Stimuli-Responsive Polymeric Nanosystems for Controlled Drug Delivery

Biocompatible nanosystems based on polymeric materials are promising drug delivery nanocarrier candidates for antitumor therapy. However, the efficacy is unsatisfying due to nonspecific accumulation and drug release of the nanoparticles in normal tissue. Recently, the nanosystems that can be triggered by tumor-specific stimuli have drawn great interest for drug delivery applications due to their controllable drug release properties. In this review, various polymers and external stimuli that can be employed to develop stimuli-responsive polymeric nanosystems are discussed, and finally, we delineate the challenges in designing this kind of Nanomedicine to improve the therapeutic efficacy.

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Stimuli-responsive polypeptides for controlled drug delivery

Chemical Communications ◽

10.1039/d1cc04053g ◽

2021 ◽

Vol 57 (75) ◽

pp. 9489-9503

Author(s):

Peng Zhang ◽

Mingqian Li ◽

Chunsheng Xiao ◽

Xuesi Chen

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Controlled Drug Delivery ◽

Delivery Systems ◽

Stimuli Responsive ◽

Drug Delivery Applications

We summarize the advances of polypeptide-based drug delivery systems that respond to various physiological stimuli for controlled drug delivery applications.

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A Closer Look to Polyesters: Properties, Synthesis, Characterization, and Particle Drug Delivery Applications

Nanoscience &Nanotechnology-Asia ◽

10.2174/2210681210999201124155313 ◽

2020 ◽

Vol 10 ◽

Author(s):

Katherine Pazmiño V. ◽

Karla Sofía Vizuete ◽

Frank Alexis ◽

Brajesh Kumar ◽

Alexis Debut

Keyword(s):

Drug Delivery ◽

Glycolic Acid ◽

Controlled Drug Delivery ◽

Polymeric Materials ◽

Synthetic Polymers ◽

Future Application ◽

In Vivo Tests ◽

Drug Delivery Applications

Background: Natural and synthetic polymeric materials can be used in the fields of biomedicine and pharmaceuticals as a material for controlled drug delivery. Among the synthetic polymers, polyesters are synthesized from two natural monomers: lactic and glycolic acid, which are biocompatible and biodegradable. Objective: Here we review broad aspects of polyesters including its properties, synthesis, characterization, and particle drug delivery applications. Conclusion: Finally, we have concluded that polyesters are certainly very versatile material that is continuously reinvented for future application in new areas of science and medicine. However, several aspects must be considered when synthesizing polyesters, which have a direct influence on biodegradability and biocompatibility. These properties may limit the performance of in vitro and in vivo tests.

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Dual stimuli-responsive polyphosphazene-based molecular gates for controlled drug delivery in lung cancer cells

RSC Advances ◽

10.1039/d0ra03210g ◽

2020 ◽

Vol 10 (46) ◽

pp. 27305-27314

Author(s):

Yolanda Salinas ◽

Michael Kneidinger ◽

Cristina Fornaguera ◽

Salvador Borrós ◽

Oliver Brüggemann ◽

...

Keyword(s):

Lung Cancer ◽

Drug Delivery ◽

Drug Release ◽

Mesoporous Silica Nanoparticles ◽

Controlled Drug Delivery ◽

Controlled Drug Release ◽

Stimuli Responsive ◽

Ph Responsive ◽

Bottle Brush ◽

Molecular Gates

Bottle-brush polyphosphazenes as dual, thermosensitive and pH responsive gatekeepers for mesoporous silica nanoparticles, and their use in controlled drug release.

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Oxidation- and thermo-responsive poly(N-isopropylacrylamide-co-2-hydroxyethyl acrylate) hydrogels cross-linked via diselenides for controlled drug delivery

RSC Advances ◽

10.1039/c4ra13500h ◽

2015 ◽

Vol 5 (6) ◽

pp. 4162-4170 ◽

Cited By ~ 35

Author(s):

Xinfeng Cheng ◽

Yong Jin ◽

Tongbing Sun ◽

Rui Qi ◽

Baozhu Fan ◽

...

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Sustained Release ◽

Controlled Drug Delivery ◽

Burst Release ◽

Stimuli Responsive

A novel diselenide crosslinked poly(NIPAM-co-HEA) hydrogel was successfully synthesized, which exhibits a dual-stimuli-responsive drug release behaviors,i.e., thermo-induced slow sustained release and oxidation-induced quick burst release.

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Responsive block copolymers for drug delivery applications. Part 1: Endogenous stimuli-responsive drug-release systems

Stimuli Responsive Polymeric Nanocarriers for Drug Delivery Applications, Volume 1 ◽

10.1016/b978-0-08-101997-9.00009-6 ◽

2018 ◽

pp. 171-220

Author(s):

Renjith P. Johnson ◽

Namitha K. Preman

Keyword(s):

Drug Delivery ◽

Block Copolymers ◽

Drug Release ◽

Stimuli Responsive ◽

Drug Delivery Applications

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Stimuli-Responsive Nanomaterials for Application in Antitumor Therapy and Drug Delivery

Pharmaceutics ◽

10.3390/pharmaceutics12070630 ◽

2020 ◽

Vol 12 (7) ◽

pp. 630 ◽

Cited By ~ 1

Author(s):

Son H. Pham ◽

Yonghyun Choi ◽

Jonghoon Choi

Keyword(s):

Drug Delivery ◽

Carbon Quantum Dots ◽

Point Of View ◽

Future Research ◽

Stimuli Responsive ◽

Antitumor Therapy ◽

New Era ◽

Bio Imaging ◽

Gold Nanomaterials ◽

External Stimuli

The new era of nanotechnology has produced advanced nanomaterials applicable to various fields of medicine, including diagnostic bio-imaging, chemotherapy, targeted drug delivery, and biosensors. Various materials are formed into nanoparticles, such as gold nanomaterials, carbon quantum dots, and liposomes. The nanomaterials have been functionalized and widely used because they are biocompatible and easy to design and prepare. This review mainly focuses on nanomaterials responsive to the external stimuli used in drug-delivery systems. To overcome the drawbacks of conventional therapeutics to a tumor, the dual- and multi-responsive behaviors of nanoparticles have been harnessed to improve efficiency from a drug delivery point of view. Issues and future research related to these nanomaterial-based stimuli sensitivities and the scope of stimuli-responsive systems for nanomedicine applications are discussed.

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Smart Supra- and Macro-Molecular Tools for Biomedical Applications

Materials ◽

10.3390/ma13153343 ◽

2020 ◽

Vol 13 (15) ◽

pp. 3343

Author(s):

Mariana Pinteala ◽

Marc J. M. Abadie ◽

Radu D. Rusu

Keyword(s):

Drug Delivery ◽

Biomedical Applications ◽

Viral Vectors ◽

Polymeric Materials ◽

External Source ◽

Stimuli Responsive ◽

Molecular Tools ◽

Field Function ◽

Materials Used ◽

External Stimuli

Stimuli-responsive, “smart” polymeric materials used in the biomedical field function in a bio-mimicking manner by providing a non-linear response to triggers coming from a physiological microenvironment or other external source. They are built based on various chemical, physical, and biological tools that enable pH and/or temperature-stimulated changes in structural or physicochemical attributes, like shape, volume, solubility, supramolecular arrangement, and others. This review touches on some particular developments on the topic of stimuli-sensitive molecular tools for biomedical applications. Design and mechanistic details are provided concerning the smart synthetic instruments that are employed to prepare supra- and macro-molecular architectures with specific responses to external stimuli. Five major themes are approached: (i) temperature- and pH-responsive systems for controlled drug delivery; (ii) glycodynameric hydrogels for drug delivery; (iii) polymeric non-viral vectors for gene delivery; (iv) metallic nanoconjugates for biomedical applications; and, (v) smart organic tools for biomedical imaging.

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