scholarly journals The Positive Relationship between Moderate-to-Vigorous Physical Activity and Bone Mineral Content Is Not Mediated by Free Leptin Index in Prepubertal Children: The PANIC Study

2021 ◽  
Vol 18 (10) ◽  
pp. 5365
Author(s):  
Annie M. Constable ◽  
Josie E. Porter ◽  
Danielle Benger ◽  
Dimitris Vlachopoulos ◽  
Alan R. Barker ◽  
...  
Keyword(s):  
Physical Activity ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Vigorous Physical Activity ◽  
Normal Weight ◽  
Cross Sectional ◽  
Prepubertal Children ◽  
Total Body ◽  
The Relationship

Purpose: Moderate-to-vigorous physical activity (MVPA) positively influences bone mineral content (BMC) in prepubertal children, but it is unknown whether this relationship is partially mediated by free leptin index. The aim of this study was to examine whether the relationship between MVPA and total body less head (TBLH) BMC is mediated or moderated by free leptin index in prepubertal children. Methods: We performed a cross-sectional analysis on 401 children (194 girls) from baseline examinations of the Physical Activity and Nutrition in Childhood Study. We applied the four-way decomposition mediation analysis method to assess whether free leptin index, measured from fasted blood samples, mediated the relationship between accelerometer-measured MVPA and TBLH BMC measured by dual-energy X-ray absorptiometry. Results: MVPA had a positive controlled direct effect on TBLH BMC in girls and boys (β = 0.010 to 0.011, p < 0.05). There was no mediation or interaction between MVPA, free leptin index and TBLH BMC in girls or boys (β = −0.000 to 0.001, p > 0.05). Conclusion: Our study indicates that MVPA positively influences TBLH BMC through pathways not related to free leptin index in predominantly normal-weight prepubertal children, likely primarily through mechanical loading. The relationships between MVPA, free leptin index and TBLH BMC may be influenced by other factors such as pubertal status and adiposity, so it is unknown whether these observations extend to overweight and obese children at different stages of puberty.

Does childhood and adolescence fracture influence bone mineral content in young adulthood?

2010 ◽  
Vol 35 (3) ◽  
pp. 235-243 ◽  
Author(s):  
Chantal E. Kawalilak ◽  
Adam D.G. Baxter-Jones ◽  
Robert A. Faulkner ◽  
Donald A. Bailey ◽  
Saija A. Kontulainen
Keyword(s):  
Physical Activity ◽  
Bone Mineral Content ◽  
Young Adulthood ◽  
Bone Mineral ◽  
Mineral Content ◽  
Bone Fragility ◽  
Primary Objective ◽  
Childhood And Adolescence ◽  
Pediatric Fracture ◽  
Total Body

Previous fracture may predispose an individual to bone fragility because of impaired bone mineral accrual. The primary objective of the study was to investigate the influence of fractures sustained during childhood and (or) adolescence on total body (TB), lumbar spine (LS), femoral neck (FN), and total hip (TH) bone mineral content (BMC) in young adulthood. It was hypothesized that there would be lower TB, LS, FN, and TH BMC in participants who had sustained a pediatric fracture. Participant anthropometrics, physical activity, and BMC (measured with dual energy X-ray absorptiometry) were assessed longitudinally during childhood and adolescence (from 1991 to 1997), and again in young adulthood (2002 to 2006). Sex, adult height, adult lean mass, adult physical activity, and adolescent BMC adjusted TB, LS, FN, and TH BMC in young adulthood, for those who reported 1 or more fractures (n = 42), were compared with those who reported no fractures (n = 101). There were no significant differences (p > 0.05) in adjusted BMC between fracture and nonfracture groups at the TB, LS, FN, and TH sites in young adulthood. These results suggest that fractures sustained during childhood and adolescence may not interfere with bone mass in young adulthood at clinically relevant bone sites.

Effects of physical activity on bone mineral content and muscle strength in women: A cross-sectional study

Bone ◽  
1992 ◽  
Vol 13 (2) ◽  
pp. 191-195 ◽  
Author(s):  
B. Jónsson ◽  
K. Ringsberg ◽  
P.O. Josefsson ◽  
O. Johnell ◽  
M. Birch-Jensen
Keyword(s):  
Physical Activity ◽  
Muscle Strength ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

Lower Relative Bone Mineral Content in Obese Adolescents: Role of Non-Weight Bearing Exercise

2010 ◽  
Vol 22 (4) ◽  
pp. 557-568 ◽  
Author(s):  
Danielle L. Templeton ◽  
Aaron S. Kelly ◽  
Julia Steinberger ◽  
Donald R. Dengel
Keyword(s):  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Weight Bearing ◽  
Normal Weight ◽  
Total Body Mass ◽  
Obese Adolescents ◽  
Total Body ◽  
The Impact

We assessed relative bone mineral content (BMC) in normal-weight (BMI < 85th percentile), overweight (BMI ≥ 85th—< 95th percentile), and obese (BMI ≥ 95th percentile) adolescents and evaluated the impact of nonweight bearing stationary cycle exercise training in a subset of obese participants. Obese and overweight adolescents had higher (p = .001) BMC than normal-weight counterparts, but after adjusting for total body mass the overweight and obese adolescents had a significantly lower (p < .001) BMC than normal-weight subjects. Although aerobic training such as cycling would seem optimal for caloric expenditure in obese adolescents, this study showed that eight weeks of cycle training did not improve BMC in obese adolescents. Weight-bearing aerobic exercise would be a better option for optimizing bone health in this population.

scholarly journals EFFECT OF CALCIUM SNACKING AND PHYSICAL ACTIVITY ON TOTAL BODY BONE MINERAL CONTENT IN 4TH AND 5TH GRADE GIRLS

2001 ◽  
Vol 33 (5) ◽  
pp. S39
Author(s):  
Sudip Bajpeyi ◽  
Eileen Dennis ◽  
Donna Boudreau ◽  
Dennis Jacobsen ◽  
Kris Sorenson ◽  
...  
Keyword(s):  
Physical Activity ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Total Body ◽  
5Th Grade ◽  
Total Body Bone Mineral ◽  
Body Bone
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