scholarly journals Sexual Dysfunction in Chronically Medicated Male Inpatients With Schizophrenia: Prevalence, Risk Factors, Clinical Manifestations, and Response to Sexual Arousal

2022 ◽  
Vol 12 ◽  
Author(s):  
Dianying Liu ◽  
Shaohua Liu ◽  
Meihong Xiu ◽  
Hongdong Deng ◽  
Huiyun Guo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Sexual Dysfunction ◽  
Sexual Arousal ◽  
Negative Symptoms ◽  
Sexual Experience ◽  
Clinical Manifestations ◽  
Common Symptom ◽  
Erotic Stimuli ◽  
Negative Factor ◽  
Male Patients

BackgroundSexual dysfunction is a common symptom in patients with schizophrenia, especially in chronically medicated patients. However, the relationship between sexual dysfunction and emotional response to sexual arousal in male patients with schizophrenia remains unclear. This study aimed to assess the incidence, risk factors of sexual dysfunction in males, and their clinical correlations to sexual arousal in male patients with schizophrenia in China.MethodsA total of 162 male patients, aged 18–50 years, with schizophrenia were recruited from a psychiatric hospital in Ganzhou. The clinical symptoms were assessed by the Positive and Negative Syndrome Scale (PANSS). The Arizona Sexual Experience Scale was utilized to evaluate sexual dysfunction. Erotic images were selected from International Affective Picture System (IAPS). Sixty-eight out of the 162 subjects completed the erotic pictures reactivity task.ResultsOverall, 48 (29.6%) patients were measured as having global sexual dysfunction, 72 (44.4%) patients as having strength of sex drive dysfunction, 51 (31.5%) patients as having sexual arousal dysfunction, 55 (34.0%) patients as having penile erection dysfunction, 60 (37.0%) patients as having reached orgasm dysfunction, and 60 (37.0%) patients as having satisfaction with orgasm dysfunction. The sexual dysfunction patients had significantly higher scores on the negative symptoms of the PANSS. The only important predictor of sexual dysfunction was the severity of PANSS negative factor. The sense of pleasure and arousal post viewing erotic images in the sexual dysfunction group were lower compared to the non-sexual dysfunction group. The sense of pleasure and approach motivation were significantly negatively correlated with the severity of sexual dysfunction.ConclusionsThis study shows that nearly one-third of young and middle-aged chronically medicated male inpatients with schizophrenia suffer from sexual dysfunction. The negative factor of the PANSS can be regarded as the risk factor of sexual dysfunction. Schizophrenia patients with sexual dysfunction experienced lower pleasure and higher avoidance motivation than non-sexual dysfunction patients when exposed to erotic stimuli.

Risk factors associated with primary and secondary reduced libido in male patients with sexual dysfunction

2013 ◽  
Author(s):  
Giovanni Corona ◽  
Giulia Rastrelli ◽  
Emmanuele Jannini ◽  
Linda Vignozzi ◽  
Edoardo Mannucci ◽  
...  
Keyword(s):  
Risk Factors ◽  
Sexual Dysfunction ◽  
Factors Associated ◽  
Male Patients

scholarly journals Risk factors and the prognosis of sexual dysfunction in male patients with pituitary adenomas: a multivariate analysis

2018 ◽  
Vol 20 (1) ◽  
pp. 43 ◽  
Author(s):  
Wang Jia ◽  
Wen-Jian-Long Zhou ◽  
Shun-Chang Ma ◽  
Min Zhao ◽  
Chang Liu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Multivariate Analysis ◽  
Sexual Dysfunction ◽  
Pituitary Adenomas ◽  
Male Patients

scholarly journals Gender Differences in Risk Factor Profile and Clinical Characteristics in 89 Consecutive Cases of Cerebral Venous Thrombosis

2021 ◽  
Vol 10 (7) ◽  
pp. 1382
Author(s):  
Zoltan Bajko ◽  
Anca Motataianu ◽  
Adina Stoian ◽  
Laura Barcutean ◽  
Sebastian Andone ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Venous Thrombosis ◽  
Cerebral Venous Thrombosis ◽  
Clinical Manifestations ◽  
Important Variable ◽  
Term Outcome ◽  
Hematological Disorders ◽  
Risk Factor Profile ◽  
Male Patients

Gender has been shown to be an important variable in cerebral venous thrombosis (CVT) risk and significantly influences its clinical manifestations and outcome. The aim of our study was to investigate the gender-specific risk factor profile and clinical picture of this rare cerebrovascular disorder. Materials and methods: We retrospectively reviewed the medical records of 89 consecutive cases of CVT at a tertiary neurology clinic in Târgu Mures, Romania, between June 2009 and January 2021 to analyze the gender-related differences in etiology, clinical presentation, and outcome. Results: Women comprised 62.5% of the cohort. Females were significantly younger than males (37.3 years versus 48.8 years, respectively, p = 0.001), and the main risk factors were hormone related in 37.9% of the cases, followed by primary thrombophilia (34.4%), smoking (25.8%), obesity (17.2%), infections (17.2%), mechanical factors (17.2%), cancer (8.6%), systemic autoimmune disorders (8.6%), and hematological disorders (8.6%). In male patients, the main risk factors were smoking (41.9%), primary thrombophilia (29%), infections (22.6%), heavy alcohol consumption (16.1%), and venous thromboembolism in the medical history (12.9%). Frequency of headache was higher in females than in males (75.9% versus 67.7%), whereas frequency of coma (6.5% in males versus 1.7% in females) and dizziness (19.4% in males versus 10.3% in females) was higher in males. CVT onset was acute in 41.4% of females and 38.7% of males. The Rankin score at discharge was significantly lower in females compared with males (0.6 versus 1.6), reflecting a more favorable short-term outcome. Mortality was 6.4% in males and 1.7% in females. Conclusions: CVT is a multifactorial disorder that has a broad spectrum of risk factors with important gender-related differences in clinical manifestation and prognosis. Female patients, especially those with hormone-related risk factors, have a more favorable outcome than male patients.

scholarly journals Sexual Dysfunction in Drug-Naive or Drug-Free Male Patients with Psychosis: Prevalence and Risk Factors

2019 ◽  
Vol 41 (5) ◽  
pp. 434-439 ◽  
Author(s):  
Dhananjayan Ravichandran ◽  
Rajesh Gopalakrishnan ◽  
Anju Kuruvilla ◽  
K. S. Jacob
Keyword(s):  
Risk Factors ◽  
Sexual Dysfunction ◽  
Drug Naïve ◽  
Male Patients ◽  
Drug Free

Risk Factors Associated with Primary and Secondary Reduced Libido in Male Patients with Sexual Dysfunction

2013 ◽  
Vol 10 (4) ◽  
pp. 1074-1089 ◽  
Author(s):  
Giovanni Corona ◽  
Giulia Rastrelli ◽  
Valdo Ricca ◽  
Emmanuele A. Jannini ◽  
Linda Vignozzi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Sexual Dysfunction ◽  
Factors Associated ◽  
Male Patients

Individual Differences in Masturbation and Erotica Consumption Predicting Levels of Sexual Concordance

2018 ◽  
Author(s):  
Graham Hutchings
Keyword(s):  
Gender Differences ◽  
Sexual Arousal ◽  
Sexual Experience ◽  
Cognitive Model ◽  
Sexual History ◽  
Emotional States ◽  
Erotic Stimuli ◽  
Subjective Sexual Arousal ◽  
Before And After ◽  
Audiovisual Stimuli

Concordance is not the only aspect of sexuality where significant gender differences are observable: men masturbate significantly more than women (Oliver & Hyde, 1993; Petersen & Hyde, 2011). There are also large gender differences in pornography consumption and consumption patterns (Hald, 2006). The study of concordance is important as it could assist in the further development of models of sexual response, and potentially reveal the role of gender differences in those models. Evidence suggests that the cognitive system one uses to process stimuli can affect one's subjective sexual arousal (Dove & Wiederman, 2000). Greater erotica consumption habits could lead to a better familiarity with the erotic stimuli used during the testing protocol, and this decreased novelty could produce more accurate responses for subjective sexual arousal. Using a "bottom-up" cognitive model in which people use physical sensations to infer emotional states, it is likely that increased sexual experience will lead to higher levels of concordance. Opposite-sex attracted participants (24 men and 25 women) will view a series of audiovisual stimuli depicting heterosexual sexual acts and neutral subjects. Participants will answer a series of questionnaires about their sexual history and attitudes, and will answer questions on their level of sexual arousal before and after each stimulus. Participants will continuously report their levels of subjective sexual arousal while simultaneously their genital responses, heart rate and skin conductance will be recorded. It is important to further our understanding of how much impact a participant's previous exposure to erotica, and masturbation behaviours to that erotica, have on their concordance rates; given the increasing pervasiveness and accessibility of erotica, this may prove extremely relevant to future  nvestigations

scholarly journals Clinical characteristics of COVID-19 and establishment of a disease risk prediction model

2020 ◽  
Author(s):  
Tao Fan ◽  
Bo Hao ◽  
Shuo Yang ◽  
Bo Shen ◽  
Zhixin Huang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Prediction Model ◽  
Risk Prediction ◽  
Clinical Characteristics ◽  
Disease Risk ◽  
Clinical Manifestations ◽  
Risk Prediction Model ◽  
Common Symptom ◽  
Severe Group ◽  
Independent Risk Factors

Abstract Background: COVID-19 is spreading worldwide. No specific medicine has been used for the treatment of coronavirus infections. The aim of this study is to establish a new risk predictive model to screen potential critical patients for early intervention.Methods: In this study, Clinical characteristics were collected and analyzed from 317 confirmed cases of COVID-19. A total of 175 of the 317 cases with detailed examination results were included to establish models for predicting the risk of disease progression. Major independent risk factors were incorporated into MuLBSTA model to establish new models for predicting critical risk. We further tracked 25 mild or moderate patients with COVID-19 to research dynamic changes of the major independent risk factors in COVID-19 progression.Results: The average age of all of the 317 patients was 47.76 (SD 17.22). A total of 48 (15.14%) were diagnosed with mild disease with a median age of 34(39.29±13.04), 116(36.59%) were diagnosed with moderate disease with a median age of 34(38.78±12.32), 38(11.99%) were diagnosed as severe with a median age of 56(58.24±15.12), and 115(36.28) were diagnosed as critical with a median age of 59(56.89+17.09). The most common symptom at onset of illness were fever(211[66.56%] patients). Age>50, CK>64, CD4≤461, and CD8≤241 were predicted to be major independent risk factors that could promote COVID-19 progression. Compared with the MuLBSTA model, the predictive ability of the CD4-CD8-MuLBSTA model and the CD4-MuLBSTA model were improved by 11.87% and 11.79%, respectively. In the prospective study, CK value began to show significant differences from day13. The average CD4 in Severe Group began to decline significantly on the fourth day, and the CD8 maintained a relatively low level in the Severe Group after day13.Conclusions: Severe COVID-19 patients were significantly older than non-severe patients. Immune systems of severe COVID-19 patients were significantly suppressed, and advanced age(>50 years), low levels of CD4(≤461) or CD8(≤241) was important clinical manifestations of rapid deterioration. CK values in severe COVID-19 patients were significantly higher than in no severe patients. CD4 and CD8 were incorporated into the MuLBSTA to establish a new model, which is an ideal risk prediction model for COVID-19 patients.

Therapeutic options in male osteoporosis

2013 ◽  
Vol 22 (04) ◽  
pp. 271-276 ◽  
Author(s):  
P. Farahmand ◽  
J. D. Ringe
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Public Health Problem ◽  
Male Osteoporosis ◽  
Individual Risk ◽  
Modes Of Action ◽  
Increased Risk ◽  
Study Results ◽  
Long Term Treatment ◽  
Male Patients

SummaryOsteoporosis in men is increasingly recognized as an important public health problem but affected patients are still under-diagnosed and -treated. As in women the diagnostic and therapeutic strategy has to be adapted to the individual case. In the practical management it is very important to detect possible causes of secondary osteoporosis, to explain the possibilities of basic therapy counteracting individual risk factors and communicate that osteoporosis is a chronic disease and adherence to a long-term treatment is crucial. In established severe osteoporosis a careful analgesic therapy is important to avoid further bone loss related to immobility. In elderly men with increased risk of falling insufficient Vitamin D supply or impaired activation of Vitamin D due to renal insufficiency must be taken into consideration. Specific medications available today for the treatment of male osteoporosis comprise among antiresorptive drugs the bis phosphonates alendronate, risedronate and zoledronic acid. Denosumab, the first biological therapy is approved for men with androgen deprivation therapy for prostate cancer. An important advantage of this potent antiresorptive drug is the increased adherence due to the comfortable application by sixmonthly subcutaneous injections. Study results from the 2-year multi-center randomized controlled ADAMO-Study will very soon allow the use of denosumab in all types of male osteoporosis. Teriparatide, the 34 N-terminal amino acid sequence of parathyroid hormone was approved for men with osteoporosis as an anabolic agent based on proven efficacy by different studies. Among drugs with other modes of action the D-hormone pro-drug alfacalcidol can be used in men alone or in combination with the advantage of pleiotropic effects on calcium absorption, parathyroids, bone and muscle. Recently also Strontium-ranelate was approved for male patients with the limitation to exclude men with clinical relevant cardiovascular risk factors. In general the possibilities to treat male osteoporosis have considerably improved during recent years. Today there is a choice of a spectrum of drugs from mild to strong potency with different modes of action on bone turnover to design strategies for individual male patients.

Prevalence and Risk Factors of Hepatitis C Virus (HCV) in Tehsil Batkhela District Malakand, KPK, Pakistan

2018 ◽  
Vol 9 (06) ◽  
pp. 20251-20256
Author(s):  
Mudassir Khan ◽  
Shahrukh Khan ◽  
Shohra Haider ◽  
Fazal Jalil ◽  
Muhsin Jamal ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Skin Color ◽  
Significant Risk ◽  
Rapid Test ◽  
Prevalence Ratio ◽  
Hcv Infection ◽  
Hcv Rna ◽  
Common Symptom

Background: Prevalence of Hepatitis C viral infection and its major risk factors has been found out in population of Batkhela, Khyber Pakhtunkhwa, Pakistan by taking number of volunteers from the interested area. HCV prevalence has not been researched in recent time here in this area, so that’s why we contributed. Materials and Methods: Ab rapid test cassette serum/plasma (USA) kit has been used for the mentioned purpose following by ELISA and finally PCR to find out active infection of virus. ICT positive individuals were reconfirmed by ELISA and then ELISA positive samples were carefully investigated by RT-PCR for Hepatitis C Virus. Results: The study population was of 770 volunteers belonging to the mentioned area of research, 453 males and 317 females. The overall prevalence was found to be 5.32% of HCV in Batkhela. This prevalence ratio was 3.12% in males and 2.20 % in females. 3rd generation ELISA was used to refine ICT positive samples which showed that 37 of the ICT positive samples had antibodies detected by ELISA. To find out active HCV infection, ELISA positive samples were refined by real time PCR which showed 2.98% of prevalence of active HCV infection in Batkhela based on HCV RNA in their blood. Principle Conclusion: Overall prevalence was found 5.32%, contaminated reused syringes and blades at Barbour’s shop, blood transfusion, surgical operations and unhygienic food in stalls etc were found significant risk factors for acquiring HCV infection. Body weakness and pale yellow skin color was common symptom in HCV positive volunteers. Safe sexual activities, blood screening before donation and sterilizing surgical equipment’s can protect us from Hepatitis C Virus.

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