scholarly journals Analytical Challenges and Metrological Approaches to Ensuring Dietary Supplement Quality: International Perspectives

2022 ◽  
Vol 12 ◽  
Author(s):  
Alessandra Durazzo ◽  
Barbara C. Sorkin ◽  
Massimo Lucarini ◽  
Pavel A. Gusev ◽  
Adam J. Kuszak ◽  
...  

The increased utilization of metrology resources and expanded application of its’ approaches in the development of internationally agreed upon measurements can lay the basis for regulatory harmonization, support reproducible research, and advance scientific understanding, especially of dietary supplements and herbal medicines. Yet, metrology is often underappreciated and underutilized in dealing with the many challenges presented by these chemically complex preparations. This article discusses the utility of applying rigorous analytical techniques and adopting metrological principles more widely in studying dietary supplement products and ingredients, particularly medicinal plants and other botanicals. An assessment of current and emerging dietary supplement characterization methods is provided, including targeted and non-targeted techniques, as well as data analysis and evaluation approaches, with a focus on chemometrics, toxicity, dosage form performance, and data management. Quality assessment, statistical methods, and optimized methods for data management are also discussed. Case studies provide examples of applying metrological principles in thorough analytical characterization of supplement composition to clarify their health effects. A new frontier for metrology in dietary supplement science is described, including opportunities to improve methods for analysis and data management, development of relevant standards and good practices, and communication of these developments to researchers and analysts, as well as to regulatory and policy decision makers in the public and private sectors. The promotion of closer interactions between analytical, clinical, and pharmaceutical scientists who are involved in research and product development with metrologists who develop standards and methodological guidelines is critical to advance research on dietary supplement characterization and health effects.

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
T. M. Schwarz ◽  
C. A. Dietrich ◽  
J. Ott ◽  
E. M. Weikum ◽  
R. Lawitzki ◽  
...  

AbstractAtom Probe Tomography (APT) is currently a well-established technique to analyse the composition of solid materials including metals, semiconductors and ceramics with up to near-atomic resolution. Using an aqueous glucose solution, we now extended the technique to frozen solutions. While the mass signals of the common glucose fragments CxHy and CxOyHz overlap with (H2O)nH from water, we achieved stoichiometrically correct values via signal deconvolution. Density functional theory (DFT) calculations were performed to investigate the stability of the detected pyranose fragments. This paper demonstrates APT’s capabilities to achieve sub-nanometre resolution in tracing whole glucose molecules in a frozen solution by using cryogenic workflows. We use a solution of defined concentration to investigate the chemical resolution capabilities as a step toward the measurement of biological molecules. Due to the evaporation of nearly intact glucose molecules, their position within the measured 3D volume of the solution can be determined with sub-nanometre resolution. Our analyses take analytical techniques to a new level, since chemical characterization methods for cryogenically-frozen solutions or biological materials are limited.


2021 ◽  
pp. 189-238
Author(s):  
Baili Li ◽  
Ziyan Wang ◽  
Bin Han ◽  
Xi Yu

2013 ◽  
Vol 8 (1) ◽  
pp. 265-278 ◽  
Author(s):  
Carl Lagoze ◽  
William C. Block ◽  
Jeremy Williams ◽  
John Abowd ◽  
Lars Vilhuber

Social science researchers increasingly make use of data that is confidential because it contains linkages to the identities of people, corporations, etc. The value of this data lies in the ability to join the identifiable entities with external data, such as genome data, geospatial information, and the like. However, the confidentiality of this data is a barrier to its utility and curation, making it difficult to fulfil US federal data management mandates and interfering with basic scholarly practices, such as validation and reuse of existing results. We describe the complexity of the relationships among data that span a public and private divide. We then describe our work on the CED2AR prototype, a first step in providing researchers with a tool that spans this divide and makes it possible for them to search, access and cite such data.


Author(s):  
Salman Mau ◽  
Shakir Saleem ◽  
Vishwadeepak Kimothi ◽  
Vineet Joshi ◽  
Sanjay Singh

Diabetes mellitus is one of the most common metabolic disorders associated with disturbed hormonal secretion. Diabetes is characterized by high blood glucose levels over a prolonged period of time. High sugar levels are due to abnormal metabolism of carbohydrates and lipids which is caused by absolute or relative insulin deficiency. Herbal medicines have been the highly esteemed source of medicine throughout the human history. Herbs are becoming more popular today because of their least side effects, holistic beliefs, easy availability and low cost. Individual herbal products and formulations are gaining popularity because of their quality manufacturing using modern analytical techniques and standardized raw materials. Herbal drugs are widely used for the treatment of diabetes worldwide in various dosage forms. India has a long list of native herbal drugs with scientifically proven blood sugar lowering properties. The seeds of Nigella sativa, Olea europaea, fruits of Aegle marmelos, Momordica charantia, Coccinia indica, Nigella sativa,Gymnema sylvestre leaves,whole plant of Pterocarpus marsupium, Syzygium cumini fruits, Swertia punicea, Urtica dioica, gum of Ferula assa-foetida and seeds of Trigonella foenum graecum were discussed along with their reported mechanisms of action. In this review paper an attempt has been made to give an overview of certain Indian plants which have shown their anti-diabetic activity in various pre-clinical studies.


Energies ◽  
2019 ◽  
Vol 12 (16) ◽  
pp. 3148 ◽  
Author(s):  
Ziad Abu El-Rub ◽  
Joanna Kujawa ◽  
Esra’a Albarahmieh ◽  
Nafisah Al-Rifai ◽  
Fathieh Qaimari ◽  
...  

Oil shale is an important possible solution to the problem of energy in Jordan. To explore the technical and the economic feasibility of oil shale deposits, numerous samples are analyzed using the standard Fischer Assay (FA) method. However, it would be useful to develop faster, cheaper, and reliable methods for determining the oil content of oil shale. Therefore, the aim of this work was to propose and investigate rapid analytical techniques for the screening of oil shale deposits and to correlate them with the FA method. The Omari deposit located east of Jordan was selected as a case study for analysis using thermogravimetric analysis (TGA) coupled with Fourier-transform infrared (FTIR), differential scanning calorimetry (DSC), elemental analysis, X-ray fluorescence (XRF), X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy-dispersive X-ray (EDX) analysis. Results obtained from the TGA method were linearly correlated with FA with high regression factor (R2 = 0.99); a quadratic correlation (R2 = 0.98) was maintained between the FA and the elemental hydrogen mass content, and a quadratic correlation (R2 = 0.97) was found between the FA and the aliphatic hydrocarbons (FTIR peak at 2927 cm−1) produced in the pyrolysis zone. Although other techniques were less correlated, further investigation might lead to better results. Subsequently, these correlated techniques can be a practical alternative to the conventional FA method when, in particular, specific correlation is made for each deposit.


JAMIA Open ◽  
2019 ◽  
Vol 2 (4) ◽  
pp. 516-520
Author(s):  
Katelyn A McKenzie ◽  
Suzanne L Hunt ◽  
Genevieve Hulshof ◽  
Dinesh Pal Mudaranthakam ◽  
Kayla Meyer ◽  
...  

Abstract Objective Managing registries with continual data collection poses challenges, such as following reproducible research protocols and guaranteeing data accessibility. The University of Kansas (KU) Alzheimer’s Disease Center (ADC) maintains one such registry: Curated Clinical Cohort Phenotypes and Observations (C3PO). We created an automated and reproducible process by which investigators have access to C3PO data. Materials and Methods Data was input into Research Electronic Data Capture. Monthly, data part of the Uniform Data Set (UDS), that is data also collected at other ADCs, was uploaded to the National Alzheimer’s Coordinating Center (NACC). Quarterly, NACC cleaned, curated, and returned the UDS to the KU Data Management and Statistics (DMS) Core, where it was stored in C3PO with other quarterly curated site-specific data. Investigators seeking to utilize C3PO submitted a research proposal and requested variables via the publicly accessible and searchable data dictionary. The DMS Core used this variable list and an automated SAS program to create a subset of C3PO. Results C3PO contained 1913 variables stored in 15 datasets. From 2017 to 2018, 38 data requests were completed for several KU departments and other research institutions. Completing data requests became more efficient; C3PO subsets were produced in under 10 seconds. Discussion The data management strategy outlined above facilitated reproducible research practices, which is fundamental to the future of research as it allows replication and verification to occur. Conclusion We created a transparent, automated, and efficient process of extracting subsets of data from a registry where data was changing daily.


2010 ◽  
Vol 25 (2) ◽  
pp. 175-181 ◽  
Author(s):  
Patrick J. Parsons ◽  
Kathryn G. McIntosh

Lead poisoning is a preventable condition caused by exposure to environmental sources such as lead-containing dust or lead-painted consumer products. The history of lead poisoning prevention has been defined to some extent by the quality of the analytical methods available for lead measurements whether in environmental samples or biological tissues and fluids. The quality of blood lead methods has improved so greatly over the last three decades that we now know far more about the adverse health effects from low-level exposures. Recent evidence suggests that effects such as deficit in IQ occur below the current (periodically revised) U.S. CDC threshold of 10μg/dL, such that no safe threshold appears to exist for children. Improvements in analytical techniques have also had an impact on the environmental measurement quality, yet many environmental thresholds have remained unchanged for decades. In light of our current understanding of the adverse health effects at low levels of exposure, new thresholds for lead in children’s products have been introduced by the U.S. CPSC. The adequacy of current analytical techniques to detect lead accurately at the new, lower thresholds is questionable. XRF offers the advantage of being rapid and nondestructive compared to techniques such as AAS that require extensive sample preparation. However, the accuracy of handheld XRF determinations of lead in painted toys is generally limited. A brief comparative study on the performance of several analytical techniques for the determination of lead in toys is presented at the end of this paper.


2018 ◽  
Vol 8 (1) ◽  
pp. 29-44
Author(s):  
Jongsawas Chongwatpol

This case is designed to illustrate how to utilize the business intelligence framework and business analytics to make proper decisions in the turbulent and competitive business environment. The case started when Jong, the junior vice president in the modeling and analyst department of ABC Bank of Thailand, and his team were drafting a proposal presentation on the new credit card approval processes. Jong believed that it was time to overhaul credit card application processes by employing more sophisticated analytical techniques to analyze customer and credit card data. ABC- Premier Card, the bank's most popular card offering, would be a serendipitous test case in which to further develop the idea about improvements in approving credit card applications. Currently, there were 5 ABC- Premier card applications pending for decision in the house file. Tightening the credit approval process was one of the important strategies for the bank to potentially avoid an increase of risky customers. However, overly strict declinations of credit card applications might alienate potential customers and causing the bank to forego profitable lending opportunities. Taking the ABC- Premier card applications as a testing scenario, Jong and his team had to come up with a new method to evaluate each credit card applicant. They could approve all of them instantly, approve some of them, or even decline all of them. Consequently, Jong hoped that this proposed credit card approval method would improve the bank's policy decision to optimally balance both risky and profitable customers in the long run.


2012 ◽  
Vol 10 (3) ◽  
pp. 675-685 ◽  
Author(s):  
Sezgin Bakırdere ◽  
Selin Bora ◽  
E. Bakırdere ◽  
Fırat Aydın ◽  
Yasin Arslan ◽  
...  

AbstractCarcinogenic and mutagenic properties of aflatoxin species are known in literature. Their intake over a long time period might be health-dangerous for human even at trace levels. It is well known that different foodstuffs can be contaminated by aflatoxin species through growing and storage. Due to the serious health effects, sensitive determination of aflatoxin species in any matrices related with the human being is very crucial at trace levels. In literature, there are sensitive techniques to analyze the different samples for the contents of their aflatoxin species. Each technique has some advantages and disadvantages over the other techniques. This review aims to summarize the different health effects of aflatoxin species, development of analytical techniques and applications of developed techniques in a variety of matrices.


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