Formulation, evaluation and anti-microbial potential of topical Licorice root extract gel

AbstractThe newly emerged coronavirus, which was designated as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the COVID-19 disease. High effective and well-tolerated medication for hospitalized and non-hospitalized patients is urgently needed. Traditional herbal medicine substances were discussed as promising candidates for the complementary treatment of viral diseases and recently suggested for the treatment of COVID-19. In the present study, we investigated aqueous licorice root extract for its neutralizing activity against SARS-CoV-2 in vitro, identified the active compound glycyrrhizin and uncovered the respective mechanism of viral neutralization. We demonstrated that glycyrrhizin, the primary active ingredient of the licorice root, potently neutralizes SARS-CoV-2 by inhibiting the viral main protease. Our experiments highlight glycyrrhizin as a potential antiviral compound that should be further investigated for the treatment of COVID-19.

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Licorice Root Extract 8008-94-4

Sax's Dangerous Properties of Industrial Materials ◽

10.1002/0471701343.sdp15605 ◽

2004 ◽

Keyword(s):

Licorice Root ◽

Root Extract ◽

Licorice Root Extract

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Identification and quantification of isoflavonoid and triterpenoid compliance markers in a licorice-root extract powder

Journal of Agricultural and Food Chemistry ◽

10.1021/jf00025a009 ◽

1993 ◽

Vol 41 (1) ◽

pp. 42-47 ◽

Cited By ~ 6

Author(s):

David S. Weinberg ◽

M. Lisa. Mainer ◽

Mark D. Richardson ◽

Frederick G. Haibach

Keyword(s):

Licorice Root ◽

Root Extract ◽

Licorice Root Extract ◽

Identification And Quantification

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AMELIORATION OF NECROSIS FORMATION IN GINGIVA BY LICORICE ROOT EXTRACT

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2018.v11i10.26736 ◽

2018 ◽

Vol 11 (10) ◽

pp. 137

Author(s):

Shivanni Ss ◽

Vishnu Priya V ◽

Gayathri R

Keyword(s):

Licorice Root ◽

Tnf Alpha ◽

Root Extract ◽

Reactive Protein ◽

Commercial Source ◽

Bacterial Plaque ◽

Reversible Condition ◽

Hepatocyte Growth ◽

Necrosis Factor ◽

Licorice Root Extract

Objective: Gingivitis is a reversible condition associated with a bacterial plaque that resolves in about 1 week after the reinstitution of oral hygiene procedures. If left untreated, may ultimately progress to periodontitis in a subset of individuals. The objective of the study was to evaluate the amelioration of necrosis formation in gingiva by Licorice root extract. The licorice compounds, licoricidin, and licorisoflavan A were the most effective antibacterial substances.Methods: Licorice root extract was prepared by macerating 50 g of dry powder with 100 ml of 70% (w/v) ethyl alcohol for a week. Human gingival fibroblasts were obtained from a commercial source and were maintained in serum-free fibroblast medium as recommended by the manufacturer. The cells were treated with licorice root extract (100 μg/ml) and incubated for 48 h. Tumor necrosis factor (TNF) and C-reactive protein (CRP) were estimated.Result: TNF-alpha levels were raised, and agglutination of CRP was observed in hepatocyte growth factor positive samples whereas after the treatment with licorice root extract the TNF-alpha levels were declined and no agglutination was seen.Conclusion: TNF and CRP levels are raised during necrosis formation. These levels are decreased when treated with licorice root extract. Thus, licorice root extract causes amelioration of necrosis formation in the gingiva.

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