 8.5 min/day of moderate-to-vigorous physical activity (MVPA) when only MVPA accumulated in bouts ≥ 10 min was considered; when considering total MVPA (including bouts < 10 min), average levels were 26.3 min/day, with 62% of pSS patients achieving the recommendation (≥ 21.4 min/day). Moreover, pSS showed lower VO2peak, lower muscle strength and function, higher fatigue, and poorer health-related quality of life when compared with CTRL ( p < 0.05). These differences (except for aerobic capacity) were sustained even when only individuals achieving the minimum of 21.4 min/day of total MVPA in both groups were compared. Finally, MVPA time was significantly correlated with aerobic conditioning, whereas total counts and sedentary time were associated with lower-body muscle strength and the bodily-pain domain of SF-36 in patients with pSS. Conclusion When compared to physical activity-matched healthy controls, pSS patients showed reduced physical capacity and function, increased fatigue and pain, and reduced health-related quality of life. Except for aerobic conditioning, these differences were sustained when only more physically active participants were compared, indicating that minimum recommended levels of physical activity for the general population may not be sufficient to counteract pSS comorbidities.

scholarly journals Investigation of Relationship Between Physical Activity Levels and Quality of Life of University Students

2019 ◽  
Vol 12 (4) ◽  
pp. 110
Author(s):  
Süleyman Gönülateş ◽  
Mehmet Ali Ozturk
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Pearson Correlation ◽  
World Health ◽  
Homogeneous Distribution ◽  
Activity Levels ◽  
Correlation Test ◽  
Physical Activity Levels ◽  
Pearson Correlation Test

The aim of this study is to investigate whether there is a positive or negative relationship between the quality of life of the students and their physical activity levels (PAL). A total of 469 students participated in the study (female = 209, male = 260). The physical activity levels of the participants were determined as "International Physical Activity Questionnaire Short Form (IPAQ-SF)" and their quality of life was determined by the World Health Organization (WHOQOL-BREF). In the statistical analysis, parametric tests were used because of the normal and homogeneous distribution of the data. The difference between PAL and quality of life scores was evaluated by MANOVA test. The relationship between PAL and quality of life of the participants was tested by Pearson Correlation test. The overall health status of the participants was 87% (n = 408) good-very good and the level of physical activity was 88.1% (n = 413) moderate-high active. There was no statistically significant difference between the PAL and quality of life scores of the participants. After Pearson Correlation test, there was no correlation between PAL and quality of life at r2 at p

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