The Effect of Extreme Cold on Complete Blood Count and Biochemical Indicators: A Case Study

Regular exposure to a cold factor—cold water swimming or ice swimming and cold air—results in an increased tolerance to cold due to numerous adaptive mechanisms in humans. Due to the lack of scientific reports on the effects of extremely low outdoor temperatures on the functioning of the human circulatory system, the aim of this study was to evaluate complete blood count and biochemical blood indices in multiple Guinness world record holder Valerjan Romanovski, who was exposed to extremely cold environment from −5 °C to −37 °C for 50 days in Rovaniemi (a city in northern Finland). Valerjan Romanovski proved that humans can function in extremely cold temperatures. Blood from the subject was collected before and after the expedition. The subject was found to have abnormalities for the following blood indices: testosterone increases by 60.14%, RBC decreases by 4.01%, HGB decreases by 3.47%, WBC decreases by 21.53%, neutrocytes decrease by 17.31%, PDW increases by 5.31%, AspAT increases by 52.81%, AlAT increase by 68.75%, CK increases by 8.61%, total cholesterol decreases by 5.88%, HDL increases by 28.18%. Percentage changes in other complete blood count and biochemical indices were within standard limits. Long-term exposure of the subject (50 days) to extreme cold stress had no noticeable negative effect on daily functioning.

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Path of least resistance: how computerised provider order entry can lead to (and reduce) wasteful practices

BMJ Open Quality ◽

10.1136/bmjoq-2018-000345 ◽

2018 ◽

Vol 7 (2) ◽

pp. e000345 ◽

Cited By ~ 1

Author(s):

Joseph Choi ◽

Cori Rebecca Atlin

Keyword(s):

Blood Count ◽

Complete Blood Count ◽

Clinical Care ◽

Work Flow ◽

Quality Improvement Initiative ◽

Order Entry ◽

Clinical Value ◽

Careful Planning ◽

Order Sets ◽

Before And After

BackgroundComputerised provider order entry (CPOE) is rapidly becoming the mainstay in clinical care and has the potential to improve provider efficiency and accuracy. However, this hinges on careful planning and implementation. Poorly planned CPOE order sets can lead to undetected errors and waste. In our emergency department (ED), lactate dehydrogenase (LDH) was bundled into various blood work panels but had little clinical value.ObjectivesThis quality improvement initiative aimed to reduce unnecessary LDH testing in the ED.MethodsA group of ED physicians reviewed CPOE blood work panels and uncoupled LDH in conditions where it was deemed not to provide any clinically useful information. We measured the daily number of LDH tests performed before and after its removal. We tracked the frequency of other serum tests as controls. We also analysed the number of add-on LDH (ie, to add LDH to samples already sent to the lab) as a balancing measure, since this can disrupt work flow and delay care.ResultsThrough this intervention, we reduced the number of LDH tests performed by 69%, from an average of 75.1 tests per day to 23.2 (P<0.0005). The baseline controls did not differ after the intervention (eg, a complete blood count was performed 197.7 and 196.1 times per day preintervention and postintervention, respectively (P=0.7663)). There was less than one add-on LDH per day on average.ConclusionsCPOE care templates can be powerful in shaping behaviours and reducing variability. However, close oversight of these panels is necessary to prevent errors and waste.

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Assessment of blood morphology, electrolyte level as well as kidney and liver function before and after leaving the water in a winter swimmers during the entire winter swimming season - a case study

Rehabilitacja Medyczna ◽

10.5604/01.3001.0013.1131 ◽

2019 ◽

Vol 22 (4) ◽

pp. 25-33

Author(s):

Bartłomiej Ptaszek ◽

Jakub Marchewka ◽

Andrzej Mikuśkiewicz ◽

Patrycja Pietraszewska ◽

Sylwia Przybyło ◽

...

Keyword(s):

Liver Function ◽

Blood Serum ◽

Liver Enzymes ◽

Cold Water ◽

Pathological Changes ◽

Electrolyte Level ◽

Blood Morphology ◽

Before And After ◽

The Subject

Study aim: The aim of the study was to assess blood morphology, electrolyte level as well as indices of kidney function and the activity of selected liver enzymes determining liver function before and after exiting the water in a winter swimmer (“Walrus”) from the “Kaloryfer” (“Radiator”) Krakow Winter Swimming Club during the whole winter bathing season. Materials and methods: The subject of research was a winter swimmer from the “Radiator” Krakow Winter Swimming Club  a 53-year-old male. Blood was collected from the subject: at the beginning of the winter swimming season, during (five times) and at the end of the season (each time before and after getting out of the water); time maintaining in water: 10 minutes. Results: Analysing the average values of the indices before and after exiting the water, statistically significant increases were noted in AST [U/L] by 6.4% and LDH [U/L] by 2.45%, as well as a decrease in Na+ [mmol/l] by 1.14%, Clˉ [mmol/l] by 1.78% and urea [mmol/l] by 3.64%. Conclusions: Regular baths taken by the winter swimmers in cold water did not affect blood morphology indices and did not cause pathological changes in kidney profile. Furthermore, slight fluctuations regarding the concentration of electrolytes in the blood serum and changes in the hepatic profile additionally “externalised” health problems, which appeared prior to winter swimming.

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What does Winter Swimming Have to do with Balneotherapy?

Acta Balneologica ◽

10.36740/abal202101109 ◽

2021 ◽

Vol 63 (1) ◽

pp. 60-64

Author(s):

Anna Kokocińska ◽

Przemysław Adamczyk ◽

Irena Ponikowska

Keyword(s):

Blood Count ◽

Cold Water ◽

Complete Blood Count ◽

Endocrine System ◽

Mechanisms Of Action ◽

Cardiorespiratory System ◽

Extreme Sports ◽

Beneficial Effects ◽

Complex Procedure ◽

Oxidative Processes

Winter swimming is a complex procedure that simultaneously includes the effects of cold, water itself, physical activity, and the climate factor. All these elements are used in thermal medicine in a milder form. They also have a lot in common with Kneipp hardening therapy. In winter swimming, belonging to extreme sports, extremely strong stimuli act simultaneously. Winter swimming positively affects the cardiorespiratory system, complete blood count, musculoskeletal system, endocrine system, immune system, the skin, metabolic processes, and the mental sphere. Empirically, many beneficial effects of winter swimming have been discovered, but there is very little scientific research showing this procedure’s mechanisms of action. Hence, they are often based on hypotheses. The mechanisms of action of winter swimming on complete blood count and the organism’s oxidative processes are best explained. However, the explanation of the mechanisms of action is mostly based on research conducted in cryotherapy. To obtain beneficial health effects, it is necessary to prepare properly for winter swimming and comply with the entire process’s rules, from preparation, through the treatment itself, to behavior after the procedure. In recent years, handbooks and guides have appeared in Poland that contain practical tips on the winter swimming procedure.

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Thermovision Analysis Changes of Human Hand Surface Temperature in Cold Pressor Test

BioMed Research International ◽

10.1155/2015/783642 ◽

2015 ◽

Vol 2015 ◽

pp. 1-5 ◽

Cited By ~ 4

Author(s):

Agnieszka Chwałczyńska ◽

Katarzyna Gruszka ◽

Ireneusz Całkosiński ◽

Krzysztof A. Sobiech

Keyword(s):

Surface Temperature ◽

Cold Water ◽

Cold Pressor Test ◽

Circulatory System ◽

Cold Pressor ◽

Human Hand ◽

Average Weight ◽

Pressor Test ◽

Significant Difference ◽

Before And After

The cold pressor test (CTP) as a diagnostic method of the circulatory system reactivity may be a basis for the qualification for thermal stimulation therapy. The aim of the work was a thermovisual assessment of the reaction to the Hines and Brown cold pressor test. A group of 30 healthy men in the age of 23.5 ± 0.8 years were examined. The average weight of the examinees was 78.4 ± 9.2 kg, their height 180.7 ± 5.9 cms, and BMI 23.9 ± 2.2 kg/m2. A thermovisual picture of a tested and not tested hand of all the subjects was taken before and after the cold pressor test. Under the influence of cold water the surface temperature of a tested hand has decreased in a statistically significant way by 8.3°C on average, which is 29% of the temperature before the test, whilst the temperature of an untested hand dropped by 0.67°C. The decreases of temperature were not even and there was a statistically significant difference between the dorsal and palmar side of the hand. The correlation between the changes of systolic blood pressure and the hand surface temperature before and after CTP was observed.

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The Efficiency of Rectal Fluid Therapy in Moderately Dehydrated Horses

Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca Veterinary Medicine ◽

10.15835/buasvmcn-vm:004917 ◽

2018 ◽

Vol 75 (1) ◽

pp. 73

Author(s):

Patricia AȘTELEAN ◽

Eva DIUGAN ◽

Cristian MOLNAR ◽

Orsolya SÁRPATAKI ◽

Răzvan CODEA ◽

...

Keyword(s):

Fluid Therapy ◽

Blood Count ◽

Animal Species ◽

Complete Blood Count ◽

Rectal Administration ◽

Response To Therapy ◽

Blood Samples ◽

Before And After ◽

Life Threatening ◽

Laboratory Investigations

Dehydration and hydro-electrolytic imbalances are relatively common and life threatening conditions in many animal species including horses. In the present study, we highlighted the efficacy of rectal rehydration in horses, nowadays less commonly used. The study was performed on eight non-pregnant mares (Romanian semigreus and Lipiţan breeds), from Beclean horse stud farm, affected by mild dehydration. The method consists in rectal administration in the form of a high enema of a balanced polyionic solution by using an esophageal tube; the solution contains water, sodium chloride and potassium chloride. Blood samples were collected on EDTA and procoagulant vacutainers, before and after fluid therapy. Laboratory investigations include complete blood count and electrolytes measurement, total protein, albumin, and creatinine. Expectedly, dehydrated animals shown borderline elevated hematocrit associated with mild relative hyperproteinemia and hypernatremia, and elevated uremia levels. In all cases, the parameters were restored in response to therapy, and no side effects were recorded.

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Investigating the genetic architecture of disease resilience in pigs by genome-wide association studies of complete blood count traits collected from a natural disease challenge model

BMC Genomics ◽

10.1186/s12864-021-07835-4 ◽

2021 ◽

Vol 22 (1) ◽

Author(s):

Xuechun Bai ◽

Tianfu Yang ◽

Austin M. Putz ◽

Zhiquan Wang ◽

Changxi Li ◽

...

Keyword(s):

Blood Cell ◽

Genetic Architecture ◽

Blood Count ◽

Complete Blood Count ◽

Association Studies ◽

Genome Wide Association ◽

Genome Wide Association Studies ◽

Genome Wide ◽

Before And After ◽

Genomic Regions

Abstract Background Genetic improvement for disease resilience is anticipated to be a practical method to improve efficiency and profitability of the pig industry, as resilient pigs maintain a relatively undepressed level of performance in the face of infection. However, multiple biological functions are known to be involved in disease resilience and this complexity means that the genetic architecture of disease resilience remains largely unknown. Here, we conducted genome-wide association studies (GWAS) of 465,910 autosomal SNPs for complete blood count (CBC) traits that are important in an animal’s disease response. The aim was to identify the genetic control of disease resilience. Results Univariate and multivariate single-step GWAS were performed on 15 CBC traits measured from the blood samples of 2743 crossbred (Landrace × Yorkshire) barrows drawn at 2-weeks before, and at 2 and 6-weeks after exposure to a polymicrobial infectious challenge. Overall, at a genome-wise false discovery rate of 0.05, five genomic regions located on Sus scrofa chromosome (SSC) 2, SSC4, SSC9, SSC10, and SSC12, were significantly associated with white blood cell traits in response to the polymicrobial challenge, and nine genomic regions on multiple chromosomes (SSC1, SSC4, SSC5, SSC6, SSC8, SSC9, SSC11, SSC12, SSC17) were significantly associated with red blood cell and platelet traits collected before and after exposure to the challenge. By functional enrichment analyses using Ingenuity Pathway Analysis (IPA) and literature review of previous CBC studies, candidate genes located nearby significant single-nucleotide polymorphisms were found to be involved in immune response, hematopoiesis, red blood cell morphology, and platelet aggregation. Conclusions This study helps to improve our understanding of the genetic basis of CBC traits collected before and after exposure to a polymicrobial infectious challenge and provides a step forward to improve disease resilience.

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Investigating the genetic architecture of disease resilience in pigs by genome-wide association studies of complete blood count traits collected from a natural disease challenge model

10.21203/rs.3.rs-50174/v1 ◽

2020 ◽

Author(s):

Xuechun Bai ◽

Tianfu Yang ◽

Austin Putz ◽

Zhiquan Wang ◽

Changxi Li ◽

...

Keyword(s):

Blood Cell ◽

Genetic Architecture ◽

Blood Count ◽

Complete Blood Count ◽

Association Studies ◽

Genome Wide Association ◽

Genome Wide Association Studies ◽

Genome Wide ◽

Before And After ◽

Genomic Regions

Abstract BackgroundGenetic improvement for disease resilience is anticipated to be a practical method to improve efficiency and profitability of the pig industry, as resilient pigs maintain a relatively undepressed level of performance in the face of infection. However, multiple biological functions are known to be involved in disease resilience and this complexity means that the genetic architecture of disease resilience remains largely unknown. Here, we conducted genome-wide association studies (GWAS) of 465,910 autosomal SNPs for complete blood count (CBC) traits that are important in an animal’s disease response. The aim was to identify the genetic control of disease resilience.ResultsUnivariate and multivariate single-step GWAS were performed on fifteen CBC traits measured from the blood samples of 2743 crossbred (Landrace × Yorkshire) barrows drawn at 2-weeks before, and at 2 and 6-weeks after exposure to a polymicrobial infectious challenge. Overall, at a genome-wise false discovery rate of 0.05, five genomic regions located on Sus scrofa chromosome (SSC) 2, SSC4, SSC9, SSC10, and SSC12, were significantly associated with white blood cell traits in response to the polymicrobial challenge, and nine genomic regions on multiple chromosomes (SSC1, SSC4, SSC5, SSC6, SSC8, SSC9, SSC11, SSC12, SSC17) were significantly associated with red blood cell and platelet traits collected before and after exposure to the challenge. By functional enrichment analyses using Ingenuity Pathway Analysis (IPA) and literature review of previous CBC studies, candidate genes located nearby significant single-nucleotide polymorphisms were found to be involved in immune response, hematopoiesis, red blood cell morphology, and platelet aggregation.ConclusionsThis study helps to improve our understanding of the genetic basis of CBC traits collected before and after exposure to a polymicrobial infectious challenge and provides a step forward to improve disease resilience.

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Complete Blood Count before and after Total Hip or Knee Arthroplasty

Journal of Orthopaedic Surgery ◽

10.1177/230949901502300220 ◽

2015 ◽

Vol 23 (2) ◽

pp. 209-212 ◽

Cited By ~ 1

Author(s):

Devin M Jagow ◽

Shahan V Yacoubian ◽

Stephan V Yacoubian

Keyword(s):

Knee Arthroplasty ◽

Blood Count ◽

Complete Blood Count ◽

Total Hip ◽

Before And After

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Evaluation of Complete Blood Count Parameters Before and After Appendectomy

European Archives of Medical Research ◽

10.4274/eamr.galenos.2018.87597 ◽

2019 ◽

Vol 35 (3) ◽

pp. 143-146

Author(s):

Burak Katipoğlu ◽

Togay Evrin ◽

Ayhan Sümer Yaman

Keyword(s):

Blood Count ◽

Complete Blood Count ◽

Before And After

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Hemoglobin, Hematocrit, Leukocyte, and Platelet Changes Due To Ultrafiltrationhemodialysis in Chronic Kidney Disease Patients

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY ◽

10.24293/ijcpml.v26i3.1565 ◽

2020 ◽

Vol 26 (3) ◽

Author(s):

Nathalya Dwi Kartikasari ◽

Paulus Budiono Notopuro ◽

Widodo Widodo ◽

Yetti Hernaningsih

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Blood Count ◽

Complete Blood Count ◽

Proper Time ◽

Cross Sectional Study ◽

Blood Sampling ◽

Sectional Study ◽

Cross Sectional ◽

Before And After

Managing anemia in Chronic Kidney Disease (CKD) patients with hemodialysis (HD) is a challenge to physicians. The present consensus does not address the proper time of blood sampling in HD patients, but higher ultrafiltration (UF) volume (a process of removing fluid excess during HD) may alter hematologic parameters. The objective of this study was to compare some parameters of the Complete Blood Count (CBC); hemoglobin (Hb), hematocrit (Hct), leukocyte (WBC), and platelet counts (Plt) before and after HD. This method was a cross-sectional study performed in the HD Unit, Dr.Soetomo Hospital, including 51 CKD patients selected consecutively, divided into two groups based on the UF volume (2 L and >2 L). Complete blood count pre- and post-HD were measured using Sysmex XN 1000. The results were 25 males and 26 females in this study, age ranged from 20 to 74-year-old, and 36 patients with UF volume >2 L. Only HD with UF >2 L showed significant increases for Hb (9.35g/dL to 10.00 g/dL), Hct (29.80% to 31.15 %), and Plt (209.00x103/µL to 213.00x103/µL) but WBC did not change significantly. These changes were believed to be caused by ultrafiltration. The conclusion was Hb, Hct, and Plt increased significantly with UF ≥2 L in HD CKD patients.

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