scholarly journals Socio-Economic Inequalities in Lung Cancer Outcomes: An Overview of Systematic Reviews

Cancers ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 398
Author(s):  
Daniel Redondo-Sánchez ◽  
Dafina Petrova ◽  
Miguel Rodríguez-Barranco ◽  
Pablo Fernández-Navarro ◽  
José Juan Jiménez-Moleón ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Systematic Reviews ◽  
Cancer Survival ◽  
Economic Status ◽  
Lung Cancer Screening ◽  
Cancer Outcomes ◽  
Overview Of Systematic Reviews ◽  
The Relationship ◽  
Economic Inequalities

In the past decade, evidence has accumulated about socio-economic inequalities in very diverse lung cancer outcomes. To better understand the global effects of socio-economic factors in lung cancer, we conducted an overview of systematic reviews. Four databases were searched for systematic reviews reporting on the relationship between measures of socio-economic status (SES) (individual or area-based) and diverse lung cancer outcomes, including epidemiological indicators and diagnosis- and treatment-related variables. AMSTAR-2 was used to assess the quality of the selected systematic reviews. Eight systematic reviews based on 220 original studies and 8 different indicators were identified. Compared to people with a high SES, people with a lower SES appear to be more likely to develop and die from lung cancer. People with lower SES also have lower cancer survival, most likely due to the lower likelihood of receiving both traditional and next-generation treatments, higher rates of comorbidities, and the higher likelihood of being admitted as emergency. People with a lower SES are generally not diagnosed at later stages, but this may change after broader implementation of lung cancer screening, as early evidence suggests that there may be socio-economic inequalities in its use.

Non-Vitamin K Antagonist Oral Anticoagulants in Pulmonary Embolism: An Overview of Systematic Reviews

2020 ◽  
Vol 26 (23) ◽  
pp. 2686-2691 ◽  
Author(s):  
Ioannis Doundoulakis ◽  
Christina Antza ◽  
Haralambos Karvounis ◽  
George Giannakoulas
Keyword(s):  
Pulmonary Embolism ◽  
Vitamin K ◽  
Systematic Reviews ◽  
Methodological Quality ◽  
Randomized Clinical Trials ◽  
Oral Anticoagulants ◽  
Vitamin K Antagonist ◽  
Language Restriction ◽  
Overview Of Systematic Reviews

Background: Anticoagulation in patients with pulmonary embolism. Objective: To identify how non-vitamin K antagonist oral anticoagulants are associated with multiple outcomes in patients with pulmonary embolism. Methods: We performed a systematic search of systematic reviews via multiple electronic databases from inception to August 19th, 2019, without language restriction. Two authors independently extracted data and assessed the methodological quality of the included systematic reviews using the ROBIS tool. Results: We found twelve systematic reviews. Eleven SRs collected their data from randomized clinical trials and one from observational studies. All the included studies were published between 2014 and 2019 in English. The methodological quality of the 12 systematic reviews was low to high. None of the systematic reviews, which are included in our overview of systematic reviews, has evaluated the overall quality of evidence outcome using the Grading of Recommendations Assessments, Development and Evaluation (GRADE) approach. Conclusion: This is the first effort to summarize evidence about non-vitamin K antagonist oral anticoagulants in an overview of systematic reviews focusing exclusively on patients with pulmonary embolism. The evidence suggests that the non-vitamin K antagonist oral anticoagulants seem to be more effective and safer than a dualdrug approach with LMWH- VKA.

scholarly journals Health-related quality of life and anxiety in the PAN-CAN lung cancer screening cohort

BMJ Open ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. e024719 ◽  
Author(s):  
Niloofar Taghizadeh ◽  
Alain Tremblay ◽  
Sonya Cressman ◽  
Stuart Peacock ◽  
Annette M McWilliams ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Screening ◽  
Lung Cancer Screening ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Anxiety Levels ◽  
Clinically Significant ◽  
Baseline Screening

ObjectivesThe impact of lung cancer screening with low-dose chest CT (LDCT) on participants’ anxiety levels and health-related quality of life (HRQoL) is an important consideration in the implementation of such programmes. We aimed to describe changes in anxiety and HRQoL in a high-risk Canadian cohort undergoing LDCT lung cancer screening.Methods2537 subjects who had 2% or greater lung cancer risk over 6 years using a risk prediction tool were recruited from eight centres across Canada in the Pan-Canadian Early Detection of Lung Cancer Study (2008–2010). We compared HRQoL and anxiety levels before and after screening of 1237 participants with LDCT (excluding a subset of 1300 participants who also underwent autofluorescence bronchoscopy screening), as well as after investigations performed because of a positive screening examination. The 12-item short-form Physical and Mental Component Scales (SF-12), EQ-5D-3L scores and State Trait Anxiety Inventory-State anxiety were used at each assessment.ResultsOverall, there were no clinically significant differences in HRQoL outcomes between baseline and each of the survey time points following initial screening. No mean change in anxiety in the overall cohort was noted following baseline LDCT, but more participants had clinically significant increase in anxiety versus decrease after baseline screening (increase >minimal clinically important difference (MCID) (n=180) vs decrease >MCID (n=50), p<0.001). This finding persisted but to a lesser degree at the 12 month time point (increase >MCID (n=146) vs decrease >MCID (n=87), p<0.001).ConclusionsCT screening for lung cancer has no major overall impact on HRQoL among participants, although a minority of participants (number-needed-to-harm=7 after baseline screening and 18 at 1 year) demonstrated clinically significant increased anxiety levels.Trialregistration numberNCT00751660; Results.

scholarly journals An Overview of Systematic Reviews of Shenmai Injection for Healthcare

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Ling-yan Lu ◽  
Guo-qing Zheng ◽  
Yan Wang
Keyword(s):  
Systematic Reviews ◽  
Cerebrovascular Disorders ◽  
Viral Myocarditis ◽  
Cerebrovascular Diseases ◽  
Current Evidence ◽  
Large Sample Size ◽  
Shenmai Injection ◽  
Wide Range ◽  
Overview Of Systematic Reviews

Shenmai injection (SMI) is widely applied in clinical practice as an organ protector. This overview is to evaluate the current evidence from systematic reviews (SRs) of SMI for healthcare. The literature searches were carried out in 6 databases without language restrictions until December 2012. The quality of the primary studies from the respective SRs was evaluated by using Jadad score. The overview quality assessment questionnaire (OQAQ) was used to evaluate the methodological quality of all included SRs. Twenty eligible SRs were identified. They reported a wide range of conditions, including SMI for cardio/cerebrovascular diseases, viral myocarditis, tumor chemotherapy, and adverse drug reactions. Most of the primary studies were of good quality only in 1 SR of non-small-cell lung cancer. According to the OQAQ scores, the quality of included SRs was variable and six reviews were of high quality with a score of 5 points. Two SRs showed that SMI had low adverse drug reaction occurrence. In conclusion, there is mixed evidence to support efficacy of SMI for an adjunct therapy to tumor chemotherapy and premature evidence for the use of SMI for cardio/cerebrovascular disorders and viral myocarditis. SMI seems generally safe for clinical application. Further large sample-size and well-designed RCTs are needed.

Abstract 3707: Baseline quality of life and genetic determinants and the impact on five-year lung cancer survival

2015 ◽  
Author(s):  
Jeanne A. Pierzynski ◽  
Michelle A. Hildebrandt ◽  
Yuanqing Ye ◽  
Jack A. Roth ◽  
Xifeng Wu
Keyword(s):  
Quality Of Life ◽  
Lung Cancer ◽  
Cancer Survival ◽  
Genetic Determinants ◽  
The Impact ◽  
Lung Cancer Survival

scholarly journals Cost-effectiveness of lung cancer screening and treatment methods: a systematic review of systematic reviews

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Farbod Ebadifard Azar ◽  
Saber Azami-Aghdash ◽  
Fatemeh Pournaghi-Azar ◽  
Alireza Mazdaki ◽  
Aziz Rezapour ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Systematic Review ◽  
Cost Effectiveness ◽  
Cancer Screening ◽  
Systematic Reviews ◽  
Lung Cancer Screening ◽  
Treatment Methods

scholarly journals The Role of the Quality of Perceived Social Support in the Emotion Regulation Strategies of Adolescents in Jakarta [Peran Kualitas Perceived Social Support Terhadap Strategi Regulasi Emosi Remaja di Jakarta]

2021 ◽  
Vol 36 (1) ◽  
Author(s):  
Edita Kristofora ◽  
Agustina Hendriati
Keyword(s):  
Social Support ◽  
Emotion Regulation ◽  
Emotional Regulation ◽  
Perceived Social Support ◽  
Economic Status ◽  
Emotion Regulation Strategies ◽  
Expressive Suppression ◽  
Regulation Strategies ◽  
The Relationship

Adolescents are prone to emotional turmoil. Feedback received from the environment, as a form of support, is required in the process of emotion regulation. Thus, it can be assumed that perceived social support will be associated with emotion regulation. However, research linking both variables has so far included only the relationship between quality social support and a single one of the emotion regulation strategies in late adolescence. This study fills the gap, and aims to examine the relationship between quantity and quality of perceived social support with emotion regulation strategies across the entire adolescent age range in Jakarta. The measuring tool used was the Social Support Questionnaire 6 (quantity of perceived social support and perceived social support satisfaction) and the Emotional Regulation Questionnaire (cognitive reappraisal and expressive suppression strategies). The sample comprised  adolescents in Jakarta who had achieved formal educational levels, and who came from families with middle to lower level Status Ekonomi Social (SES; Socio-Economic Status; N = 427). The authors used Pearson Product Correlation and linear regression data analysis techniques. The results showed that thequantity of perceived social support was not significantly associated witheither dimension of emotion regulation. Perceived social support satisfaction was significantly associated with both dimensions of emotional regulation.   Teenagers are prone to emotional turmoil. Feedback received from the environment as a form of support is required in the process of emotional regulation. Thus, it can be assumed that perceived social support will be associated to emotion regulation. But researches linking both variables so far only included the relationship of quality social support and one of the emotion regulation strategies in late adolescence. This study fills the gap and aims to examine the relationship between quantity and quality of perceived social support with emotion regulation strategies across the entire adolescence age range in Jakarta. The measuring tool used was Social Support Questionnaire 6 (number of perceived social support and perceived social support satisfaction) and Emotion Regulation Questionnaire (cognitive reappraisal and expressive suppression strategies). The sample was adolescents who have formal education in Jakarta and come from families with middle to lower Status Ekonomi Social (SES; Socio-Economic Status; N = 427). The authors used Pearson Product Correlation and linear regression data analysis techniques. The results showed that the number of perceived social support was not significantly associated with both dimensions of emotion regulation. Perceived social support satisfaction was significantly associated with both dimensions of emotional regulation.

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