scholarly journals Does Irrigation with Treated and Untreated Wastewater Increase Antimicrobial Resistance in Soil and Water: A Systematic Review

2021 ◽  
Vol 18 (21) ◽  
pp. 11046
Author(s):  
Stacy Slobodiuk ◽  
Caitlin Niven ◽  
Greer Arthur ◽  
Siddhartha Thakur ◽  
Ayse Ercumen
Keyword(s):  
Systematic Review ◽  
Wastewater Treatment ◽  
Antimicrobial Resistance ◽  
Domestic Wastewater ◽  
Positive Association ◽  
Wastewater Irrigation ◽  
Treated Wastewater ◽  
Resistant Bacteria ◽  
Untreated Wastewater ◽  
The Impact

Population growth and water scarcity necessitate alternative agriculture practices, such as reusing wastewater for irrigation. Domestic wastewater has been used for irrigation for centuries in many historically low-income and arid countries and is becoming more widely used by high-income countries to augment water resources in an increasingly dry climate. Wastewater treatment processes are not fully effective in removing all contaminants, such as antimicrobial resistant bacteria (ARB) and antimicrobial resistance genes (ARGs). Literature reviews on the impact of wastewater irrigation on antimicrobial resistance (AMR) in the environment have been inconclusive and mostly focused on treated wastewater. We conducted the first systematic review to assess the impact of irrigation with both treated or untreated domestic wastewater on ARB and ARGs in soil and adjacent water bodies. We screened titles/abstracts of 3002 articles, out of which 41 were screened in full text and 26 were included in this review. Of these, thirteen investigated irrigation with untreated wastewater, and nine found a positive association with ARB/ARGs in soil. Out of thirteen studies focused on treated wastewater, six found a positive association with ARB/ARGs while six found mixed/negative associations. Our findings demonstrate that irrigation with untreated wastewater increases AMR in soil and call for precautionary action by field workers, their families, and consumers when untreated wastewater is used to irrigate crops. The effect of irrigation with treated wastewater was more variable among the studies included in our review, highlighting the need to better understand to what extent AMR is disseminated through this practice. Future research should assess factors that modify the effect of wastewater irrigation on AMR in soil, such as the degree and type of wastewater treatment, and the duration and intensity of irrigation, to inform guidelines on the reuse of wastewater for irrigation.

Possible impact of treated wastewater discharge on incidence of antibiotic resistant bacteria in river water

2001 ◽  
Vol 43 (2) ◽  
pp. 91-99 ◽  
Author(s):  
T. Iwane ◽  
T. Urase ◽  
K. Yamamoto
Keyword(s):  
Wastewater Treatment ◽  
River Water ◽  
Wastewater Treatment Plant ◽  
Treatment Process ◽  
Treatment Plant ◽  
Treated Wastewater ◽  
Resistant Bacteria ◽  
Wastewater Discharge ◽  
Wastewater Treatment Process ◽  
Antibiotic Resistant

Escherichia coli and coliform group bacteria resistant to seven antibiotics were investigated in the Tama River, a typical urbanized river in Tokyo, Japan, and at a wastewater treatment plant located on the river. The percentages of antibiotic resistance in the wastewater effluent were, in most cases, higher than the percentages in the river water, which were observed increasing downstream. Since the possible increase in the percentages in the river was associated with treated wastewater discharges, it was concluded that the river, which is contaminated by treated wastewater with many kinds of pollutants, is also contaminated with antibiotic resistant coliform group bacteria and E.coli. The percentages of resistant bacteria in the wastewater treatment plant were mostly observed decreasing during the treatment process. It was also demonstrated that the percentages of resistance in raw sewage are significantly higher than those in the river water and that the wastewater treatment process investigated in this study works against most of resistant bacteria in sewage.

scholarly journals Biological Activity of Wastewater Assessed Using in Vitro Cell-Based Assays

2021 ◽  
Author(s):  
Adamo R. Petosa ◽  
Monica Nowierski ◽  
Viviane Yargeau
Keyword(s):  
Wastewater Treatment ◽  
Wastewater Treatment Plants ◽  
Estrogenic Activity ◽  
Solid Phase ◽  
Treated Wastewater ◽  
Chemical Analyses ◽  
Untreated Wastewater ◽  
17Β Estradiol ◽  
Receiving Waters

Abstract Bioanalytical tools, namely in vitro bioassays, can be employed in tandem with chemical analyses to assess the efficacy of wastewater treatment and the potential for adverse effects from the discharges of wastewater into receiving waters. In the present study, samples of untreated wastewater (i.e. influent) and treated wastewater (i.e. effluent) were collected from two wastewater treatment plants and a wastewater treatment lagoon serving municipalities in southern Ontario, Canada. In addition, grab samples of surface water were collected downstream of the lagoon discharge. After solid phase extraction (SPE) using ion-exchange columns for basic/neutral and acidic compounds, respectively, the extracts were analyzed for a suite of 16 indicator compounds. The two SPE extracts were combined for analysis of biological responses in four in vitro cell-based bioassays. The concentrations of several indicator compounds, including the estrogens, 17β-estradiol and 17α-ethinylestradiol, were below the limits of detection. However, androstenedione and estrone were detected in several influent samples. The concentrations of these steroid hormones and some of the other indicator compounds declined during treatment but acesulfame K, carbamazepine, trimethoprim and DEET persisted in the effluent. The MTS- CellTiter 96® AQueous One Solution Cell Proliferation Assay (MTS) indicated that cell viability was not affected by exposure to the extracts. The Qiagen Nuclear Receptors 10-Pathway Reporter Array indicated that several cellular pathways were upregulated, with the greatest upregulation observed with the estrogen receptor (i.e. induction ratios 12 to 47) and the liver X receptor (i.e. induction ratios 10 to 45). The ERα CALUX assay indicated that estrogenic activity was lower in effluents compared to influents, with the greatest estrogenic activity observed for grab samples of influent from the lagoon (i.e. 56-215 ng L-1 17β-estradiol equivalents). Finally, the results of the Nrf2 Luciferase Luminescence Assay indicated a lower oxidative stress in the effluent samples. Overall, the present study demonstrates that chemical analyses are limited in their ability to predict or explain reductions in the toxicity of treated wastewater. There are thus advantages to using a combination of chemical analyses and in vitro bioassays to monitor the treatment efficiency of wastewater treatment plants and to predict the potential impacts of wastewater discharges into receiving waters.

scholarly journals The Impact of Social Support and Pregnancy on Subjective Well-Being: A Systematic Review

2021 ◽  
Vol 12 ◽  
Author(s):  
Buyantungalag Battulga ◽  
Marc Reginald Benjamin ◽  
Hong Chen ◽  
Enkhmandakh Bat-Enkh
Keyword(s):  
Social Support ◽  
Systematic Review ◽  
Life Satisfaction ◽  
Pregnant Women ◽  
Positive Association ◽  
Well Being ◽  
Protective Role ◽  
Subjective Well Being ◽  
Health Maintenance ◽  
The Impact

Background: Subjective well-being (SWB) has a protective role in mental health maintenance and is prone to change during short stressful moments, such as pregnancy. Longstanding research suggests that social support (SS) from the partner and family members of pregnant women directly or indirectly acts as a buffer against negative mental outcomes. For happier pregnancies, it is important to understand how SS and pregnancy affect the SWB.Objective: This review aims to examine the extended association of being pregnant and SS on the SWB of pregnant women.Methods: A systematic review was conducted in PubMed, ScienceDirect, and Google Scholar. Articles published in peer-reviewed journals were included regardless of the year and if they had assessed the impact of at least one SWB or SS outcome among healthy pregnant women. The tools of the National Heart, Lung, and Blood Institute were used for quality assessment.Results: Thirty-four studies that assessed the domains of SWB measurements, such as happiness, quality of life (QoL), life satisfaction, positive and negative effects, and well-being, were included and its association with either pregnancy or SS was summarized. Variable results, such as life satisfaction, happiness, and mental component of QoL, were found to be high during pregnancy, but positive emotion and physical components of QoL had decreased. Almost universally, SS during pregnancy was found to have a positive association with all measurements of SWB.Conclusion: This study had found that, despite some arising trends, pregnancy itself does not necessarily have similar impacts on SWB across healthy pregnant women. However, SS had a significant effect on SWB.

scholarly journals Antimicrobial resistance three ways: healthcare crisis, major concepts and the relevance of biofilms

2019 ◽  
Vol 95 (8) ◽  
Author(s):  
Paula Jorge ◽  
Andreia Patrícia Magalhães ◽  
Tânia Grainha ◽  
Diana Alves ◽  
Ana Margarida Sousa ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Molecular Mechanisms ◽  
Resistant Bacteria ◽  
Adaptive Resistance ◽  
Considerable Research ◽  
Ecological Aspects ◽  
The Social ◽  
Healthcare Crisis ◽  
The Impact ◽  
First World

ABSTRACTWorldwide, infections are resuming their role as highly effective killing diseases, as current treatments are failing to respond to the growing problem of antimicrobial resistance (AMR). The social and economic burden of AMR seems ever rising, with health- and research-related organizations rushing to collaborate on a worldwide scale to find effective solutions. Resistant bacteria are spreading even in first-world nations, being found not only in healthcare-related settings, but also in food and in the environment. In this minireview, the impact of AMR in healthcare systems and the major bacteria behind it are highlighted. Ecological aspects of AMR evolution and the complexity of its molecular mechanisms are explained. Major concepts, such as intrinsic, acquired and adaptive resistance, as well as tolerance and heteroresistance, are also clarified. More importantly, the problematic of biofilms and their role in AMR, namely their main resistance and tolerance mechanisms, are elucidated. Finally, some of the most promising anti-biofilm strategies being investigated are reviewed. Much is still to be done regarding the study of AMR and the discovery of new anti-biofilm strategies. Gladly, considerable research on this topic is generated every day and increasingly concerted actions are being engaged globally to try and tackle this problem.

Recycling of domestic wastewater treated by vertical-flow wetlands for watering of vegetables

2015 ◽  
Vol 10 (3) ◽  
pp. 445-464 ◽  
Author(s):  
S. A. A. A. N. Almuktar ◽  
M. Scholz ◽  
R. H. K. Al-Isawi ◽  
A. Sani
Keyword(s):  
Capsicum Annuum ◽  
Tap Water ◽  
Aggregate Size ◽  
Domestic Wastewater ◽  
Sweet Pepper ◽  
Treated Wastewater ◽  
Nutrient Concentrations ◽  
Growth Media ◽  
Vertical Flow ◽  
Untreated Wastewater

The aim was to assess if domestic wastewater treated by different vertical-flow wetlands can be successfully recycled to water commercially grown crops. The growth of both Sweet Pepper (California Wonder; cultivar of Capsicum annuum Linnaeus Grossum Group) and Chilli (De Cayenne; Capsicum annuum (Linnaeus) Longum Group 'De Cayenne') fed with different treated and untreated wastewater types were assessed. The overall growth development of Sweet Peppers was poor due to the high concentrations of nutrients and trace minerals. In contrast, chilies did reasonably well but the growth of foliage was excessive and the harvest was delayed. High yields were associated with tap water and an organic growth medium, and a wetland with a high aggregate size, leaving sufficient space for biomass. Low fruit numbers correlated well with inorganic growth media and irrigation water contaminated by hydrocarbons. Findings indicate that nutrient concentrations supplied to the Chillies by a combination of compost and treated waste water are usually too high to produce a good harvest. However, as the compost is depleted of nutrients after about 8 months, the harvest increased for pots that received pre-treated wastewater. Findings will lead to a better understanding of the effects of different wetland treatment processes.

scholarly journals In vivo studies on antibiotic combination for the treatment of carbapenem-resistant Gram-negative bacteria: a systematic review and meta-analysis protocol

2020 ◽  
Vol 4 (1) ◽  
pp. e100055
Author(s):  
Elda Righi ◽  
Luigia Scudeller ◽  
Margherita Chiamenti ◽  
Kamilia Abdelraouf ◽  
Thomas Lodise ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Resistant Bacteria ◽  
Gram Negative Bacteria ◽  
In Vivo Models ◽  
Gram Negative ◽  
Carbapenem Resistant ◽  
The Impact ◽  
Antibiotic Combination

ObjectiveThere is poor evidence to determine the superiority of combination regimens versus monotherapy against infections due to carbapenem-resistant (CR) Gram-negative bacteria. In vivo models can simulate the pathophysiology of infections in humans and assess antibiotic efficacy. We aim to investigate in vivo effects of antibiotic combination on mortality and disease burden for infections due to CR Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacteriaceae and provide an unbiased overview of existing knowledge. The results of the study can help prioritising future research on the most promising therapies against CR bacteria.Methods and analysisThis protocol was formulated using the Systematic Review Protocol for Animal Intervention Studies (SYRCLE) Checklist. Publications will be collected from PubMed, Scopus, Embase and Web of Science. Quality checklists adapted by Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies and SYRCLE’s risk of bias tool will be used. If the meta-analysis seems feasible, the ES and the 95% CI will be analysed. The heterogeneity between studies will be assessed by I2 test. Subgroup meta-analysis will be performed when possible to assess the impact of the studies on efficacy of the treatments. Funnel plotting will be used to evaluate the risk of publication bias.DisseminationThis systematic review and meta-analysis is part of a wider research collaboration project, the COmbination tHErapy to treat sepsis due to carbapenem-Resistant bacteria in adult and paediatric population: EvideNCE and common practice (COHERENCE) study that includes also the analyses of in vitro and human studies. Data will be presented at international conferences and the results will be published in peer-reviewed journals.PROSPERO registration numberCRD42019128104(available at: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42019128104).

scholarly journals Impact of azithromycin mass drug administration on the antibiotic-resistant gut microbiome: a randomized, controlled trial

2021 ◽  
Author(s):  
Harry Pickering ◽  
John D. Hart ◽  
Sarah Burr ◽  
Richard Stabler ◽  
Ken Maleta ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Drug Administration ◽  
Mass Drug Administration ◽  
Gut Microbiome ◽  
Controlled Trial ◽  
Diarrhoeal Disease ◽  
Childhood Mortality ◽  
Resistant Bacteria ◽  
Clinical Benefits ◽  
The Impact

AbstractBackgroundMass drug administration (MDA) with azithromycin is the primary strategy for global trachoma control efforts. Numerous studies have reported secondary effects of MDA with azithromycin, including reductions in childhood mortality, diarrhoeal disease and malaria. Most recently, the MORDOR clinical trial demonstrated that MDA led to an overall reduction in all-cause childhood mortality in targeted communities. There is however concern about the potential of increased antimicrobial resistance in treated communities.MethodsThis study evaluated the impact of azithromycin MDA on the prevalence of gastrointestinal carriage of macrolide-resistant bacteria in communities within the MORDOR Malawi study, additionally profiling changes in the gut microbiome after treatment. For faecal metagenomics, 60 children were sampled prior to treatment and 122 children after four rounds of MDA, half receiving azithromycin and half placebo.FindingsThe proportion of bacteria carrying macrolide resistance increased after azithromycin treatment; the effect was enhanced in children treated within six months of sampling. Diversity and global community structure of the gut was minimally impacted by treatment, however abundance of several species was altered by treatment. Notably, the putative human enteropathogen Escherichia albertii was more abundant after treatment.InterpretationThe impacts of MDA with azithromycin, including increased carriage of macrolide-resistant bacteria, were enhanced in children treated more recently, suggesting effects may be transient. Increased abundance of enteropathogenic Escherichia species after treatment requires further, higher resolution investigation. Future studies should focus on the number of treatments and administration schedule to ensure clinical benefits continue to outweigh costs in antimicrobial resistance carriage.FundingBill and Melinda Gates Foundation

Sign in / Sign up

Export Citation Format

Share Document