scholarly journals Probiotics in the Prevention of the Calcium Oxalate Urolithiasis

Cells ◽  
2022 ◽  
Vol 11 (2) ◽  
pp. 284
Author(s):  
Paulina Wigner ◽  
Michał Bijak ◽  
Joanna Saluk-Bijak

Nephrolithiasis ranks third among urological diseases in terms of prevalence, making up about 15% of cases. The continued increase in the incidence of nephrolithiasis is most probably due to changes in eating habits (high protein, sodium, and sugar diets) and lifestyle (reduced physical activity) in all developed countries. Some 80% of all kidney stones cases are oxalate urolithiasis, which is also characterized by the highest risk of recurrence. Frequent relapses of nephrolithiasis contribute to severe complications and high treatment costs. Unfortunately, there is no known effective way to prevent urolithiasis at present. In cases of diet-related urolithiasis, dietary changes may prevent recurrence. However, in some patients, the condition is unrelated to diet; in such cases, there is evidence to support the use of stone-related medications. Interestingly, a growing body of evidence indicates the potential of the microbiome to reduce the risk of developing renal colic. Previous studies have primarily focused on the use of Oxalobacterformigenes in patients with urolithiasis. Unfortunately, this bacterium is not an ideal probiotic due to its antibiotic sensitivity and low pH. Therefore, subsequent studies sought to find bacteria which are capable of oxalate degradation, focusing on well-known probiotics including Lactobacillus and Bifidobacterium strains, Eubacterium lentum, Enterococcus faecalis, and Escherichia coli.

PEDIATRICS ◽  
1992 ◽  
Vol 89 (6) ◽  
pp. 1189-1193
Author(s):  
Avner Goren ◽  
Serem Freier ◽  
Justen H. Passwell

Shigellosis results in considerable morbidity in endemic areas, but mortality is rare in developed countries. All pediatric deaths (n = 15) in Israel following shigellosis in the past 10 years were reviewed. The patients' ages ranged from 5 months to 11 years; there were eight boys and seven girls. Three were institutionalized mentally retarded patients, 11 were healthy children. Twelve had definite clinical signs of brain death within 48 hours of onset of disease. Cause of death in all patients was consistent with toxic encephalopathy. No other systemic complication was implicated as the cause of death except for one case consistent with a "Reye-like" syndrome. Shigella species were as follows: 8 flexneri, 4 sonnei, 1 dysenteriae, and 2 were not identified. Case-control study of these patients vs surviving, hospitalized patients with shigellosis showed similar severity of fever, diarrhea, vomiting, and dehydration and similar incidence of convulsions. Headache was a prominent feature of patients who died; 5 of 7 verbal patients complained of this symptom as opposed to 2 of 20 in the control group (P < .01). There were no significant differences in the hematological and biochemical profile (except for an increased incidence of hyponatremia in the study group), pattern of shigella species, or antibiotic sensitivity. These findings indicate that mortality from shigellosis in a developed country is due primarily to the toxic encephalopathy syndrome.


2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Luigi Barrea ◽  
Claudia Vetrani ◽  
Ludovica Verde ◽  
Bruno Napolitano ◽  
Silvia Savastano ◽  
...  

Abstract Background Cardiometabolic diseases (CMD) are recognized as the main causes of morbidity and mortality in developed countries. In recent years eating speed (ES) has been of particular interest since some studies have associated it with the development of obesity and CMD. However, the different impact of the ES at which main meals are eaten on the risk of developing these diseases has not yet been identified. Thus, we aimed to investigate the effect of ES at the main meals (breakfast, lunch, and dinner) on the risk of developing cardiometabolic diseases (type 2 diabetes mellitus, dyslipidaemia and hypertension) in middle-aged Caucasian subjects with obesity. Methods For this purpose we carried out a cross-sectional, observational study. One hundred and eighty-seven middle-aged subjects aged 43.6 ± 16 years were enrolled of which anthropometric parameters and lifestyle habits were studied. A dietary interview was performed to collect information about meal duration and eating habits at the main meals. According to median value of meal duration, meals were classified in two groups: fast eating group (FEG) and slow eating group (SEG). Results The prevalence of dyslipidaemia was more than twice in FEG compared to SEG at lunch and dinner. For all main meals, FEG had a significantly higher risk of dyslipidaemia than SEG (p < 0.05) in unadjusted model. However, when the model was adjusted for age, BMI, physical activity, smoking and alcohol use and medication, the result remained significant for lunch and dinner (p < 0.05). Conclusion The results of our study suggest that fast eating increases at lunch and dinner increase the risk of developing dyslipidaemia in obesity.


2018 ◽  
Vol 21 (6) ◽  
pp. 1048-1056 ◽  
Author(s):  
Herbert Sagbo ◽  
Didier Koumavi Ekouevi ◽  
Dorland Tafitarilova Ranjandriarison ◽  
Serge Niangoran ◽  
Tchaa Abalo Bakai ◽  
...  

AbstractObjectiveOverweight and obesity in childhood are serious public health issues, both in developing and developed countries. The present study aimed to ascertain overweight and obesity prevalence rates among Togolese schoolchildren in Lomé, Togo, and their correlation with physical activity, socio-economic conditions and eating habits.DesignCross-sectional survey conducted in December 2015. Overweight and obesity were defined using age- and sex-specific BMI cut-off points of the International Obesity Task Force. Physical activity, socio-economic conditions and eating habits were assessed with a standardized questionnaire. Specially trained medical students interviewed children and collected the data. After bivariate regression analyses, factors associated with overweight/obesity were identified by multivariate logistic regression. Statistical significance was two-sided P<0·05.SettingLomé, Togo.SubjectsRepresentative sample of 634 children (288 boys, 346 girls), aged 8–17 years, who were studying in primary schools.ResultsOverweight and obesity respectively affected 5·2 and 1·9 % of children surveyed. Watching television (>4 h) on weekends (OR; 95 % CI: 3·8; 1·2, 12·0, P=0·02) and medium dietary diversity score (3·0; 1·1, 8·1, P=0·03) were independently associated with overweight/obesity in a multivariate regression model. Eating breakfast in the school cafeteria (0·2; 0·1, 0·8, P=0·03) and eating fruits (0·4; 0·1, 0·9, P=0·03) significantly reduced the risk of overweight/obesity.ConclusionsOverweight and obesity prevalence were linked with sedentary behaviour and non-optimal food diversity. Promoting physical activity and fruit consumption should be explored as interventions to reduce and prevent overweight and obesity in Lomé schoolchildren. In addition, preventive approaches in the social environment of children should be considered.


2019 ◽  
pp. 29-38
Author(s):  
Hania Kassem ◽  
Bernard G. Jaar

Chronic kidney disease (CKD) represents a significant public health burden worldwide and several risk factors have been identified over the years; these have been well-described in the medical literature. Common risk factors such as diabetes mellitus and hypertension will be described in other chapters. While this chapter will focus mainly on CKD risk factors observed in developed countries, several of these are also observed in developing countries. It is now well-established that some risk factors are modifiable while others are non-modifiable. In this chapter, we will explore several of these non-modifiable risk factors in more detail, such as age, gender, race, family history, and low birth weight. But we will also discuss some of the modifiable risk factors such as kidney stones, obstructive sleep apnea, smoking, drugs (excluding NSAIDs), diet, obesity, metabolic syndrome, and hyperuricemia. We will provide a balanced and up to date review of the evidence linking these risk factors with CKD.


2020 ◽  
Vol 21 (17) ◽  
pp. 6075
Author(s):  
Deborah Rotoli ◽  
Laura Santana-Viera ◽  
Maria L. Ibba ◽  
Carla L. Esposito ◽  
Silvia Catuogno

Non-small-cell lung cancer (NSCLC) is the most common type of lung cancer worldwide, with the highest incidence in developed countries. NSCLC patients often face resistance to currently available therapies, accounting for frequent relapses and poor prognosis. Indeed, despite great recent advancements in the field of NSCLC diagnosis and multimodal therapy, most patients are diagnosed at advanced metastatic stage, with a very low overall survival. Thus, the identification of new effective diagnostic and therapeutic options for NSCLC patients is a crucial challenge in oncology. A promising class of targeting molecules is represented by nucleic-acid aptamers, short single-stranded oligonucleotides that upon folding in particular three dimensional (3D) structures, serve as high affinity ligands towards disease-associated proteins. They are produced in vitro by SELEX (systematic evolution of ligands by exponential enrichment), a combinatorial chemistry procedure, representing an important tool for novel targetable biomarker discovery of both diagnostic and therapeutic interest. Aptamer-based approaches are promising options for NSCLC early diagnosis and targeted therapy and may overcome the key obstacles of currently used therapeutic modalities, such as the high toxicity and patients’ resistance. In this review, we highlight the most important applications of SELEX technology and aptamers for NSCLC handling.


Author(s):  
Vijayan Sharmila ◽  
Thirunavukkarasu Arun Babu

Background: Group B streptococcus (GBS) is one of the important cause of early onset neonatal sepsis in developed countries leading to increased neonatal morbidity and mortality. Penicillin and Ampicillin are the drugs of choice for prevention of GBS infections. Antibiotic resistance amongst GBS isolates is an emerging health problem affecting neonates. Hence, this study was performed to determine the antibiotic susceptibility pattern of Group B Streptococcus (GBS) in a population of pregnant women.Methods: A prospective study was done to screen pregnant women for vaginal and rectal GBS colonization during their regular visits to antenatal clinic. Todd-Hewitt broth, an enrichment medium for GBS was used for isolation. The antibiotic susceptibility pattern of the isolates were studied.  Results: A total of 300 pregnant women were screened for GBS colonization. GBS colonization rate in our study was 2.3%. The antibiotic susceptibility pattern of the isolates revealed that none of the isolates were resistant to penicillin or clindamycin, while resistance was noted to erythromycin (14.3%) and   tetracycline (71.4%).Conclusions: GBS continues to remain sensitive to Penicillin which is the drug of choice for prevention and treatment of GBS.  Consistent surveillance of antibiotic sensitivity pattern of GBS as well as for other organisms implicated in new born sepsis and maternal infections is required to formulate guidelines for prevention and treatment.


2021 ◽  
Vol 29 (1) ◽  
pp. 73-82
Author(s):  
Adele Lillo ◽  
Ettore Antoncecchi ◽  
Valeria Antoncecchi

Sex and gender differences change biology and pathophysiology. Up to now there has been no attention to this problem and the results of scientific research conducted mainly in men were inappropriately shifted to the female sex. The female “umbrella-hormone” bias has come to minimize the impact of risk factors and cardiovascular disease which instead are the leading cause of death in women in developed countries. To take stock of female awareness in Italy and identify methods and topics of intervention, ARCA (Associazioni Regionali Cardiology Ambulatoriali), with the collaboration of GISeG (Gruppo Italiano Salute e Genere), conducted a survey enrolling 2,856 women, mainly interviewed in cardiological outpatient clinics. The mean age of the enrolled patients was 53.8 ± 13.4 years, school attendance was generally low for a European country (with 53% of senior high school diploma or degree). Forty percent of respondents were single. Awareness of traditional risk factors was high, slightly less for diabetes mellitus (81%). The presence of cardiovascular events was strongly correlated with age and the number of conventional risk factors. Lifestyle change seemed to be difficult for a large percentage of women, mainly the eating habits (45%). Ninety one percent declared to need more information about the CVR and over 80% would like the family doctor to provide it. In conclusion, women’s awareness of their cardiovascular risk is still not optimal and the interviewees believe that they need to be primarily informed by their family doctor.


2020 ◽  
Vol 8 (2) ◽  
pp. 1011-1018
Author(s):  
Lilis Banowati ◽  
Jongga Adiyaksa

Anemia merupakan masalah kesehatan masyarakat global di negara berkembang maupun negara maju dengan konsekuensi yang besar bagi kesehatan manusia serta pembangunan nasional dan ekonomi. Anemia pada remaja akibat  kurang gizi dapat berdampak buruk pada kesehatan, pertumbuhan, dan sistem imun. Penyebab utama anemia gizi ialah konsumsi zat besi yang tidak cukup, absorbsi zat besi yang rendah, dan pola makan yang sebagian besar terdiri dari nasi dan menu yang kurang beraneka ragam. Kebiasaan makan pagi termasuk dalam salah satu dari 13 pesan dasar gizi seimbang. Bagi mahasiswa/remaja, makan pagi dapat meningkatkan konsentrasi belajar dan memudahkan menyerap pelajaran yang akan meningkatkan prestasi belajar. Makan pagi juga sangat berperan terhadap pemenuhan gizi seimbang pada anak. Tujuan penelitian ini untuk mengetahui hubungan antara kebiasaan makan pagi dengan kejadian anemia pada mahasiswa program studi D III Gizi Cirebon Poltekkes Kemenkes Tasikmalaya.Penelitian ini merupakan penelitian observational dengan menggunakan desain cross-sectional. Populasi pada penelitian ini adalah mahasiswa Prodi D III Gizi Cirebon Poltekkes Kemenkes Tasikmalaya dengan jumlah 122 orang. Teknik pengambilan sampel menggunakan  teknik  random  sampling  yaitu   sejumlah  35 orang.Hasil penelitian  menunjukkan  bahwa dari 35 mahasiswa, 29 mahasiswa memiliki kebiasaan makan pagi 29 mahasiswa (83%) yang tidak anemia, jarang sarapan pagi yaitu 1 mahasiswa (2,8%) dan yang tidak pernah sarapan yaitu 5 mahasiswa. Nilai pValue dari uji Chi square yaitu 0,125 (P<0,05). Sehingga hasilnya yaitu ada hubungan kebiasaan sarapan pagi dengan kejadian anemia pada mahasiswaKata kunci: kebiasaan makan pagi, anemia, mahasiswa ABSTRACTAnemia is a global public health problem in both developing and developed countries with great consequences for human health as well as national and economic development. Anemia in adolescents due to malnutrition can adversely affect health, growth, and the immune system. The main causes of nutritional anemia are insufficient intake of iron, low iron absorption, and a diet consisting mostly of rice and a less varied menu. Breakfast habits are included in one of 13 basic messages of balanced nutrition. For students, breakfast can increase the concentration of learning and make it easier to absorb lessons that will improve learning achievement. Breakfast also greatly contribute to the fulfillment of balanced nutrition in children. The purpose of this study to determine the relationship between morning eating habits with the incidence of anemia in the students of study program D III Gizi Cirebon Poltekkes Kemenkes Tasikmalaya.This research is an observational research using cross-sectional design. The population in this study is a student of Study Program D III Gizi Cirebon Poltekkes Kemenkes Tasikmalaya with the number of 122 people. Sampling technique using random sampling technique that is a number of 35 people.The result of the research shows that from 35 students, 29 students have breakfast habit of 29 students (83%) who are not anemic, rarely breakfast that is 1 student (2.8%) and who never breakfast is 5 students. The pValue value of Chi square test is 0,125 (P <0,05). So the result is a relationship between breakfast habits with the incidence of anemia in studentsKeywords: breakfast habits, anemia, students


1927 ◽  
Vol 23 (1) ◽  
pp. 126-126

The authors utilized the property of the cerebral appendage extract to induce smooth muscle contractions to expel kidney stones, recommending this remedy for renal colic.


1987 ◽  
Vol 5 (1-2) ◽  
pp. 79-94 ◽  
Author(s):  
Arthur Wynn

Inequalities in nutrition are associated with inequalities in health. Many surveys, mainly American, show that there are large variations between individuals in the quality and quantity of food consumed. Variations depend upon up-bringing, education, income and availability of food. In the United Kingdom there is a steep social-class gradient in age-specific death-rates for heart disease and other diseases including cancer. Of all the many possible nutritional factors the strongest inverse correlates with death-rates within the United Kingdom and in other developed countries are the consumption of fresh vegetables and fruit. Among the individual nutrients a low consumption of vitamin A, or its precursor carotene is associated with an increased cancer risk. Whole milk is a major source of vitamin A and carotene in the British diet and is also reported to be protective against osteoporosis and some forms of hypertension including preeclampsia. School meals can set a pattern of life-long eating habits.


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