scholarly journals Association between Soluble α-Klotho Protein and Metabolic Syndrome in the Adult Population

Biomolecules ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. 70
Author(s):  
Yung-Wen Cheng ◽  
Chun-Chi Hung ◽  
Wen-Hui Fang ◽  
Wei-Liang Chen
Keyword(s):  
Metabolic Syndrome ◽  
Adult Population ◽  
Fibroblast Growth Factor 23 ◽  
Cross Sectional Study ◽  
Signal Pathways ◽  
Linear Regression Models ◽  
Ion Regulation ◽  
Cross Sectional ◽  
Klotho Protein ◽  
Definition Of

Klotho protein is an anti-aging protein and plays multiple roles in ion-regulation, anti-oxidative stress, and energy metabolism through various pathways. Metabolic syndrome is a combination of multiple conditions that compose of multiple risk factors of cardiovascular disease and type 2 diabetes. Gene regulation and protein expression are discovered associated with metabolic syndrome. We aimed to figure out the correlation between Klotho protein and metabolic syndrome in generally healthy adults. A cross-sectional study of 9976 respondents ≥ 18 years old from the US National Health and Nutrition Examination Survey (2007–2012) by utilizing their soluble Klotho protein concentrations. Multivariate linear regression models were used to analyze the effect of soluble Klotho protein on the prevalence of metabolic syndrome. Soluble Klotho protein concentration was inversely correlated with the presence of metabolic syndromes (p = 0.013) and numbers of components that met the definition of metabolic syndrome (p < 0.05). The concentration of Soluble Klotho protein was negatively associated with abdominal obesity and high triglyceride (TG) in the adjusted model (p < 0.05). Soluble Klotho protein is correlated with changing metabolic syndrome components in adults, especially central obesity and high TG levels. Despite conventional function as co-factor with fibroblast growth factor-23 (FGF23) that regulates phosphate and vitamin D homeostasis, FGF23-independent soluble Klotho protein may act on multiple signal pathways in different organs and tissue in roles of anti-aging and protection from metabolic syndrome.

scholarly journals Starchy Vegetables and Metabolic Syndrome in Costa Rica

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1639
Author(s):  
Zhongyao Li ◽  
Dongqing Wang ◽  
Edward A. Ruiz-Narváez ◽  
Karen E. Peterson ◽  
Hannia Campos ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Regression Models ◽  
Fasting Blood Glucose ◽  
Population Based ◽  
Cross Sectional Study ◽  
Costa Rican ◽  
Least Square ◽  
Inverse Association ◽  
Linear Regression Models ◽  
Cross Sectional

Only a few studies primarily examined the associations between starchy vegetables (other than potatoes) and metabolic syndrome (MetS). We aimed to evaluate the association between starchy vegetables consumption and MetS in a population-based sample of Costa Rican adults. We hypothesized that a higher overall intake of starchy vegetables would not be associated with higher MetS prevalence. In this cross-sectional study, log-binomial regression models were used to estimate prevalence ratios (PRs) of MetS across quintiles of total, unhealthy, healthy starchy vegetables, and individual starchy vegetables (potatoes, purple sweet potatoes, etc.), among 1881 Costa Rican adults. Least square means and 95% confidence intervals (CIs) from linear regression models were estimated for each MetS component by categories of starchy vegetable variables. Higher intakes of starchy vegetables were associated with a higher prevalence of MetS in crude models, but no significant trends were observed after adjusting for confounders. A significant inverse association was observed between total starchy and healthy starchy vegetables consumption and fasting blood glucose. In this population, starchy vegetables might be part of a healthy dietary pattern.

scholarly journals Association of Dietary and Lifestyle Inflammation Score With Metabolic Syndrome in a Sample of Iranian Adults

2021 ◽  
Vol 8 ◽  
Author(s):  
Fatemeh Dehghani Firouzabadi ◽  
Ahmad Jayedi ◽  
Elaheh Asgari ◽  
Zahra Akbarzadeh ◽  
Nasim Janbozorgi ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Adult Population ◽  
Positive Association ◽  
Population Based ◽  
Cross Sectional Study ◽  
Significant Positive Association ◽  
Cross Sectional ◽  
General Adult Population ◽  
Education Status ◽  
Inflammation Score

Objective: We aimed to evaluate the association between the dietary and lifestyle inflammation score (DLIS) and metabolic syndrome (MetS) and its components in a sample of Iranian adults.Design: Population-based cross-sectional study.Setting: General adult population living in Tehran, Iran.Subjects: We included 827 adult men and women with an age range of 18–59 years who were referred to health centers in different districts of Tehran, Iran. Dietary intake was assessed by a semiquantitative food frequency questionnaire with 168 items. The DLIS was calculated based on four components, including dietary inflammation score, physical activity, cigarette smoking, and general obesity. Higher DLIS represents a more proinflammatory diet and lifestyle. The odds ratio (OR) and 95% confidence interval (CI) of the MetS across quartiles of the DLIS was calculated by using logistic regression analysis, controlling for age, sex, energy intake, marital status, education status, and occupation.Results: A total of 827 participants (31% men) were included, with a mean age of 44.7 ± 10.7 years. The prevalence of the MetS was 30.5%. The DLIS ranged between −2.35 and +3.19 (mean ± SD: 0.54 ± 1.09). There was a significant positive association between the DLIS and odds of MetS (OR fourthvs.thefirstquartile: 1.57, 95% CI: 1.01–2.45) in the fully adjusted model.Conclusion: Our results showed a significant positive association between the DLIS and odds of MetS. The results of the present crosssectional study suggested that having a more proinflammatory lifestyle can be associated with MetS. More prospective studies are needed to confirm the findings.

scholarly journals Perceived Stress During the COVID-19-Related Confinement in Cyprus

2021 ◽  
Vol 9 ◽  
Author(s):  
Maria Kyprianidou ◽  
Costas A. Christophi ◽  
Konstantinos Giannakou
Keyword(s):  
Perceived Stress ◽  
Adult Population ◽  
Cross Sectional Study ◽  
Current Smoker ◽  
Vulnerable Groups ◽  
Linear Regression Models ◽  
Cross Sectional ◽  
Stress Score ◽  
The Government ◽  
Republic Of Cyprus

The COVID-19 pandemic is a serious global health emergency that could potentially have a significant impact on both somatic as well as psychological level. The aim of this study was to assess the prevalence of perceived stress in the general adult population of Cyprus during the first COVID-19 lockdown period. This was an internet-based cross-sectional study conducted between 6 April and 20 June 2020, one to two and a half months after the introduction of and the first mandatory lockdown on its entire territory imposed by the government of the Republic of Cyprus on 24 March 2020. Data collection was done using a self-administered questionnaire that included information about socioeconomic and demographic characteristics, physical activity, smoking habits, and stress level. A total of 1,485 adults participated in the study. The median perceived stress score was 10 (q1 = 6, q3 = 15). Linear regression models showed that having a medium monthly income (€501-1,500) and being a current smoker was positively associated with the perceived stress score, while being male and physically active was negatively associated with the perceived stress score (all p &lt;0.05). People with medium average salary and current smokers were at a higher risk for perceived stress. Psychological interventions and/or psychological services provided in certain vulnerable groups would be beneficial in future lockdowns due to either COVID-19 or a new pandemic.

PREVALENCE OF METABOLIC SYNDROME IN COPD CASES IN CENTRAL INDIA AND ITS CORRELATION WITH BMI

2021 ◽  
pp. 73-75
Author(s):  
Aditya Tejwani ◽  
Lokendra Dave ◽  
Anubhav Agrawal ◽  
Simmi Dube
Keyword(s):  
Metabolic Syndrome ◽  
Adult Population ◽  
Central India ◽  
Cross Sectional Study ◽  
Anthropometric Parameters ◽  
Cross Sectional ◽  
Middle Income ◽  
Institutional Ethics ◽  
Copd Patients ◽  
Gandhi Medical College

BACKGROUND: COPD is the third leading cause of death worldwide with more than 90% of COPD deaths occuring in low and middle income countries. While metabolic syndrome is a cluster of the most dangerous cardiovascular risk factors , dened to be associated with prothrombotic and proinammatory states. About 20%- 25% adult population of the world have Metabolic syndrome and are three times more likely to have coronary artery disease or stroke . Increasing evidence shows association between Metabolic Syndrome in COPD. However, the frequency of Metabolic Syndrome and its individual components are not still been clearly shown especially in Indian population in central India . METHODS: This was a cross sectional study conducted at Department of Respiratory Medicine, Gandhi Medical College & Hamidia hospital, Bhopal. 100 spirometrically conrmed COPD cases were enrolled after permission from institutional ethics committee . Detailed history , clinical examination , laboratory parameters and anthropometric parameters were taken. RESULTS: Mean age of patients with COPD was 60.34±10.39 years .Mean weight, height and BMI of patients was 55.86±9.43 2. 2 kg, 160.47±7.58 m and 21.65±3.01kg/m .Majority - 57% patients had normal BMI (18.5 to 22.9 kg/m ). About 25% and 11% patients were overweight and underweight respectively. Metabolic syndrome was found to be present in 32% of the patients with COPD. BMI of patients with metabolic syndrome was signicantly higher as compared to COPD patients without metabolic syndrome (p<0.01). CONCLUSION: The prevalence of metabolic syndrome in COPD was 32% and BMI in COPD patients with metabolic syndrome was signicantly higher than those without metabolic syndrome .

Breakfast consumption is inversely associated with metabolic syndrome in a sample of Iranian adults

2020 ◽  
Author(s):  
Elnaz Lorzadeh ◽  
Zohreh Sadat Sangsefidi ◽  
Masoud Mirzaei ◽  
Mahdieh Hosseinzadeh
Keyword(s):  
Metabolic Syndrome ◽  
Logistic Regression ◽  
Dietary Habits ◽  
Adult Population ◽  
Middle Eastern ◽  
Population Based ◽  
Cross Sectional Study ◽  
Health Study ◽  
Cross Sectional ◽  
Breakfast Consumption

Abstract Background: Central obesity, insulin resistance, dyslipidemia and hypertension are the core components of metabolic syndrome (MetS) which is coincident with unhealthy dietary habits in the Middle-Eastern countries. The aim of this study was to explore the association between dietary habits and metabolic syndrome of adult population living in Yazd Greater Area, Iran. Methods: This is a cross-sectional study which uses the data of a population-based cohort study on Iranian adults, known as Yazd Health Study (YaHS). The relationship between dietary habits and metabolic syndrome among adults (n= 2896) were analyzed using multiple logistic regression method. Results: Outcomes from logistic regression examining show that breakfast consumption has a significant inverse effect on the occurrence of metabolic syndrome after adjustment for age, education level, physical activity statue, history of chronic diseases and smoking (odds ratio (OR)= 0.38, 95% confidence interval (CI)= 0.14, 0.97). This effect remains significant even after adjustment for body mass index (BMI) and reveals that odds of having MetS is 69 % lower in breakfast consumers in contrast to non-consumers (OR=0.31, 95% CI= 0.11, 0.87). However, no significant relationship was observed between other dietary habits and MetS after adjustment for all potential confounders Conclusions: This study revealed that eating breakfast has an inverse relationship with metabolic syndrome. Finding out stronger evidence in relation between dietary habits and metabolic syndrome, more researches especially population-based cohort studies are needed to be conducted.

Abstract P068: Use of Plastic Food Wrappers High in Phthalates is Associated with Metabolic Syndrome Among Mexican Women

Circulation ◽  
2016 ◽  
Vol 133 (suppl_1) ◽  
Author(s):  
Jordan Rodriguez ◽  
Humberto Gomez ◽  
Eduardo Ortiz-Panozo ◽  
Elsa Yunes ◽  
Martin Lajous ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Cross Sectional Study ◽  
Microwave Oven ◽  
Mexican Women ◽  
Continuous Variables ◽  
Linear Regression Models ◽  
Metabolic Syndrome Component ◽  
Cross Sectional ◽  
Frequency Of Use ◽  
Independent Association

Introduction: Exposure to phthalates has been associated to metabolic abnormalities and cardiovascular risk. Commonly used plastic food wrappers may contain up to 40% of phthalates and could be an important source of exposure to these chemicals especially when heated. Hypothesis: Use of plastic food wrappers high in phthalates affects metabolic homeostasis. Methods: We assessed the cross-sectional relation of plastic food wrappers use and metabolic syndrome in 188 women from the Mexican Teachers’ Cohort. We evaluated self-reported frequency of use of food wrappers based on 3 questions and categorized participants in tertiles. Fasting blood samples and anthropometry were obtained in a clinical visit to determine metabolic syndrome status. Continuous variables were log-transformed. We used multivariable logistic and linear regression models to estimate odds ratios, mean % change and 95% confidence intervals (CI) for metabolic syndrome and its components using the lowest tertile of exposure as the reference. Results: Mean (±SD) frequency use of total plastic food wrapper was 1.52± 3 times/week and the prevalence of metabolic syndrome was 34%. Use of total plastic food wrappers was associated with metabolic syndrome even after adjusting for diet and other important confounders. The multivariable-adjusted odds ratio (OR) comparing extreme tertiles was 2.61 (95% CI: 1.03, 6.61; ptrend = 0.10). The association appeared to be driven by use of plastic food wrappers that were heated in a microwave oven. We did not observe an independent association with metabolic syndrome components. Conclusions: In this cross-sectional study use of plastic food wrappers, especially when heated in the microwave oven, was associated with the presence of metabolic syndrome. These associations did not appear to be driven by a particular metabolic syndrome component. Longitudinal studies are warranted to confirm this association, ideally with measures of urinary phthalate metabolites to confirm its mediation in the association.

scholarly journals Prevalence and determinants of metabolic syndrome in Spanish salaried workers: evidence from 15 614 men and women

2019 ◽  
Author(s):  
Nuria Matilla-Santander ◽  
Marina Espinola ◽  
Àurea Cartanyà-Hueso ◽  
Cristina Lidón-Moyano ◽  
Adrián González-Marrón ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
At Risk ◽  
Social Class ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Men And Women ◽  
Salaried Workers ◽  
Lower Social Class ◽  
Definition Of

Abstract Objective To describe the prevalence of Spanish workers with Metabolic Syndrome (MetS) and those at risk of developing MetS in 2015. Methods Cross-sectional study of workers (n = 15 614). We used a modified definition of the NCEP:ATPIII criteria for MetS (we used body mass index (BMI) above 28.8 kg/m2 instead of the waist circumference criterion). We calculated the prevalence of MetS (having at least three components) and of being at risk of MetS (having one or two components). We calculated adjusted odds ratios (aOR) of MetS according to socio-economic and workplace characteristics. Results The proportions of workers with and at risk of MetS were 7.1 and 31.9%, respectively. The most prevalent criterion was having a BMI > 28.8 kg/m2 (24.1%) in men and cHDL < 40 mg/dl in women (12.9%). There were significant associations between MetS and men (aOR compared to women = 3.73, CI 95%: 3.19; 4.36); age (higher among oldest, aOR = 5.75, CI 95%: 4.37;7.56); and social class (higher among lower social class, aOR = 2.03, CI 95%: 1.65;2.48). Conclusion Reducing any of the five MetS components, while taking into account the differences found by socio-economic and workplace characteristics, should be one priority for reducing MetS prevalence.

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