scholarly journals 18F-FDG PET/CT in a Case of Urothelial Carcinoma in the Urachus Presenting as Colon Cancer

Diagnostics ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 31
Author(s):  
Jeannette D. Andersen ◽  
Knud Fabrin ◽  
Astrid Petersen ◽  
Helle D. Zacho
Keyword(s):  
Urothelial Carcinoma ◽  
Sigmoid Colon ◽  
Fdg Pet ◽  
Bladder Wall ◽  
Urogenital Sinus ◽  
Histologic Subtype ◽  
Normal Bladder ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

Urachal cancer arises from an embryologic remnant of the urogenital sinus and allantois and accounts for approximately 1% of bladder malignancies. The most encountered histologic subtype is adenocarcinoma. We present a 76-year-old man suspected to have an advanced sigmoid cancer infiltrating nearby organs. A supplemental 18F-FDG PET/CT showed high tracer uptake in a tumorous process coherent with the dome of the bladder wall involving the sigmoid colon. Cystoscopy revealed a normal bladder wall, except for a small edematous area in the anterior bladder. Biopsies from the sigmoid colon and transurethral resection from the bladder confirmed a urothelial carcinoma originating from the urachus.

scholarly journals 18F-FDG PET/CT and Urothelial Carcinoma: Impact on Management and Prognosis—A Multicenter Retrospective Study

Cancers ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 700 ◽  
Author(s):  
Fabio Zattoni ◽  
Elena Incerti ◽  
Fabrizio Dal Moro ◽  
Marco Moschini ◽  
Paolo Castellucci ◽  
...  
Keyword(s):  
Overall Survival ◽  
Urothelial Carcinoma ◽  
Fdg Pet ◽  
Patient Management ◽  
Survival Prediction ◽  
Primary Tumor Site ◽  
Kaplan Meier ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

Objectives: To evaluate the ability of 18F-labeled fluoro-2-deoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) to predict survivorship of patients with bladder cancer (BC) and/or upper urinary tract carcinoma (UUTC). Materials: Data from patients who underwent FDG PET/CT for suspicion of recurrent urothelial carcinoma (UC) between 2007 and 2015 were retrospectively collected in a multicenter study. Disease management after the introduction of FDG PET/CT in the diagnostic algorithm was assessed in all patients. Kaplan-Meier and log-rank analysis were computed for survival assessment. A Cox regression analysis was used to identify predictors of recurrence and death, for BC, UUTC, and concomitant BC and UUTC. Results: Data from 286 patients were collected. Of these, 212 had a history of BC, 38 of UUTC and 36 of concomitant BC and UUTC. Patient management was changed in 114/286 (40%) UC patients with the inclusion of FDG PET/CT, particularly in those with BC, reaching 74% (n = 90/122). After a mean follow-up period of 21 months (Interquartile range: 4–28 mo.), 136 patients (47.4%) had recurrence/progression of disease. Moreover, 131 subjects (45.6%) died. At Kaplan-Meier analyses, patients with BC and positive PET/CT had a worse overall survival than those with a negative scan (log-rank < 0.001). Furthermore, a negative PET/CT scan was associated with a lower recurrence rate than a positive examination, independently from the primary tumor site. At multivariate analysis, in patients with BC and UUTC, a positive FDG PET/CT resulted an independent predictor of disease-free and overall survival (p < 0,01). Conclusions: FDG PET/CT has the potential to change patient management, particularly for patients with BC. Furthermore, it can be considered a valid survival prediction tool after primary treatment in patients with recurrent UC. However, a firm recommendation cannot be made yet. Further prospective studies are necessary to confirm our findings.

BCGitis detected by 18F-FDG PET/CT after treatment of bladder urothelial carcinoma

2016 ◽  
Vol 35 (2) ◽  
pp. 141-142 ◽  
Author(s):  
G.A. Jiménez Londoño ◽  
A.M. García Vicente ◽  
J. Ros Izquierdo ◽  
M.J. Tello Galán ◽  
B. González García ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Fdg Pet ◽  
Bladder Urothelial Carcinoma ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

scholarly journals Prediction of Histologic Subtype and FNCLCC Grade by SUVmax Measured on 18F-FDG PET/CT in Patients with Retroperitoneal Liposarcoma

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Cheng-Peng Li ◽  
Dao-Ning Liu ◽  
Ni-Na Zhou ◽  
Xiu-Yun Tian ◽  
Zhen Wang ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Imaging Modality ◽  
Standardized Uptake Value ◽  
High Sensitivity ◽  
Roc Curves ◽  
Histologic Subtype ◽  
Retroperitoneal Liposarcoma ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

This study aimed to evaluate the usefulness of maximum standardized uptake value (SUVmax) on 18F-fluorodeoxyglucose positron emission tomography with computed tomography (18F-FDG PET/CT) in differentiating the subtypes and tumor grades of retroperitoneal liposarcoma (RPLS). The data of RPLS patients who underwent surgical resection from November 2013 to December 2019 at the sarcoma center of our institute were reviewed. The demographics, clinical features, and SUVmax of 84 patients who underwent preoperative 18F-FDG PET/CT scans were analyzed. Of these, 19 patients (22.6%) were with well-differentiated liposarcoma (WDLPS), 60 patients (71.4%) were with dedifferentiated liposarcoma (DDLPS), and 5 patients (6.0%) were with pleomorphic liposarcoma (PMLPS). The median SUVmax of WDLPS, DDLPS, and PMLPS groups was 2.8 (IQR: 1.9–3.2), 6.2 (IQR: 4.1–11.3), and 4.5 (IQR: 4.0–7.4). The ROC curve suggested 3.8 as an approximate cutoff value of SUVmax for distinguishing WDLPS and non-WDLPS (sensitivity = 0.769; specificity = 0.895). The median SUVmax for FNCLCC Grades 1, 2, and 3 of RPLS was 2.5 (IQR: 1.9–3.2), 4.5 (IQR: 3.2–6.7), and 9.0 (IQR: 6.0–13.3). The ROC curves suggest that SUVmax of ≤3.8 and >5.3 can be used for predicting FNCLCC Grades 1 and 3, respectively. The result showed that 18F-FDG PET/CT exhibited high sensitivity and specificity for identifying the subtypes and FNCLCC grades of RPLS. Additionally, 18F-FDG PET/CT might be a useful complementary imaging modality for guiding suitable biopsy location of RPLS.

scholarly journals Diagnostic and Clinical Impact of 18F-FDG PET/CT in Staging and Restaging Soft-Tissue Sarcomas of the Extremities and Trunk: Mono-Institutional Retrospective Study of a Sarcoma Referral Center

2020 ◽  
Vol 9 (8) ◽  
pp. 2549
Author(s):  
Alessio Annovazzi ◽  
Sandra Rea ◽  
Carmine Zoccali ◽  
Rosa Sciuto ◽  
Jacopo Baldi ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Soft Tissue ◽  
Fdg Pet ◽  
Soft Tissue Sarcomas ◽  
Emission Computed Tomography ◽  
Therapy Planning ◽  
Histologic Subtype ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

Background: Soft-tissue sarcomas (STS) represent a wide heterogeneous class of rare tumors. The exact role 18F-fluorodeoxyglucose positron emission/computed tomography (18F-FDG PET/CT) in the evaluation of STS is not well established. The aim of the present study was to evaluate how the use of 18F-FDG PET/CT in STS could influence patient therapy planning, looking for a possible added value over computed tomography and magnetic resonance imaging—the most used modalities in the study of STS. Differences in SUVmax according to histologic subtype and tumor grade were also considered. Methods: a total of 345 consecutive 18F-FDG PET/CT scans performed for initial staging (n = 171) or for suspected disease relapse (n = 174) in 282 patients with STS extracted from the local Information System database were retrospectively reviewed. Results: 18F-FDG PET/CT altered therapy planning in 80 cases (16.4% for staging and 29.9% in restaging), both for disease upstaging (58.8%) and downstaging (41.2%) Conclusions: 18F-FDG PET/CT could significantly influence management of patients with STS, particularly for restaging.

18F-FDG PET/CT Findings of Metastasis to Spongy Body of Penis From Urothelial Carcinoma of Bladder

2016 ◽  
Vol 41 (5) ◽  
pp. e251-e252 ◽  
Author(s):  
Yan-li Wang ◽  
Na Fang ◽  
Lei Zeng ◽  
Zeng-jie Wu ◽  
Xin-jian Cui
Keyword(s):  
Urothelial Carcinoma ◽  
Fdg Pet ◽  
Ct Findings ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Urothelial Carcinoma Of Bladder

scholarly journals Multicentric Primary Angiosarcoma of Bone Mimicking Metastasis on 18F-FDG PET/CT in a Patient with a History of Sigmoid Colon Cancer: a Case Report

2015 ◽  
Vol 49 (4) ◽  
pp. 321-324 ◽  
Author(s):  
Min Young Yoo ◽  
Eun Seong Lee ◽  
Seok-ki Kim ◽  
Seog-Yun Park ◽  
Youngmee Kwon ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Case Report ◽  
Sigmoid Colon ◽  
Fdg Pet ◽  
Sigmoid Colon Cancer ◽  
Primary Angiosarcoma ◽  
Pet Ct ◽  
History Of ◽  
18F Fdg ◽  
Fdg Pet Ct

scholarly journals Diagnostic Value of Conventional PET Parameters and Radiomic Features Extracted from 18F-FDG-PET/CT for Histologic Subtype Classification and Characterization of Lung Neuroendocrine Neoplasms

Biomedicines ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 281
Author(s):  
Philippe Thuillier ◽  
Virginia Liberini ◽  
Osvaldo Rampado ◽  
Elena Gallio ◽  
Bruno De Santi ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Pearson Correlation ◽  
Area Under The Curve ◽  
Tnm Staging ◽  
Neuroendocrine Neoplasms ◽  
Histological Subtypes ◽  
Histologic Subtype ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

Aim: To evaluate if conventional Positron emission tomography (PET) parameters and radiomic features (RFs) extracted by 18F-FDG-PET/CT can differentiate among different histological subtypes of lung neuroendocrine neoplasms (Lu-NENs). Methods: Forty-four naïve-treatment patients on whom 18F-FDG-PET/CT was performed for histologically confirmed Lu-NEN (n = 46) were retrospectively included. Manual segmentation was performed by two operators allowing for extraction of four conventional PET parameters (SUVmax, SUVmean, metabolic tumor volume (MTV), and total lesion glycolysis (TLG)) and 41 RFs. Lu-NENs were classified into two groups: lung neuroendocrine tumors (Lu-NETs) vs. lung neuroendocrine carcinomas (Lu-NECs). Lu-NETs were classified according to histological subtypes (typical (TC)/atypical carcinoid (AC)), Ki67-level, and TNM staging. The least absolute shrink age and selection operator (LASSO) method was used to select the most predictive RFs for classification and Pearson correlation analysis was performed between conventional PET parameters and selected RFs. Results: PET parameters, in particular, SUVmax (area under the curve (AUC) = 0.91; cut-off = 5.16) were higher in Lu-NECs vs. Lu-NETs (p < 0.001). Among RFs, HISTO_Entropy_log10 was the most predictive (AUC = 0.90), but correlated with SUVmax/SUVmean (r = 0.95/r = 0.94, respectively). No statistical differences were found between conventional PET parameters and RFs (p > 0.05) and TC vs. AC classification. Conventional PET parameters were correlated with N+ status in Lu-NETs. Conclusion: In our study, conventional PET parameters were able to distinguish Lu-NECs from Lu-NETs, but not TC from AC. RFs did not provide additional information.

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