RNA Drug Delivery Using Biogenic Nanovehicles for Cancer Therapy

RNA-based therapies have been promising method for treating all kinds of diseases, and four siRNA-based drugs and two mRNA-based drugs have been approved and are on the market now. However, none of them is applied for cancer treatment. This is not only because of the complexity of the tumor microenvironment, but also due to the intrinsic obstacles of RNAs. Until now, all kinds of strategies have been developed to improve the performance of RNAs for cancer therapy, especially the nanoparticle-based ones using biogenic materials. They are much more compatible with less toxicity compared to the ones using synthetic polymers, and the most widely studied biogenic materials are oligonucleotides, exosomes, and cell membranes. Particular characteristics make them show different capacities in internalization and endosomal escape as well as specific targeting. In this paper, we systematically summarize the RNA-based nano-delivery systems using biogenic materials for cancer therapy, and we believe this review will provide a valuable reference for researchers involved in the field of biogenic delivery and RNA-based therapies for cancer treatment.

Download Full-text

Lipid-Coated Nanosized Drug Delivery Systems For An Effective Cancer Therapy

Current Drug Delivery ◽

10.2174/1567201817666200512104441 ◽

2020 ◽

Vol 17 ◽

Author(s):

Ozge Esim ◽

Canan Hascicek

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Cancer Treatment ◽

Drug Delivery Systems ◽

Polymeric Nanoparticles ◽

Drug Loading ◽

Delivery Systems ◽

Inorganic Nanoparticles ◽

Coated Nanoparticle

: Currently, despite many active compounds have been introduced to the treatment, cancer remains one of the most vital causes of mortality and reduced quality of life. Conventional cancer treatments may have undesirable consequences due to the continuously differentiating, dynamic and heterogeneous nature of cancer. Recent advances in the field of cancer treatment have promoted the development of several novel nanoformulations. Among them, the lipid coated nanosized drug delivery systems have gained an increasing attention by the researchers in this field owing to the attractive properties such as high stability and biocompatibility, prolonged circulation time, high drug loading capacity and superior in vivo efficacy. They possess the advantages of both the liposomes and polymeric nanoparticles which makes them a chosen one in the field of drug delivery and targeting. Core-shell type lipid-coated nanoparticle systems, which provide the most prominent advantages of both liposomes such as biocompatibility and polymeric/inorganic nanoparticles such as mechanic properties, offer a new approach to cancer treatment. This review discusses design and production procedures used to prepare lipid-coated nanoparticle drug delivery systems, their advantages and multifunctional role in cancer therapy and diagnosis, as well as the applications they have been used in.

Download Full-text

Engineered polymer nanoplatforms for targeted tumor cells and controlled release cargos to enhance cancer treatment

Current Medicinal Chemistry ◽

10.2174/0929867328666210226143148 ◽

2021 ◽

Vol 28 ◽

Author(s):

Zhenjie Wang ◽

Longguang Tang ◽

Qingchun Mu ◽

Siyao Che ◽

Yongbing Sun ◽

...

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Cancer Treatment ◽

Drug Delivery Systems ◽

Polymeric Nanoparticles ◽

Delivery Systems ◽

The Body ◽

Great Effort ◽

Imaging Probes ◽

Effective Diagnosis

: Cancer is composed of a serious of uncontrollably c ells, which finally form tumors to negatively impact the functions of the body and induce other serious diseases, even lead people to death. During the last decades, scientists devote great effort to study cancer, however there are no effective diagnosis and treatments. Nanomaterials have attracted great attention in biomedical field in recent years, which have been widely used as optical imaging probes and delivery systems for cancer therapy. Among the numerous nanomaterials, polymeric nanoparticles occupy a prominent position because of their tunable micro-size, multifunctional surface, prominent biocompatibility and high drug-carrying capacity. These significant advantages endow them over the traditional nanomaterials and become a potential therapy for cancer. In this review, we focus on the applications of polymeric nanoparticles in cancer theranostics, especially as the drug delivery systems for cancer treatment. This review provides an overview of the advancement of synthesis, application of polymeric nanoparticles-based drug delivery systems and highlights the evaluation for cancer therapy.

Download Full-text

Environment-responsive Polymeric Nanoparticles as Drug Delivery Systems for Cancer Therapy

ACTA AGRONOMICA SINICA ◽

10.3724/sp.j.1206.2013.00431 ◽

2013 ◽

Vol 40 (10) ◽

pp. 1039

Author(s):

Yang YANG ◽

Wen-Chuan SHE ◽

Kui LUO ◽

Zhong-Wei GU

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Drug Delivery Systems ◽

Polymeric Nanoparticles ◽

Delivery Systems

Download Full-text

Nanoparticle-based Drug Delivery Systems for Targeted Epigenetics Cancer Therapy

Current Drug Targets ◽

10.2174/1389450121666200514222900 ◽

2020 ◽

Vol 21 (11) ◽

pp. 1084-1098

Author(s):

Fengqian Chen ◽

Yunzhen Shi ◽

Jinming Zhang ◽

Qi Liu

Keyword(s):

Drug Delivery ◽

Side Effects ◽

Cancer Therapy ◽

Drug Delivery Systems ◽

Therapeutic Index ◽

Delivery Systems ◽

Epigenetic Therapy ◽

Cancer Therapies ◽

Therapeutic Benefits ◽

High Therapeutic Index

This review summarizes the epigenetic mechanisms of deoxyribonucleic acid (DNA) methylation, histone modifications in cancer and the epigenetic modifications in cancer therapy. Due to their undesired side effects, the use of epigenetic drugs as chemo-drugs in cancer therapies is limited. The drug delivery system opens a door for minimizing these side effects and achieving greater therapeutic benefits. The limitations of current epigenetic therapies in clinical cancer treatment and the advantages of using drug delivery systems for epigenetic agents are also discussed. Combining drug delivery systems with epigenetic therapy is a promising approach to reaching a high therapeutic index and minimizing the side effects.

Download Full-text

Matrix Metalloproteinases (MMPs) in Targeted Drug Delivery: Synthesis of a Potent and Highly Selective Inhibitor against Matrix Metalloproteinase- 7

Current Topics in Medicinal Chemistry ◽

10.2174/1568026620666200722104928 ◽

2020 ◽

Vol 20 (27) ◽

pp. 2459-2471

Author(s):

Ling-Li Wang ◽

Bing Zhang ◽

Ming-Hua Zheng ◽

Yu-Zhong Xie ◽

Chang-Jiang Wang ◽

...

Keyword(s):

Drug Delivery ◽

Tumor Microenvironment ◽

Matrix Metalloproteinases ◽

Cancer Treatment ◽

Targeted Drug Delivery ◽

Selective Inhibitor ◽

Migration And Invasion ◽

Side Chains ◽

Mesenchymal Transition ◽

Targeted Drug

Background: Matrix metalloproteinases (MMPs) are a family of zinc endopeptidases that play a key role in both physiological and pathological tissue degradation. MMPs have reportedly shown great potentials in the degradation of the Extracellular Matrix (ECM), have shown great potentials in targeting bioactive and imaging agents in cancer treatment. MMPs could provoke Epithelial to Mesenchymal Transition (EMT) of cancer cells and manipulate their signaling, adhesion, migration and invasion to promote cancer cell aggressiveness. Therefore, targeting and particularly inhibiting MMPs within the tumor microenvironment is an effective strategy for cancer treatment. Based on this idea, different MMP inhibitors (MMPIs) have been developed to manipulate the tumor microenvironment towards conditions appropriate for the actions of antitumor agents. Studies are ongoing to improve the selectivity and specificity of MMPIs. Structural optimization has facilitated the discovery of selective inhibitors of the MMPs. However, so far no selective inhibitor for MMP-7 has been proposed. Aims: This study aims to comprehensively review the potentials and advances in applications of MMPs particularly MMP-7 in targeted cancer treatment approaches with the main focus on targeted drug delivery. Different targeting strategies for manipulating and inhibiting MMPs for the treatment of cancer are discussed. MMPs are upregulated at all stages of expression in cancers. Different MMP subtypes have shown significant targeting applicability at the genetic, protein, and activity levels in both physiological and pathophysiological conditions in a variety of cancers. The expression of MMPs significantly increases at advanced cancer stages, which can be used for controlled release in cancers in advance stages. Methods: Moreover, this study presents the synthesis and characteristics of a new and highly selective inhibitor against MMP-7 and discusses its applications in targeted drug delivery systems for therapeutics and diagnostics modalities. Results: Our findings showed that the structure of the inhibitor P3’ side chains play the crucial role in developing an optimized MMP-7 inhibitor with high selectivity and significant degradation activities against ECM. Conclusion: Optimized NDC can serve as a highly potent and selective inhibitor against MMP-7 following screening and optimization of the P3’ side chains, with a Ki of 38.6 nM and an inhibitory selectivity of 575 of MMP-7 over MMP-1.

Download Full-text