A New Look at Vaccine Strategies Against PPRV Focused on Adenoviral Candidates

Peste des petits ruminants virus (PPRV) is a virus that mainly infects goats and sheep causing significant economic loss in Africa and Asia, but also posing a serious threat to Europe, as recent outbreaks in Georgia (2016) and Bulgaria (2018) have been reported. In order to carry out the eradication of PPRV, an objective set for 2030 by the Office International des Epizooties (OIE) and the Food and Agriculture Organization of the United Nations (FAO), close collaboration between governments, pharmaceutical companies, farmers and researchers, among others, is needed. Today, more than ever, as seen in the response to the SARS-CoV2 pandemic that we are currently experiencing, these goals are feasible. We summarize in this review the current vaccination approaches against PPRV in the field, discussing their advantages and shortfalls, as well as the development and generation of new vaccination strategies, focusing on the potential use of adenovirus as vaccine platform against PPRV and more broadly against other ruminant pathogens.

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Eradicating the Scourge of Peste Des Petits Ruminants from the World

Viruses ◽

10.3390/v12030313 ◽

2020 ◽

Vol 12 (3) ◽

pp. 313 ◽

Cited By ~ 2

Author(s):

Felix Njeumi ◽

Dalan Bailey ◽

Jean. Jacques Soula ◽

Bouna Diop ◽

Berhe G. Tekola

Keyword(s):

Animal Movement ◽

Animal Health ◽

Small Ruminants ◽

Viral Disease ◽

Peste Des Petits Ruminants ◽

International Consensus ◽

Food And Agriculture ◽

Food And Agriculture Organization ◽

Eradication Strategy ◽

The World

Peste des Petits Ruminants (PPR) is a highly contagious viral disease of both domestic (goats and sheep) and wild ruminants. Caused by a morbillivirus, that belongs to the family Paramyxoviridae. The disease is clinically and pathologically similar to rinderpest of cattle and human measles. PPR is one of the most economically devastating viral diseases of small ruminants. In April 2015, the Food and Agriculture Organization of the United Nations (FAO) and the World Organisation for Animal Health (OIE) launched the PPR Global Control and Eradication Strategy (PPR GCES) with the vision for global eradication by 2030. There is a strong and lasting international consensus to eradicate the disease in order to protect the livelihoods of the world’s poorest populations. As with any disease, eradication is feasible when, policy, scientific and technical challenges are addressed. Ten majors challenges are described in this paper namely: understanding small ruminant production, facilitating research to support eradication, refining laboratory testing, improving epidemiological understanding of the virus, defining infection of wildlife and other species, optimizing vaccine delivery and novel vaccines, developing better control of animal movement, heightening serological monitoring, understanding socio-economic impact, and garnering funding and political will.

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Progress towards Eradication of Peste des Petits Ruminants through Vaccination

Viruses ◽

10.3390/v13010059 ◽

2021 ◽

Vol 13 (1) ◽

pp. 59

Author(s):

Hang Zhao ◽

Felix Njeumi ◽

Satya Parida ◽

Camilla T. O. Benfield

Keyword(s):

United Nations ◽

Assessment Tool ◽

Animal Health ◽

National Level ◽

Peste Des Petits Ruminants ◽

Food And Agriculture ◽

Food And Agriculture Organization ◽

Eradication Strategy ◽

The United Nations ◽

Vaccination Campaigns

Peste des petits ruminants (PPR) is a transboundary viral disease that threatens more than 1.74 billion goats and sheep in approximately 70 countries globally. In 2015, the international community set the goal of eradicating PPR by 2030, and, since then, Food and Agriculture Organization of the United Nations (FAO) and World Organization for Animal Health (OIE) have jointly developed and implemented the Global Control and Eradication Strategy for PPR. Here, data from the United Nations Food and Agriculture Organization Statistical Database (FAOSTAT), the OIE World Animal Health Information System (WAHIS), Regional Roadmap Meetings, and countries’ responses to PPR Monitoring and Assessment Tool (PMAT) questionnaires were analyzed to inform on current progress towards PPR eradication. OIE recorded the use of over 333 million doses of vaccine in 12 countries from 2015 to 2018, 41.8% of which were used in Asia and 58.2% in Africa. Between 2015 and 2019, a total of 12,757 PPR outbreaks were reported to OIE: 75.1% in Asia, 24.8% in Africa, and 0.1% in Europe. The number of global outbreaks in 2019 fell to 1218, compared with 3688 in 2015. Analysis of vaccine use and PPR outbreaks in countries indicates that disease control strategies, particularly vaccination campaigns and vaccine distribution strategies, still require scientific evaluation. It is imperative that vaccination is undertaken based on the epidemiology of the disease in a region and is coordinated between neighboring countries to restrict transboundary movements. Strengthening surveillance and post-vaccination sero-monitoring at the national level is also essential. The PPR vaccine stock/bank established by FAO, OIE, and other partners have improved the quality assurance and supply of vaccines. However, to achieve PPR eradication, filling the funding gap for vaccination campaigns and other program activities will be critical.

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Silver Nanoparticles Offer Effective Control of Pathogenic Bacteria in a Wide Range of Food Products

Pathogenic Bacteria ◽

10.5772/intechopen.89403 ◽

2020 ◽

Author(s):

Graciela Dolores Avila-Quezada ◽

Gerardo Pavel Espino-Solis

Keyword(s):

Silver Nanoparticles ◽

Pathogenic Bacteria ◽

Fruits And Vegetables ◽

Single Cells ◽

Thiol Group ◽

Economic Loss ◽

Cellular Level ◽

Bacterial Populations ◽

Food And Agriculture ◽

Food And Agriculture Organization

According to the Food and Agriculture Organization (FAO), food wastage still causes massive economic loss. A major role in this loss is played by the activities of microbial organisms. Treatments such as heat and irradiation can reduce microorganisms in fruits and vegetables and hence reduce postharvest loss. However, some of these treatments can injure the fruit. Effective chemical treatments against bacterial infestations can result in resistance. A more recent method is the use of silver nanoparticles. These can act in a number of ways including at cellular level by inhibiting the cell wall synthesis, by binding to the surface of the cell membrane and by interposing between the DNA base pairs, and by inhibiting biofilm formation, affecting the thiol group of enzymes, affecting bacterial peptides and hence interfering with cell signaling and attaching to the 30S ribosome subunit. A ground-breaking way to survey the effects of the silver nanoparticles on bacterial populations is by flow cytometry. It allows measurement of many characteristics of single cells, including their functional characteristics such as viability and cell cycle. Bacterial viability assays are used with great efficiency to evaluate antibacterial activity by evaluating the physical rupture of the membrane of the bacteria.

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Food waste and dynamic complex systems: The case of Peru and a solution model proposal Part 1: Peruvian Anchoveta (Engraulis ringens)

10.31234/osf.io/3bjpv ◽

2020 ◽

Author(s):

Carlos A Almenara

Keyword(s):

United Nations ◽

Complex Systems ◽

Revenue Management ◽

Food Waste ◽

Intelligent Systems ◽

Solution Model ◽

Food And Agriculture ◽

Food And Agriculture Organization ◽

Engraulis Ringens ◽

The United Nations

[THE MANUSCRIPT IS A DRAFT] According to the Food and Agriculture Organization of the United Nations (FAO, 2020), food waste and losses comprises nearly 1.3 billion tonnes every year, which equates to around US$ 990 billion worldwide. Ironically, over 820 million people do not have enough food to eat (FAO, 2020). This gap production-consumption puts in evidence the need to reformulate certain practices such as the controversial monocropping (i.e., growing a single crop on the same land on a yearly basis), as well as to improve others such as revenue management through intelligent systems. In this first part of a series of articles, the focus is on the Peruvian anchoveta fish (Engraulis ringens).

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To the Empire and Beyond

10.1093/oso/9780199642533.003.0007 ◽

2018 ◽

Author(s):

Gregory A. Barton

Keyword(s):

Second World War ◽

World War ◽

Chemical Fertilizers ◽

Basic Principles ◽

Food And Agriculture ◽

Food And Agriculture Organization ◽

Organic Farmers ◽

Southern Rhodesia ◽

The Government ◽

Second World

This chapter traces the expansion of industrial agricultural methods after the Second World War. Western governments and the Food and Agriculture Organization pushed for increased use of chemical fertilizers to aid development and resist Soviet encroachment. Meanwhile small groups of organic farmers and gardeners adopted Howard’s methods in the Anglo-sphere and elsewhere in the world. European movements paralleled these efforts and absorbed the basic principles of the Indore Method. British parliament debated the merits of organic farming, but Howard failed to persuade the government to adopt his policies. Southern Rhodesia, however, did implement his ideas in law. Desiccation theory aided his attempts in South Africa and elsewhere, and Louise Howard, after Albert’s death, kept alive a wide network of activists with her publications.

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Impact of Nisin and Nisin-Producing Lactococcus lactis ssp. lactis on Clostridium tyrobutyricum and Bacterial Ecosystem of Cheese Matrices

Foods ◽

10.3390/foods10040898 ◽

2021 ◽

Vol 10 (4) ◽

pp. 898

Author(s):

Hebatoallah Hassan ◽

Daniel St-Gelais ◽

Ahmed Gomaa ◽

Ismail Fliss

Keyword(s):

Lactococcus Lactis ◽

Cheddar Cheese ◽

Economic Loss ◽

Gas Production ◽

Clostridium Tyrobutyricum ◽

Nisin Production ◽

Genus Clostridium ◽

Milk Pasteurization ◽

Cheese Slurry ◽

Significant Economic Loss

Clostridium tyrobutyricum spores survive milk pasteurization and cause late blowing of cheeses and significant economic loss. The effectiveness of nisin-producing Lactococcus lactis ssp. lactis 32 as a protective strain for control the C. tyrobutyricum growth in Cheddar cheese slurry was compared to that of encapsulated nisin-A. The encapsulated nisin was more effective, with 1.0 log10 reductions of viable spores after one week at 30 °C and 4 °C. Spores were not detected for three weeks at 4 °C in cheese slurry made with 1.3% salt, or during week 2 with 2% salt. Gas production was observed after one week at 30 °C only in the control slurry made with 1.3% salt. In slurry made with the protective strain, the reduction in C. tyrobutyricum count was 0.6 log10 in the second week at 4 °C with both salt concentration. At 4 °C, nisin production started in week 2 and reached 97 µg/g after four weeks. Metabarcoding analysis targeting the sequencing of 16S rRNA revealed that the genus Lactococcus dominated for four weeks at 4 °C. In cheese slurry made with 2% salt, the relative abundance of the genus Clostridium decreased significantly in the presence of nisin or the protective strain. The results indicated that both strategies are able to control the growth of Clostridium development in Cheddar cheese slurries.

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Ensuring Agricultural Sustainability through Remote Sensing in the Era of Agriculture 5.0

Applied Sciences ◽

10.3390/app11135911 ◽

2021 ◽

Vol 11 (13) ◽

pp. 5911

Author(s):

Vanesa Martos ◽

Ali Ahmad ◽

Pedro Cartujo ◽

Javier Ordoñez

Keyword(s):

Remote Sensing ◽

Sustainable Agriculture ◽

Information Acquisition ◽

Industrial Revolution ◽

Structural Parameters ◽

Special Focus ◽

World Population ◽

Food And Agriculture ◽

Food And Agriculture Organization ◽

Zero Hunger

Timely and reliable information about crop management, production, and yield is considered of great utility by stakeholders (e.g., national and international authorities, farmers, commercial units, etc.) to ensure food safety and security. By 2050, according to Food and Agriculture Organization (FAO) estimates, around 70% more production of agricultural products will be needed to fulfil the demands of the world population. Likewise, to meet the Sustainable Development Goals (SDGs), especially the second goal of “zero hunger”, potential technologies like remote sensing (RS) need to be efficiently integrated into agriculture. The application of RS is indispensable today for a highly productive and sustainable agriculture. Therefore, the present study draws a general overview of RS technology with a special focus on the principal platforms of this technology, i.e., satellites and remotely piloted aircrafts (RPAs), and the sensors used, in relation to the 5th industrial revolution. Nevertheless, since 1957, RS technology has found applications, through the use of satellite imagery, in agriculture, which was later enriched by the incorporation of remotely piloted aircrafts (RPAs), which is further pushing the boundaries of proficiency through the upgrading of sensors capable of higher spectral, spatial, and temporal resolutions. More prominently, wireless sensor technologies (WST) have streamlined real time information acquisition and programming for respective measures. Improved algorithms and sensors can, not only add significant value to crop data acquisition, but can also devise simulations on yield, harvesting and irrigation periods, metrological data, etc., by making use of cloud computing. The RS technology generates huge sets of data that necessitate the incorporation of artificial intelligence (AI) and big data to extract useful products, thereby augmenting the adeptness and efficiency of agriculture to ensure its sustainability. These technologies have made the orientation of current research towards the estimation of plant physiological traits rather than the structural parameters possible. Futuristic approaches for benefiting from these cutting-edge technologies are discussed in this study. This study can be helpful for researchers, academics, and young students aspiring to play a role in the achievement of sustainable agriculture.

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Rapid Multi-Hybridisation FISH Screening for Balanced Porcine Reciprocal Translocations Suggests a Much Higher Abnormality Rate Than Previously Appreciated

Cells ◽

10.3390/cells10020250 ◽

2021 ◽

Vol 10 (2) ◽

pp. 250

Author(s):

Rebecca E O’Connor ◽

Lucas G Kiazim ◽

Claudia C Rathje ◽

Rebecca L Jennings ◽

Darren K Griffin

Keyword(s):

Semen Analysis ◽

In Situ Hybridisation ◽

Economic Loss ◽

Environmental Damage ◽

Fluorescence In Situ Hybridisation ◽

Reciprocal Translocations ◽

Chromosome Translocations ◽

Farrowing Rate ◽

Significant Economic Loss

With demand rising, pigs are the world’s leading source of meat protein; however significant economic loss and environmental damage can be incurred if boars used for artificial insemination (AI) are hypoprolific (sub-fertile). Growing evidence suggests that semen analysis is an unreliable tool for diagnosing hypoprolificacy, with litter size and farrowing rate being more applicable. Once such data are available, however, any affected boar will have been in service for some time, with significant financial and environmental losses incurred. Reciprocal translocations (RTs) are the leading cause of porcine hypoprolificacy, reportedly present in 0.47% of AI boars. Traditional standard karyotyping, however, relies on animal specific expertise and does not detect more subtle (cryptic) translocations. Previously, we reported development of a multiple hybridisation fluorescence in situ hybridisation (FISH) strategy; here, we report on its use in 1641 AI boars. A total of 15 different RTs were identified in 69 boars, with four further animals XX/XY chimeric. Therefore, 4.5% had a chromosome abnormality (4.2% with an RT), a 0.88% incidence. Revisiting cases with both karyotype and FISH information, we reanalysed captured images, asking whether the translocation was detectable by karyotyping alone. The results suggest that chromosome translocations in boars may be significantly under-reported, thereby highlighting the need for pre-emptive screening by this method before a boar enters a breeding programme.

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Strengthening implementation of antimicrobial resistance national action plans

European Journal of Public Health ◽

10.1093/eurpub/ckaa165.1200 ◽

2020 ◽

Vol 30 (Supplement_5) ◽

Author(s):

M Anderson ◽

K Schulze ◽

A Cassini ◽

D Plauchoras ◽

E Mossialos

Keyword(s):

Antimicrobial Resistance ◽

Policy Design ◽

Animal Health ◽

Monitoring And Evaluation ◽

Basic Structure ◽

Infection Prevention And Control ◽

Action Plans ◽

Governance Framework ◽

Food And Agriculture ◽

Food And Agriculture Organization

Abstract Antimicrobial resistance is one of the major challenges of our time. Countries use national action plans as a mechanism to build engagement among stakeholders and coordinate a range of actions across human, animal, and environmental health. However, implementation of recommended policies such as stewardship of antimicrobials, infection prevention and control, and stimulating research and development of novel antimicrobials and alternatives remains inconsistent. Improving the quality of governance within antimicrobial resistance national action plans is an essential step to improving implementation. To date, no systematic approach to governance of national action plans on AMR exists. To address this issue, we aimed to develop the first governance framework to offer guidance for both the development and assessment of national action plans on AMR. We reviewed health system governance framework reviews to inform the basic structure of our framework, international guidance documents from WHO, the Food and Agriculture Organization, the World Organisation for Animal Health, and the European Commission, and sought the input of 25 experts from international organisations, government ministries, policy institutes, and academic institutions to develop and refine our framework. The framework consists of 18 domains with 52 indicators that are contained within three governance areas: policy design, implementation tools, and monitoring and evaluation. Countries must engage with a cyclical process of continuous design, implementation, monitoring and evaluation to achieve these aims.

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Plasma and Urinary Amino Acid-Derived Catabolites as Potential Biomarkers of Protein and Amino Acid Deficiency in Rats

Nutrients ◽

10.3390/nu13051567 ◽

2021 ◽

Vol 13 (5) ◽

pp. 1567

Author(s):

Joanna Moro ◽

Nadezda Khodorova ◽

Daniel Tomé ◽

Claire Gaudichon ◽

Catherine Tardivel ◽

...

Keyword(s):

Amino Acid ◽

Dietary Intakes ◽

Analysis Model ◽

Factorial Method ◽

New Methods ◽

Food And Agriculture ◽

Food And Agriculture Organization ◽

Weanling Rats ◽

Urinary Amino ◽

One Way Anova

Objective: Dietary intakes must cover protein and essential amino acid (EAA) requirements. For this purpose, different methods have been developed such as the nitrogen balance method, factorial method, or AA tracer studies. However, these methods are either invasive or imprecise, and the Food and Agriculture Organization of the United Nations (FAO, 2013) recommends new methods and, in particular, metabolomics. The aim of this study is to determine total protein/EAA requirement in the plasma and urine of growing rats. Methods: 36 weanling rats were fed with diets containing 3, 5, 8, 12, 15, and 20% protein for 3 weeks. During experimentation, urine was collected using metabolic cages, and blood from the portal vein and vena was taken at the end of the experiment. Metabolomics analyses were performed using LC-MS, and the data were analyzed with a multivariate analysis model, partial least Squares (PLS) regression, and independent component-discriminant analysis (ICDA). Each discriminant metabolite identified by PLS or ICDA was tested by one-way ANOVA to evaluate the effect of diet. Results: PLS and ICDA allowed us to identify discriminating metabolites between different diet groups. Protein deficiency led to an increase in the AA catabolism enzyme systems inducing the production of breakdown metabolites in the plasma and urine. Conclusion: These results indicate that metabolites are specific for the state of EAA deficiency and sufficiency. Some types of biomarkers such as AA degradation metabolites appear to be specific candidates for protein/EAA requirement.

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