Limb Salvage through Intermediary Wound Coverage with Acellular Dermal Matrix Template after Persistent Pseudomonas Aeruginosa Infection in a Burn Patient

Secondary infections of skin grafts pose a continuous problem in burn patients, very often leading to loss of transplanted skin grafts and making multiple surgical revisions necessary. We present a case report about persisting Pseudomonas aeruginosa infection in burn patients with known diabetes. The burn wounds in lower extremities required repeated debridements, multiple skin grafting attempts and finally an application of the dermal scaffold NovoSorb BTM. With these measures, we managed to undertake a successful reconstruction of infected burn defects and pre-vent an amputation. We concluded that the NovoSorb BTM could be seen as an additional promising tool in a burn surgery armamentarium. In cases where radical surgical wound decontamination is not possible without risking the loss of the limb, the application of NovoSorb BTM over a contaminated field can win extra time for topical infection treatment and additionally provide an excellent skin grafting ground.

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Adoption of a Newly Introduced Dermal Matrix: Preliminary Experience and Future Directions

BioMed Research International ◽

10.1155/2020/3261318 ◽

2020 ◽

Vol 2020 ◽

pp. 1-5

Author(s):

Andrea Vittorio Emanuele Lisa ◽

Leonardo Galtelli ◽

Valeriano Vinci ◽

Alessandra Veronesi ◽

Luca Cozzaglio ◽

...

Keyword(s):

Soft Tissues ◽

Skin Grafting ◽

Acellular Dermal Matrix ◽

Full Thickness ◽

Dermal Matrix ◽

Full Thickness Skin ◽

Thickness Skin ◽

Chronic Ulcers ◽

Fast Reconstruction ◽

Traditional Approaches

Introduction. Acellular dermal matrix (ADM) products are adopted in the management of injuries to soft tissues. ADMs have been increasingly employed for their clinical advantages, and they are acquiring relevance in the future of plastic surgery. The aim of our study is to evaluate the application of ADMs in our patients who could not undergo fast reconstruction. Materials and Methods. We performed a retrospective study on 12 patients who underwent ADM placement for scalp and limb surgical reconstructions at the Humanitas Research Hospital, Rozzano (Milano), Italy. Wounds resulted from 9 tumor resections and 3 chronic ulcers. The ADM substrate used to treat these lesions was PELNAC™ (Gunze, Japan), a double-layered matrix composed of atelocollagen porcine tendon and silicon reinforcement. All patients underwent a second surgical operation to complete the treatment with a full-thickness skin graft to cover the lesion. Results. In this study, 12 patients were treated with PELNAC™: 11 out of 12 patients showed a good attachment over a median time of 21.3 days (range 14-27). After almost 23 days, all patients were ready to undergo a full-thickness skin grafting. Conclusion. This study assesses the benefits of PELNAC™ and proposes this method as an alternative to traditional approaches, especially in situations where the latter techniques cannot be applied.

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Early Escharectomy and Concurrent Composite Skin Grafting over Human Acellular Dermal Matrix Scaffold for Covering Deep Facial Burns

Plastic & Reconstructive Surgery ◽

10.1097/prs.0b013e31820a63e8 ◽

2011 ◽

Vol 127 (4) ◽

pp. 1533-1538 ◽

Cited By ~ 14

Author(s):

Bing Tang ◽

Bin Zhu ◽

Yue-Ying Liang ◽

Liang-Kuan Bi ◽

Bin Chen ◽

...

Keyword(s):

Skin Grafting ◽

Acellular Dermal Matrix ◽

Dermal Matrix ◽

Facial Burns ◽

Acellular Dermal ◽

Human Acellular Dermal Matrix

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Acellular Dermal Matrix Combined with Autologous Skin Grafts for Closure of Chronic Wounds after Reconstruction of Skull Defects with Titanium Mesh

Journal of Neurological Surgery Part A Central European Neurosurgery ◽

10.1055/s-0035-1559810 ◽

2016 ◽

Vol 77 (04) ◽

pp. 297-299 ◽

Cited By ~ 1

Author(s):

Cai Lin ◽

Xinling Wang ◽

Xiangwei Lin ◽

Sunyue He ◽

Yunfeng Liu ◽

...

Keyword(s):

Chronic Wounds ◽

Acellular Dermal Matrix ◽

Skin Grafts ◽

Titanium Mesh ◽

Dermal Matrix ◽

Skull Defects ◽

Acellular Dermal

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A Short History of Skin Grafting in Burns: From the Gold Standard of Autologous Skin Grafting to the Possibilities of Allogeneic Skin Grafting with Immunomodulatory Approaches

Medicina ◽

10.3390/medicina57030225 ◽

2021 ◽

Vol 57 (3) ◽

pp. 225

Author(s):

Frederik Schlottmann ◽

Vesna Bucan ◽

Peter M. Vogt ◽

Nicco Krezdorn

Keyword(s):

Skin Grafting ◽

Burn Patients ◽

Skin Substitutes ◽

Therapeutic Approaches ◽

The Past ◽

Thickness Skin ◽

Split Thickness Skin Grafting ◽

Burn Surgery ◽

History Of ◽

Transplant Immunology

Due to groundbreaking and pioneering developments in the last century, significant improvements in the care of burn patients have been achieved. In addition to the still valid therapeutic standard of autologous split-thickness skin grafting, various commercially available skin substitutes are currently available. Significant progress in the field of tissue engineering has led to the development of promising therapeutic approaches. However, scientific advances in the field of allografting and transplant immunology are of great importance. The achievement of various milestones over the past decades has provided thought-provoking impulses in the field of skin allotransplantation. Thus, biologically viable skin allotransplantation is still not a part of the clinical routine. The purpose of this article is to review the achievements in burn surgery with regards to skin allotransplantation in recent years.

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