Afamin Levels and Their Correlation with Oxidative and Lipid Parameters in Non-diabetic, Obese Patients

Background: Afamin is a liver-produced bioactive protein and features α- and γ-tocopherol binding sites. Afamin levels are elevated in metabolic syndrome and obesity and correlate well with components of metabolic syndrome. Afamin concentrations, correlations between afamin and vitamin E, afamin and lipoprotein subfractions in non-diabetic, obese patients have not been fully examined. Methods: Fifty non-diabetic, morbidly obese patients and thirty-two healthy, normal-weight individuals were involved in our study. The afamin concentrations were measured by ELISA. Lipoprotein subfractions were determined with gel electrophoresis. Gas chromatography–mass spectrometry was used to measure α- and γ tocopherol levels. Results: Afamin concentrations were significantly higher in the obese patients compared to the healthy control (70.4 ± 12.8 vs. 47.6 ± 8.5 μg/mL, p < 0.001). Positive correlations were found between afamin and fasting glucose, HbA1c, hsCRP, triglyceride, and oxidized LDL level, as well as the amount and ratio of small HDL subfractions. Negative correlations were observed between afamin and mean LDL size, as well as the amount and ratio of large HDL subfractions. After multiple regression analysis, HbA1c levels and small HDL turned out to be independent predictors of afamin. Conclusions: Afamin may be involved in the development of obesity-related oxidative stress via the development of insulin resistance and not by affecting α- and γ-tocopherol levels.

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Oxidized LDL and other lipids as risk factors for cardiovascular disease in the patients with metabolic syndrome

Jugoslovenska medicinska biohemija ◽

10.2298/jmh0502099z ◽

2005 ◽

Vol 24 (2) ◽

pp. 99-106

Author(s):

Danijela Trifunovic ◽

Tanja Milicic ◽

Tatjana Potpara ◽

Emina Colak

Keyword(s):

Metabolic Syndrome ◽

Oxidized Ldl ◽

Ldl Oxidation ◽

Molar Ratio ◽

Diabetic Patients ◽

Obese Patients ◽

Apo B ◽

Significant Difference ◽

Healthy Control ◽

Lipids Profile

We estimated relationship between lipids, LDL oxidation, antioxidant activity and CRP in diabetic patients with metabolic syndrome (MS), with and without coronary heart disease (CHD), in non diabetic patients with and without CHD and in obese patients, with and without diabetes. We didn't-t find significant difference in lipids among diabetic MS patients. Patients from all subgroups have similar level of oxLDL, but significant higher comparing with healthy control. MS diabetic patients have oxLDL in positive correlation with TC, LDL-C, non HDLC and apo B 100, as vell as with molar ratio LDL-C/HDL-C and TG/HDL-C (p<0.001). Among non diabetics, CHD patients had higher Lp(a), but oxLDL was similar in both subgroups. In the nondiabetics we found correlation between oxLDL, TC, LDL-C and TG (p<0.01) and apo B 100 (p<0.001), but not with TG/HDL-C molar ratio. Obese patients from both groups had similar lipids profile but, oxLDL was higher, not significant, in non diabetics. We didn't-t find significant differences in antioxidative activity and CRP in both diabetics MS subgroups, and both obese subgroups. Nondiabetics with CHD have lower E-SOD and E-GPX activity and higher level of CRP than non CHD patients (p<0.05). MS diabetics and non diabetics didn't have significant correlation between levels of oxLDL and CRP, but CHD patients (with or without diabetes) had (p<0. 01).

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Up-Regulation of mRNA Levels of 11β-Hydroxysteroid Dehydrogenase Type 1 in the Liver of Morbidly Obese Patients with Metabolic Syndrome

10.1210/endo-meetings.2011.part3.p8.p2-583 ◽

2011 ◽

pp. P2-583-P2-583

Author(s):

Esther Torrecilla-Garcia ◽

Gumersindo Fernandez-Vazquez ◽

David Vicent-Lopez ◽

Franco Sanchez-Franco ◽

Lucio Cabrerizo-Garcia ◽

...

Keyword(s):

Metabolic Syndrome ◽

Hydroxysteroid Dehydrogenase ◽

Morbidly Obese ◽

Mrna Levels ◽

Obese Patients

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Evaluation of Metabolic Syndrome in morbidly Obese Patients Submitted to Laparoscopic Bariatric Surgery: Comparison of the Results between Roux-En-Y Gastric Bypass and Sleeve Gastrectomy

Obesity Surgery ◽

10.1007/s11695-017-2547-3 ◽

2017 ◽

Vol 27 (7) ◽

pp. 1719-1723 ◽

Cited By ~ 8

Author(s):

Rodrigo Koprovski Menguer ◽

Antônio Carlos Weston ◽

Helena Schmid

Keyword(s):

Bariatric Surgery ◽

Metabolic Syndrome ◽

Gastric Bypass ◽

Sleeve Gastrectomy ◽

Morbidly Obese ◽

Laparoscopic Bariatric Surgery ◽

Obese Patients ◽

Comparison Of The Results

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Roux-en-Y-Bariatric Surgery Reduces Markers of Metabolic Syndrome in Morbidly Obese Patients

Obesity Surgery ◽

10.1007/s11695-019-04190-y ◽

2019 ◽

Vol 30 (2) ◽

pp. 391-400 ◽

Cited By ~ 5

Author(s):

G. Rega-Kaun ◽

C. Kaun ◽

G. Jaegersberger ◽

M. Prager ◽

M. Hackl ◽

...

Keyword(s):

Bariatric Surgery ◽

Metabolic Syndrome ◽

Gastric Bypass ◽

Bypass Surgery ◽

Gastric Bypass Surgery ◽

Morbidly Obese ◽

Diabetic Patients ◽

Obese Patients ◽

C Peptide ◽

Hepatic Insulin Clearance

Abstract Background Obesity is closely linked to increased markers of metabolic syndrome and development of diabetes. Roux-en-Y bariatric surgery reduces hyperinsulinemia and improves insulin sensitivity and hence benefits morbidly obese patients. Aim To determine changes in markers of metabolic syndrome, pancreatic function, and hepatic insulin sensitivity in patients before and 1 year after undergoing Roux-en-Y gastric bypass surgery. Methods We enrolled 43 consecutive patients in a single center. Markers for metabolic syndrome included proinsulin, insulin, C-peptide, liver enzymes, and serum levels of selected microRNAs hsa-miR-122, hsa-miR-130, hsa-miR-132, and hsa-miR-375. Results After surgery, all patients showed a significant 37% drop of body mass index (p < 0.001). Furthermore, proinsulin (59% reduction, p < 0.001), insulin (76% reduction, p < 0.001), and C-peptide (56% reduction, p < 0.001) were all reduced 1 year after surgery. Using the hepatic insulin clearance score, we determined a significant increase in hepatic insulin clearance after surgery (76% increase, p < 0.001). Especially diabetic patients showed a marked 2.1-fold increase after surgery. Hepatic enzymes ALT (35% reduction, p = 0.002) and γGT (48% reduction, p < 0.001) were significantly reduced in all patients with similar improvement in diabetic and non-diabetic patients. miRNAs hsa-miR-122, hsa-miR-130, and hsa-miR-132 were all significantly reduced whereas hsa-miR-375 was increased after gastric bypass surgery (p < 0.001 for all miRNAs). Conclusion Both liver and pancreatic stress parameters were reduced significantly 1 year after Roux-en-Y gastric bypass surgery suggesting an overall amelioration of the metabolic syndrome in all patients regardless of previous health status.

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Appendicitis, Body Mass Index, and CT: Is CT More Valuable for Obese Patients than Thin Patients?

The American Surgeon ◽

10.1177/000313481107700425 ◽

2011 ◽

Vol 77 (4) ◽

pp. 471-475 ◽

Cited By ~ 4

Author(s):

Courtney A. Coursey ◽

Rendon C. Nelson ◽

Ricardo D. Moreno ◽

Mayur B. Patel ◽

Craig A. Beam ◽

...

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Normal Weight ◽

Morbidly Obese ◽

Negative Appendectomy ◽

Obese Patients ◽

Procedure Code ◽

Preoperative Ct ◽

The Difference ◽

Underweight Patients

The purpose of our study is to determine whether body mass index (BMI = weight in kg/height in meters2) was related to the rate of negative appendectomy in patients who underwent preoperative CT. A surgical database search performed using the procedure code for appendectomy identified 925 patients at least 18 years of age who underwent urgent appendectomy between January 1998 and September 2007. BMI was computed for the 703 of these 925 patients for whom height and weight information was available. Patients were stratified based on body mass index (BMI 15-18.49 = underweight; 18.5-24.9 = normal weight; 25–29.9 = overweight; 30-39.9 = obese; > 40 = morbidly obese). Negative appendectomy rates were computed. Negative appendectomy rates for patients who did and did not undergo preoperative CT were 27 per cent and 50 per cent for underweight patients, 10 per cent and 15 per cent for normal weight patients, 12 per cent and 17 per cent for overweight patients, 7 per cent and 30 per cent for obese patients, and 10 per cent and 100 per cent for morbidly obese patients. The difference in negative appendectomy rates for overweight patients, obese patients, and morbidly obese patients who underwent preoperative CT as compared with patients in the same BMI category who did not undergo preoperative CT was statistically significant ( P ≤ 0.001). The negative appendectomy rates for overweight patients, obese patients, and morbidly obese patients who underwent preoperative CT were significantly lower than for patients in these same BMI categories who did not undergo preoperative CT.

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Serum uric acid (SUA) in morbidly obese patients and its relationship with metabolic syndrome

The Aging Male ◽

10.1080/13685538.2020.1713742 ◽

2020 ◽

pp. 1-5 ◽

Cited By ~ 2

Author(s):

Mehmet İnanir

Keyword(s):

Metabolic Syndrome ◽

Uric Acid ◽

Serum Uric Acid ◽

Morbidly Obese ◽

Obese Patients

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A Longitudinal Study of the Antioxidant Barrier and Oxidative Stress in Morbidly Obese Patients after Bariatric Surgery. Does the Metabolic Syndrome Affect the Redox Homeostasis of Obese People?

Journal of Clinical Medicine ◽

10.3390/jcm9040976 ◽

2020 ◽

Vol 9 (4) ◽

pp. 976 ◽

Cited By ~ 5

Author(s):

Barbara Choromańska ◽

Piotr Myśliwiec ◽

Magdalena Łuba ◽

Piotr Wojskowicz ◽

Jacek Dadan ◽

...

Keyword(s):

Bariatric Surgery ◽

Metabolic Syndrome ◽

Superoxide Dismutase ◽

Uric Acid ◽

Oxidative Damage ◽

Redox Homeostasis ◽

Morbidly Obese ◽

Obese Patients ◽

Obese People ◽

Oxidative Damage To Proteins

This is the first study to evaluate both the antioxidant barrier, glutathione metabolism, and oxidative damage to proteins and lipids in morbidly obese patients undergoing bariatric treatment. The study included 65 patients with class 3 obesity divided into two subgroups: morbidly obese patients without metabolic syndrome (OB) and obese patients with metabolic syndrome (OB + MS). Blood samples were collected before surgery as well as one, three, six, and twelve months after the bariatric treatment. Superoxide dismutase and reduced glutathione (GSH) were significantly decreased, whereas glutathione reductase and uric acid were enhanced in morbidly obese patients before bariatric surgery as compared to lean control. Moreover, in the OB group, we observed the increase of superoxide dismutase (SOD) and the decrease of uric acid (UA) after the bariatric treatment; however, these changes were not observed in the OB + MS group. The oxidative damage to proteins (advanced glycation end products, AGE; advanced oxidation protein products, AOPP) and lipids (8-isoprostanes, 8-isop; 4-hydroxynoneal) was higher in OB as well as OB + MS patients. We noticed that AGE and AOPP levels diminished after the bariatric treatment, whereas redox status (ratio of GSH to oxidized glutathione) was still reduced in the OB + MS group. Summarizing, morbid obesity is associated with disturbances in the antioxidant barrier and enhanced oxidative damage to proteins and lipids. Although bariatric surgery improves redox homeostasis in obese patients, those with metabolic syndrome show a continuous decrease in the antioxidant status. In patients undergoing bariatric treatment, antioxidant supplementation may be considered.

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The clinical research office of the endourological society percutaneous nephrolithotomy global study: Outcomes in the morbidly obese patient – a case control analysis

Canadian Urological Association Journal ◽

10.5489/cuaj.2258 ◽

2014 ◽

Vol 8 (5-6) ◽

pp. 393 ◽

Cited By ~ 11

Author(s):

Andrew Fuller ◽

Hassan Razvi ◽

John D. Denstedt ◽

Linda Nott ◽

Ad Hendrikx ◽

...

Keyword(s):

Clinical Research ◽

Percutaneous Nephrolithotomy ◽

Normal Weight ◽

Obese Group ◽

Morbidly Obese ◽

Transfusion Rate ◽

Control Analysis ◽

Obese Patients ◽

Operative Duration ◽

Research Office

Background: Efficacy and safety of percutaneous nephrolithotomy (PCNL) have been demonstrated in obese individuals. Yet, there is a paucity of data on the outcomes of PCNL in morbidly obese patients (body mass index [BMI] >40).Methods: Perioperative and stone-related outcomes following PCNL in morbidly obese patients was assessed using a prospective database administered by the Clinical Research Office of the Endourological Society (CROES). A multidimensional match of 97 morbidly obese patients with those of normal weight was created using propensity score matching. Student’s t-test and Chi-square tests were used to assess for differences between the groups.Results: In total, 97 patients with a BMI >40 kg/m2 were matched by stone characteristics with 97 patients of normal weight. The morbidly obese population demonstrated higher rates of diabetes mellitus (43% vs. 6%, p < 0.001) and cardiovascular disease (56% vs. 18%, (p < 0.001). Access was achieved more frequently by radiologists in the morbidly obese group (19% vs. 6%, p = 0.016). Mean operative duration was longer in the morbidly obese group (112 ± 56 min vs. 86 ± 43.5 min, p < 0.001). Stone-free rates were lower in the morbidly obese group (66% vs. 77%, p = 0.071). There was no significant difference in length of hospital stay or transfusion rate. Morbidly obese patients were significantly more likely to experience a postoperative complication (22% vs. 6%, p = 0.004).Interpretation: PCNL in morbidly obese patients is associated with longer operative duration, higher rates of re-intervention and an increased risk of perioperative complications. With this knowledge, urologists should seek to develop strategies to optimize the perioperative management of such patients.

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