Medical Cannabis Use and Pain: An Experience Sampling Study

Background: Little research has tested associations of pain and MC use after long-term treatment and through methods that have external validity outside experimental settings. The study examined associations of pain, associated painful experiences, and long-term medical cannabis (MC) use in chronic pain (CP) patients using a naturalistic daily diary study that provided novel and externally valid data.Methods: Data were obtained from 78 MC users with CP three times daily over a 10-day period (nobservations = 1,688). Mixed-effects models were used to test the associations between MC use and momentary experiences of pain, affect, and fatigue.Results: Within persons, elevated experiences of pain intensity were associated with greater intention to use MC within the next hour. No evidence was found that the time lapse since last MC use was associated with pain levels, negative affect, or fatigue.Conclusions: The results imply that after long-term use, CP patients intend to use MC in response to pain experiences. Yet, they may not actually achieve the pain relief. More research is needed to examine whether continued MC use despite lack of pain relief is related to relief of other symptoms (e.g., dependence, withdrawal) or positive benefits (e.g., general sense of well-being) or tolerance.

Download Full-text

Sustained improvement in functional health and well-being in MDD patients following long-term treatment with Levomilnacipran SR

Value in Health ◽

10.1016/j.jval.2013.03.1553 ◽

2013 ◽

Vol 16 (3) ◽

pp. A56 ◽

Cited By ~ 3

Author(s):

S.I. Blum ◽

S. Tourkodimitris ◽

C. Gommoll ◽

A. Bose

Keyword(s):

Well Being ◽

Term Treatment ◽

Functional Health ◽

Sustained Improvement ◽

Long Term Treatment ◽

Health And Well Being

Download Full-text

Galantamine in long-term treatment formild cognitive impairment: Efficacy and safety

European Psychiatry ◽

10.1016/s0924-9338(11)73001-2 ◽

2011 ◽

Vol 26 (S2) ◽

pp. 1296-1296

Author(s):

J. Zarra ◽

L. Schmidt ◽

B. Grecco

Keyword(s):

Cognitive Impairment ◽

Adverse Effects ◽

Acetylcholine Receptors ◽

Well Being ◽

Cognitive Disorder ◽

Term Treatment ◽

Open Label ◽

Global Deterioration Scale ◽

Long Term Treatment

IntroductionTo evaluate the efficacy of galantamine in patients with Mild Cognitive Impairment. So there is a possible benefit in the deficit in executive and cognitive cerebral function (cholinergic system) with treatment with Galantamine.PurposeGalantamine is a reversible, competitive cholinesterasa inhibitor that also allosterically modulates nicotine acetylcholine receptors. Inhibition of acetylcholinesterase, the enzyme responsible for hydrolisis of acetylcholine at the cholinergic cognitive impairment. To evaluate the efficacy, safety and tolerability of galantamine in long-term in Mild Cognitive Disorder.MethodsA multicenter, open label, prospective, observational study enrolled 1028 patients, more 55 years old with Mild Neurocognitive Disorder (DSM IV criteria), during 30 months of treatment with galantamine 16 mg./day. Assessments included the MMSE, CDR, ADAS-GOG, FAQ, GCI, Trail making test, Global Deterioration Scale, and UKU scale of Adverse Effects.ResultsA total 1028 outpatients were treated with 16 mg./day galantamine during 30 months, the therapeutic response evaluated with CDR, MMSE and the tests and scales of function cognitive measuring, GCI and UKU scale of adverse effects, comparing the baseline to final scores.ConclusionMild Cognitive Disorder is being examined, so there aren’t enought treatment for this. A long-term treatment (30 months) galantamine improves cognition and global function, behavioural symptoms and the general state well being of patients with MCD. With incidence of adverse effects not significant and a very good profile of safety, the final results of the study suggest that galantamine may be particularly appropiate in the Mild Cognitive Disorder.

Download Full-text

Long-term treatment of macroprolactinomas with CV 205-502

Acta Endocrinologica ◽

10.1530/acta.0.1280301 ◽

1993 ◽

Vol 128 (4) ◽

pp. 301-307 ◽

Cited By ~ 11

Author(s):

Anette Kvistborg ◽

Johan Halse ◽

Soren Bakke ◽

Trine Bjøro ◽

Egill Hansen ◽

...

Keyword(s):

Adverse Effects ◽

Adverse Reactions ◽

Well Being ◽

Term Treatment ◽

Gonadal Function ◽

Serious Adverse Events ◽

Receptor Affinity ◽

Discontinuation Of Treatment ◽

Long Term Treatment

The long-term efficacy and tolerability of CV 205-502, a non-ergot dopamine agonist with D-2 receptor affinity, were studied for up to 36 months in 16 patients with macroprolactinomas. Prolactin values were reduced in all cases, becoming either normalized or suppressed in 12. The pituitary tumor size was reduced in the 13 patients with an obvious tumor and visual function normalized in all six patients with initial defects. Concomitantly we observed improvement in gonadal function, galactorrhea, headache, libido and general well-being. Adverse reactions were experienced by 1 5 patients during dosage increment and caused one patient to discontinue the medication. Seven patients had persistent adverse effects which prohibited a dosage increase of CV 205-502, sufficient to normalize PRL levels in three. Two patients experienced serious adverse events, causing the discontinuation of treatment in one case. In eight patients treatment with CV 205-502 and bromocriptine could be compared. Three patients responded better to CV 205-502 than to bromocriptine treatment. Only one patient preferred bromocriptine to CV 205-502 for long-term treatment. We conclude that CV 205-502 is an effective and in most cases well-tolerated treatment for patients with macroprolactinomas. CV 205-502 is preferable to bromocriptine as an initial treatment and should also be tried in patients where treatment with bromocriptine has failed.

Download Full-text

Hemodialysis as long term treatment: Patients satisfaction and its impact on quality of life

Pakistan Journal of Medical Sciences ◽

10.12669/pjms.37.2.2747 ◽

2021 ◽

Vol 37 (2) ◽

Author(s):

Muhammad Sajid Iqbal ◽

Quratulain Iqbal ◽

Shahreen Iqbal ◽

Sania Ashraf

Keyword(s):

Quality Of Life ◽

Financial Burden ◽

Well Being ◽

Term Treatment ◽

Dialysis Session ◽

Subjective Well Being ◽

Patients Satisfaction ◽

Long Term Treatment

Objective: To determine the level of satisfaction as hemodialysis a long term treatment and quality of life in patients off End Stage Kidney Disease ESKD on hemodialysis. Methods: A cross-sectional study was carried out from January to April 2019 in hemodialysis unit of Lahore General Hospital on 141 ESKD patients by using self-designed questionnaire after informed consent. Results: Majority (82.56%) of the participants were satisfied with the care provided at the dialysis center. except with the time spent with doctor and 36.9% were not satisfied with their cannulation technique for dialysis. About 89.9% were satisfied with the knowledge provided to them about self-care. Satisfaction is subjective well-being in different aspects of life, including mental health and behavior of people experiencing serious health concerns. Quality of Life (QOL) is defined as “perception of one’s position in life, in the light of his culture and customs, consisting someone’s goals, standards or expectations. Financial problems to the patient was limited to the transportation as dialysis session and erythropoietin were free, but 54.1% of the patients were unable to earn due to their disease even those who were working ,80% of them had to take the day off for dialysis. The financial burden and debilitating illness didn’t cause separation/divorce from spouse but led to increased frequency of scuffles. Among the unmarried population, 40% of it does not want to start a relationship and 40% is facing difficulties in finding a partners while 97.9% of the population is satisfied with the psychological and emotional support of family. Conclusion: Most patients were satisfied with their decision of opting hemodialysis as treatment and care provided at dialysis centre, although Quality of Life was badly affected in terms of financial and psycho-social aspects. Employed, married with good income have good quality of life. Loopholes of unit environment and health education were also exposed. Despite the medical advancement and emerging techniques to make dialysis better, the outcome of hemodialysis has yet to reach a safe level and more work should be done to improve patient’s outcome. doi: https://doi.org/10.12669/pjms.37.2.2747 How to cite this:Iqbal MS, Iqbal Q, Iqbal S, Ashraf S. Hemodialysis as long term treatment: Patients satisfaction and its impact on quality of life. Pak J Med Sci. 2021;37(2):---------. doi: https://doi.org/10.12669/pjms.37.2.2747 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download Full-text

Increasing Psychological Well-Being in Children with Chronic Illness through Social Support Intervention in Haji Adam Malik Hospital, Medan Tuntungan

Journal of Saintech Transfer ◽

10.32734/jst.v1i2.855 ◽

2019 ◽

Vol 1 (2) ◽

pp. 116-120

Author(s):

Indri Kemala Nasution ◽

Debby Anggraini Daulay ◽

Ade Rahmawati Siregar ◽

Rahmi Putri Rangkuti ◽

Rahma Yurliani ◽

...

Keyword(s):

Social Support ◽

Chronic Illness ◽

Well Being ◽

Term Treatment ◽

Psychological Well Being ◽

Support Intervention ◽

The Social ◽

Long Term Treatment ◽

Chronic Childhood

Chronic illness is a disorder/ disability due to medical conditions that are present continuously for 3 months or more which may affect the functioning of a child's life (Fritz & McQuaid in Wenar & Kerig, 2005). The effects of chronic illness and long-term treatment lead to individual psychological problems for children, such as feeling sad, withdrawing and other emotional problems. Poor psychological well-being conditions often exacerbate chronic childhood illness. Children become lazy to take medication and not obedient in doing treatment. The purpose of this devotion is to improve psychological well-being of children with chronic illness through social support interventions. This program will be carried out with a cadre of 3 partners who are nurses from Haji Adam Malik hospital. The nurses will be trained, so they can provide the social support for children during hospitalization to improve the psychological wellbeing of the children. After the training, social support interventions implementation module will be tested to 20 chronic illness children in Haji Adam Malik hospital with the nurse as a facilitator. While the team from Psychology Faculty will supervise the implementation and provide feedback.

Download Full-text