A series of 1-(5-(5-(4-chlorophenyl)furan-2-yl)-4,5-dihyropyrazol-1-yl ethanone (5a-h) was synthesized
through E-(3-(5-(4-chloro-phenyl)furan-2-yl)-1-phenylprop-2-en-1-one (3a-h) with hydrazine
monohydrate and sodium acetate. Totally, eight compounds were synthesized and their structures
were elucidated by infrared, 1H & 13C NMR, elemental analysis, antimicrobial studies, in silico molecular
docking studies and also in silico ADME prediction. Antimicrobial studies of the synthesized
compounds showed good to moderate activity against the all the stains compared with standard drugs.
in silico Molecular docking study was carried out using bacterial protein and BC protein. Synthesized
compounds (5a-h) showed good docking score compared with ciprofloxacin. Antimicrobial study
was carried out for 4-chlorophenyl furfuran pyrazole derivatives (5a-h). The results of assessment of
toxicities, drug likeness and drug score profiles of compounds (5a-j) are promising
Synthesis, Characterization, in vitro Antimicrobial Evaluation and in silico
Molecular Docking and ADME Prediction of 4-Chlorophenyl
Furfuran Derivatives bearing Pyrazole Moieties