scholarly journals Adapting Imaging Protocols for PET-CT and PET-MRI for Immunotherapy Monitoring

Cancers ◽  
2021 ◽  
Vol 13 (23) ◽  
pp. 6019
Author(s):  
Bettina Beuthien-Baumann ◽  
Christos Sachpekidis ◽  
Regula Gnirs ◽  
Oliver Sedlaczek
Keyword(s):  
Hybrid Imaging ◽  
Resonance Imaging ◽  
Mri Scan ◽  
Imaging Protocols ◽  
Diagnostic Potential ◽  
Positron Emission ◽  
Pet Ct ◽  
Tissue Contrast ◽  
Magnetic Resonance Imaging Mri ◽  
Clinical Scanner

Hybrid imaging with positron emission tomography (PET) in combination with computer tomography (CT) is a well-established diagnostic tool in oncological staging and restaging. The combination of PET with magnetic resonance imaging (MRI) as a clinical scanner was introduced approximately 10 years ago. Although MRI provides superb soft tissue contrast and functional information without the radiation exposure of CT, PET-MRI is not as widely introduced in oncologic imaging as PET-CT. One reason for this hesitancy lies in the relatively long acquisition times for a PET-MRI scan, if the full diagnostic potential of MRI is exploited. In this review, we discuss the possible advantages of combined imaging protocols of PET-CT and PET-MRI, within the context of staging and restaging of patients under immunotherapy, in order to achieve “multi-hybrid imaging” in one single patient visit.

scholarly journals Possibilities of small-size glioblastoma visualization by PET-CT with 11C-choline (experimental study)

2021 ◽  
Vol 11 (4) ◽  
pp. 30-36
Author(s):  
N. A. Kostenikov ◽  
V. F. Dubrovskaya ◽  
E. G. Kovan'ko ◽  
O. Yu. Mirolyubova ◽  
Yu. R. Ilyushchenko ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Treatment Effectiveness ◽  
Minimum Size ◽  
Resonance Imaging ◽  
Malignant Brain Tumors ◽  
Glioma C6 ◽  
Positron Emission ◽  
Pet Ct ◽  
Magnetic Resonance Imaging Mri ◽  
Intracerebral Tumor

Introduction. The minimum size of malignant brain tumors detected by positron emission and computed tomography (PET-CT) exceeds 6-7 mm. One of the ways to increase the sensitivity of PET-CT in detecting of malignant brain tumors is to increase the administered activity of the radiopharmaceutical 11C-choline.Purpose & tasks. The aim of the study was to experimentally study the possibility of obtaining a small-size glioblastoma (GB) images (up to 4 mm) by PET-CT with the 11C-choline.Materials and methods. The study was performed on 24 rats with implanted intracerebral tumor «Glioma C6» (glioblastoma). Animals underwent magnetic resonance imaging (MRI) with contrast enhancement (CE) and PET-CT with 11C-choline for 21 days after tumor transplantation.Results. It was shown that using two methods: MRI with CE and PET-CT with 11C-choline, a glioblastoma up to 4 mm can be convincingly visualized.Conclusion. The data obtained can be crucial for early detection of glioblastoma, justification of treatment tactics, evaluation of the treatment effectiveness and prediction the outcome of the disease.

MULTICENTRIC RETROPERITONEAL LEIOMYOSARCOMA WITH SATELLITE LESIONS NOT FOUND ON PET-CT: A CASE REPORT AND LITERATURE REVIEW

2014 ◽  
Vol 17 (03) ◽  
pp. 1472004
Author(s):  
Chin-Chiang Hsieh ◽  
Rong-Sen Yang ◽  
Yih-Jyh Lin ◽  
Kuo-Yuan Huang
Keyword(s):  
Clinical Presentation ◽  
Left Kidney ◽  
Resonance Imaging ◽  
Iliac Arteries ◽  
Large Size ◽  
Bony Destruction ◽  
Positron Emission ◽  
Pet Ct ◽  
Magnetic Resonance Imaging Mri ◽  
Operative Findings

Most retroperitoneal leiomyosarcomas are clinically silent and are usually detected late, so a large size main tumor accompanied by satellite lesions might be presented. We report a case of a large multicentric retroperitoneal leiomyosarcoma with satellite lesions in the left iliac region, mimicking an abscess, was found on pre-operative pelvic computed tomography (CT). Positron emission tomography (PET-CT) was performed, but revealed only focal bony destruction of the left ilium and no discernable lesions in the abdomen. After resection of the iliacus satellite lesion, CT and magnetic resonance imaging (MRI) of the abdomen revealed another huge retroperitoneal leiomyosarcoma with invasion of the left kidney and ureter, descending colon and left iliac arteries. The patient was then treated with a multidisciplinary extensive excision operation. The clinical presentation, operative findings and imaging findings were reported and related articles were reviewed.

Comparison Between 18F-Dopa and 18F-Fet PET/CT in Patients with Suspicious Recurrent High Grade Glioma: A Literature Review and Our Experience

2019 ◽  
Vol 12 (3) ◽  
pp. 220-228 ◽  
Author(s):  
Laura Evangelista ◽  
Lea Cuppari ◽  
Luisa Bellu ◽  
Daniele Bertin ◽  
Mario Caccese ◽  
...  
Keyword(s):  
Case Series ◽  
High Grade Glioma ◽  
High Grade ◽  
True Negative ◽  
Fet Pet ◽  
Positron Emission ◽  
Pet Ct ◽  
Magnetic Resonance Imaging Mri ◽  
Definition Of ◽  
Sensitivity Specificity

Purpose: The aims of the present study were to: 1- critically assess the utility of L-3,4- dihydroxy-6-18Ffluoro-phenyl-alanine (18F-DOPA) and O-(2-18F-fluoroethyl)-L-tyrosine (18F-FET) Positron Emission Tomography (PET)/Computed Tomography (CT) in patients with high grade glioma (HGG) and 2- describe the results of 18F-DOPA and 18F-FET PET/CT in a case series of patients with recurrent HGG. Methods: We searched for studies using the following databases: PubMed, Web of Science and Scopus. The search terms were: glioma OR brain neoplasm and DOPA OR DOPA PET OR DOPA PET/CT and FET OR FET PET OR FET PET/CT. From a mono-institutional database, we retrospectively analyzed the 18F-DOPA and 18F-FET PET/CT of 29 patients (age: 56 ± 12 years) with suspicious for recurrent HGG. All patients underwent 18F-DOPA or 18F-FET PET/CT for a multidisciplinary decision. The final definition of recurrence was made by magnetic resonance imaging (MRI) and/or multidisciplinary decision, mainly based on the clinical data. Results: Fifty-one articles were found, of which 49 were discarded, therefore 2 studies were finally selected. In both the studies, 18F-DOPA and 18F-FET as exchangeable in clinical practice particularly for HGG patients. From our institutional experience, in 29 patients, we found that sensitivity, specificity and accuracy of 18F-DOPA PET/CT in HGG were 100% (95% confidence interval- 95%CI - 81-100%), 63% (95%CI: 39-82%) and 62% (95%CI: 39-81%), respectively. 18F-FET PET/CT was true positive in 4 and true negative in 4 patients. Sensitivity, specificity and accuracy for 18F-FET PET/CT in HGG were 100%. Conclusion: 18F-DOPA and 18F-FET PET/CT have a similar diagnostic accuracy in patients with recurrent HGG. However, 18F-DOPA PET/CT could be affected by inflammation conditions (false positive) that can alter the final results. Large comparative trials are warranted in order to better understand the utility of 18F-DOPA or 18F-FET PET/CT in patients with HGG.

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