scholarly journals Efficacy of Neuro-Psychomotor Approach in Children Affected by Autism Spectrum Disorders: A Multicenter Study in Italian Pediatric Population

2021 ◽  
Vol 11 (9) ◽  
pp. 1210
Author(s):  
Mariarosaria Caliendo ◽  
Anna Di Sessa ◽  
Elisa D’Alterio ◽  
Alessandro Frolli ◽  
Domenico Verde ◽  
...  
Keyword(s):  
Social Relations ◽  
Pediatric Population ◽  
Economic Loss ◽  
Autism Spectrum ◽  
Long Term Effects ◽  
Observational Period ◽  
Campania Region ◽  
Medical Interventions ◽  
Spectrum Disorders

Background: Autism Spectrum Disorder (ASD) is characterized by impairments in social interaction and reciprocal communication. ASD affects about 1% of the general population and is associated with substantial disability and economic loss. A variety of approaches to improve the core deficits and lives of people with ASD have been developed, including behavioral, developmental, educational, and medical interventions. The main objective of this study was to evaluate the efficacy of a neuro-psychomotor approach in children affected by ASD. Methods: The sample consisted of 84 children (66 males, mean age 56.9 ± 15.8 months) affected by ASD assessed between September 2020 to March 2021. The trained therapist was asked to complete the ASD behavior inventory (ASDBI) test at baseline (T0) (September 2020) and after six months (T1) (March 2021) to assess the child’s evolution over the observational period. The study was carried out in southern Italy (Campania Region). Results: ASD children showed a significant improvement for AUTISM composite after 6 months of neuro-psychomotor treatment (T1) compared to baseline (65.4 ± 12.2 vs. 75.8 ± 11.5, p < 0.0001). In particular, significant changes were observed for such domains as the problems of excitability (ECCIT), aggression (AGG), behaviors in social relations (RELSOC), expressive (all p < 0.001), sense/perceptual contact modes (SENS) (p = 0.0007), ritualisms/resistance to changes (RIT) (p = 0.0002), pragmatic/social problems (PPSOC) (p = 0.0009), specific fears (FEARS) (p = 0.01), and learning and memory (AMLR) (p = 0.0007). No differences for the domains Semantic/pragmatic problems (PPSEM) and language (LESP) were found. Conclusions: Our preliminary results suggest the usefulness of the neuro-psychomotor treatment in children with ASD. Although promising, these findings need to be tested further to better understand the long-term effects of this specific type of approach.

A follow-up study on the long-term effects of rehabilitation in children with autism spectrum disorders

2019 ◽  
Vol 44 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Lili Zhang ◽  
Yimei Liu ◽  
Ziyun Zhou ◽  
Yan Wei ◽  
Jie Wang ◽  
...  
Keyword(s):  
Autism Spectrum Disorders ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Long Term Effects ◽  
Follow Up Study ◽  
Spectrum Disorders

Long-Term Effects of Risperidone in Children With Autism Spectrum Disorders: A Placebo Discontinuation Study

2005 ◽  
Vol 44 (11) ◽  
pp. 1137-1144 ◽  
Author(s):  
Pieter W. Troost ◽  
Bertine E. Lahuis ◽  
Mark-Peter Steenhuis ◽  
Cees E.J. Ketelaars ◽  
Jan K. Buitelaar ◽  
...  
Keyword(s):  
Autism Spectrum Disorders ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Long Term Effects ◽  
Spectrum Disorders

scholarly journals Heterogeneous neurodevelopmental disorders in children with Kawasaki disease: what is new today?

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Chien-Heng Lin ◽  
Wei-De Lin ◽  
I-Ching Chou ◽  
Inn-Chi Lee ◽  
Syuan-Yu Hong
Keyword(s):  
Kawasaki Disease ◽  
Neurodevelopmental Disorders ◽  
Pediatric Population ◽  
Autism Spectrum ◽  
Study Group ◽  
Hyperactivity Disorder ◽  
The Past ◽  
Spectrum Disorders ◽  
Neurodevelopmental Problems

Abstract Background Kawasaki disease (KD) is a common vasculitis of childhood in East Asia. The complications of KD ascribed to long-term cardiovascular sequelae are considerably diverse. Although studies have investigated neurodevelopmental problems following KD in the past few decades, they have reported inconsistent conclusions. This study investigated potential epilepsy and associated neurodevelopmental disorders (NDDs) following KD in Taiwanese children. Methods We retrospectively analyzed the data of children aged < 18 years with clinically diagnosed KD from January 1, 2005, to December 31, 2015. These patients were followed up to estimate the prevalence of epilepsy and associated NDDs in comparison with the prevalence in general pediatric population in Taiwan and worldwide. Results A total of 612 patients with an average age of 1.6 years were included. The prevalence of associated NDDs was 16.8% (n = 103/612) in the study group, which consisted of epilepsy, intellectual disability (ID), autism spectrum disorders, Tourette syndrome (TS), attention deficit hyperactivity disorder, (ADHD), and others. Moreover, children with KD had a higher prevalence of epilepsy and TS in both Taiwan and worldwide (epilepsy: 2.61% in the KD group vs 0.33% in Taiwan and 0.05–0.8% in worldwide, p < 0.05; TS: 2.77% in the KD group vs 0.56% in Taiwan and 0.3–1% in worldwide, p < 0.05). The prevalence of ID, ADHD, and developmental language disorders was not significantly different between our study patients and those in Taiwan or worldwide. Conclusions Results revealed a higher prevalence rate of NDDs, especially epilepsy and TS, in Taiwanese children with KD than in the general pediatric population in Taiwan. However, these NDDs could be heterogeneous. Children diagnosed with KD were followed up because they had a higher risk of heterogeneous NDDs.

scholarly journals Heterogeneous Neurodevelopmental Disorders in Children with Kawasaki Disease: What is New Today?

2019 ◽  
Author(s):  
Chien-Heng Lin ◽  
Wei-De Lin ◽  
I-Ching Chou ◽  
Inn-Chi Lee ◽  
Syuan-Yu Hong
Keyword(s):  
Kawasaki Disease ◽  
Tourette Syndrome ◽  
Neurodevelopmental Disorders ◽  
Pediatric Population ◽  
Autism Spectrum ◽  
Hyperactivity Disorder ◽  
Spectrum Disorders ◽  
Neurodevelopmental Problems ◽  
Keywords Kawasaki Disease

Abstract Background: Kawasaki disease (KD) is a common vasculitis of childhood in East Asia. The complications of KD ascribed to long-term cardiovascular sequelae are considerably diverse. Although studies have investigated neurodevelopmental problems following KD in the past few decades, they have reported inconsistent conclusions. This study investigated potential epilepsy and associated neurodevelopmental disorders (NDDs) following KD in Taiwanese children. Methods: We retrospectively analyzed the data of children aged <18 years with clinically diagnosed KD from January 1, 2005, to December 31, 2015. These patients were followed up to estimate the prevalence of epilepsy and associated NDDs in comparison with the prevalence in general pediatric population in Taiwan and worldwide. Results: A total of 612 patients with an average age of 1.6 years were included. The prevalence of associated NDDs was 16.8% (n = 103/612) in the study group, which consisted of epilepsy, intellectual disability (ID), autism spectrum disorders , Tourette syndrome (TS), attention deficit hyperactivity disorder, (ADHD), and others. Moreover, children with KD had a higher prevalence of epilepsy and TS in both Taiwan and worldwide (epilepsy: 2.61% in the KD group vs 0.33% in Taiwan and 0.05%–0.8% in worldwide, p < 0.05; TS: 2.77% in the KD group vs 0.56% in Taiwan and 0.3%–1% in worldwide, p < 0.05). The prevalence of ID, ADHD, and developmental language disorders was not significantly different between our study patients and those in Taiwan or worldwide. Conclusions: Results revealed a higher prevalence rate of NDDs, especially epilepsy and TS, in Taiwanese children with KD than in the general pediatric population in Taiwan. However, these NDDs could be heterogeneous. Children diagnosed with KD were followed up because they had a higher risk of heterogeneous NDDs. Keywords: Kawasaki disease, Neurodevelopmental Disorders, Children, Epilepsy, Tourette syndrome

scholarly journals Heterogeneous Neurodevelopmental Disorders in Children with Kawasaki Disease: What is New Today?

2019 ◽  
Author(s):  
Chien-Heng Lin ◽  
Wei-De Lin ◽  
I-Ching Chou ◽  
Inn-Chi Lee ◽  
Syuan-Yu Hong
Keyword(s):  
Kawasaki Disease ◽  
Neurodevelopmental Disorders ◽  
Pediatric Population ◽  
Autism Spectrum ◽  
Study Group ◽  
Hyperactivity Disorder ◽  
The Past ◽  
Spectrum Disorders ◽  
Neurodevelopmental Problems

Abstract Background Kawasaki disease (KD) is a common vasculitis of childhood in East Asia. The complications of KD ascribed to long-term cardiovascular sequelae are considerably diverse. Although studies have investigated neurodevelopmental problems following KD in the past few decades, they have reported inconsistent conclusions. This study investigated potential epilepsy and associated neurodevelopmental disorders (NDDs) following KD in Taiwanese children. Methods We retrospectively analyzed the data of children aged <18 years with clinically diagnosed KD from January 1, 2005, to December 31, 2015. These patients were followed up to estimate the prevalence of epilepsy and associated NDDs in comparison with the prevalence in general pediatric population in Taiwan and worldwide. Results A total of 612 patients with an average age of 1.6 years were included. The prevalence of associated NDDs was 16.8% (n = 103/612) in the study group, which consisted of epilepsy, intellectual disability (ID), autism spectrum disorders, Tourette syndrome (TS), attention deficit hyperactivity disorder, (ADHD), and others. Moreover, children with KD had a higher prevalence of epilepsy and TS in both Taiwan and worldwide (epilepsy: 2.61% in the KD group vs 0.33% in Taiwan and 0.05%–0.8% in worldwide, p < 0.05; TS: 2.77% in the KD group vs 0.56% in Taiwan and 0.3%–1% in worldwide, p < 0.05). The prevalence of ID, ADHD, and developmental language disorders was not significantly different between our study patients and those in Taiwan or worldwide. Conclusions Results revealed a higher prevalence rate of NDDs, especially epilepsy and TS, in Taiwanese children with KD than in the general pediatric population in Taiwan. However, these NDDs could be heterogeneous. Children diagnosed with KD were followed up because they had a higher risk of heterogeneous NDDs.

scholarly journals Future Directions in Reducing Gastrointestinal Disorders in Children With ASD Using Fecal Microbiota Transplantation

2021 ◽  
Vol 11 ◽  
Author(s):  
Paulina Żebrowska ◽  
Izabela Łaczmańska ◽  
Łukasz Łaczmański
Keyword(s):  
Pediatric Patients ◽  
Fecal Microbiota Transplantation ◽  
Neurodevelopmental Disorder ◽  
Fecal Microbiota ◽  
Autism Spectrum ◽  
Long Term Effects ◽  
Gi Symptoms ◽  
Inflammatory Bowel ◽  
Age Range

Research on the use of fecal microbiota transplantation (FMT) in the treatment of disorders related to digestive system ailments in children with autism spectrum disorders (ASDs) is a new attempt in a therapeutic approach. There are very little scientific evidences available on this emerging alternative method. However, it appears to be interesting not only because of its primary outcome, relieving the gastrointestinal (GI) symptoms, but also secondary therapeutic effect of alleviating autistic behavioral symptoms. FMT seems to be also promising method in the treatment of another group of pediatric patients, children with inflammatory bowel disease (IBD). The aim of this study is to discuss the potential use of FMT and modified protocols (MTT, microbiota transfer therapy) in the treatment of GI disorders in ASD children supported by reports on another disease, IBD concerning pediatric patients. Due to the few reports of the use of FMT in the treatment of children, these two patients groups were selected, although suffering from distant health conditions: neurodevelopmental disorder and gastrointestinal tract diseases, because of the the fact that they seem related in aspects of the presence of GI symptoms, disturbed intestinal microbiota, unexplained etiology of the condition and age range of patients. Although the outcomes for all are promising, this type of therapy is still an under-researched topic, studies in the group of pediatric patients are sparse, also there is a high risk of transmission of infectious and noninfectious elements during the procedure and no long-term effects on global health are known. For those reasons all obtained results should be taken with a great caution. However, in the context of future therapeutic directions for GI observed in neurodevelopmental disorders and neurodegenerative diseases, the topic seems worthy of attention.

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