scholarly journals HOXC10 Promotes the Metastasis of Human Lung Adenocarcinoma and Indicates Poor Survival Outcome

2017 ◽  
Vol 8 ◽  
Author(s):  
Xiao-Lei Tang ◽  
Bang-Xian Ding ◽  
Ying Hua ◽  
Hao Chen ◽  
Tao Wu ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Human Lung ◽  
Survival Outcome ◽  
Poor Survival ◽  
Human Lung Adenocarcinoma ◽  
Poor Survival Outcome

scholarly journals Dissecting the multi-omics atlas of the exosomes released by human lung adenocarcinoma stem-like cells

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Hai-Tao Luo ◽  
Yuan-Yuan Zheng ◽  
Jun Tang ◽  
Li-Juan Shao ◽  
Yi-Heng Mao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Lung Adenocarcinoma ◽  
Human Lung ◽  
Regulatory Mechanisms ◽  
Cancer Development ◽  
Circular Rnas ◽  
Cell Populations ◽  
Poor Survival ◽  
Human Lung Adenocarcinoma ◽  
Tumor Exosomes

AbstractLung adenocarcinoma is heterogeneous and hierarchically organized, with a subpopulation of stem-like cells (CSCs) that reside at the apex of the hierarchy, in which exosomes act as important mediators by transporting specific molecules among different cell populations. Although there have been numerous studies on tumor exosomes, the constituents and functional properties of CSC-derived exosomes are still poorly characterized. Here we present a detail transcriptome and proteome atlas of the exosomes released by human lung adenocarcinoma stem-like cells (LSLCs). The transcriptome analysis indicates the specific patterns of exosomal constituents, including the fragmentation of transcripts and the low-level presence of circular RNAs, and identifies multiple exosomal-enriched mRNAs and lncRNAs. Integrative analysis of transcriptome and proteome data reveals the diverse functions of exosomal-enriched RNAs and proteins, many of which are associated with tumorigenesis. Importantly, several LSLC markers we identified are highly expressed in LSLC-derived exosomes and associate with poor survival, which may serve as promising liquid biopsy biomarkers for lung adenocarcinoma diagnosis. Our study provides a resource for the future elucidation of the functions of tumor-derived exosomes and their regulatory mechanisms in mediating lung cancer development.

FOX-A1 Contributes to Acquisition of Chemoresistance in Human Lung Adenocarcinoma via Transactivation of SOX5

2019 ◽  
Author(s):  
Dongqin Chen ◽  
Rui Wang ◽  
Chen Yu ◽  
Fei Cao ◽  
Xuefeng Zhang ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Human Lung ◽  
Human Lung Adenocarcinoma

scholarly journals Retroperitoneal Extragastrointestinal Stromal Tumors Have a Poor Survival Outcome: A Multicenter Observational Study

2020 ◽  
Vol Volume 12 ◽  
pp. 10491-10504
Author(s):  
Weixian Hu ◽  
Chengbin Zheng ◽  
Renjie Li ◽  
Xingyu Feng ◽  
Guoliang Zheng ◽  
...  
Keyword(s):  
Observational Study ◽  
Survival Outcome ◽  
Poor Survival ◽  
Multicenter Observational Study ◽  
Stromal Tumors ◽  
Poor Survival Outcome

Determination of the collage phenotype of H441 human lung adenocarcinoma cells in culture

1996 ◽  
Vol 15 (3) ◽  
pp. 171
Author(s):  
J. Shooks ◽  
J. Freeman ◽  
S.J. DiMari ◽  
M.A. Haralson
Keyword(s):  
Lung Adenocarcinoma ◽  
Human Lung ◽  
Human Lung Adenocarcinoma ◽  
Cells In Culture ◽  
Adenocarcinoma Cells ◽  
Human Lung Adenocarcinoma Cells ◽  
Lung Adenocarcinoma Cells

scholarly journals Antimigratory Effects of the Methanol Extract fromMomordica charantiaon Human Lung Adenocarcinoma CL1 Cells

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Hsue-Yin Hsu ◽  
Jung-Hsuan Lin ◽  
Chia-Jung Li ◽  
Shih-Fang Tsang ◽  
Chun-Hao Tsai ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Leaf Extract ◽  
Methanol Extract ◽  
Human Lung ◽  
Human Cancer ◽  
Momordica Charantia ◽  
Invasive Ability ◽  
Human Cancer Cells ◽  
Human Lung Adenocarcinoma ◽  
Significant Difference

Momordica charantiahas been found to exhibit anticancer activity, in addition to its well-known therapeutic functions. We have demonstrated that the leaf extract ofMomordica charantia(MCME) induces apoptosis in several human cancer cells through caspase- and mitochondria-dependent pathways. In this study, a different susceptibility to MCME was found in human lung adenocarcinoma CL1 cells with different metastatic ability, leading to the significant difference of cell viability and invasiveness between MCME-treated CL1-0 and CL1-5 cells. MCME was found to upregulate the expression of Wnt-2 and affect the migratory and invasive ability of CL1 cells through suppressed MMP-2 and MMP-9 enzymatic activities. We proposed that MCME mediates inhibition against migration of CL1 cells by reducing the expression and activation of Src and FAK to decrease the expression of downstream Akt,β-catenin, and MMPs.

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