scholarly journals Polyunsaturated Fatty Acids, Exercise, and Cancer-Related Fatigue in Breast Cancer Survivors

2021 ◽  
Vol 12 ◽  
Author(s):  
Yutaka Matsuoka ◽  
Katsunori Tsuji ◽  
Eisuke Ochi
Keyword(s):  
Breast Cancer ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Exercise Group ◽  
Control Group ◽  
Omega 3 ◽  
Pufa Supplementation ◽  
Exercise Interventions ◽  
Cancer Related Fatigue ◽  
Omega 6

Cancer-related fatigue (CRF) is one of the most frequently reported and disabling symptoms in cancer survivors. With its negative impact on the activities of daily living, work, social activities, and mood, CRF causes severe impairment of quality of life. A previous study showed that omega-6 polyunsaturated fatty acid (PUFA) supplementation unexpectedly reduced CRF compared with omega-3 PUFA supplementation and that omega-6 PUFA supplementation reduced pro-inflammatory serum markers in fatigued American breast cancer survivors. Meanwhile, a recent meta-analysis of individual patient data revealed significant benefits of exercise interventions on CRF. Recently, we completed our randomized controlled trial among early-stage Japanese breast cancer survivors, in which we examined the effect of baseline blood PUFA characteristics on change in CRF during the 12-week trial by exercise group and confirmed that increased Cancer Fatigue Scale (CFS) was associated with both docosahexaenoic acid (DHA) (p = 0.06) and omega-3 index (p = 0.08) at baseline in all participants (n = 46, omega-6/omega-3 ratio = 6.79, SD = 1.90). On the contrary, DHA at baseline was positively correlated with change in CRF (r = 0.40, p = 0.06) in the control group (n = 24, omega-6/omega-3 ratio = 7.0). Moreover, eicosapentaenoic acid (EPA) at baseline was positively correlated with leg strength (r = 0.39, p = 0.10) in the exercise group. In conclusion, blood PUFA balance might be associated with the effect of exercise on CRF. In addition, higher EPA in individuals who conducted exercise likely has a beneficial effect on muscle strength. Further investigation is needed to clarify the interaction between PUFAs and exercise for alleviating CRF.

scholarly journals Multicenter Randomized Controlled Trial of Omega-3 Fatty Acids Versus Omega-6 Fatty Acids for the Control of Cancer-Related Fatigue Among Breast Cancer Survivors

2019 ◽  
Vol 3 (2) ◽  
Author(s):  
Luke J Peppone ◽  
Julia E Inglis ◽  
Karen M Mustian ◽  
Charles E Heckler ◽  
Gilbert D A Padula ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fatty Acids ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Mrna Levels ◽  
Omega 3 ◽  
Symptom Index ◽  
Cancer Related Fatigue ◽  
Brief Fatigue Inventory ◽  
Omega 6

Abstract Background Cancer-related fatigue (CRF) is a common side effect of adjuvant therapy and becomes a chronic problem for approximately one-third of survivors. Omega-3 polyunsaturated fatty acids (O3-PUFA) demonstrated preliminary antifatigue effects in previous research, but have not been investigated in fatigued cancer survivors. Methods Breast cancer survivors 4–36 months posttreatment with a CRF score of 4 or more of 10 using the symptom inventory (SI) were randomly assigned to O3-PUFA (fish oil, 6 g/d), omega-6 PUFA (O6-PUFA; soybean oil, 6 g/d), or a low-dose combination of O3-/O6-PUFA (3 g/d O3-PUFA and O6-PUFA) for 6 weeks. CRF was assessed by the SI (screening question), the Brief Fatigue Inventory, and the Multidimensional Fatigue Symptom Index. Protein and mRNA levels of inflammatory and antioxidant biomarkers, along with fatty acid and lipid levels, were assessed at baseline and week 6. Statistical tests were two-sided. Results A total of 108 breast cancer survivors consented; 97 subjects were randomly assigned and 81 completed the trial. The SI CRF score decreased by 2.51 points at week 6 with O6-PUFA and by 0.93 points with O3-PUFA, with statistically significant between-group difference (effect size = −0.86, P < .01). Similar changes were observed for the Brief Fatigue Inventory and Multidimensional Fatigue Symptom Index but were not statistically significant. Stratified analyses showed the largest benefit was observed in those with severe baseline CRF (≥7). Compared with O3-PUFA, O6-PUFA supplementation statistically significantly decreased proinflammatory markers in the TNF-α signaling pathway. Conclusion Contrary to our original hypothesis, O6-PUFA statistically significantly reduced CRF compared with O3-PUFA. Further research is needed to confirm these findings and to elucidate mechanisms of action.

scholarly journals OR-052 Effects of Exercise Intervention on Cancer-Related Fatigue in Breast Cancer Survivors

2018 ◽  
Vol 1 (2) ◽  
Author(s):  
Zhiling Xie ◽  
Weibing Ye
Keyword(s):  
Breast Cancer ◽  
Cancer Survivors ◽  
Aerobic Exercise ◽  
Breast Cancer Survivors ◽  
Exercise Intervention ◽  
Moderate Intensity ◽  
Control Group ◽  
Short Term ◽  
Cancer Related Fatigue ◽  
Significant Difference

Objective cancer-related fatigue(CRF) is the most commonly reported and most distressing symptom in cancer patient.The purpose of this study was to review the effect of exercise intervention on cancer-related fatigue in breast cancer survivors. Methods From 1998 to 2018 in Chinese and English literature of Wanfang Database, Pubmed, SportDiscus and Springer databases, picked out the randomized controlled trials which up to standard. Keywords cancer, exercise, fatigue, etc. were used for systematic search and tracking. 12 experiments were reviewed to analyze the effect differences between exercise intervention and exercise-related fatigue. Results Most interventions use aerobic exercise as the primary form of exercise. Generally, exercise interventions are effective for cancer-related fatigue, but some findings are not. Many studies have shown that moderate intensity aerobic exercise has a significant effect on cancer-related fatigue, with 50-70% heart rate reserve and 3-5 times of exercise per week for at least 30 minutes each time. Exercise methods mainly include walking, yoga, cycling and tai chi. Firstly, Supervised aerobic exercise was statistically more effective than conventional care in improving CRF among breast cancer survivors. It has been shown that group-based, supervised exercise produces positive psychosocial‘side-effects’ due to social interactions, improved self-efficacy, and attention from a trainer. Secondly, Cancer fatigue is divided into acute and chronic fatigue, 18 weeks of exercise intervention can reduce the short-term fatigue, at 36 weeks, baseline levels of fatigue index responses and contrast on the issue of the multivariate statistics. Thirdly, usual-care group were reported that they had been actively engaged in regular exercise before study enrollment. During the exercise intervention, most studies on the control ways are according to the daily life or to take care of, but studies have reported, before intervention, to a high level of 40% in the control group often exercise, exercise also as usual during the intervention, which causes the control to the baseline level is higher, but the intervention group and control group will be difference, no significant difference, lead to the result is invalid. Conclusions First, the exercise intervention of cancer-related fatigue needs to be supervised; second, the exercise intervention is effective for short-term cancer-related fatigue; third, the daily exercise level of the control group will affect the intervention effect.

scholarly journals PO-285 A review of effects of exercise on the quality of life in breast cancer survivors

2018 ◽  
Vol 1 (5) ◽  
Author(s):  
Feng Hong
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Physical Exercise ◽  
Cancer Survivors ◽  
Aerobic Exercise ◽  
Breast Cancer Survivors ◽  
Exercise Group ◽  
Control Group ◽  
Supervised Exercise

Objective Breast cancer is one of the most common malignant tumors in women.The number of women diagnosed with breast cancer each year is also increasing.It is also the leading cause of cancer deaths in women, accounting for 14-23% of cancer deaths.However, with the development of medical technology, the survival rate of breast cancer patients is improving.In general, the treatment of breast cancer mainly includes surgical treatment, adjuvant chemotherapy and radiotherapy，But these treatments can do a lot of damage to breast cancer patients.These injuries can limit some of the physical activity of breast cancer patients, and can be accompanied by significant psychological damage，Therefore, the quality of life of breast survivors is largely destroyed.Physical exercise is one of the important ways to improve the overall health of the human body.It also plays an important role in increasing people's mood and quality of life.So whether physical exercise has a positive impact on improving the quality of life of breast cancer survivors or there is some doubt.Therefore, the main purpose of this study is to explore the impact of physical exercise on the quality of life of breast cancer survivors, and then to prove the impact of supervised exercise and individual exercise on the quality of life of breast cancer survivors. Methods Data bases searched were MEDLINE, EMBASE, CINAHL, PubMed.Keywords were“breast cancer and quality of life” in combination with “exercise”or “physical activity”.At the same time, the references of the included articles were reviewed to obtain more relevant studies.In terms of the criteria for inclusion and exclusion of literature, the paper was initially screened to determine whether the title and abstract of the paper were consistent with the research topic.The criteria for inclusion are ①the subjects were breast cancer survivors,②the type of intervention was physical exercise,③the measured result is quality of life,④the type of experiment is randomized controlled trial.The exclusion criteria of the article are ①the subject's occupation was athlete，②quality of life is not measured on a formal scale，③article type is review or abstract. Results A total of 14 articles are included in our review.Quality of life was measured using scale tools in all included studies, of which two scales were used in all included articles.The two scales used can reflect the real life quality of the subjects, of which FACT-G is a mass life quality scale and FACT-B is a life quality scale designed specifically for breast cancer patients. Both scales are globally recognized by the public.In our review, we found that exercise significantly improved the quality of life of breast cancer survivors, particularly aerobic exercise.In the studies included in our study, except Nanette et al. used aerobic exercise combined with resistance strength training as the intervention method in their study, all the other studies used aerobic exercise as the intervention method for the subjects.Among the 14 included studies, 10 indicated that physical exercise significantly increased the quality of life of breast cancer survivors, and 4 found that compared with the control group, the quality of life of breast cancer survivors did not have significant changes, but there was a trend of improving the quality of life.At the same time, our review found that monitoring breast cancer survivors improved quality of life.In two of the studies we included, subjects were divided into individual exercise groups and supervised exercise groups.In their study, Anne et al. divided the recruited research samples into the supervision intervention group and the routine control group. Among them, the supervision intervention group received physical exercise 5 times a week for 12 weeks, and the quality of life of breast cancer survivors was significantly improved.In the study of Cadmus et al., the subjects recruited were divided into individual exercise group, supervised exercise group and routine control group, and the exercise group performed physical exercise with the same load and frequency. The result was that there was no physical activity in the home individual exercise group or the routine control group that improved the quality of life for breast cancer survivors.However, in the supervised exercise group, breast cancer survivors' scores for FACT-B and SF-36 (a measure reflecting quality of life) were significantly improved. Conclusions Exercise can improve the quality of life for breast cancer survivors, especially aerobic exercise. Supervised exercise intervention for breast cancer survivors can better improve their quality of life and alleviate social and psychological problems than individual exercise.The supervised aerobic exercise can be integrated into the life of breast cancer survivors so as to better promote the recovery of breast cancer survivors.

Concurrent Exercise Interventions in Breast Cancer Survivors with Cancer-related Fatigue

2020 ◽  
Author(s):  
Itiziar Pagola ◽  
Javier S. Morales ◽  
Lidia B. Alejo ◽  
Olga Barcelo ◽  
Marta Montil ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Survivors ◽  
Training Program ◽  
High Intensity ◽  
Breast Cancer Survivors ◽  
Moderate Intensity ◽  
Concurrent Training ◽  
Exercise Interventions ◽  
Cancer Related Fatigue ◽  
Intensity Training

AbstractThis study compared the effects of two supervised concurrent training interventions in breast cancer survivors with cancer-related fatigue at baseline. Twenty-three female breast cancer survivors (50±8 years) were randomized to a high- (n=13) or a moderate-intensity (n=10) training program. Both interventions lasted 16 weeks and included the same resistance exercises, but the aerobic component was supervised and more intense in the former (i.e., rating of perceived exertion of 7–8 vs. 6 on a 1–10 scale for the high and moderate-intensity intervention, respectively). The primary endpoint was fatigue perception. Endpoints were assessed at baseline and after 16 weeks. The p-value for statistical significance was set at 0.004 after Bonferroni correction for multiple comparisons. The high-intensity training program increased lower-limb muscle strength significantly (p=0.002) and tended to improve fatigue perception (p=0.006), waist circumference (p=0.013), neutrophil-to-lymphocyte ratio (p=0.028) and some quality of life items (p=0.011). Although the moderate-intensity training program did not provide such benefits in general (i.e., higher p-values for pre vs post-intervention comparisons), no significant differences were found between interventions (all p>0.004). Further research is needed to elucidate if the benefits provided by high-intensity concurrent training are superior to those elicited by moderate-intensity training in breast cancer survivors.

Perceived physical fatigability improves after an exercise intervention among breast cancer survivors: A pilot randomized clinical trial.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 12050-12050
Author(s):  
Yujia (Susanna) Qiao ◽  
G J. Van Londen ◽  
Jill Brufsky ◽  
Janette T. Poppenberg ◽  
Rebecca W. Cohen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Trial ◽  
Cancer Survivors ◽  
Randomized Clinical Trial ◽  
Breast Cancer Survivors ◽  
Exercise Intervention ◽  
Exercise Group ◽  
Whole Body ◽  
Control Group ◽  
Patient Reported

12050 Background: Among breast cancer populations, exercise interventions resulted in positive but relatively small improvements on fatigue, which may have been masked by using single-item, non-specific measures of global fatigue. Perceived fatigability – whole-body tiredness anchored to standardized tasks/activities of specific intensity and duration – accounts for self-pacing bias as an individual likely titrates their usual activities and exertion level to avoid exhaustion. We examined whether this novel fatigability measure could replace global fatigue in an exercise intervention trial in breast cancer survivors. Methods: This pilot single-center randomized clinical trial of 49 breast cancer survivors was conducted from 2015-17, among which 41 participants (exercise = 22, control = 19) completed the trial and reported their perceived physical fatigability and global fatigue at the first (V1) and the last visit (V3). Perceived physical fatigability was measured using the 10-item, self-administered Pittsburgh Fatigability Scale (PFS) scored 0-50, higher PFS Physical scores = greater fatigability. Global fatigue was assessed with a single question “I have a lack of energy” scored 0 “not at all” to 4 “very much” from the Functional Assessment of Cancer Therapy-Endocrine Subscale (FACT-ES). The exercise intervention consisted of three one-on-one training sessions over 6-14 weeks, plus two optional email/phone consultations. The trainer developed a personalized, home-based exercise program with a goal of achieving the recommended ≥150 minutes/week of moderate to vigorous exercise based on ACSM guidelines. Those randomized to the control group met the trainer for V1 and again 6-14 weeks later at V3, but no exercise prescription was provided. We computed mean differences in perceived physical fatigability and global fatigue between V3 and V1 and compared by intervention groups. Results: Among the 41 women in the study (mean age = 54.9±9.8 years; 80% white), sociodemographic and clinical characteristics were similar by intervention groups, except for antiestrogen use. Post-intervention changes (mean ± SE) in PFS Physical scores were -4.4±1.4 (-22.5%) in the exercise group and 0.2±1.4 (+1.0%) in the control group (p =.022), whereas change in global fatigue scores were -0.64±0.23 in the exercise group and 0.00±0.22 in the control group (p =.054). Conclusions: These findings add to mounting evidence that an exercise intervention reduces fatigue among breast cancer survivors. Importantly, the PFS showed a clinically meaningful reduction after the exercise intervention that was masked when using global fatigue as the measurement. Therefore, the PFS serves as a more sensitive instrument to measure perceived physical fatigability and can better evaluate patient-reported outcomes in future cancer trials, especially those focused on cancer survivorship. Clinical trial information: NCT 02770781.

Randomized Controlled Trial of Exercise Training in Postmenopausal Breast Cancer Survivors: Cardiopulmonary and Quality of Life Outcomes

2003 ◽  
Vol 21 (9) ◽  
pp. 1660-1668 ◽  
Author(s):  
Kerry S. Courneya ◽  
John R. Mackey ◽  
Gordon J. Bell ◽  
Lee W. Jones ◽  
Catherine J. Field ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Oxygen Consumption ◽  
Exercise Training ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Postmenopausal Breast Cancer ◽  
Exercise Group ◽  
Peak Oxygen Consumption ◽  
Control Group

Purpose: To determine the effects of exercise training on cardiopulmonary function and quality of life (QOL) in postmenopausal breast cancer survivors who had completed surgery, radiotherapy, and/or chemotherapy with or without current hormone therapy use. Methods: Fifty-three postmenopausal breast cancer survivors were randomly assigned to an exercise (n = 25) or control (n = 28) group. The exercise group trained on cycle ergometers three times per week for 15 weeks at a power output that elicited the ventilatory equivalent for carbon dioxide. The control group did not train. The primary outcomes were changes in peak oxygen consumption and overall QOL from baseline to postintervention. Peak oxygen consumption was assessed by a graded exercise test using gas exchange analysis. Overall QOL was assessed by the Functional Assessment of Cancer Therapy–Breast scale. Results: Fifty-two participants completed the trial. The exercise group completed 98.4% of the exercise sessions. Baseline values for peak oxygen consumption (P = .254) and overall QOL (P = .286) did not differ between groups. Peak oxygen consumption increased by 0.24 L/min in the exercise group, whereas it decreased by 0.05 L/min in the control group (mean difference, 0.29 L/min; 95% confidence interval [CI], 0.18 to 0.40; P < .001). Overall QOL increased by 9.1 points in the exercise group compared with 0.3 points in the control group (mean difference, 8.8 points; 95% CI, 3.6 to 14.0; P = .001). Pearson correlations indicated that change in peak oxygen consumption correlated with change in overall QOL (r = 0.45; P < .01). Conclusion: Exercise training had beneficial effects on cardiopulmonary function and QOL in postmenopausal breast cancer survivors.

Omega-3 (ω3) supplementation versus omega-6 (ω6) supplementation for fatigue among breast cancer survivors: A URCC NCORP RCT.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. 10128-10128 ◽  
Author(s):  
Luke Joseph Peppone ◽  
Karen Michelle Mustian ◽  
Gilbert D. A. Padula ◽  
Charles Stewart Kamen ◽  
Joseph John Guido ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Omega 3 ◽  
Omega 6

Effects of a personal trainer led exercise intervention on physical activity and physical function of breast cancer survivors.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e23053-e23053
Author(s):  
Linda F. Wang ◽  
Yvonne L. Eaglehouse ◽  
Janette T. Poppenberg ◽  
Jill Brufsky ◽  
Emily Geramita ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Cancer Survivors ◽  
Physical Function ◽  
Breast Cancer Survivors ◽  
Exercise Intervention ◽  
Exercise Group ◽  
Step Test ◽  
Control Group ◽  
Personal Trainer

e23053 Background: Regular exercise is an important tool to address physical and emotional effects of breast cancer treatment. However, many breast cancer survivors do not meet minimum recommended levels of physical activity. This study examines effects of a personal trainer led exercise intervention on physical activity levels and physical function in breast cancer survivors. Methods: Women who completed active treatment for breast cancer were recruited from oncology clinics and survivorship programs from September 2015-to September 2017. Subjects were randomized to an immediate exercise or a wait-list control group. The intervention included 3 personal training sessions over a period of up to 30 weeks. Physical activity and function were assessed before and after intervention by pedometer (7-day record) and endurance step test (steps in 2 minutes). Results: 60 women were randomized to immediate intervention (n = 31) or wait-list control (n = 29). Subjects were an average of (mean ± SD) 56 ± 10 years old and 2 ± 1 years since breast cancer diagnosis. At baseline, the exercise group averaged (mean ± SD) 5236 ± 2214 steps/day and 101 ± 23 steps on 2-minute step test while the control group averaged 5856 ± 2916 steps/day and 106 ± 23 steps on 2-minute step test. After intervention, change (mean ∆ ± SD) was 143 ± 1842 steps/day in the exercise group and 79 ± 1862 steps/day in the control group ( p= 0.9). On the 2-minute step test, the exercise group increased 18 ± 20 steps and the control group increased 9 ± 12 steps ( p= 0.07). Conclusions: While there was some improvement in physical function after the personal-trainer led intervention, the short duration and intensity of the intervention may have diminished the effects. Our results suggest a multi-faceted approach may be needed to support significant changes in breast cancer survivors’ physical activity. Future efforts employing a multidisciplinary team, which includes a certified personal trainer, and with larger patient samples may help address this possibility. Clinical trial information: NCT02770781.

scholarly journals Cancer Related Fatigue and Upper Limb Disabilities Cannot Improve after 6 Weeks Resistance Training with Thera-Band in Breast Cancer Survivors

2018 ◽  
Vol 7 (2) ◽  
pp. 76-84
Author(s):  
Reza Nouri ◽  
Klaus Michaeil Braumann ◽  
Bahareh Mahmoudieh ChamPiri ◽  
Jan Schröder ◽  
Mahdieh Akochakian
Keyword(s):  
Breast Cancer ◽  
Resistance Training ◽  
Cancer Survivors ◽  
Upper Limb ◽  
Breast Cancer Survivors ◽  
Control Group ◽  
Large Sample Size ◽  
Warm Up ◽  
Cancer Related Fatigue ◽  
Band Group

Aim. Breast cancer and its treatments lead to cancer related fatigue and upper limb disabilities. On the other hand, resistance training has positive benefits for breast cancer survivors. Thus, the aim of present study was to clarify the effect of resistance training with Thera – Band on CRF and upper limb disabilities in breast cancer survivors. Methods. Fifty women with breast cancer aged 29-65 were divided in to 2 groups: 1) resistance training with Thera- Band group (n=25) and 2) control group (n=25). Resistance training with Thera- Band group, after 5 minutes warm up, were performed the 9 resistance training with Thera – Band, from 8 to 12 repetitions and 2 sets in the first two weeks, 8 to 12 repetitions and 3 sets in the second two weeks and 8 to 12 repetitions and 4 sets in the third two weeks. The rest between each set was started from 90 seconds in the first week and was decreased to 45 seconds in the sixth week. Control group didn’t have any supervised or regular physical activity. Cancer related fatigue (CRF) and upper limb disabilities were surveyed by Piper Fatigue Scale and DASH questionnaire, respectively.  Data were analyzed using by 2-way ANOVA (p≤0.05).  Statistical Results. The findings of this study demonstrated that 6 weeks resistance training by Thera – Band has no significant effect on CRF and upper limb disabilities (p≥0.05). Conclusion. It can be concluded that exercise training with Thera- Band for 6 weeks cannot improve CRF and upper limb disabilities in breast cancer survivors. Future studies with large sample size and long period of intervention is suggested.

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