scholarly journals Heart Rate Variability Indices as Possible Biomarkers for the Severity of Post-traumatic Stress Disorder Following Pregnancy Loss

2022 ◽  
Vol 12 ◽  
Author(s):  
Cláudia de Faria Cardoso ◽  
Natalia Tiemi Ohe ◽  
Yazan Bader ◽  
Nariman Afify ◽  
Zahrah Al-Homedi ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Pregnancy Loss ◽  
Stress Disorder ◽  
Self Report ◽  
Deep Breathing ◽  
Post Traumatic Stress ◽  
Time Data ◽  
Normal Sinus ◽  
Deep Breathing Test

Background: Psychological distress, such as posttraumatic stress disorder (PTSD), is commonly evaluated using subjective questionnaires, a method prone to self-report bias. The study's working hypothesis was that levels of autonomic dysfunction determined by heart rate variability (HRV) measures are associated with the severity of PTSD in women following pregnancy loss.Methods: This was an observational prospective cohort study with 53 patients enrolled. The DSM-5 (Diagnostic and Statistical Manual of Mental Disorders) PTSD scale (PCL-5) was used to assess the severity of PTSD in women after pregnancy loss. The cardiac autonomic function was assessed using HRV measurements during a deep breathing test using an HRV scanner system with wireless ECG enabling real-time data analysis and visualization. HRV measures were: standard deviation (SD) of normal R-R wave intervals [SDNN, ms], square root of the mean of the sum of the squares of differences between adjacent normal R wave intervals [RMSSD, ms], and the number of all R-R intervals in which the change in consecutive normal sinus intervals exceeds 50 milliseconds divided by the total number of R-R intervals measured [pNN50 = (NN50/n-1)*100%] [pNN50%].Results: The PCL-5 scores had a statistically significant association with HRV indices (SDNN; RMSSD, and pNN50%). Patients with PTSD had similar mean heart rate values as compared to patients without PTSD (PCL-5), but significantly higher SDNN [median[IQR, interquartile range]: 90.1 (69.1–112.1) vs. 52.5 (36.8–65.6)], RMSSD [59.4 (37.5–74.9) vs. 31.9 (19.3 – 44.0)], and PNN50% values [25.7 (16.4–37.7) vs. 10.6 (1.5–21.9)]. The SDNN of the deep breathing test HRV was effective at distinguishing between patients with PTSD and those without, with an AUC = 0.83 +/− 0.06 (95 % CI 0.94, p = 0.0001) of the ROC model.Conclusions: In this study, HRV indices as biomarkers of cardiac dysautonomia were found to be significantly related to the severity of PTSD symptoms in women after pregnancy loss.

scholarly journals Features of heart rate variability in patients with takotsubo syndrome

2021 ◽  
Vol 10 (Supplement_1) ◽  
Author(s):  
D Evdokimov ◽  
SA Boldueva ◽  
VS Feoktistova ◽  
TA Baeva
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Sinus Rhythm ◽  
Autonomic Regulation ◽  
Deep Breathing ◽  
Takotsubo Syndrome ◽  
Orthostatic Test ◽  
Rate Regulation ◽  
Heart Rate Regulation ◽  
Deep Breathing Test

Abstract Funding Acknowledgements Type of funding sources: None. Main funding source(s): North-Western State Medical University named after I.I. Mechnikov Objective to study the features of autonomic regulation of sinus rhythm features of autonomic regulation of cardiac sinus rhythm in patients with Takotsubo syndrome (TTS) during inpatient stay in hospital. Materials and methods. The study included 25 female patients (the median age 57.5 ± 28.5 years) with TTS, diagnosis was based on the InterTAK criteria. On the 5-7th day after admission, the heart rate variability (HRV) was assessed both at rest and cardiac autonomic function tests: the deep breathing test (DBT) and active orthostatic test (AOT) with the usage of a computer diagnostic system «Valenta». RESULTS According to HRV data, initially at rest, the majority of the studied patients predominantly had a parasympathetic impact on the heart rate regulation: in 70% - increased parasympathetic influence, in 17% - increased sympathetic influence, in 13% - a balanced heart rate regulation. When performing a DBT, the predominance of the parasympathetic influence on the heart rate was noted both in spectral parameters and according to the data of time analysis (HF  during DBT  increased 1.8 times  up to  489.6 ± 114.2 ms2 (p <0.05) ; LF  decreased 1.7 times  up to 254.1 ± 70.3 ms2 (p <0.05); VLF  increased 2.8 times up to 402.3 ± 101.8 ms2 (p <0, 05); TP  increased 1.4 times up to 1145.9 ± 251.3 ms2; CV increased 1.3 times up to 6.5 ± 0.7% (p <0.05); SDNN increased 1.3 times up to - 58.7 ± 6.6 ms (p <0.05). HRV measured during an AOT  showed a paradoxical  evaluation  in the parasympathetic impact on the heart rate (HF increased by 1.8 times and reached - 488.0 ± 104.7 ms2 (p <0.05); LF decreased by 1.1 times up to  408 , 4 ± 103.6 ms2; VLF increased 1.2 times  up to  166.4 ± 52.2 ms2; TP increased 1.3 times  up to 1062.8 ± 181.1 ms2 (p <0.05); CV increased 1.6 times  up to 8.0 ± 0.9% (p <0.05); SDNN increased 1.4 times  up to 62.6 ± 7.5 ms (p <0.05)). Conclusions During the index hospital inpatient stays the majority of patients with TTS have a vegetative imbalance due to increased parasympathetic influence on the heart rate, both at rest and  during a deep breathing test and an active orthostatic test. This fact is quite unexpected and requires further study.

Heart Rate Variability, Sleep, and the Early Detection of Post-traumatic Stress Disorder

2018 ◽  
pp. 253-263 ◽  
Author(s):  
Geert J. M. van Boxtel ◽  
Pierre J. M. Cluitmans ◽  
Roy J. E. M. Raymann ◽  
Martin Ouwerkerk ◽  
Ad J. M. Denissen ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Early Detection ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Post Traumatic Stress ◽  
Post Traumatic

scholarly journals The effect of deep breathing test on heart rate variability in obese and non-obese patients with myocardial infarction

Biomedicine ◽  
2021 ◽  
Vol 41 (1) ◽  
pp. 93-98
Author(s):  
Srinath C. Galag ◽  
R Rajalakshmi ◽  
Nagaraj Desai ◽  
H Basavanagowdappa
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Obese Group ◽  
Total Power ◽  
P Value ◽  
Obese Patients ◽  
Deep Breathing ◽  
Deep Breathing Test

Introduction and Aim:Obesity and metabolic syndrome increases the risk of cardiovascular diseases (CVD).The acute myocardial infarction may be associated with autonomic dysfunction and it may have a bearing on the prognosis. The objective of the study wasto examine the effect of deep breathing test on heart rate variability in obese and non-obese patients with myocardial infarction (MI).   Materials and Methods:The patients with acute myocardial infarction were confirmed by universal definition and treatment was administered. At 12 weeks of follow up, the MI patients were screened and divided into two groups. 30 patients of MI with BMI 25 to 30 kg/m2 formed the obese group.30 patients of MI with BMI 18.5 to 24.9 kg/m2 formed the non-obese group. The baseline ECG was taken for 5 minutes by using Niviqure B3 machine for HRV analysis. Then, deep breathing test (DBT) was performed in a standardized manner.   Results:The two groupswere well matched for the age (53.7±11.5 vs.55.2±9.2years).In the baseline there was a statistically significant decrease in the total power (TP) of the heart i.e., HF plus LF (2178±762ms2 vs2991±771ms2 with a ‘p’ value 0.001) in the obese group when compared to non-obese group. On DBT there was a significant decrease in heart rate (81bpm to 65bpm) in non-obese group. However, in obese group there was no significant decrease in heart rate (79bpm to 72bpm) on DBT.   Conclusion: Accordingly, we concludethat in obese patients with MI there is a reduction in respiratory vagal modulation of heart rate during DBT.  

scholarly journals Characteristics of Heart Rate Variability in War Veterans with Post-Traumatic Stress Disorder after Myocardial Infarction

2007 ◽  
Vol 172 (11) ◽  
pp. 1190-1193 ◽  
Author(s):  
Nenad Lakusic ◽  
Krunoslav Fuckar ◽  
Darija Mahovic ◽  
Dusko Cerovec ◽  
Marcel Majsec ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Post Traumatic Stress ◽  
War Veterans ◽  
Post Traumatic

Abstract 17013: Post-traumatic Stress Disorder is Associated with Adverse Non-Linear Heart Rate Variability in Veteran Twins

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Danesh K Kella ◽  
Rachel Lampert ◽  
Forrester Lee ◽  
Jack Goldberg ◽  
Douglas Bremner ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Power Law ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Post Traumatic Stress ◽  
Vietnam Era ◽  
Post Traumatic ◽  
Current Ptsd

BACKGROUND: Veterans with post-traumatic stress disorder (PTSD) have higher risk of coronary heart disease (CHD) incidence and mortality. Psychological conditions may have an adverse effect on the autonomic nervous system, and may in part have genetic origins. Novel non-linear measures of heart rate variability (HRV), such as fractal dimension (FD) and power law slope have been associated with mortality and may signify autonomic dysfunction. We hypothesized that PTSD is associated with reduced FD and increased power law slope, suggesting higher mortality risk. METHODS: FD and power law slope were measured from 24-hour Holter recordings in 416 predominantly healthy middle-aged male twins from the Vietnam Era Twin Registry. Current (symptoms within the past month) and remitted (past history of) PTSD were measured using the Structured Clinical Interview for Psychiatry Disorders. Mixed-effect regression models were used to adjust for twin clustering and account for genetic/familial influences. RESULTS: The mean age was 56 ± 3 years, 35 had current PTSD, and 46 had remitted PTSD. In models that analyzed twins as individuals, current PTSD was significantly associated with 22% reduced FD and 18% increased power law slope. This association persisted for power law slope after adjustment for traditional risk factors, lifestyle factors, depression, and anti-depressant medication use (table). After controlling for genetic/familial factors by comparing twin brothers discordant for current PTSD within pairs (20 pairs), both measures remained significantly associated with current PTSD. Remitted PTSD did not influence HRV measures. No interaction by zygosity was found. CONCLUSIONS: Vietnam era veterans with PTSD have reduced FD and increased power law slope persisting after multivariable adjustment. This suggests that autonomic mechanisms, independent of genetic and familial effects, may contribute to increased CHD and mortality in veterans with PTSD.

scholarly journals Post-Traumatic Stress Disorder, Depression, and Heart-Rate Variability among North Korean Defectors

2011 ◽  
Vol 8 (4) ◽  
pp. 297 ◽  
Author(s):  
Byoung-A Song ◽  
So-Young Yoo ◽  
Hee-Young Kang ◽  
Seong-Hye Byeon ◽  
Sang-Ho Shin ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Post Traumatic Stress ◽  
North Korean Defectors ◽  
Post Traumatic

Lower Heart Rate Variability Associated With Military Sexual Trauma Rape and Posttraumatic Stress Disorder

2012 ◽  
Vol 14 (4) ◽  
pp. 412-418 ◽  
Author(s):  
Elizabeth Ann Davis Lee ◽  
Sue A. Theus
Keyword(s):  
Heart Rate ◽  
Posttraumatic Stress Disorder ◽  
Heart Rate Variability ◽  
Stress Disorder ◽  
Normal Sinus Rhythm ◽  
Military Sexual Trauma ◽  
Female Veterans ◽  
Normal Sinus ◽  
Cardiac Symptoms ◽  
The Mean

Low heart rate variability (HRV) can occur with psychological disorders such as posttraumatic stress disorder (PTSD). The purpose of this study was to examine the association between PTSD by trauma type and decreased HRV measures in female veterans with cardiac symptoms. This secondary analysis utilized data from a previous study of female veterans ( n = 125) examined for cardiac symptoms by Holter and electrocardiogram recordings at a Veterans Affairs medical center. The mean HRV measure from three 10-s data segments with spontaneous respirations was obtained for each subject. PTSD diagnosis and type of trauma exposure were collected from mental health consult notes. Chi-square was used for frequency of subject characteristics; independent t tests and one-way analysis of variance (ANOVA) compared means of HRV measures between trauma types. Statistical significance was set at p < .05 a priori. By ANOVA, significantly lower log-transformed standard deviation of all normal sinus rhythm R-R intervals (SDNN) and log-transformed square root of the mean of the sum of the squares of differences between adjacent normal sinus rhythm R-R intervals (RMSSD) were found in the PTSD group with documented rape military sexual trauma (MST) compared to other groups including no PTSD, PTSD following MST with rape not specified, combat exposure, and nonmilitary-related trauma; lower HRV measures were not found with other PTSD types of trauma. This study suggests rape MST with concomitant PTSD may be a risk factor for decreased HRV in female veterans examined for cardiac symptoms.

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