scholarly journals Pharmacology, Toxicology, and Metabolism of Sennoside A, A Medicinal Plant-Derived Natural Compound

2021 ◽  
Vol 12 ◽  
Author(s):  
Jiamei Le ◽  
Houlin Ji ◽  
Xiaoxiao Zhou ◽  
Xindong Wei ◽  
Yifan Chen ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Natural Compound ◽  
Pharmacological Properties ◽  
Clinical Use ◽  
Pharmacological Effects ◽  
Health Food ◽  
Melanosis Coli ◽  
Anti Fungal ◽  
Toxicity Effects

Sennoside A (SA) is a natural dianthrone glycoside mainly from medicinal plants of Senna and Rhubarb, and used as a folk traditional irritant laxative and slimming health food. Accumulating evidences suggest that SA possesses numerous pharmacological properties, such as laxative, anti-obesity, hypoglycemic, hepatoprotective, anti-fibrotic, anti-inflammatory, anti-tumor, anti-bacterial, anti-fungal, anti-viral, and anti-neurodegenerative activities. These pharmacological effects lay the foundation for its potential application in treating a variety of diseases. However, numerous published studies suggest that a long-term use of SA in large doses may have some adverse effects, including the occurrence of melanosis coli and carcinogenesis of colon cancer, thereby limiting its clinical use. It remains to be established whether SA or its metabolites are responsible for the pharmacological and toxicity effects. In this review, the latest advances in the pharmacology, toxicology, and metabolism of SA were summarizedbased on its biological characteristics and mechanism.

Biologically Active 2,5-Disubstituted-1,3,4-Oxadiazoles

2009 ◽  
Vol 2 (1) ◽  
pp. 390-406
Author(s):  
Harish Rajak ◽  
Murli Dhar Kharya ◽  
Pradeep Mishra
Keyword(s):  
Heterocyclic Compounds ◽  
Medical Literature ◽  
Biological Activities ◽  
Biologically Active ◽  
Pharmacological Properties ◽  
Clinical Use ◽  
Synthetic Drugs ◽  
Physiologic Activity ◽  
Pharmacologically Active

There are vast numbers of pharmacologically active heterocyclic compounds in regular clinical use. The presence of heterocyclic structures in diverse types of compounds is strongly indicative of the profound effects such structure exerts on physiologic activity, and recognition of this is abundantly reflected in efforts to find useful synthetic drugs. The 1,3,4-oxadiazole nucleus has emerged as one of the potential pharmacophore responsible for diverse pharmacological properties. Medical Literature is flooded with reports of a variety of biological activities of 2,5-Disubstituted-1,3,4-oxadiazoles. The present work is an attempt to summarize and enlist the various reports published on biologically active 2,5-disubstituted-1,3,4-oxadiazoles.

scholarly journals Statin therapy and its association with long-term survival after colon cancer surgery

Surgery ◽  
2021 ◽  
Author(s):  
Arvid Pourlotfi ◽  
Rebecka Ahl Hulme ◽  
Maximilian Peter Forssten ◽  
Gabriel Sjolin ◽  
Gary A. Bass ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Statin Therapy ◽  
Cancer Surgery ◽  
Term Survival ◽  
Long Term Survival ◽  
Colon Cancer Surgery

scholarly journals Prolonged Maternal and Child Health, Food and Nutrition Problems after the Kumamoto Earthquake: Semantic Network Analysis of Interviews with Dietitians

2021 ◽  
Vol 18 (5) ◽  
pp. 2309
Author(s):  
Nobuyo Tsuboyama-Kasaoka ◽  
Mari Hamada ◽  
Kae Ohnishi ◽  
Sakiko Ueda ◽  
Yukako Ito ◽  
...  
Keyword(s):  
Child Health ◽  
Descriptive Analysis ◽  
Health Food ◽  
Surrounding Area ◽  
Kumamoto Earthquake ◽  
Food And Nutrition ◽  
Mothers And Children ◽  
Qualitative Descriptive ◽  
And Child Health

Infants need sufficient nutrients even during disasters. Only qualitative descriptive analysis has been reported regarding nutritional problems of mothers and children after the Kumamoto earthquake, and non-subjective analysis is required. This study examined issues concerning maternal and child health, food and nutrition after the Kumamoto earthquake using automatic computer quantitative analysis from focus group interviews (FGIs). Study participants (n = 13) consisted of dietitians in charge of nutrition assistance of infants in affected areas. The content of the interviews was converted into text, nouns were extracted, and co-occurrence network diagram analysis was performed. In the severely damaged area, there were hygienic problems not only in the acute phase but also in the mid-to-long-term phase. “Allergy” was extracted in the surrounding area in the acute and the mid-to-long-term phase, but not in the severely damaged area as the acute phase issue. In the surrounding area, problems have shifted to health and the quality of diet in the mid-to-long-term phase. This objective analysis suggested that dietary problems for mothers and children after disaster occurred also in the mid-to-long-term phase. It will be necessary to combine the overall trends obtained in this study with the results of qualitative descriptive analysis.

The Use of 5-HTP in the Treatment of Down's Syndrome

PEDIATRICS ◽  
1974 ◽  
Vol 54 (2) ◽  
pp. 165-168
Author(s):  
Phillip Weise ◽  
Richard Koch ◽  
Kenneth N.F. Shaw ◽  
Martin J. Rosenfeld
Keyword(s):  
Down's Syndrome ◽  
Initial Dosage ◽  
Down’S Syndrome ◽  
Clinical Use ◽  
Developmental Quotient ◽  
Rate Of Development ◽  
The Difference ◽  
Age Category ◽  
Treatment Of Down's Syndrome

The clinical use of 5-HTP in the treatment of patients with Down's syndrome was reported by Bazelon and her colleagues in 1967. This approach appeared to offer the hope of improving subnormal development of children with this chromosomal defect. The rationale for the use of 5-HTP is related to its role as the natural biochemical precursor for serotonin (5-hydroxytryptamine). The blood level of this hormone is said to be decreased in Down's syndrome. The present study concerns 26 children with Down's syndrome who were treated with 5-HTP from early infancy until 3 to 4 years of age: 19 completed the course of treatment. DL-5-HTP was given orally with an initial dosage of 0.5 to 1.5 mg/kg/day. The dose was increased stepwise in 1 mg/kg/day increments to a maximum of 5 mg/kg/day. Children were seen by a clinic physician every 1 to 4 months and were assessed by a clinic psychologist every six months. The Gesell Test of Developmental Abilities was used to assess each child's level of development in terms of a total Developmental Quotient (DQ). The psychological findings were analyzed by applying a t test of the difference between independent mean DQs obtained for each age category. The results of this study indicate that long-term systematic use of 5-HTP is not effective in increasing the rate of development of Down's syndrome children.

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