scholarly journals Cognitive Efficiency and Fitness-to-Drive along the Lifespan: The Mediation Effect of Visuospatial Transformations

2021 ◽  
Vol 11 (8) ◽  
pp. 1028
Author(s):  
Luigi Tinella ◽  
Antonella Lopez ◽  
Alessandro Oronzo Caffò ◽  
Francesco Nardulli ◽  
Ignazio Grattagliano ◽  
...  
Keyword(s):  
Cognitive Functioning ◽  
Mental Rotation ◽  
Indirect Effect ◽  
Perspective Taking ◽  
Cognitive Status ◽  
Mediation Effect ◽  
Spatial Transformation ◽  
Perceptual Speed ◽  
Fitness To Drive ◽  
Cognitive Efficiency

The way people represent and transform visuospatial information affects everyday activities including driving behavior. Mental rotation and perspective taking have recently been found to predict cognitive prerequisites for fitness-to-drive (FtD). We argue that the relationship between general cognitive status and FtD is mediated by spatial transformation skills. Here, we investigated the performance in the Mental Rotation Test (MRT) and the Perspective-Taking Test (PT) of 175 male active drivers (aged from 18 to 91 years), by administering the Montreal Cognitive Assessment (MoCA) to measure their global cognitive functioning. All participants were submitted to a computerized driving assessment measuring resilience of attention (DT), reaction speed (RS), motor speed (MS), and perceptual speed (ATAVT). Significant results were found for the effect of global cognitive functioning on perceptual speed through the full mediation of both mental rotation and perspective-taking skills. The indirect effect of global cognitive functioning through mental rotation was only found to significantly predict resilience of attention whereas the indirect effect mediated by perspective taking only was found to significantly predict perceptual speed. Finally, the negative effect of age was found on each driving measure. Results presented here, which are limited to male drivers, suggest that general cognitive efficiency is linked to spatial mental transformation skills and, in turn, to driving-related cognitive tasks, contributing to fitness-to-drive in the lifespan.

scholarly journals GPS use negatively affects environmental learning through spatial transformation abilities

2019 ◽  
Author(s):  
Ian Tanner Ruginski ◽  
Sarah Creem-Regehr ◽  
Jeanine Stefanucci ◽  
Elizabeth Cashdan
Keyword(s):  
Theoretical Model ◽  
Mental Rotation ◽  
Perspective Taking ◽  
Spatial Transformation ◽  
Laboratory Studies ◽  
Spatial Transformations ◽  
Environmental Learning ◽  
Learning Tasks ◽  
Learning Capabilities

Research has established that GPS use negatively affects environmental learning and navigation in laboratory studies. Furthermore, the ability to mentally rotate objects and imagine locations from other perspectives (both known as spatial transformations) is positively related to environmental learning. Using previously validated spatial transformation and environmental learning tasks, the current study assessed a theoretical model where long-term GPS use is associated with worse mental rotation and perspective-taking spatial transformation abilities, which then predicts decreased ability to learn novel environments. We expected this prediction to hold even after controlling for self-reported navigation ability, which is also associated with better spatial transformation and environmental learning capabilities. We found that mental rotation and perspective-taking ability fully account for the effect of GPS use on learning of a virtual environment. This relationship remained after controlling for existing navigation ability. Specifically, GPS use is negatively associated with perspective-taking indirectly through mental rotation; we propose that GPS use affects the transformation ability common to mental rotation and perspective-taking.

scholarly journals HOW ARE SOCIAL ISOLATION AND LONELINESS RELATED TO COGNITIVE FUNCTIONING AMONG CHINESE OLDER ADULTS?

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S850-S851
Author(s):  
Rumei Yang ◽  
Haocen Wang ◽  
Eunjin L Tracy ◽  
Linda S Edelman ◽  
Katherine Sward ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Functioning ◽  
Social Isolation ◽  
Social Relations ◽  
Indirect Effect ◽  
Cultural Context ◽  
Mediation Effect ◽  
Equation Modeling ◽  
Chinese Older Adults ◽  
Increased Risk

Abstract Older adults have increased risk of social isolation, loneliness, and cognitive functioning decline, but the relationships among these factors are not conclusive. We used the 2011 and 2012 waves of the harmonized China Health and Retirement Longitudinal Study to: 1) measure the association between social isolation and cognitive functioning among Chinese older adults within their cultural context, and 2) investigate the potential mediation mechanism of loneliness on this association. Specifically, we applied a multiple indicator multiple cause approach to determine whether the construct of social isolation is well defined by four indicators (social activity engagement, weekly adult children contact, caregiving for grandchildren, and living alone). We used structural equation modeling to examine the direct and indirect effects among variables of interest. The results demonstrated that three indicators of social isolation were significantly associated with cognitive functioning (β =-0.26 to -0.28, all ps<0.05). The indirect effect of social isolation on cognitive functioning through loneliness was significant (β = -0.15, p<0.05), indicating loneliness was an important mediator. After controlling for the indirect effect of loneliness, the direct effect of social isolation on cognitive functioning remained significant (β =-0.83, p<0.05), suggesting a partial mediation effect. Our study confirms that social isolation contributes to cognitive functioning decline among Chinese older adults and that loneliness plays a mediating role. The findings suggest maintaining social relations and coping with feelings of loneliness are beneficial to older adults’ cognitive functioning.

Interindividual Differences in Cognitive Functioning Are Associated with Autobiographical Memory Retrieval Specificity in Older Adults

GeroPsych ◽  
2020 ◽  
Vol 33 (1) ◽  
pp. 15-29 ◽  
Author(s):  
Sarah Peters ◽  
Signy Sheldon
Keyword(s):  
Older Adults ◽  
Cognitive Functioning ◽  
Autobiographical Memory ◽  
Memory Retrieval ◽  
Cognitive Status ◽  
Specific Information ◽  
Generation Task ◽  
Interindividual Differences ◽  
Retrieval Cues ◽  
Contextual Support

Abstract. We examined whether interindividual differences in cognitive functioning among older adults are related to episodic memory engagement during autobiographical memory retrieval. Older adults ( n = 49, 24 males; mean age = 69.93; mean education = 15.45) with different levels of cognitive functioning, estimated using the Montreal Cognitive Assessment (MoCA), retrieved multiple memories (generation task) and the details of a single memory (elaboration task) to cues representing thematic or event-specific autobiographical knowledge. We found that the MoCA score positively predicted the proportion of specific memories for generation and episodic details for elaboration, but only to cues that represented event-specific information. The results demonstrate that individuals with healthy, but not unhealthy, cognitive status can leverage contextual support from retrieval cues to improve autobiographical specificity.

scholarly journals Variable selection for causal mediation analysis using LASSO-based methods

2021 ◽  
pp. 096228022199750
Author(s):  
Zhaoxin Ye ◽  
Yeying Zhu ◽  
Donna L Coffman
Keyword(s):  
Propensity Score ◽  
Indirect Effect ◽  
Adaptive Lasso ◽  
Mediation Effect ◽  
Regularization Methods ◽  
Causal Mediation ◽  
Outcome Information ◽  
Causal Mediation Analysis ◽  
Selection For ◽  
Mimic Iii

Causal mediation effect estimates can be obtained from marginal structural models using inverse probability weighting with appropriate weights. In order to compute weights, treatment and mediator propensity score models need to be fitted first. If the covariates are high-dimensional, parsimonious propensity score models can be developed by regularization methods including LASSO and its variants. Furthermore, in a mediation setup, more efficient direct or indirect effect estimators can be obtained by using outcome-adaptive LASSO to select variables for propensity score models by incorporating the outcome information. A simulation study is conducted to assess how different regularization methods can affect the performance of estimated natural direct and indirect effect odds ratios. Our simulation results show that regularizing propensity score models by outcome-adaptive LASSO can improve the efficiency of the natural effect estimators and by optimizing balance in the covariates, bias can be reduced in most cases. The regularization methods are then applied to MIMIC-III database, an ICU database developed by MIT.

Effects of perceived social isolation, fear of social isolation and gratitude during COVID-19 pandemic on anxiety in Malaysia (Preprint)

2021 ◽  
Author(s):  
Cher Yi Tan ◽  
Jia Yi Ng ◽  
Mei-Hua Lin ◽  
Min Hooi Yong
Keyword(s):  
Older Adults ◽  
Young Adults ◽  
Social Isolation ◽  
Indirect Effect ◽  
Moderating Effect ◽  
Mediating Effect ◽  
Mediation Effect ◽  
Mediation Model ◽  
Middle Aged ◽  
Perceived Social Isolation

BACKGROUND The COVID-19 pandemic compelled many countries including Malaysia to impose movement restrictions to curb spreading the virus. Evidence shows that prolonged isolation has negative effects on both physical and mental health. OBJECTIVE Our aims were to examine (1) the mediating effect of perceived social isolation (SI) and fear of social isolation (FSI) on the relationship between gratitude and anxiety, and (2) to explore the moderating effect of age, education and socioeconomic status on the mediation model. METHODS We collected data from 427 participants currently living in Malaysia during the movement restriction order (Mage = 37.90, SD = 16.51, 313 females) from an online survey containing questions pertaining to isolation and gratitude. RESULTS Our mediation analysis showed that gratitude has a positive effect on overcoming anxiety as it also lowers feelings of SI and FSI (B = -.229, β = .128, bootstrap SE = .049, 95% bootstrap CI = [-.332, -.138]). The moderated mediation analyses revealed the indirect effect of gratitude on anxiety through SI was significant for young adults (B = -.148, β = .083, 95% bootstrap CI [-.274, -.042]) and middle-aged (B = -.099, β = -.055, 95% bootstrap CI [-.177, -.033]) but not for older adults (B = -.026, β = -.015, 95% bootstrap CI [-.129, .047]). Results were similar for FSI in that it was significant for middle aged and not significant for older adults (all CIs does not include zero). However the mediation effect was not significant for young adults (B = -.020, β = -.011, 95% bootstrap CI [-.066, .016]). When we examined the moderating effect of education and SES in the parallel mediation model, results showed that the mediation effect of SI and FSI for those with lower levels of education was significant for all SES levels (all CIs did not contain zero). As for those with medium levels of education, the conditional indirect effect of SI and FSI was significant only for low and medium levels of SES but not for high SES. CONCLUSIONS Our findings highlight the importance of having some coping mechanism and social connection during the pandemic to have higher wellbeing and quality of life, especially for middle-aged sample and people from low education and SES background. CLINICALTRIAL None

scholarly journals Causal mediation analysis with multiple causally non-ordered mediators

2015 ◽  
Vol 27 (1) ◽  
pp. 3-19 ◽  
Author(s):  
Masataka Taguri ◽  
John Featherstone ◽  
Jing Cheng
Keyword(s):  
Indirect Effect ◽  
Interactive Effect ◽  
Mediation Effect ◽  
Mediation Effects ◽  
Mediation Analyses ◽  
Intermediate Variable ◽  
Causal Mediation ◽  
Health Studies ◽  
Using Data ◽  
The Individual

In many health studies, researchers are interested in estimating the treatment effects on the outcome around and through an intermediate variable. Such causal mediation analyses aim to understand the mechanisms that explain the treatment effect. Although multiple mediators are often involved in real studies, most of the literature considered mediation analyses with one mediator at a time. In this article, we consider mediation analyses when there are causally non-ordered multiple mediators. Even if the mediators do not affect each other, the sum of two indirect effects through the two mediators considered separately may diverge from the joint natural indirect effect when there are additive interactions between the effects of the two mediators on the outcome. Therefore, we derive an equation for the joint natural indirect effect based on the individual mediation effects and their interactive effect, which helps us understand how the mediation effect works through the two mediators and relative contributions of the mediators and their interaction. We also discuss an extension for three mediators. The proposed method is illustrated using data from a randomized trial on the prevention of dental caries.

scholarly journals Benefits of Higher Cardiovascular and Motor Coordinative Fitness on Driving Behavior Are Mediated by Cognitive Functioning: A Path Analysis

2021 ◽  
Vol 13 ◽  
Author(s):  
Robert Stojan ◽  
Navin Kaushal ◽  
Otmar Leo Bock ◽  
Nicole Hudl ◽  
Claudia Voelcker-Rehage
Keyword(s):  
Older Adults ◽  
Physical Fitness ◽  
Cognitive Functioning ◽  
Indirect Effect ◽  
Dual Task ◽  
Processing Speed ◽  
Cognitive Functions ◽  
Driving Performance ◽  
Cardiovascular Fitness ◽  
Lane Keeping

Driving is an important skill for older adults to maintain an independent lifestyle, and to preserve the quality of life. However, the ability to drive safely in older adults can be compromised by age-related cognitive decline. Performing an additional task during driving (e.g., adjusting the radio) increases cognitive demands and thus might additionally impair driving performance. Cognitive functioning has been shown to be positively related to physical activity/fitness such as cardiovascular and motor coordinative fitness. As such, a higher fitness level might be associated with higher cognitive resources and may therefore benefit driving performance under dual-task conditions. For the first time, the present study investigated whether this association of physical fitness and cognitive functioning causes an indirect relationship between physical fitness and dual-task driving performance through cognitive functions. Data from 120 healthy older adults (age: 69.56 ± 3.62, 53 female) were analyzed. Participants completed tests on cardiovascular fitness (cardiorespiratory capacity), motor coordinative fitness (composite score: static balance, psychomotor speed, bimanual dexterity), and cognitive functions (updating, inhibition, shifting, cognitive processing speed). Further, they performed a virtual car driving scenario where they additionally engaged in cognitively demanding tasks that were modeled after typical real-life activities during driving (typing or reasoning). Structural equation modeling (path analysis) was used to investigate whether cardiovascular and motor coordinative fitness were indirectly associated with lane keeping (i.e., variability in lateral position) and speed control (i.e., average velocity) while dual-task driving via cognitive functions. Both cardiovascular and motor coordinative fitness demonstrated the hypothesized indirect effects on dual-task driving. Motor coordinative fitness showed a significant indirect effect on lane keeping, while cardiovascular fitness demonstrated a trend-level indirect effect on speed control. Moreover, both fitness domains were positively related to different cognitive functions (processing speed and/or updating), and cognitive functions (updating or inhibition), in turn, were related to dual-task driving. These findings indicate that cognitive benefits associated with higher fitness may facilitate driving performance. Given that driving with lower cognitive capacity can result in serious consequences, this study emphasizes the importance for older adults to engage in a physically active lifestyle as it might serve as a preventive measure for driving safety.

scholarly journals Smartphone Addiction, Narcissism and Aggression: A Mediation Analysis Method

2019 ◽  
Author(s):  
Anjelica Simsek ◽  
Cahit Nuri ◽  
Cemaliye Direktor ◽  
Ahmet Arnavut
Keyword(s):  
Direct Effect ◽  
Indirect Effect ◽  
Mediation Analysis ◽  
Total Effect ◽  
Mediation Effect ◽  
Smartphone Addiction ◽  
Analysis Method ◽  
Variable Effect ◽  
Independent Variable ◽  
Mediator Variable

<p>At this study, meditation effect of aggression was analyzed using Baron and Kenny’s mediation analysis method. Baron and Kenny (1986) indicates that to analyze the effect of mediator variable 3 criteria have to be actualized:</p> <p>1. Independent variable have a significant effect on a mediator variable (way a)</p> <p>2. Mediator variable have a significant effect on a dependent variable (way b)</p> <p>3. Independent variable have a significant effect on a dependent variable (way c)</p> <p>PROCESS program were used the meditational effect, it is an extra macro that is downloading to the Daniel and Hayes’s (2016) SPSS program. In this program mediation effect could be evaluated as; total effect, direct effect and indirect effect scores of mediation variable effect on dependent variable (Preacher & Hayes, 2008).</p>

scholarly journals 178Depression but not physical activity mediates the fatigue-mental quality of life relationship in multiple sclerosis

2021 ◽  
Vol 50 (Supplement_1) ◽  
Author(s):  
Alexander Fidao ◽  
Alysha De Livera ◽  
Tracey Weiland ◽  
George Jelinek ◽  
Sandra Neate ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Multiple Sclerosis ◽  
Indirect Effect ◽  
Mediation Effect ◽  
Study Cohort ◽  
Wide Range ◽  
Clinically Significant

Abstract Background Fatigue is among the most prevalent symptoms of multiple sclerosis (MS), and significantly detrimental to mental quality of life. We examined the role of depression and physical activity as mediators in the fatigue-QoL relationship in MS. Methods Using an international study cohort measuring a wide range of lifestyle and clinical factors, determinants of fatigue (Fatigue Severity Scale) and mental quality of life (MSQoL-54; QoL) were assessed in 2,104 participants using log-binomial and linear regression, respectively. Structural equation modelling (SEM) was used to assess the mediating role of depression and physical activity between fatigue and mental QoL. Results The median mental QoL score in the sample was 73.8/100. The mean fatigue score was 40.5/63, with 65.6% having clinically significant fatigue. In SEM analyses evaluating depression as a mediator of the fatigue-QoL relationship, mental QoL was 14.17-points lower in those with clinically significant fatigue, of which the indirect effect via depression accounted for over 30.8% (p &lt; 0.001). This mediation effect was most pronounced for the Role Limitations from Emotional Issues (44.9%, p &lt; 0.001) and Emotional Wellbeing (41.6%, p &lt; 0.001) subdomains. Evaluating physical activity as a mediator of the fatigue-QoL relationship, mental QoL was 11.03-points lower in those with clinically significant fatigue, of which the indirect effect via physical activity accounted for only 1.0% (p = 0.001). Conclusions This study provides evidence that depression accounts for a majority of the fatigue-mental QoL relationship, while physical activity only plays a small role. While replication and longitudinal studies are required for validation, our findings may inform the development of treatments for reducing the impacts of fatigue and improving QoL in people with MS. Key messages Fatigue’s negative impact on emotional quality of life in multiple sclerosis is not a function of reduced ambulation but instead its impact on depression. Reducing depression may thus markedly improve quality of life in this population.

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