scholarly journals Pharmacological and Therapeutic Approaches in the Treatment of Epilepsy

Biomedicines ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 470
Author(s):  
Shampa Ghosh ◽  
Jitendra Kumar Sinha ◽  
Tarab Khan ◽  
Kuramkote Shivanna Devaraju ◽  
Prabhakar Singh ◽  
...  

Epilepsy affects around 50 million people across the globe and is the third most common chronic brain disorder. It is a non-communicable disease of the brain that affects people of all ages. It is accompanied by depression, anxiety, and substantially increased morbidity and mortality. A large number of third-generation anti-epileptic drugs are available, but they have multiple side-effects causing a decline in the quality of life. The inheritance and etiology of epilepsy are complex with multiple underlying genetic and epigenetic mechanisms. Different neurotransmitters play intricate functions to maintain the normal physiology of various neurons. If there is any dysregulation of neurotransmission due to aberrant transmitter levels or their receptor biology, it can result in seizures. In this review, we have discussed the roles played by various neurotransmitters and their receptors in the pathophysiology of epilepsy. Drug-resistant epilepsy (DRE) has remained one of the forefront areas of epilepsy research for a long time. Understanding the mechanisms underlying DRE is of utmost importance because of its high incidence rate among epilepsy patients and increased risks of psychosocial problems and premature death. Here we have enumerated various hypotheses of DRE. Further, we have discussed different non-conventional therapeutic strategies, including combination therapy and non-drug treatment. The recent studies supporting the modern approaches for the treatment of epilepsy have been deliberated with particular reference to the mTOR pathway, breakdown of the blood-brain barrier, and inflammatory pathways.

Author(s):  
Е.Г. Демьяновская ◽  
А.С. Васильев

При инфаркте мозга окклюзия церебральной артерии приводит к очаговой ишемии. Ишемический очаг представлен центральной зоной некроза, которая окружена областью так называемой ишемической полутени, нейроны которой потенциально жизнеспособны, однако кровоснабжение данной зоны длительно сохраняется на уровне ниже функциональных пороговых значений. Реабилитационные мероприятия играют важнейшую роль в улучшении качества жизни пациентов, перенесших церебральную мозговую катастрофу, а также их родственников и окружающих. Знание организационных аспектов, самых современных методик постинсультной реабилитации, а также понимание патогенеза нейронального повреждения и восстановления позволяют оптимизировать работу с такими пациентами. Накопленные на сегодняшний день данные свидетельствуют о том, что при правильно подобранном своевременном лечении восстановление утраченных функций после инсульта не только желательно, но и в значительной степени возможно. Условием успешной реабилитации является применение всех доступных методов немедикаментозного воздействия и лекарственной терапии. In cerebral infarction, occlusion of the cerebral artery leads to focal ischemia. The ischemic focus is represented by the central zone of necrosis, which is surrounded by an area of the so-called ischemic penumbra, the neurons of which are potentially viable, but the blood supply to this zone remains for a long time at a level below the functional threshold values. Rehabilitation plays a crucial role in improving quality of life in patients after acutevascular brain disorder, as well as their relatives and others. Understandingof legal basis, most modern methods of post-stroke rehabilitation, as well as an understanding of the pathogenesis of neuronal damage and recovery allow to optimize work with these patients. The data accumulated to date indicate that with properly selected timely treatment, the restoration of lost functions after a stroke is not only desirable, but also to a large extent possible. A condition for successful rehabilitation is the use of all available methods of non-drug exposure and drug therapy.


2020 ◽  
Vol 21 (1) ◽  
pp. 102-117
Author(s):  
Novia Zalmita ◽  
Muhajirah Muhajirah ◽  
Abdul Wahab Abdi

One that influences human resource indicators is education. The teacher is a profession as a job of academic specialization in a relatively long time in college. Understanding related to teacher competence is very important to have by a prospective teacher because it can affect the quality of performance as a professional teacher. The teacher's competence is known as pedagogic, professional, social and personality competencies. The issue in this study is how the competency of the teacher of the Department of Geography Education FKIP Unsyiah as a prospective teacher of geography? The purpose of this study was to determine the competence of teachers in the Department of Geography Education FKIP Unsyiah as prospective geography teachers. Quantitative description approach is used in this study to find answers to the issue. The population in this study were students of the Department of Geography Education FKIP Unsyiah class of 2015 and 2016 who had been declared to have passed the Micro Teaching and Magang Kependidikan 3 course totaling 50 people. Because the population is small and can be reached, the determination of the sample using total sampling techniques so that the sample in this study is the whole population. Data collection is done by distributing test questions to respondents. The data was analyzed using the descriptive statistics percentage formula. The results of the study indicate that the level of teacher competence of Geography Education Department students as prospective teachers is in the moderate category, namely as many as 22 respondents (44%). A total of 12 respondents (24%) were in the high category, 15 respondents (30%) were in the low category and 1 respondent (2%) were in the very low category.


1991 ◽  
Vol 223 ◽  
Author(s):  
Hans P. Zappe ◽  
Gudrun Kaufel

ABSTRACTThe effect of numerous plasma reative ion etch and physical milling processes on the electrical behavior of GaAs bulk substrates has been investigated by means of electric microwave absorption. It was seen that plasma treatments at quite low energies may significantly affect the electrical quality of the etched semiconductor. Predominantly physical plasma etchants (Ar) were seen to create significant damage at very low energies. Chemical processes (involving Cl or F), while somewhat less pernicious, also gave rise to electrical substrate damage, the effect greater for hydrogenic ambients. Whereas rapid thermal anneal treatments tend to worsen the electrical integrity, some substrates respond positively to long-time high temperature anneal steps.


2020 ◽  
Vol 3 (1) ◽  
pp. 97-103 ◽  
Author(s):  
Oladimeji Adebayo ◽  
Kehinde Kanmodi ◽  
Olusegun Olaopa ◽  
Omotayo Francis Fagbule ◽  
Iyanu Adufe ◽  
...  

AbstractBackgroundEarly career doctors (ECDs) are faced with many challenges due to their transition from undergraduate medical/dental studentship to being postgraduate doctors and being in an early phase of their career. The specific factors that affect ECDs in their careers and endeavors at the workplace range from poor remuneration, particularly in developing countries, to psychosocial problems (such as burnout [BO] syndrome). There is a dearth of information on BO among ECDs in Nigeria. This qualitative study aims to explore the opinions of ECDs in Nigeria on the causal/predisposing factors of BO, effects of BO, and strategies for mitigating BO among ECDs in Nigeria.MethodUsing purposive sampling method, two sessions of focus group discussions (FGDs) involving 14 ECDs (key informants) holding key leadership positions and who were delegates of other ECDs in Nigeria were conducted to explore their experiences on psychological issues among ECDs. Data collected were transcribed and analyzed thematically.ResultsBO is an issue of serious concern among ECDs in Nigeria. The causes of BO are diverse, some of which include low staff strength, prolonged work hours, wrong counseling, lack of job description and specification, and abuse of powers by trainers. In order to mitigate the issue of BO among ECDs, the respondents recommended that work policy review, medical workforce strengthening, stakeholder dialog on ECDs’ welfare, regular psychological review of ECDs, and provision of free yearly medicals need to be looked into. Conclusion: Our findings revealed that the participants considered BO issues among ECDs to be common, and it affected their performance and the overall quality of care in Nigeria health system. Based on our findings, there is an urgent need to mitigate the problem of emotional exhaustion among ECDs in Nigeria.


2020 ◽  
Vol 10 (2) ◽  
pp. 175
Author(s):  
Nomensen Freddy Siahaan

After a long time was not heard to the public area, lately death penalty toward the criminal cases that classified as extraordinary crime are appear. The author discovers electronic article about the execution of the death penalty which is the prosecutor prepares to execute death penalty toward the drugs dealer. The president of Republic of Indonesia stated that it is necessary to give a deterrent effect to the convicted  criminal and keep the morality of Indonesian teenagers. According to my opinion, the author argues that it will be better and wiser if we discuss about renovating all of the Penitentiary in Indonesia than debating whether death penalty could be done in Indonesia or not, because it will be displeasure many parties, death penalty infringed the human rights of the convicted criminals and cause psychological burden to them, families, the executor of the death penalty, and other parties. Because if we have to improve the quality of the Penitentiary, if the function of Penitentiary for fostering moralily has been optimal or properly enough to the convicted criminals, Indonesia will be no longer need the death penalty option as sanction to the convicted crimanals including for the extraordinary crime (especially for drugs trafficking in our country). Penitentiary is one of the public services which aims for fostering the people that initially have bad habits (commited to the crime), so that they will have the awareness to change their bad attitude into the be better ones, will not harm others, and positively contributed to the society. Already Penitentiary’s conditions should be designed in such a way and as good as possible, so that the inmates feels like at their own home (like having a second home after his own home), and feel humaner to spend their days in the Penitentiary. The author believes that if the Penitentiary has been improved and optimized its function well, then the real purpose of Penitentiary will definitely achieved. As stated in Law Number 12 Year 1995 regarding to Penitentiary Article 2 which states "sanction system are organized in order to fostering the convicted criminals in order to be the real man, aware of their fault, improve themselves, and not to repeat the criminal act so that they can be friendly received by the community, can actively participated in the development of our country, and can socialize themselves as good citizen."Article 3 on this regulation also intensifies the function of Penitentiary "the function of Penitentiary is to prepare convicted criminals to be able to properly integrated to the society, so they can be accepted again as members of the public who are free and responsible ones." 


2019 ◽  
Vol 21 (2) ◽  
pp. 564-580
Author(s):  
Eloiza Rocha Queiroz ◽  
José Falcão Sobrinho

A região Nordeste do Brasil vem sendo alvo de medidas do Estado a mais de um século, na tentativa de solucionar o problema da falta de água em época de secas. O Estado do Ceará, por sua vez, apresenta boa parte de seu território inserido no semiárido brasileiro, uma região caracterizada pelo clima seco, com poucas chuvas e elevada evapotranspiração. A problemática da água existe há bastante tempo, principalmente o acesso em quantidade e qualidade suficientes para atender a população. O presente trabalho tem como tema central a questão dos recursos hídricos, com enfoque no abastecimento humano do município de Cariré, localizado na região noroeste do Ceará. Nosso objetivo consiste em apresentar um panorama de como atualmente a população carireense tem acesso à água potável. A metodologia adotada constitui-se em duas etapas: na primeira, realizamos levantamento de material bibliográfico e a segunda diz respeito a parte prática realizada em saídas a campo. Segundo a ONU, a água é um bem comum e que deve ser de acesso a todos, é um direito humano. Nesta perspectiva, o gerenciamento adequado dos recursos hídricos é essencial para a manutenção da qualidade de vida. Palavras-chave: Recursos Hídricos; Abastecimento Humano; Cariré-Ce. ABSTRACTThe pnortheast region from Brazil has been subject of measures for more than a century in attempts to solve the problems lack of water in dry season. The state of Ceará has a good part of its territorial inserted in Brazilian semiarid, a region characterized by dry climate, short rains and high evapotranspiration. The water issue has existed for a long time, mainly in a sufficient access of quantity and quality to serve the population. Then, this article has as a central theme the water resources focusing on water supply of the Cariré localized at Northeast region from Ceará. Therefore the purpose of the paper is to present a study about how the Carire’s population has had access to potable water currently. The methodology adopted to this research consists of two stages: Firstly it was carried out a survey of bibliographical material and secondly it concerned the practical part carried out in the field trips. In accordance to United nations, water is a commom good and it has to be available to everyone, it is a human rights. In that sense, the proper management of water resources is essential to keep the quality of life.Key-words: Human supply; Water resources; Cariré – Ce. RÉSUMÉLa région du nord-est du Brésil est la cible de mesures prises par l’État depuis plus d’un siècle pour tenter de résoudre le problème de la pénurie d’eau en saison sèche. L’État du Ceará, en revanche, présente une bonne partie de son territoire inséré dans le semi-aride brésilien, région caractérisée par un climat sec, avec peu de pluies et une forte évapotranspiration. Le problème de l'eau existe depuis longtemps, principalement l'accès en quantité et qualité suffisantes pour satisfaire la population. Le travail actuel a pour thème central la question des ressources en eau, en mettant l'accent sur l'approvisionnement humain de la municipalité de Cariré, située dans la région nord-ouest du Ceará. Notre objectif est de présenter un aperçu de la façon dont la population carioca a actuellement accès à l’eau potable. La méthodologie adoptée comporte deux étapes: dans le premier, nous procédons à une enquête sur le matériel bibliographique et le second à la partie pratique réalisée lors des visites sur le terrain. Selon l'ONU, l'eau est un bien commun et doit être accessible à tous, c'est un droit humain. Dans cette perspective, la gestion adéquate des ressources en eau est essentielle au maintien de la qualité de la vie.Mots-clés: Ressources en eau; Approvisionnement humain; Cariré-Ce.


1993 ◽  
Vol 28 (11-12) ◽  
pp. 257-261
Author(s):  
M. Truett Garrett ◽  
Zaki Ahmad ◽  
Shelly Young

The recent requirements by U.S.E.P.A. for dechlorination and biomonitoring have increased the importance of automatic control of effluent chlorination in wastewater treatment plants. Difficulties with the Ziegler-Nichols controller tuning procedure were reported at the Kyoto Workshop, 1990. Problems are caused by the noise of incomplete mixing, a long time constant, and the disturbances of changing flow and chlorine demand. The Astrom-Hagglund relay feedback procedure provides acceptable control while data is logged to determine the controller constants. Experiences in using the procedure in existing facilities (not redesigning the mixing point) and the quality of control are presented.


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