COVID-19 in Pediatrics: Demographic, Clinical, Laboratory, and Radiological Characteristics of Infected Patients With SARS-CoV-2

The COVID-19 disease usually leads to mild infectious disease in children, but some develop serious complications. Here, we describe the characteristics of children with COVID-19 in northern Iran, the Golestan province. Ninety-one confirmed cases were enrolled in the study, aged 0–18 years. Demographic, clinical, comorbidity, laboratory, and radiological data were compared based on the disease severity (admitted to intensive care unit (ICU) or not) and disease outcome (recovered or deceased). Sixteen (17.5%) cases were hospitalized in ICU, and 8/91 (8.8%) deceased. Fever and cough were the most common clinical symptoms. Among all symptoms notified there were no significant differences between severe and milder cases, or between those who deceased and recovered. Failure to thrive (FTT), malignant disease and neurological disease were significantly more prevalent in severe cases as was frequently reported comorbidities. Laterality, ground-glass opacity, and lung consolidation were the most common findings in chest computed tomography. The data confirms that the COVID-19 disease has various presentations in children, and clinical, laboratory, and radiological findings may help predict the development of severe forms of COVID-19 among children.

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Clinical, laboratory and chest computed tomography aspects of hospitalized patients with COVID-19 in northern Iran

10.22541/au.160673226.66738260/v1 ◽

2020 ◽

Author(s):

ali sharifpour ◽

sepideh Safanavaei ◽

Rabeeh Tabaripour ◽

fatemeh Taghizadeh ◽

maryam nakhaei ◽

...

Keyword(s):

Computed Tomography ◽

Clinical Laboratory ◽

Clinical Symptoms ◽

Laboratory Data ◽

Ground Glass Opacity ◽

Hospitalized Patients ◽

Critical Factors ◽

High Resolution Computed Tomography ◽

Northern Iran ◽

Laboratory Findings

The clinical symptoms, blood laboratory data, O2 saturation and high resolution computed tomography (HRCT) findings are critical factors in diagnosis of COVID-19 infection. In this study, 105 hospitalized patients suspected of having COVID-19 were evaluated. Finally, the data of 83 confirmed cases by HRCT and RT-PCR were analyzed. 61.40% of the patients had a comorbidity disease. 89.20% had fever, 92.00% cough, 91.40% dyspnea. Abnormal CRP seen in 77.80% of the patients following by 66.70% lymphopenia, and 60.30% neutrophilia. Also, ALP (abnormal vs. normal) and score of HRCT assessment variables had a significant effect on the positiveness of HRCT findings. 87.95% had abnormal HRCT with 41% bilateral multilobar patchy ground glass opacity (GGO). Moreover, there was a statistically significant association between level of O2 saturation and HRCT results. Our findings showed that male patients with middle age and comorbidity disease were more susceptible to the COVID-19 infection. Additionally, clinical features, blood laboratory findings, O2 saturation and HRCT findings are critical factors in prognosis of COVID-19 infection.

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Clinical Characteristics of 107 Patients with COVID-19 in Ningbo, China: Single Center Experience Outside Hubei

10.21203/rs.3.rs-44830/v1 ◽

2020 ◽

Author(s):

Boming Wu ◽

Junjie Li ◽

Hongping Xuan ◽

Nanhong Zheng ◽

Honghua Ye ◽

...

Keyword(s):

Clinical Characteristics ◽

Clinical Laboratory ◽

Ground Glass Opacity ◽

Underlying Disease ◽

Good Prognosis ◽

Radiological Findings ◽

Single Center Experience ◽

Radiological Data ◽

History Of

Abstract Background Since December 2019, there has be an outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Wuhan, China. Nowadays, it rapidly spread across the country and then the worldwide. We aimed to investigate the clinical characteristics of patients with COVID-19.Methods The patients with confirmed COVID-19 admitted between January 25 and February 10, 2020, were enrolled. Epidemiological, demographic, clinical, laboratory, radiological data, and antivirus therapies, were retrospectively collected and analyzed. The 90-day follow-up of these patients was also performed.Results A total of 107 patients were included. The median age was 55.0 years (range from 18.0 to 85.0 years), and 72 (67.3%) were female. Ninety-three (86.9%) of the patients had a history of contacting with residents from Wuhan (n=31), or contacting with confirmed COVID-19 patients (n=62) within 2 weeks. Fifty-eight (54.2%) had a family cluster onset. Fever and cough were the most common symptoms. Only two patients had diarrhea. The most common underlying disease was hypertension. Lymphopenia was observed in 26 patients. Fifty-two patients with an elevated level of IL-6. On admission, bilateral patchy shadowing and ground-glass opacity were the typical radiological findings on chest computed tomography. Six patients had an intensive care unit (ICU) stay. Antivirus therapy was performed to all patients. 105 patients discharged with an improved condition, and no death was occurred during our 90-day follow-up for these patients.Conclusions Patients with COVID-19 in our hospital had relatively mild symptoms, and good prognosis. This study also highlights the importance of human-to-human transmission in COVID-19.

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Differential diagnosis of bilateral lungs opacities in the hospital for admission of community-acquired pneumonia – not only COVID-19

Medical Visualization ◽

10.24835/1607-0763-2020-2-78-95 ◽

2020 ◽

Vol 24 (2) ◽

pp. 78-95

Author(s):

A. S. Vinokurov ◽

O. I. Belenkaya ◽

E. A. Zolotova ◽

S. V. Michurina ◽

O. O. Vinokurova ◽

...

Keyword(s):

Differential Diagnosis ◽

Clinical Laboratory ◽

Clinical Symptoms ◽

Community Acquired Pneumonia ◽

Lung Damage ◽

Ground Glass ◽

Small Areas ◽

Radiological Data ◽

Coronavirus Infection ◽

To Receive

Due to the current epidemiological situation caused by the spread of the new SARS-CoV-2 coronavirus, in March 2020 several Moscow hospitals were completely or partially redesigned to receive patients with community- acquired pneumonia.Purpose. The aim of the survey is to analyze clinical, laboratory and radiological data in patients with coronavirus infection at the early stages of its spread in Russia, and to clarify diseases for differential diagnosis mainly based on CT evidence.Materials and methods. We studied data from 21 patients with verified coronavirus infection admitted to the hospital for community-acquired pneumonia. Clinical symptoms, laboratory and physical indicators, as well as typical lung changes on the CT were evaluated.Results. Major clinical symptoms in coronavirus patients are fever (100%), cough (90.5%), shortness of breath (76.1%). Laboratory indicators showed increases in CRP (85.7%), leukocytosis (66.6%), and LDG (84.6%). According to CT, 95.2% of lung changes involved both sides, and 66.7% occurred in all lung fields. The sign of “ground glass” was observed in a 100% of the cases, its combination with the “paving stone” – in 61,9%, “ground glass” coupled with small areas of consolidations were detected in 33,3% of the cases. Changes such as nodules, cavities and massive areas of consolidation were not identified.Conclusion. On the basis of our own data we confirmed the main trends of diagnostics and clinical features, which were identified by authors from Asia and Europe, who faced this infection earlier, and also considered important CT characteristics useful for differential diagnosis of coronavirus lung damage and other lung diseases.

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Clinical and CT features of mild-to-moderate COVID-19 cases after two sequential negative nucleic acid testing results: a retrospective analysis

10.21203/rs.3.rs-29848/v1 ◽

2020 ◽

Author(s):

Yan Rong ◽

Jing Wang ◽

Jinfei Tian ◽

Xinhua Liang ◽

Yang Zhou ◽

...

Keyword(s):

Nucleic Acid ◽

Clinical Laboratory ◽

Clinical Symptoms ◽

Ground Glass Opacity ◽

Ct Imaging ◽

Ground Glass ◽

Imaging Features ◽

Nucleic Acid Testing ◽

Imaging Data ◽

Negative Results

Abstract Background Numerous studies have been focused on the clinical and imaging features among COVID-19 patients positive for SARS-CoV-2, but the data after negative is limited. We aims to describe these features after negative respiratory nucleic acid testing results.Methods From January 31 to February 28, 2020, 51 mild-to-moderate COVID-19 cases (median: 34.0 years and 47.1% male) were retrospectively enrolled. Demographic, clinical, laboratory, and CT imaging data were collected before and after two sequential negative results for respiratory SARS-CoV-2 .Results After negative for respiratory SARS-CoV-2, the clinical symptoms continued to recover and the abnormal imaging were observed for all of the moderate cases. 77.4% of the moderate patients had multi-lobar involvement and lesions were more frequent in the lower lobes. The most common CT imaging manifestations were ground glass opacity (51.6%) and fibrous stripes (54.8%%). Among 12 out of 31 moderate patients with repeated chest CT scan after negative for SARS-CoV-2, 7 patients (58.3%) with ground-glass absorption reduced over 60% within one week, but there were still 4 cases (13.8%) with absorption less than 5%.Conclusions The clinical symptoms and abnormal imaging persisted but continued to recover after negative for respiratory SARS-CoV-2.

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Clinical imaging characteristics of inpatients with COVID-19 in Heilongjiang Province, China: a retrospective study

10.21203/rs.3.rs-31215/v1 ◽

2020 ◽

Author(s):

Hao Jiang ◽

Wei Guo ◽

Huijie Jiang ◽

Mingyu Zhang ◽

Lai Wei ◽

...

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

Clinical Laboratory ◽

Clinical Symptoms ◽

Ground Glass Opacity ◽

Care Group ◽

Heilongjiang Province ◽

Care Groups ◽

Imaging Characteristics ◽

Lung Lobes

Abstract Objectjve: To investigate the clinical, laboratory, and radiological characteristics of patients with coronavirus disease 2019 (COVID-19) in Heilongjiang Province. Methods: The present study carried out a retrospective analysis of 59 patients with COVID-19, including 44 patients in the intensive care unit (ICU) and 15 patients in the non-intensive care unit. The characteristics of the two groups of patients were compared.Results: ICU care group was older and the incidence was higher than that of non-ICU group. Lymphopenia, neutrophils, and increased D-dimer levels were high-risk causes of COVID-19 patients. Compared to the non-ICU care group, the incidence of pulmonary consolidation and Ground-glass opacity combined consolidation in the ICU care group was significantly higher, all lung lobes were more likely to be involved, and the number of lung lobes involved was greater and the area around the bronchi was more likely to be involved. Of the 59 patients with COVID-19 in this group, 15 received mechanical ventilation. All the intubated patients involved lung lobes, and a large number of lesions were seen in the area around the bronchial vessels. Conclusion: Significant differences were observed in clinical symptoms, laboratory tests, and CT features between the ICU and non-ICU care groups.

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A study on the Chrysomelidae (Coleoptera) from the Golestan province, Northern Iran

Acta Phytopathologica et Entomologica Hungarica ◽

10.1556/aphyt.49.2014.2.11 ◽

2014 ◽

Vol 49 (2) ◽

pp. 253-260 ◽

Cited By ~ 2

Author(s):

N. Samin ◽

H. Ghahari ◽

W.B. Jedryczkowski

Keyword(s):

Northern Iran ◽

Golestan Province

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Coronavirus disease (COVID-19) pandemic: an overview of systematic reviews

BMC Infectious Diseases ◽

10.1186/s12879-021-06214-4 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Israel Júnior Borges do Nascimento ◽

Dónal P. O’Mathúna ◽

Thilo Caspar von Groote ◽

Hebatullah Mohamed Abdulazeem ◽

Ishanka Weerasekara ◽

...

Keyword(s):

Systematic Reviews ◽

Troponin I ◽

Clinical Symptoms ◽

Meta Analysis ◽

Severe Disease ◽

Ground Glass Opacity ◽

Cochrane Library ◽

Reactive Protein ◽

Overview Of Systematic Reviews ◽

The Impact

Abstract Background Navigating the rapidly growing body of scientific literature on the SARS-CoV-2 pandemic is challenging, and ongoing critical appraisal of this output is essential. We aimed to summarize and critically appraise systematic reviews of coronavirus disease (COVID-19) in humans that were available at the beginning of the pandemic. Methods Nine databases (Medline, EMBASE, Cochrane Library, CINAHL, Web of Sciences, PDQ-Evidence, WHO’s Global Research, LILACS, and Epistemonikos) were searched from December 1, 2019, to March 24, 2020. Systematic reviews analyzing primary studies of COVID-19 were included. Two authors independently undertook screening, selection, extraction (data on clinical symptoms, prevalence, pharmacological and non-pharmacological interventions, diagnostic test assessment, laboratory, and radiological findings), and quality assessment (AMSTAR 2). A meta-analysis was performed of the prevalence of clinical outcomes. Results Eighteen systematic reviews were included; one was empty (did not identify any relevant study). Using AMSTAR 2, confidence in the results of all 18 reviews was rated as “critically low”. Identified symptoms of COVID-19 were (range values of point estimates): fever (82–95%), cough with or without sputum (58–72%), dyspnea (26–59%), myalgia or muscle fatigue (29–51%), sore throat (10–13%), headache (8–12%) and gastrointestinal complaints (5–9%). Severe symptoms were more common in men. Elevated C-reactive protein and lactate dehydrogenase, and slightly elevated aspartate and alanine aminotransferase, were commonly described. Thrombocytopenia and elevated levels of procalcitonin and cardiac troponin I were associated with severe disease. A frequent finding on chest imaging was uni- or bilateral multilobar ground-glass opacity. A single review investigated the impact of medication (chloroquine) but found no verifiable clinical data. All-cause mortality ranged from 0.3 to 13.9%. Conclusions In this overview of systematic reviews, we analyzed evidence from the first 18 systematic reviews that were published after the emergence of COVID-19. However, confidence in the results of all reviews was “critically low”. Thus, systematic reviews that were published early on in the pandemic were of questionable usefulness. Even during public health emergencies, studies and systematic reviews should adhere to established methodological standards.

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Stepwise progression from ground-glass opacity towards invasive adenocarcinoma: Long-term follow-up of radiological findings

Lung Cancer ◽

10.1016/j.lungcan.2007.09.001 ◽

2008 ◽

Vol 60 (2) ◽

pp. 298-301 ◽

Cited By ~ 21

Author(s):

Hiroshi Soda ◽

Yoichi Nakamura ◽

Katsumi Nakatomi ◽

Nanae Tomonaga ◽

Hiroyuki Yamaguchi ◽

...

Keyword(s):

Ground Glass Opacity ◽

Ground Glass ◽

Radiological Findings ◽

Invasive Adenocarcinoma ◽

Long Term Follow Up

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440. Clinical Characteristics of Early Noncritical Hospitalized Patients with Coronavirus Disease 2019 (COVID-19): A Single-Center Retrospective Study in New York City

Open Forum Infectious Diseases ◽

10.1093/ofid/ofaa439.633 ◽

2020 ◽

Vol 7 (Supplement_1) ◽

pp. S287-S288

Author(s):

Michelle Lee ◽

Mona Fayad ◽

Tarub Mabud ◽

Paulino Tallon de Lara ◽

Adiac Espinosa Hernandez ◽

...

Keyword(s):

New York ◽

New York City ◽

York City ◽

Clinical Laboratory ◽

Clinical Symptoms ◽

New York State ◽

General Medicine ◽

Retrospective Chart Review ◽

Clinical Severity ◽

Study Cohort

Abstract Background COVID-19 first originated in Wuhan, China, in December 2019. As of April 9, 2020, New York State had become the single largest global epicenter of COVID-19. Methods This is a retrospective chart review of the first 33 patients with RT-PCR-confirmed COVID-19 admitted from the emergency department to a general medicine unit in a single academic hospital in New York City between March 11th to March 27th, 2020. Patient’s demographic, clinical, laboratory, radiographic investigations, treatments and clinical outcomes were retrospectively extracted from the electronic medical record and followed until April 10th, 2020. Patients were divided into severe and nonsevere sub-cohorts. Statistics were descriptive in nature. Results The study cohort (median age 68 yr, 67% male) presented with subjective fevers (82%), cough (88%), and dyspnea (76%). The median incubation period was 3 days. Most cases met SIRS criteria upon admission (76%). Patients had elevated inflammatory markers. Patients were treated with antimicrobials, corticosteroids, hydroxychloroquine, and varying levels of supplemental oxygen. Mortality was 15% and 18% of the cohort required intensive care services. Conclusion Patient age, presenting clinical symptoms, comorbidity profile, laboratory biomarkers, and radiographic features are consistent with findings published from China. Severe patients had peaks in inflammatory biomarkers later in the hospitalization, which may be useful to trend. Further studies are necessary to create guidelines to better risk-stratify COVID-19 patients based on clinical severity. Disclosures All Authors: No reported disclosures

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Periaortic air in native and post-operative aorta on computed tomography

British Journal of Radiology ◽

10.1259/bjr.20210878 ◽

2021 ◽

Author(s):

Mansi Verma ◽

Amit Ajit Deshpande ◽

Niraj Nirmal Pandey ◽

Sanjeev Kumar

Keyword(s):

Computed Tomography ◽

Clinical Laboratory ◽

Radical Surgery ◽

Imaging Finding ◽

Radiological Findings ◽

Catastrophic Event ◽

Cross Sectional ◽

Pictorial Review ◽

Cross Sectional Imaging ◽

Indispensable Tool

Periaortic air can be seen in various conditions which can be a benign imaging finding or harbinger of a catastrophic event. The causes vary in native aorta and post-operative aorta. A radiologist has an important part in the management process of these patients, as the treatment varies from conservative to radical surgery based on the aetiology. The presence of periaortic air seen in the light of various clinical, laboratory and radiological findings can guide the radiologist towards a particular aetiology. Cross-sectional imaging, mainly computed tomography, is an indispensable tool in recognising ectopic periaortic air and to identify the associated findings and eventually make an accurate diagnosis. We present a pictorial review of various causes of the periaortic air in native and postoperative aorta, the salient features and management of the described conditions.

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