scholarly journals Associations Between Symptoms of Depression and Air Pollutant Exposure Among Older Adults: Results From the Taiwan Longitudinal Study on Aging (TLSA)

2022 ◽  
Vol 9 ◽  
Author(s):  
Kuan-Chin Wang ◽  
Yuan-Ting C. Lo ◽  
Chun-Cheng Liao ◽  
Yann-Yuh Jou ◽  
Han-Bin Huang
Keyword(s):  
Older Adults ◽  
Depressive Symptoms ◽  
Longitudinal Study ◽  
Air Pollutants ◽  
Ambient Air ◽  
Community Dwelling ◽  
Air Pollutant ◽  
Moving Averages ◽  
Short Term ◽  
Symptoms Of Depression

Background: Little epidemiological research has investigated the associations of air pollutant exposure over various time windows with older adults' symptoms of depression. This study aimed to analyze the relationships of long- and short-term ambient air pollution exposure (to coarse particulate matter, O3, SO2, CO, and NOx) with depressive symptoms in a sample of community-dwelling older adults.Methods: A sample of older adults (n = 1,956) was recruited from a nationally representative multiple-wave study (Taiwan Longitudinal Study on Aging). Between 1996 and 2007, four waves of surveys investigated depressive symptoms by using the 10-item Center for Epidemiologic Studies Depression questionnaire. We approximated air pollutant concentrations from 1995 to 2007 by using daily concentration data for five air pollutants at air quality monitoring stations in the administrative zone of participants' residences. after adjusting for covariates, we applied generalized linear mixed models to analyze associations for different exposure windows (7-, 14-, 21-, 30-, 60-, 90-, and 180-day and 1-year moving averages).Results: In a one-pollutant model, long- and short-term exposure to CO and NOx was associated with heightened risks of depressive symptoms; the odds ratio and corresponding 95% confidence interval for each interquartile range (IQR) increment in CO at 7-, 14-, 21-, 30-, 60-, 90-, and 180-day and 1-year moving averages were 1.232 (1.116, 1.361), 1.237 (1.136, 1.348), 1.216 (1.128, 1.311), 1.231 (1.133, 1.338), 1.224 (1.124, 1.332), 1.192 (1.106, 1.285), 1.228 (1.122, 1.344), and 1.180 (1.102, 1.265), respectively. Those for each IQR increment in NOx were 1.312 (1.158, 1.488), 1.274 (1.162, 1.398), 1.295 (1.178, 1.432), 1.310 (1.186, 1.447), 1.345 (1.209, 1.496), 1.348 (1.210, 1.501), 1.324 (1.192, 1.471), and 1.219 (1.130, 1.314), respectively. The exposure to PM10, O3, and SO2 over various windows were not significant. In the two-pollutant model, only the associations of NOx exposure with depressive symptoms remained robust after adjustment for any other pollutant.Conclusions: Exposure to traffic-associated air pollutants could increase depression risks among older adults.

scholarly journals Exposure to Ambient Air Pollution and Cognitive Impairment in Community-Dwelling Older Adults: The Korean Frailty and Aging Cohort Study

2019 ◽  
Vol 16 (19) ◽  
pp. 3767 ◽  
Author(s):  
Shin ◽  
Han ◽  
Choi
Keyword(s):  
Older Adults ◽  
Cognitive Impairment ◽  
Air Pollutants ◽  
Meteorological Data ◽  
Digit Span ◽  
Multiple Logistic Regression Analysis ◽  
Ambient Air ◽  
Community Dwelling ◽  
Ambient Air Pollution ◽  
Global Cognition

The aim of this study was to investigate the associations between ambient air pollutants and cognitive impairment in Korean older adults. The cognitive function of 2,896 participants aged 70 to 84 years was measured using the Korean version of the mini-mental state examination, the digit span test, the word list learning test, and the frontal assessment battery. After matching the average concentrations of particulate matter (PM) <10 μm in size (PM10) and <2.5 μm (PM2.5), NO2, CO, SO2, and O3 between 2013 and 2017, the association between air pollutants and cognitive scales was analyzed using a linear mixed regression and a multiple logistic regression analysis (after adjusting for age, sex, health related behaviors, socioeconomic status, comorbidity, and meteorological data). Exposure to PM2.5, PM10, NO2, SO2, and CO was associated with cognitive impairment above and beyond age or education level effects. Specifically, PM2.5 was negatively associated with most components of the cognitive scales (interquartile range for PM2.5: 2.0 μg/m3, odds ratio for poor global cognition: 2.28, 95% confidence interval: 1.60–3.26). These associations may be affected by sex, residence area, or alcohol intake. Conclusively, air pollutants, especially PM2.5, were associated with cognitive impairment, including global cognition, attention, memory, and executive function in Korean older adults aged ≥70 years.

scholarly journals Estimating health burden and economic loss attributable to short-term exposure to multiple air pollutants in China

2019 ◽  
Author(s):  
Minghong Yao ◽  
Gonghua Wu ◽  
Xing Zhao ◽  
Juying Zhang
Keyword(s):  
Respiratory Disease ◽  
Air Pollutants ◽  
Hospital Admissions ◽  
Ambient Air ◽  
Economic Loss ◽  
Air Pollutant ◽  
Limited Information ◽  
Short Term ◽  
Health Burden ◽  
Short Term Exposure

Abstract Background Existing studies focused on the evaluation of health burden of long-term exposure to air pollutants, whereas limited information is available on short-term exposure, particularly in China.Methods Air pollutants concentrations in 338 Chinese cities in 2017 were used to estimate the air pollutants related health burden which was defined as premature mortalities from all-cause, cardiovascular and respiratory disease as well as hospital admissions (HAs) for cardiovascular and respiratory disease. Log-linear model was used as the exposure-response function to estimate the health burden attributable to each air pollutant. The value of statistical life and cost of illness methods were used to estimate economic loss of the premature mortalities and HAs, respectively.Results The national all-cause premature mortalities attributable to all air pollutants was 1.35 million, accounting for 17.2% of reported deaths in China in 2017. Among all-cause premature mortality, contributions of PM10, SO2, NO2, CO, and O3 were 16.3%, 9.6%, 28.9%, 22.2% and 23.0%, respectively. The national cardiovascular and respiratory premature mortalities were 0.78 and 0.21 million, respectively. About 6.79 million cardiovascular and respiratory disease HAs were attributed to short-term exposure to PM10, SO2, NO2, and O3. The economic loss of the overall health burden was 2057.66 billion Yuan, which was equivalent to 2.5% of the national GDP in 2017.Conclusions The health burden and economic loss attributable to short-term exposure to ambient air pollutant are substantial in China. It suggested that the adverse health effects attributable to short-term exposure to air pollutant should not be neglected in China.

Depressive symptoms with cognitive dysfunction increase the risk of cognitive impairment: analysis of the Korean Longitudinal Study of Aging (KLoSA), 2006–2018

2020 ◽  
pp. 1-11
Author(s):  
Minyoung Shin
Keyword(s):  
Older Adults ◽  
Cognitive Impairment ◽  
Depressive Symptoms ◽  
Longitudinal Study ◽  
Cognitive Dysfunction ◽  
Healthcare Providers ◽  
Final Analysis ◽  
Community Dwelling ◽  
The Impact ◽  
Community Dwelling Older Adults

ABSTRACT Objectives: Geriatric depression complicates cognitive health in older adults. This study aims to investigate the impact of depressive symptoms on cognitive impairment in community-dwelling older adults, depending on whether cognitive dysfunction accompanied. Design: A community-based longitudinal cohort study. Setting: This study analyzed data from the Korean Longitudinal Study of Aging (KLoSA) from 2006 to 2018. Participants: Among 10,254 individuals who were registered in the KLoSA study, a total of 9119 subjects met the criteria, and 4547 subjects were included in the final analysis. The subjects were grouped into 4 categories based on depressive symptoms and cognitive dysfunction at baseline assessment: “normal control” (NC, n = 3341), “depression only” (Dep-only, n = 652), “cognitive dysfunction only” (CD-only, n = 393), and “depression with cognitive dysfunction” (Dep-CD, n = 161). Measurements: Cognitive impairment 10 years later was defined as K-MMSE scores below two percentile on demographically adjusted norms. Results: Ten-year survival, that is, not experiencing cognitive impairment, was 80 $$ \pm \,$$ 1% in NC group, 72 $$ \pm $$ 2% in Dep-only group, 52 $$ \pm $$ 3% in CD-only group, and 44 $$ \pm $$ 5% in Dep-CD group. The hazard ratio (HR) of the Dep-only group (HR = 1.18, 95% CI, 0.97–1.43, n.s.) did not differ from that of the NC group, but the HR of the Dep-CD group was significantly higher (HR = 2.85, 95% CI, 2.23–3.66, p < 0.001) than the NC group. When the Dep-CD group was compared to the CD-only group, the HR was 1.13 (95% CI, 0.85–1.49, n.s.), which indicates that it did not significantly differ from the CD-only group. Conclusions: Our findings suggest that depressive symptoms with cognitive dysfunction are associated with a higher risk of cognitive impairment. Furthermore, cognitive dysfunction occurring with depressive symptoms is as much a risk for cognitive impairment as is pure cognitive dysfunction. Thus, healthcare providers should pay close attention to the community-dwelling elderly when depressive symptoms occur with cognitive dysfunction.

scholarly journals Low vitamin B12 but not folate is associated with incident depressive symptoms in community-dwelling older adults: a 4 year longitudinal study

2021 ◽  
pp. 1-22
Author(s):  
Eamon Laird ◽  
Aisling M. O’Halloran ◽  
Anne M Molloy ◽  
Martin Healy ◽  
Belinda Hernandez ◽  
...  
Keyword(s):  
Older Adults ◽  
Depressive Symptoms ◽  
Longitudinal Study ◽  
Regression Models ◽  
Plasma Concentrations ◽  
Depression Scale ◽  
Community Dwelling ◽  
Vitamin B ◽  
Folate Status ◽  
Antidepressant Use

Abstract The objective was to examine the prospective relationship between folate and vitamin B12 (B12) status and incident depressive symptoms in a representative cohort of community-dwelling older people. This was a longitudinal study utilising the Irish Longitudinal Study on Aging (n =3,849 aged ≥50 years) and investigated the relationship between blood plasma folate and B12 levels at baseline (wave 1) and incident depressive symptoms at 2 and 4 years (waves 2 and 3). Participants with depression at wave 1 were excluded. A score ≥9 on the Center for Epidemiologic Studies Depression Scale-8 at wave 2 or 3 was indicative of incident depressive symptoms. Plasma B12 and folate concentrations were determined by microbiological assay. B12 status profiles (pmol/l) were defined as: <185, deficient-low; 185 - <258, low normal; >258 - 601, normal and >601 high. Folate status profiles (nmol/l) were defined as: ≤10.0, deficient-low; >10 - 23.0, low normal; >23.0 - 45.0, normal; >45.0, high. Logistic regression models reporting odds ratios were used to analyse the longitudinal association of B-vitamin categories with incident depression. Both B12 and folate plasma concentrations were lower in the group with incident depressive symptoms vs. non depressed (folate: 21.4 vs. 25.1 nmol/L; P=0.0003); (B12: 315.7 vs. 335.9 pmol/L; P=0.0148). Regression models demonstrated that participants with deficient-low B12 status at baseline had a significantly higher likelihood of incident depression four years later (odds ratio 1.51, 95% CI 1.01-2.27, P=0.043). This finding remained robust after controlling for relevant covariates including physical activity, chronic disease burden, vitamin D status. cardiovascular disease and antidepressant use. No associations of folate status with incident depression were observed. Older adults with deficient-low B12 status had a 51% increased likelihood of developing depressive symptoms over 4 years. Given the high rates of B12 deficiency, these findings are important and highlight the need to further explore the low cost benefits of optimising vitamin B12 status for depression in older adults.

scholarly journals Association of tau tangle burden with depressive symptoms in community‐dwelling older adults: A longitudinal study

2020 ◽  
Vol 16 (S6) ◽  
Author(s):  
Jennifer R. Gatchel ◽  
Gad A. Marshall ◽  
Joseph J. Locascio ◽  
Hyun‐Sik Yang ◽  
Nancy J. Donovan ◽  
...  
Keyword(s):  
Older Adults ◽  
Depressive Symptoms ◽  
Longitudinal Study ◽  
Community Dwelling ◽  
Community Dwelling Older Adults

scholarly journals Association of tau tangle burden with depressive symptoms in community‐dwelling older adults: A longitudinal study

2020 ◽  
Vol 16 (S5) ◽  
Author(s):  
Jennifer R Gatchel ◽  
Gad A Marshall ◽  
Joseph J Locascio ◽  
Hyun‐Sik Yang ◽  
Nancy J Donovan ◽  
...  
Keyword(s):  
Older Adults ◽  
Depressive Symptoms ◽  
Longitudinal Study ◽  
Community Dwelling ◽  
Community Dwelling Older Adults

scholarly journals Haemoglobin A1c, fasting glucose and future risk of elevated depressive symptoms over 2 years of follow-up in the English Longitudinal Study of Ageing

2011 ◽  
Vol 41 (9) ◽  
pp. 1889-1896 ◽  
Author(s):  
M. Hamer ◽  
G. D. Batty ◽  
M. Kivimaki
Keyword(s):  
Risk Factors ◽  
Older Adults ◽  
Depressive Symptoms ◽  
Longitudinal Study ◽  
Glucose Metabolism ◽  
Fasting Glucose ◽  
Community Dwelling ◽  
English Longitudinal Study ◽  
Hba1c Levels

BackgroundThe cross-sectional association between impaired glucose/diabetes and depression is inconsistent. We examined the longitudinal associations between diabetes, indicators of glucose metabolism and depressive symptoms over 2 years of follow-up.MethodParticipants were 4338 men and women from the English Longitudinal Study of Ageing, a prospective study of community-dwelling older adults [aged 62.9 (s.d.=9.0) years, 45.2% men]. Depressive symptoms were assessed at baseline and after 2 years of follow-up using the eight-item Centre of Epidemiological Studies – Depression (CES-D) scale. Glycated haemoglobin (HbA1c) levels, fasting glucose and other biological and behavioural risk factors were also assessed at baseline.ResultsApproximately 11.5% of the sample were categorized with elevated depressive symptoms at follow-up (a score ⩾4 on the CES-D). There was an association between HbA1c and depressive symptoms at follow-up [per unit increase, odds ratio (OR) 1.17, 95% confidence interval (CI) 1.03–1.33] after adjustment for age and baseline CES-D. Cross-sectionally, the probability of depressive symptoms increased with increasing HbA1c levels until the value of 8.0% after which there was a plateau [p(curve)=0.03]. Compared with those with normal fasting glucose, participants with diabetes (confirmed through self-report or elevated fasting blood glucose) at baseline had an elevated risk of depressive symptoms at follow-up (OR 1.52, 95% CI 1.01–2.30) after adjusting for depressive symptoms at baseline, behavioural and sociodemographic variables, adiposity and inflammation.ConclusionsThese data suggest that poor glucose metabolism and diabetes are risk factors for future depression in older adults. There was no evidence of a U-shaped association.

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