scholarly journals Concurrent Performance of Executive Function during Acute Bouts of Exercise in Adults: A Systematic Review

2021 ◽  
Vol 11 (10) ◽  
pp. 1364
Author(s):  
Kefeng Zheng ◽  
Liye Zou ◽  
Gao-Xia Wei ◽  
Tao Huang
Keyword(s):  
Executive Function ◽  
Data Extraction ◽  
Moderate Intensity ◽  
Moderate Intensity Exercise ◽  
Acute Bout ◽  
Literature Searches ◽  
Study Selection ◽  
Concurrent Performance ◽  
Core Executive ◽  
Quality Assessments

The purpose of the study was to systematically review the evidence on the effects of an acute bout of exercise on concurrent performance of core executive function (EF) during exercise in adults. Four electronic databases (i.e., PubMed, Web of Science, PsycINFO, and SportDiscus) were searched from inception dates to 30 December 2020. The literature searches were conducted using the combinations of two groups of relevant items related to exercise and executive function. Articles were limited to human studies in adults. The search process, study selection, data extraction, and study quality assessments were carried out independently by two researchers. A total of 4899 studies were identified. Twenty-two studies met our inclusion criteria. Of the 42 reported outcomes in the 22 studies, 13 (31%) of the 42 outcomes showed that core EF performance was enhanced during exercise and 14 (33%) found that core EF performance did not differ from control conditions. Fifteen (36%) found that core EF performance was impaired. Notably, improved EF performances tend to be observed during moderate-intensity exercise, whereas impaired EF performances were more likely to be observed at vigorous-high intensity. The review suggests mixed findings regarding the effects of an acute bout of exercise on concurrent performance of core EF. Exercise intensity seems to influence the effects. The underlying neural mechanisms remain to be elucidated.

Dose–Response and Time Course Effects of Acute Resistance Exercise on Executive Function

2016 ◽  
Vol 38 (4) ◽  
pp. 396-408 ◽  
Author(s):  
Christopher J. Brush ◽  
Ryan L. Olson ◽  
Peter J. Ehmann ◽  
Steven Osovsky ◽  
Brandon L. Alderman
Keyword(s):  
Executive Function ◽  
Resistance Exercise ◽  
Dose Response ◽  
Time Course ◽  
Moderate Intensity ◽  
Moderate Intensity Exercise ◽  
Acute Bout ◽  
Delayed Effects ◽  
Core Executive ◽  
Improved Performance

The purpose of this study was to examine possible dose–response and time course effects of an acute bout of resistance exercise on the core executive functions of inhibition, working memory, and cognitive flexibility. Twenty-eight participants (14 female; Mage = 20.5 ± 2.1 years) completed a control condition and resistance exercise bouts performed at 40%, 70%, and 100% of their individual 10-repetition maximum. An executive function test battery was administered at 15 min and 180 min postexercise to assess immediate and delayed effects of exercise on executive functioning. At 15 min postexercise, high-intensity exercise resulted in less interference and improved reaction time (RT) for the Stroop task, while at 180 min low- and moderate-intensity exercise resulted in improved performance on plus–minus and Simon tasks, respectively. These findings suggest a limited and task-specific influence of acute resistance exercise on executive function in healthy young adults.

The Effects of Exercise Serum From Prepubertal Girls and Women on In Vitro Myoblast and Osteoblast Proliferation and Differentiation

2021 ◽  
Vol 33 (2) ◽  
pp. 82-89
Author(s):  
Yasmeen Mezil ◽  
Joyce Obeid ◽  
Inna Ushcatz ◽  
Sandeep Raha ◽  
Brian W. Timmons
Keyword(s):  
Moderate Intensity ◽  
Osteoblast Proliferation ◽  
Moderate Intensity Exercise ◽  
Acute Bout ◽  
Myotube Formation ◽  
Proliferation And Differentiation ◽  
Proliferation In Vitro ◽  
Prepubertal Girls ◽  
Time Point

Purpose: In girls and women, the authors studied the effects of an acute bout of low-impact, moderate-intensity exercise serum on myoblast and osteoblast proliferation in vitro. Methods: A total of 12 pre/early pubertal girls (8–10 y old) and 12 women (20–30 y old) cycled at 60% VO2max for 1 hour followed by 1-hour recovery. Blood samples were collected at rest, mid-exercise, end of exercise, mid-recovery, and end of recovery. C2C12 myoblasts and MC3T3E1 osteoblasts were incubated with serum from each time point for 1 hour, then monitored for 24 hours (myoblasts) or 36 hours (osteoblasts) to examine proliferation. Cells were also monitored for 6 days (myoblasts) to examine myotube formation and 21 days (osteoblasts) to examine mineralization. Results: Exercise did not affect myoblast or osteoblast proliferation. Girls exhibited lower cell proliferation relative to women at end of exercise (osteoblasts, P = .041; myoblasts, P = .029) and mid-recovery (osteoblasts, P = .010). Mineralization was lower at end of recovery relative to rest (P = .014) in both girls and women. Myotube formation was not affected by exercise or group. Conclusion: The systemic environment following one acute bout of low-impact moderate-intensity exercise in girls and women does not elicit osteoblast or myoblast activity in vitro. Differences in myoblast and osteoblast proliferation between girls and women may be influenced by maturation.

Distinct effects of acute exercise and breaks in sitting on working memory and executive function in older adults: a three-arm, randomised cross-over trial to evaluate the effects of exercise with and without breaks in sitting on cognition

2019 ◽  
Vol 54 (13) ◽  
pp. 776-781 ◽  
Author(s):  
Michael J Wheeler ◽  
Daniel J Green ◽  
Kathryn A Ellis ◽  
Ester Cerin ◽  
Ilkka Heinonen ◽  
...  
Keyword(s):  
Older Adults ◽  
Working Memory ◽  
Executive Function ◽  
Light Intensity ◽  
Visual Learning ◽  
Moderate Intensity ◽  
Moderate Intensity Exercise ◽  
Intermittent Light ◽  
Time Points ◽  
Serum Bdnf

BackgroundSedentary behaviour is associated with impaired cognition, whereas exercise can acutely improve cognition.ObjectiveWe compared the effects of a morning bout of moderate-intensity exercise, with and without subsequent light-intensity walking breaks from sitting, on cognition in older adults.MethodsSedentary overweight/obese older adults with normal cognitive function (n=67, 67±7 years, 31.2±4.1 kg/m2) completed three conditions (6-day washout): SIT (sitting): uninterrupted sitting (8 hours, control); EX+SIT (exercise + sitting): sitting (1 hour), moderate-intensity walking (30 min), uninterrupted sitting (6.5 hours); and EX+BR (exercise + breaks): sitting (1 hour), moderate-intensity walking (30 min), sitting interrupted every 30 min with 3 min of light-intensity walking (6.5 hours). Cognitive testing (Cogstate) was completed at four time points assessing psychomotor function, attention, executive function, visual learning and working memory. Serum brain-derived neurotrophic growth factor (BDNF) was assessed at six time points. The 8-hour net area under the curve (AUC) was calculated for each outcome.ResultsWorking memory net AUC z-score·hour (95% CI) was improved in EX+BR with a z-score of +28 (−26 to +81), relative to SIT, −25 (−79 to +29, p=0.04 vs EX+BR). Executive function net AUC was improved in EX+SIT, −8 (− 71 to +55), relative to SIT, −80 (−142 to −17, p=0.03 vs EX+SIT). Serum BDNF net AUC ng/mL·hour (95% CI) was increased in both EX+SIT, +171 (−449 to +791, p=0.03 vs SIT), and EX+BR, +139 (−481 to +759, p=0.045 vs SIT), relative to SIT, −227 (−851 to +396).ConclusionA morning bout of moderate-intensity exercise improves serum BDNF and working memory or executive function in older adults, depending on whether or not subsequent sitting is also interrupted with intermittent light-intensity walking.Trial registration numberACTRN12614000737639.

Evolution of Equations for Estimating Renal Function and Their Application to the Dosing of New Antimicrobials

2019 ◽  
Vol 54 (5) ◽  
pp. 496-503
Author(s):  
Alison K. Lew ◽  
Ryan L. Crass ◽  
Gregory Eschenauer
Keyword(s):  
Dose Adjustment ◽  
English Language ◽  
Antimicrobial Agents ◽  
Data Extraction ◽  
New Era ◽  
Mdrd Equation ◽  
Language Studies ◽  
Fda Approval ◽  
Literature Searches ◽  
Study Selection

Objective: To address the background and rationale for the recent introduction of the Modification of Diet in Renal Disease (MDRD) equation for renal dose adjustment of antimicrobials and to provide recommendations for pharmacists dosing new antimicrobial agents. Data Sources: Comprehensive MEDLINE and EMBASE literature searches (from August 2018 to October 2019) were performed. Search terms included creatinine clearance, Cockcroft-Gault, MDRD, and glomerular filtration rate and a subsequent search included the preceding terms AND antimicrobials OR antibiotics. Study Selection and Data Extraction: Available English-language studies on the derivation and/or use of the Cockcroft-Gault (CG) and MDRD study equation were evaluated as well as those that specifically discussed their use for dosing antimicrobial agents. Data Synthesis: The US Food and Drug Administration (FDA) approval of delafloxacin and meropenem-vaborbactam in 2017 ushered in a new era in renal dosing of antibiotics, in that both agents are recommended to be dosed by the MDRD equation. Studies demonstrate that the CG and MDRD equations can result in discrepant dosing recommendations. Relevance to Patient Care and Clinical Practice: The renal estimation equation recommended in a new antibiotic label should dictate the dosing of that medication. It is noteworthy that these equations are not interchangeable. Conclusion: Recently approved antimicrobials utilizing the MDRD equation for renal dose adjustment will be interspersed with old and new antimicrobials utilizing the CG equation because of lack of singular guidance by the FDA. This requires pharmacists to be vigilant in evaluating drug labels to determine which equation is recommended and to understand the differences, strengths, and limitations of each equation.

Insect Repellent (N,N-Diethyl-m-Toluamide) Cardiovascular Toxicity in an Adult

1993 ◽  
Vol 27 (3) ◽  
pp. 289-293 ◽  
Author(s):  
James R. Clem ◽  
David F. Havemann ◽  
Marsha A. Raebel
Keyword(s):  
Medical Literature ◽  
Case Reports ◽  
Data Extraction ◽  
Clinical Manifestations ◽  
Personal Contact ◽  
Cardiovascular Toxicity ◽  
Insect Repellents ◽  
Literature Searches ◽  
Study Selection ◽  
Animal Data

OBJECTIVE: To describe a case of N,N-diethyl- m-toluamide (DEET)-induced cardiovascular toxicity in an adult and reviews other cases that have been reported in the published literature. Human and animal data available on DEET pharmacokinetics are reviewed and factors that predispose an individual to DEET toxicity are identified. DATA SOURCES: Case report information was obtained through personal contact with the patient during hospitalization and by telephone, and also from the patient's medical records. Computerized literature searches were conducted with the following systems to obtain medical literature on DEET toxicity: TOXLINE, International Pharmaceutical Abstracts, and MEDLINE. Index Medicus was searched manually. STUDY SELECTION: All reported cases of DEET toxicity in children and adults were reviewed. DATA EXTRACTION: Case reports were evaluated for the quantity of the DEET exposure (topical or oral), the clinical manifestations of the exposure, and the outcome of the exposure. DATA SYNTHESIS: This case is similar in some aspects to those already in the literature; however, very few cases of DEET toxicity in adults have been reported. Cardiovascular toxicity in humans related to DEET application has not been previously reported in the published medical literature. DEET exposure (topical or oral) results in a highly variable clinical course. Whether the outcome is death or recovery without sequelae is difficult to predict. CONCLUSIONS: Adults, as well as children, are at risk for toxicity from insect repellents. The use of highly concentrated DEET-containing insect repellents should be avoided to reduce the risk of toxicity in both children and adults. The consequences of DEET toxicity are variable and unpredictable.

Moderate Intensity Exercise Ameliorates Negative Impacts of Simulated Altitude on Executive Function.

2017 ◽  
Vol 49 (5S) ◽  
pp. 671-672
Author(s):  
Laura Q. Jimenez ◽  
Brian Arwari ◽  
Arlette C. Perry ◽  
Joseph F. Signorile ◽  
Soyeon Ahn ◽  
...  
Keyword(s):  
Executive Function ◽  
Moderate Intensity ◽  
Simulated Altitude ◽  
Moderate Intensity Exercise ◽  
Negative Impacts

Characterizing the affective responses to an acute bout of moderate-intensity exercise among outpatients with schizophrenia

2016 ◽  
Vol 237 ◽  
pp. 264-270 ◽  
Author(s):  
Markus J. Duncan ◽  
Guy Faulkner ◽  
Gary Remington ◽  
Kelly Arbour-Nicitopoulos
Keyword(s):  
Affective Responses ◽  
Moderate Intensity ◽  
Moderate Intensity Exercise ◽  
Acute Bout

Effects of an Acute Bout of Exercise on Cognitive Aspects of Stroop Performance

2006 ◽  
Vol 28 (3) ◽  
pp. 285-299 ◽  
Author(s):  
Benjamin A. Sibley ◽  
Jennifer L. Etnier ◽  
Guy C. Le Masurier
Keyword(s):  
Executive Functioning ◽  
Cognitive Performance ◽  
Negative Priming ◽  
Color Word ◽  
Positive Impact ◽  
Control Period ◽  
Moderate Intensity ◽  
Moderate Intensity Exercise ◽  
Acute Bout ◽  
The Impact

Recent reviews of the literature have demonstrated that exercise has a positive impact on cognitive performance. The purpose of this study was to assess the impact of an acute bout of aerobic exercise on executive functioning in college-age adults. For the experimental intervention, the effects of 20 min of self-paced moderate-intensity exercise on a treadmill were compared to the effects of a 20-min sedentary control period. Executive functioning was assessed using Stroop color-word interference and negative priming tests. Results indicated that the bout of exercise led to improved performance on the Stroop color-word interference task but no change in performance on the negative priming task. This finding suggests that exercise may facilitate cognitive performance by improving the maintenance of goal-oriented processing in the brain.

scholarly journals A new method for testing reproducibility in systematic reviews was developed, but needs more testing

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Dawid Pieper ◽  
Simone Heß ◽  
Clovis Mariano Faggion
Keyword(s):  
Random Sample ◽  
Systematic Reviews ◽  
Data Extraction ◽  
Risk Of Bias ◽  
New Method ◽  
Literature Searches ◽  
Study Selection ◽  
The Future ◽  
Number Of Citations

Abstract Background To develop and test an approach to test reproducibility of SRs. Methods Case study. We have developed an approach to test reproducibility retrospectively while focusing on the whole conduct of an SR instead of single steps of it. We replicated the literature searches and drew a 25% random sample followed by study selection, data extraction, and risk of bias (ROB) assessments performed by two reviewers independently. These results were compared narratively with the original review. Results We were not able to fully reproduce the original search resulting in minor differences in the number of citations retrieved. The biggest disagreements were found in study selection. The most difficult section to be reproduced was the RoB assessment due to the lack of reporting clear criteria to support the judgement of RoB ratings, although agreement was still found to be satisfactory. Conclusion Our approach as well as other approaches needs to undergo testing and comparison in the future as the area of testing for reproducibility of SRs is still in its infancy.

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