scholarly journals Dopamine Transporter Imaging, Current Status of a Potential Biomarker: A Comprehensive Review

2021 ◽  
Vol 22 (20) ◽  
pp. 11234
Author(s):  
Giovanni Palermo ◽  
Sara Giannoni ◽  
Gabriele Bellini ◽  
Gabriele Siciliano ◽  
Roberto Ceravolo
Keyword(s):  
Dopamine Transporter ◽  
Predictive Biomarker ◽  
Current Status ◽  
Imaging Biomarker ◽  
Target Engagement ◽  
Major Goal ◽  
Dopamine Transporter Imaging ◽  
Potential Biomarker ◽  
The Status

A major goal of current clinical research in Parkinson’s disease (PD) is the validation and standardization of biomarkers enabling early diagnosis, predicting outcomes, understanding PD pathophysiology, and demonstrating target engagement in clinical trials. Molecular imaging with specific dopamine-related tracers offers a practical indirect imaging biomarker of PD, serving as a powerful tool to assess the status of presynaptic nigrostriatal terminals. In this review we provide an update on the dopamine transporter (DAT) imaging in PD and translate recent findings to potentially valuable clinical practice applications. The role of DAT imaging as diagnostic, preclinical and predictive biomarker is discussed, especially in view of recent evidence questioning the incontrovertible correlation between striatal DAT binding and nigral cell or axon counts.

The Status, Development and Future Role of Radiobeacon Differential GNSS

1998 ◽  
Vol 51 (2) ◽  
pp. 152-158 ◽  
Author(s):  
N. Ward
Keyword(s):  
Global Navigation Satellite Systems ◽  
Current Status ◽  
Automatic Identification ◽  
Future Role ◽  
Satellite Systems ◽  
Advantages And Disadvantages ◽  
The Status ◽  
Differential Corrections ◽  
Global Navigation Satellite

Marine radiobeacons have been used to broadcast differential corrections for global navigation satellite systems (DGNSS) for nearly a decade. The method has become the accepted international standard for maritime applications. The background to the development of the system is described and the current status of radiobeacon DGNSS services around the world reported. The applications are discussed, including the function of radiobeacon DGNSS as the position sensor within integrated systems, together with the performance requirements imposed by associated systems such as ECDIS and Automatic Identification Systems. The advantages and disadvantages of the radiobeacon system in regulatory, administrative and technical terms are discussed and the potential for development of the system is considered. The future role of radiobeacon DGNSS in the overall mix of systems is assessed taking into account the introduction of geo-stationary overlays, and possibly Loran-C, for provision of DGNSS corrections.

Role of dopamine transporter imaging in the diagnosis of atypical tremor disorders

2003 ◽  
Vol 18 (S7) ◽  
pp. S22-S27 ◽  
Author(s):  
Vicky Marshall ◽  
Donald G. Grosset
Keyword(s):  
Dopamine Transporter ◽  
Dopamine Transporter Imaging

Current Status of Breast Ultrasound

2011 ◽  
Vol 62 (1) ◽  
pp. 31-40 ◽  
Author(s):  
Anat Kornecki
Keyword(s):  
High Risk ◽  
Breast Imaging ◽  
Breast Ultrasound ◽  
Current Status ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Tumour Extension ◽  
The Status ◽  
High Risk Populations

Ultrasound (US) has a significant role in diagnostic breast imaging. It is most commonly used as an adjunctive test in characterizing lesions detected by other imaging modalities or by clinical examination. US is recognized as the modality of choice in the evaluation of women who are symptomatic and younger than 30 years of age, pregnant, or lactating. Combined mammography and US appear to have a role in screening high-risk populations. The use of standard Breast Imaging Reporting and Data System US lexicon is helpful in guiding the differentiation between benign and malignant sonographic signs. Biopsy is warranted when benign features are absent or for any feature consistent with malignancy, despite other benign findings. Whole breast and axillary US are useful in assessing tumour extension, multifocality, and the status of axillary lymph nodes. US is the modality of choice for guiding interventional breast procedures. The role of US as a guidance tool for nonoperative breast treatment is being investigated.

The role of dopamine transporter imaging agent [ 99m Tc]TRODAT-1 in hemi-parkinsonism rat brain

2001 ◽  
Vol 28 (8) ◽  
pp. 923-928 ◽  
Author(s):  
Yen-Kung Chen ◽  
Ren-Shyan Liu ◽  
Wen-Sheng Huang ◽  
Shiaw-Pyng Wey ◽  
Gann Ting ◽  
...  
Keyword(s):  
Rat Brain ◽  
Dopamine Transporter ◽  
Imaging Agent ◽  
Dopamine Transporter Imaging

Dementia with Lewy bodies versus Alzheimer's disease: Role of dopamine transporter imaging

2003 ◽  
Vol 18 (S7) ◽  
pp. S34-S38 ◽  
Author(s):  
Durval C. Costa ◽  
Zuzana Walker ◽  
Rodney W.H. Walker ◽  
Fl�via R.G. Fontes
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Dopamine Transporter ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Dopamine Transporter Imaging

scholarly journals Disaster Management and Role of Academic Institutions in Nepal: Current Status and Way Forward

2020 ◽  
pp. 27-35
Author(s):  
Ramesh Raj Pant ◽  
Kiran Bishwakarma ◽  
Archana Ghimire ◽  
Kripa Shrestha ◽  
Rejina Maskey ◽  
...  
Keyword(s):  
Current Status ◽  
Academic Institutions ◽  
Great Loss ◽  
Knowledge Based ◽  
Legal Provisions ◽  
Research Activities ◽  
Resilient Communities ◽  
The Status ◽  
Policies And Programs

The intense natural disasters have been causing the great loss of life and properties in Nepal. This study attempts to figure out the status and role of Nepalese academia for the contribution of disaster risk reduction and management (DRRM). The methodology adopted for the study is reviewing the literature, policies, and academic documents including university curricula. The study highlighted that the constitution of Nepal 2015 and DRRM Act 2017 have provided ample opportunities via several legal provisions for federal, provincial, and local government to make their own modalities for making a disaster-resilient society. The universities and higher academic institutions are responsible for sound knowledge-based research activities to address the issues of DRRM which could be directly adopted by different levels of governments in terms of their plans, policies, and programs. In this connection, attempts are being made by governments and academic institutions to develop disaster resilient communities by shifting the traditional way of just responding during disaster focusing on the disaster cycle. Precisely, ten major universities of Nepal have incorporated disaster components including preparedness, response, recovery, and mitigation-related academic curricula in their undergraduate and graduate levels academic programs. Introducing the Environmental Health in Disaster, and Public Health and Disaster Engineering in Tribhuvan University and Pokhara University, respectively is one of the good initiatives taken by the academia. However, there is still room for improvement in terms of the integration of DRRM courses in the curricula of higher academic institutions for making disaster-resilient communities.

Engineer to Educator

2019 ◽  
pp. 63-67
Author(s):  
Sara B. Smith
Keyword(s):  
High School ◽  
Present State ◽  
Gifted And Talented ◽  
School Teacher ◽  
High School Teacher ◽  
Status Quo ◽  
Current Status ◽  
Highly Qualified ◽  
The Status

In this chapter, the author traces her path from youth all the way through her current status as a high school teacher. The author describes some of the benefits and difficulties experienced as a gifted and talented adult who has found herself in the role of teacher. The hope is that some of what she shares will stimulate thought and discussion about the present state of education and how to hold on to truly highly qualified educators. Our students need great teachers; teachers who are passionate, knowledgeable, and who are not afraid to push the status quo. Gifted and talented educators can provide a tough, lasting education. We can teach students more than the content. At the same time we are nurturing our students, we, too, need to be nurtured.

scholarly journals Dilated Virchow-Robin Space and Dopamine Transporter Imaging in the Striatum of Patients with Parkinsonism

2015 ◽  
Vol 42 (4) ◽  
pp. 248-254 ◽  
Author(s):  
Dokyung Lee ◽  
Il Ki Hong ◽  
Tae-Beom Ahn
Keyword(s):  
Dopamine Transporter ◽  
Clinical Status ◽  
Brain Magnetic Resonance Imaging ◽  
Caudate Nuclei ◽  
Dopamine Transporter Imaging ◽  
Positron Emission ◽  
Mini Mental Status Examination ◽  
The Relationship ◽  
Virchow Robin Space

AbstractObjective: The radiological and clinical significance of a dilated Virchow-Robin space (dVRS) in the striatum (STR) remains unclear. We investigated the role of dVRS in STR on parkinsonism and dopamine transporter positron emission tomography (DaT-PET) findings. Methods: Patients with parkinsonism who underwent both brain magnetic resonance imaging and DaT-PET were included. Clinical status was evaluated by Hoehn and Yahr (HY) stage, Korean-Mini Mental Status Examination (K-MMSE), Montreal Cognitive Assessment Korea (MoCA-K), and Frontal Assessment Battery (FAB). dVRS was assessed by semi-quantitative and quantitative scales in each of the three segments of STR (caudate nuclei, anterior and posterior putamen) and was expressed as a dVRS score. DaT-PET was qualitatively assessed as either normal or abnormal in each segment. The relationship between dVRS and DaT-PET abnormality (ab-DaT-PET) was designated in each segment as either concordant or discordant. A concordant segment was defined by the presence of dVRS with ab-DaT-PET [Concordance rate (CR)=number of concordant segments/number of concordant and discordant segments]. Results: Eleven patients were included. There was no significant correlation between the presence of dVRS and ab-DaT-PET. The mean CR was 0.39. CR was not significantly correlated with any clinical or neuroimaging scales. The dVRS score was significantly correlated with K-MMSE, MoCA-K, and FAB (r=−0.675, −0.847, and −0.868, respectively) but not with HY stage. Conclusion: dVRS in STR played no significant role on dopaminergic innervation revealed by DaT-PET and made little contribution to clinical parkinsonism; however, it was correlated with cognitive impairment.

Sign in / Sign up

Export Citation Format

Share Document