scholarly journals Effect of Lactobacillus paracasei HII01 Supplementation on Total Cholesterol, and on the Parameters of Lipid and Carbohydrate Metabolism, Oxidative Stress, Inflammation and Digestion in Thai Hypercholesterolemic Subjects

2021 ◽  
Vol 11 (10) ◽  
pp. 4333
Author(s):  
Chaiyavat Chaiyasut ◽  
Yaowalak Tirawat ◽  
Bhagavathi Sundaram Sivamaruthi ◽  
Periyanaina Kesika ◽  
Subramanian Thangaleela ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Placebo Group ◽  
Total Cholesterol ◽  
Blood Lipid ◽  
Lactobacillus Paracasei ◽  
Blood Lipid Profile ◽  
Beneficial Effects ◽  
Tnf Α ◽  
Total Antioxidant ◽  
Hypercholesterolemic Subjects

Hypercholesterolemia is one of the leading causes of cardiovascular disease. Probiotics can help to improve high blood lipid levels in hypercholesterolemia patients. Lactobacillus paracasei has been reported to have beneficial effects in several subjects; however, there is a lack of studies on Thai hypercholesterolemic subjects. Thus, this study was conducted in order to investigate the effect of L. paracasei HII01 on cholesterol, oxidative stress, and other biomarkers. Fifty-two subjects were randomized into two groups: the L. paracasei treatment group and the placebo group. The study was conducted over an intervention period of 12 weeks of supplementation. The results show that L. paracasei HII01 significantly reduced the total cholesterol (TCH), triglycerides (TGs), tumor necrosis factor (TNF)-α and lipopolysaccharide (LPS) of the patients, and increased their HDL, total antioxidant capacity (TAC) and propionic acid compared to the placebo group. Moreover, the supplementation of L. paracasei HII01 significantly increased lactic acid, IL-10 and IFN-γ, and substantially decreased malondialdehyde (MDA) at the end of the treatment. The results suggest that L. paracasei HII01 improves the blood lipid profile, reduces oxidative stress, and is beneficial for health among Thai hypercholesterolemic subjects.

Attenuation of Diabetes-induced Cardiac and Subcellular Defects by Sulphur-containing Amino Acids

2018 ◽  
Vol 25 (3) ◽  
pp. 336-345 ◽  
Author(s):  
Paramjit S. Tappia ◽  
Adriana Adameova ◽  
Naranjan S. Dhalla
Keyword(s):  
Oxidative Stress ◽  
Amino Acids ◽  
Antioxidant Properties ◽  
Blood Lipid ◽  
Cardiovascular Complications ◽  
Blood Lipid Profile ◽  
Beneficial Effects ◽  
Risk Of Mortality ◽  
Increased Risk ◽  
Patients With Diabetes

Background: Patients with diabetes mellitus have an increased risk of mortality due to cardiovascular complications. Supplementation with specific sulphur-containing amino acids is rapidly emerging as a possible therapeutic adjuvant for diabetes and associated cardiovascular complications. Observations: It is well-known that oxidative stress plays an important role in the pathogenesis of diabetes-induced cardiovascular disease, which is invariably associated with abnormal blood lipid profile, insulin resistance and other symptoms of metabolic syndrome. Cysteine and taurine are among the most common sulphur-containing amino acids and their cellular levels decline during diabetes that may contribute to the development of the cardiomyopathy. Although sulphur-containing agents exert multiple actions on cellular and subcellular functions in the heart, they also exhibit antioxidant properties and thus may exert beneficial effects in different pathophysiological conditions. Conclusion: It is concluded that reduction of oxidative stress by cysteine and taurine may serve as an important mechanism for the attenuation of diabetes-induced subcellular and functional abnormalities in the heart.

scholarly journals Effects of Pueraria candollei var mirifica (Airy Shaw and Suvat.) Niyomdham on Ovariectomy-Induced Cognitive Impairment and Oxidative Stress in the Mouse Brain

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3442
Author(s):  
Yaowared Chulikhit ◽  
Wichitsak Sukhano ◽  
Supawadee Daodee ◽  
Waraporn Putalun ◽  
Rakvajee Wongpradit ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cognitive Impairment ◽  
Morris Water Maze Test ◽  
Object Recognition Test ◽  
Pueraria Mirifica ◽  
Beneficial Effects ◽  
Maze Test ◽  
Y Maze ◽  
Tnf Α ◽  
17Β Estradiol

The effects of the phytoestrogen-enriched plant Pueraria mirifica (PM) extract on ovari-ectomy (OVX)-induced cognitive impairment and hippocampal oxidative stress in mice were investigated. Daily treatment with PM and 17β-estradiol (E2) significantly elevated cognitive behavior as evaluated by using the Y maze test, the novel object recognition test (NORT), and the Morris water maze test (MWM), attenuated atrophic changes in the uterus and decreased serum 17β-estradiol levels. The treatments significantly ameliorated ovariectomy-induced oxidative stress in the hippocampus and serum by a decrease in malondialdehyde (MDA), an enhancement of superoxide dismutase, and catalase activity, including significantly down-regulated expression of IL-1β, IL-6 and TNF-α proinflammatory cytokines, while up-regulating expression of PI3K. The present results suggest that PM extract suppresses oxidative brain damage and dysfunctions in the hippocampal antioxidant system, including the neuroinflammatory system in OVX animals, thereby preventing OVX-induced cognitive impairment. The present results indicate that PM exerts beneficial effects on cognitive deficits for which menopause/ovariectomy have been implicated as risk factors.

scholarly journals Alleviation of Oxidative Stress in Dental Pulp Cells Following 4-Hexylresorcinol Administration in a Rat Model

2021 ◽  
Vol 11 (8) ◽  
pp. 3637
Author(s):  
Jun-Ho Chang ◽  
Dae-Won Kim ◽  
Seong-Gon Kim ◽  
Tae-Woo Kim
Keyword(s):  
Oxidative Stress ◽  
Dental Pulp ◽  
Therapeutic Effects ◽  
Protective Effects ◽  
Mandibular Incisor ◽  
Tnf Α ◽  
Total Antioxidant ◽  
Pulp Cells ◽  
Pre Treatment

Damaged dental pulp undergoes oxidative stress and 4-hexylresorcinol (4HR) is a well-known antioxidant. In this study, we aimed to evaluate the therapeutic effects of a 4HR ointment on damaged dental pulp. Pulp cells from rat mandibular incisor were cultured and treated with 4HR or resveratrol (1–100 μM). These treatments (10–100 μM) exerted a protective effect during subsequent hydrogen peroxide treatments. The total antioxidant capacity and glutathione peroxidase activity were significantly increased following 4HR or resveratrol treatment (p < 0.05), while the expression levels of TNF-α and IL1β were decreased following the exposure to 4HR pre-treatment in an in vitro model. Additionally, the application of 4HR ointment in an exposed dental pulp model significantly reduced the expression of TNF-α and IL1β (p < 0.05). Conclusively, 4HR exerted protective effects against oxidative stress in dental pulp tissues through downregulating TNF-α and IL1β.

Kaempferol ameliorates symptoms of metabolic syndrome by improving blood lipid profile and glucose tolerance

2021 ◽  
Author(s):  
Ayasa Ochiai ◽  
Mahmoud Ben Othman ◽  
Kazuichi Sakamoto
Keyword(s):  
Metabolic Syndrome ◽  
Glucose Tolerance ◽  
Molecular Mechanisms ◽  
Ldl Receptor ◽  
Blood Lipid ◽  
Apolipoprotein A1 ◽  
High Density Lipoproteins ◽  
Blood Lipid Profile ◽  
Beneficial Effects ◽  
Apoa1 Gene

Abstract Kaempferol (KPF) is a dietary polyphenol reported to have various beneficial effects on human health. However, its molecular mechanisms in regulating lipid and glucose metabolism are not fully understood. This study examined the effects of KPF on obesity, dyslipidemia, and diabetes in Tsumura, Suzuki, Obese Diabetes (TSOD) mice. The six-week administration of KPF decreased fat weight, serum total cholesterol, and low-density lipoproteins (LDLs); increased high-density lipoproteins (HDLs); and improved glucose tolerance. Additionally, KPF increased LDL receptor (LDLR) and apolipoprotein A1 (ApoA1) gene expression and decreased serum resistin levels. These findings suggest that the decrease in LDL and the increase in HDL caused by KPF may be due to increases in hepatic LDLR and ApoA1 expression, respectively. Furthermore, it is possible that the improvement in glucose tolerance by KPF may occur via resistin reduction. These mechanisms may be parts of complex mechanism by which KPF improves metabolic syndrome.

scholarly journals Management of blood lipid profile and oxidative status in Holstein and Simmental dairy cows during lactation

2019 ◽  
Vol 69 (2) ◽  
pp. 116-124
Author(s):  
Dejan Obućinski ◽  
Nikola Puvača ◽  
Olivera Đuragić ◽  
Dragana Ljubojević Pelić ◽  
Mirela Tomaš Simin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Profile ◽  
Dairy Cows ◽  
Blood Lipid ◽  
Oxidative Status ◽  
Early Lactation ◽  
Blood Lipid Profile ◽  
Lactation Stage ◽  
Holstein Friesian ◽  
Peak Lactation

Managing and determination of the blood lipid profile and oxidative status are useful tool to show the influence of foreign chemical substances on production of dairy cows. Investigation of various biomarkers of oxidative stress related to various problems in the production dairy cows presents a very important issue. The aim of this research was to investigate different biological markers in two different breeds of dairy cows – the Holstein Friesian and the Simmental, during different stages of lactation. The total of 60 Holstein Friesian and Simmental cows were divided into two treatments (HF and S) which was further divided into three groups each, respectively. Lactating groups of each cow breed was divided into three stages at early lactation of 32-75 days (HF1 and S1), peak lactation of 80-165 days (HF2 and S2) and low lactation of 175 days onward (HF3 and S3). During the research the total milk production and the percentage of milk fat and protein were determined. Blood samples were collected from jugular vein of each cow, the serum was harvested without anticoagulant and stored at -20 °C in small aliquots till further analysis. Serum was then analyzed for triglyceride, cholesterol, HDL, LDL, AST, ALT, GGT, the total antioxidant status (TAS), the total oxidant status (TOS), MDA, SOD, catalase and paraoxonase (PON1). Significantly (P&lt;0.05) higher values of cholesterol, TOS and SOD at peak lactation stage was observed in all cows. A gradual decline from early lactation to low lactation was observed in the values of triglycerides and ALT, while MDA gradually increased from the same stage in all cows. The values of LDL and catalase showed an irregular pattern of variations in various lactation stages among all groups. The Holstein Friesian breed showed significantly higher values of ALT and PON1, while values of HDL, TAS and TOS were the lowest in Simmental group (P&lt;0.05). By measuring the signs of oxidative stress, it was concluded that metabolic efforts of cows during the peak of lactation affected the investigated parameters. Disturbance in feed intake and rise in metabolic processes lift up oxidative stress in cows, especially during the peak of lactation, which might be determined by monitoring blood alterations. Results of our study indicated that the Holstein Friesian breed was under higher oxidative stress during different lactation stages compared to Simmental dairy cows.

Krill oil to improve blood lipids status in advanced cancer patient with cachexia.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e19634-e19634
Author(s):  
Roberto Serpe ◽  
Clelia Madeddu ◽  
Filomena Panzone ◽  
Giorgia Antoni ◽  
Maria Chiara Cau ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Cancer Cachexia ◽  
Blood Lipid ◽  
Blood Levels ◽  
Krill Oil ◽  
Omega 3 ◽  
Blood Lipid Profile ◽  
Cholesterol Levels

e19634 Background: Cancer patients with cachexia symptoms often show a lipid profile disorder, consisting in severe hypertriglyceridemia due to increased circulating free fatty acids and variable total cholesterol levels, decreased activity of lipoprotein lipase and increased lipolysis, which is correlated with proinflammatory cytokines levels, particularly IL-6 and TNFα. Recent evidence further confirms impairment of adipose tissue metabolism in inflammatory condition like cancer cachexia. The aim of this study was to assess the effect of nutritional supplementation with Omega 3 fatty acids (EPA and DHA) in the form of Krill Oil, on main parameters of blood lipid profile and on IL-6 and TNFα blood levels. Methods: In 2011, 34 IV stage cachectic patients (M/F 20/14; age range 55-85 y) with cancer at different sites were enrolled. 21 healthy subjects were studied as controls. All patients had high blood tryglicerides, low total cholesterol levels , high levels of blood IL-6 and TNFα compared to controls. Patients received 3 capsules (3 g/day) of krill oil (Superba™ Krill Oil, Aker Biomarine, Norway), which is an oil extract from the crustacean krill (Euphausia Superba) which contains Omega-3 series unsaturated fatty acids in phospholipidic form, of which 98 % are EPA and DHA mainly in phospholipid form. Treatment duration was 2 months. Results: A significant reduction of tryglicerides blood levels (148.23 ± 88.06 vs 114 ± 55.8 mg/dl) and a significant improvement of HDL cholesterol (42.5 ± 15.6 vs 60.9 ± 12.3 mg/dl) and Total Cholesterol (135.6 ± 46.3 vs 159 ± 41.1 mg/dl) was observed after treatment. Cytokines Il-6 and TNFα blood levels did not change significantly after treatment Conclusions: Nutritional supplementation with krill oil showed a positive activity in the regulation of blood lipid profile, involving different metabolic and inflammatory pathways, probably mainly affecting hormone-sensitive lipase activity. Our data suggest that krill oil could be useful in multi-targeted combined pharmaco-nutritional approaches to treat cancer-cachexia. Additional phase III clinical studies are warranted.

scholarly journals Calcium intake and the associations with faecal fat and energy excretion, and lipid profile in a free-living population

2017 ◽  
Vol 6 ◽  
Author(s):  
Louise Kjølbæk ◽  
Janne K. Lorenzen ◽  
Lesli H. Larsen ◽  
Arne Astrup
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Calcium Intake ◽  
Blood Lipid ◽  
Normal Weight ◽  
Urine Collection ◽  
Free Living ◽  
Blood Lipid Profile ◽  
Habitual Diet

AbstractThe aim of the present study was to investigate the associations between the habitual Ca intake and faecal fat and energy excretion as well as blood lipid profile in free-living normal-weight and overweight individuals. The participants were enrolled for an 8-d period where data from a 7-d diet registration (days 1–7), a 5-d faeces collection (days 3–7), a 2-d urine collection (days 5–7), and anthropometric measurements and a fasting blood sample (day 8) were collected. Analyses showed that dietary Ca intake (g/10 MJ per d) was positively associated with excretion of faecal fat (P = 0·004) and energy (P = 0·031) when adjusted for BMI, age, sex and intake of Ca-containing supplements. However, after adjustment for intake of fibre, the effect of Ca intake disappeared. Nevertheless, total cholesterol (CHOL) and LDL-CHOL concentrations were associated negatively with Ca intake (β −0·62 (95 % CI −0·96, −0·28) mmol/l, P < 0·001, and β −0·49 (95 % CI −0·78, −0·20) mmol/l, P = 0·001, respectively, per 1000 mg/10 MJ per d increase in Ca intake). In conclusion, incorporation of Ca-rich food products in a habitual diet was associated with reduced total CHOL and LDL-CHOL concentrations, which may lower the risk of CVD in the long term.

scholarly journals Effect of Mixed-Tocotrienols in Hypercholesterolemic Subjects

2011 ◽  
Vol 1 (3) ◽  
pp. 106 ◽  
Author(s):  
Kah Hay Yuen ◽  
Jia Woei Wong ◽  
Ai Beoy Lim ◽  
Bee Hong Ng ◽  
Wai Peng Choy
Keyword(s):  
Placebo Group ◽  
Total Cholesterol ◽  
Serum Cholesterol ◽  
Ldl Cholesterol ◽  
Density Lipoprotein ◽  
Fold Increase ◽  
Double Blind ◽  
Cholesterol Lowering ◽  
Hypercholesterolemic Subjects ◽  
Lowering Activity

Background: Studies on the cholesterol lowering activity of tocotrienols have yielded mixed results, with some showing cholesterol lowering effect while some showing no activity.Aim: A randomized, double-blind, parallel group study was conducted to investigate the cholesterol lowering activity of tocotrienols. Methods: Thirty-two hypercholesterolemic subjects were randomly assigned to orally receive either 300 mg of mixed tocotrienols capsules daily or placebo capsules containing 300 mg of soya bean oil for a period of 6 months. The subjects were monitored before supplementation and monthly thereafter for their serum cholesterol as well as tocotrienol and tocopherol concentrations.Results: The serum total cholesterol and low density lipoprotein (LDL) cholesterol of the subjects in the tocotrienol supplementation group were decreased significantly by -8.9 ± 0.9% and -12.8 ± 2.6% respectively after 4 months of supplementation and the reduction persisted till the end of the 6-month study, with a reduction of -10.8 ± 1.0% and  -17.3 ± 1.8%, respectively from baseline. Moreover, there was a 22-fold increase in the total tocotrienol concentrations from baseline during supplementation compared to the placebo group, while the concentration of α-tocopherol recorded only a modest increase. On the other hand, the serum cholesterol, total tocotrienol and α-tocopherol concentrations of subjects in the placebo group remained essentially unchanged.Conclusions: Supplementation with mixed tocotrienols at dose of 300 mg per day resulted in the lowering of the serum total and LDL cholesterol levels after 5 months of supplementation.Keywords: tocotrienols, cholesterol-lowering, total cholesterol, LDL cholesterol, tocopherols

scholarly journals Antioxidant Potential and Peroxidative State of `Golden Smoothee' Apples Treated with 1-Methylcyclopropene

2006 ◽  
Vol 131 (1) ◽  
pp. 104-109 ◽  
Author(s):  
Rosa Vilaplana ◽  
M. Carme Valentines ◽  
Peter Toivonen ◽  
Christian Larrigaudière
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Antioxidant Activity ◽  
Storage Period ◽  
Antioxidant Potential ◽  
Total Antioxidant Activity ◽  
Pulp Tissue ◽  
Antioxidant Metabolism ◽  
Beneficial Effects ◽  
Total Antioxidant

In order to determine the effects that 1-methylcyclopropene (1-MCP) may have on antioxidant metabolism during cold storage, apples (Malus ×domestica Borkh. cv. Golden Smoothee) were treated with 625 nL·L−1 1-MCP immediately after harvest and stored in air for 3 months. Differences in total antioxidant activity and ascorbate levels were determined during storage and related to the activity of the antioxidant enzymes superoxide dismutase [SOD (EC 1.15.1.1)], catalase [CAT (EC 1.11.1.6)], and peroxidase [POX (EC 1.11.1.7)] in pulp. The level of oxidative stress in the pulp tissue was also established by determining changes in levels of hydrogen peroxide and in the content of peroxidative markers during storage. Controls and 1-MCP-treated fruit exhibited similar changes in total antioxidant activity and ascorbate levels. However, significant differences in oxidative stress levels were found between treated and untreated fruit. 1-MCP-treated fruit exhibited lower levels of hydrogen peroxide and significantly lower levels in peroxidative markers, especially at the end of the storage period. In line with this last result, 1-MCP-treated fruit also exhibited greater enzymatic antioxidant potential and, more specifically, a higher level of POX activity. Collectively, these results showed that 1-MCP did not detrimentally affect the antioxidant potential of the fruit and provided evidence to support the hypothesis that the beneficial effects of 1-MCP on ripening are not exclusively limited to its effect on ethylene, but also include direct effects on peroxidation and POX enzyme activity.

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