scholarly journals Patient-Derived Human Basal and Cutaneous Squamous Cell Carcinoma Tissues Display Apoptosis and Immunomodulation Following Gas Plasma Exposure with a Certified Argon Jet

2021 ◽  
Vol 22 (21) ◽  
pp. 11446
Author(s):  
Fariba Saadati ◽  
Juliane Moritz ◽  
Julia Berner ◽  
Eric Freund ◽  
Lea Miebach ◽  
...  

Reactive oxygen species (ROS) have been subject of increasing interest in the pathophysiology and therapy of cancers in recent years. In skin cancer, ROS are involved in UV-induced tumorigenesis and its targeted treatment via, e.g., photodynamic therapy. Another recent technology for topical ROS generation is cold physical plasma, a partially ionized gas expelling dozens of reactive species onto its treatment target. Gas plasma technology is accredited for its wound-healing abilities in Europe, and current clinical evidence suggests that it may have beneficial effects against actinic keratosis. Since the concept of hormesis dictates that low ROS levels perform signaling functions, while high ROS levels cause damage, we investigated herein the antitumor activity of gas plasma in non-melanoma skin cancer. In vitro, gas plasma exposure diminished the metabolic activity, preferentially in squamous cell carcinoma cell (SCC) lines compared to non-malignant HaCaT cells. In patient-derived basal cell carcinoma (BCC) and SCC samples treated with gas plasma ex vivo, increased apoptosis was found in both cancer types. Moreover, the immunomodulatory actions of gas plasma treatment were found affecting, e.g., the expression of CD86 and the number of regulatory T-cells. The supernatants of these ex vivo cultured tumors were quantitatively screened for cytokines, chemokines, and growth factors, identifying CCL5 and GM-CSF, molecules associated with skin cancer metastasis, to be markedly decreased. These findings suggest gas plasma treatment to be an interesting future technology for non-melanoma skin cancer topical therapy.

2021 ◽  
Vol 15 (12) ◽  
pp. 3402-3404
Author(s):  
Hina , Manzoor ◽  
Najeeb Ahmad ◽  
Zafar H Tanveer ◽  
Khush Naseed Ahmed ◽  
Munir , Ahmed ◽  
...  

Background: Skin cancer is a broad term that refers to a variety of different types of cancer. It is usually recognized as non-melanoma and melanoma skin cancer. In many parts of the world, the prevalence is high, with significant ecological and ethical variation. Objectives: Objective was to determine demographic and histological features of skin cancer in Southwest region of Pakistan. Methodology: This retrospective study was carried out on skin cancer 1169 cases of Centre for Nuclear Medicine and Radiotherapy (CENAR) in Quetta. The data from January 2000 to December 2009 (10Years) was retrieved from record. The aim was to determine the importance of skin cancer in this area, its gender wise distribution and its pathological types. Results: Record of total 9308 cancer patients was retrieved from patients presenting to CENAR Quetta. From 9308 case, 1169(12.5%) patients were of skin cancer which was second most prevalent category of cancer in this area. Prevalence was higher in males with 713(61%) cases as compared to females. Pathologically with 634(54%) cases, the most prevalent category was Squamous cell carcinoma (SCC). Conclusion: Skin cancer is wide-spread type of cancer in patients of south-west region of Pakistan. The findings of this study are not aligned with published data. The difference is because of high altitude of the study area, dry climate and long skin exposure particularly in low socio-economic field workers. Keywords: Skin cancer, gender, Melanoma skin cancer (MSC), Squamous cell carcinoma (SCC), Non-melanoma skin cancer (NMSC), Basal cell carcinoma (BCC),


2009 ◽  
Vol 8 (1) ◽  
pp. 91
Author(s):  
Sarah Regina de Paula Sousa ◽  
Júlio Cesar Andriotti Borges ◽  
Pedro Aquino Ferreira Paulo ◽  
Raimundo F. de Araújo-Júnior

O Carcinoma de Células Escamosas (SCC) é a segunda neoplasia maligna cutânea mais freqüente, causada primordialmente pela exposição crônica e excessiva à radiação ultravioleta. O objetivo deste trabalho é discutir o perfil epidemiológico global do SCC através de uma revisão sistemática. Foi realizada uma busca na base de dados PUBMED com a utilização dos termos: squamous cells skin cancer, epidemiology squamous cells skin cancer, penile squamous cell carcinoma, squamous cell carcinoma of the penis, vulva SCC epidemiology e depletion of ozone layer. Outra busca foi realizada na base de dados SCIENCE DIRECT, com os termos: epidemiology of non-melanoma skin cancer, epidemiology of squamous cells carcinoma, squamous cells carcinoma, skin cancer, e, por fim, o termo UV radiation. No total, 19 artigos foram selecionados, sendo considerados aqueles publicados a partir de 2000. A revisão permitiu verificar que estudos em países de todos os continentes mostram um número crescente de casos, o que configura um grave problema de saúde pública mundial.


2015 ◽  
Vol 19 (3) ◽  
pp. 249-259 ◽  
Author(s):  
Mariusz Sapijaszko ◽  
David Zloty ◽  
Marc Bourcier ◽  
Yves Poulin ◽  
Peter Janiszewski ◽  
...  

Background Squamous cell carcinoma (SCC) is the second-most common form of non-melanoma skin cancer (NMSC). Objective To provide guidance to Canadian health care practitioners regarding management of SCCs. Methods Literature searches and development of graded recommendations were carried out as discussed in the accompanying introduction (chapter 1 of the NMSC guidelines). Results SCCs are sometimes confined to the epidermis, but they can also invade nearby tissues and, in some cases, metastasize to neighbouring lymph nodes or other organs. This chapter discusses the natural history, staging, prognosis, and management of SCC—a tumour type that is less common but typically more aggressive than BCC. For this reason, margin control is strongly preferred in treating SCCs. Conclusions Although approaches such as cryosurgery and radiation therapy may be considered for some patients, surgical excision—sometimes coupled with radiation—remains the cornerstone of SCC management. Patients with high-risk SCC may also be considered for referral to an appropriate multidisciplinary clinic.


2015 ◽  
Vol 20 (2) ◽  
pp. 166-175 ◽  
Author(s):  
Mariam Abbas ◽  
Sunil Kalia

Background: Despite its increased incidence and status as the most prevalent cancer in Canada, there is a paucity of epidemiological data on non-melanoma skin cancer (NMSC). Objective: To assess trends of keratinocyte carcinomas (KC) in Canada over 5 decades. Methods: Articles published from 1960 to 2015 on NMSC in Canada were identified through MEDLINE. Six articles met our search criteria. Results: Overall, KC has increased. However, the rate of increase in the past decade has slowed down and decreased in younger age cohorts. Men had higher incidences of KC. In both sexes, the basal cell carcinoma and squamous cell carcinoma ratio was ≥2.5:1. Keratinocyte carcinomas were most commonly located on the head and neck, and increasing rates are occurring on the trunk. Limitations: The methods of registering skin cancer cases vary among different provinces. Conclusion: Keratinocyte carcinomas incidence is overall increasing; however, there may be evidence that the incidence is leveling off and decreasing in younger age cohorts.


2022 ◽  
Vol 2 (1) ◽  
pp. 107-114
Author(s):  
LUZ DARY GUTIÉRREZ-CASTAÑEDA ◽  
JOHN NOVA ◽  
MARÍA IRENE CEREZO-CORTÉS

Background/Aim: Non-melanoma skin cancer is the most common cancer in the world. Somatic mutations in the TP53 gene are associated with the development of this cancer. To describe mutations in exons 5-8 of the TP53 gene in a sample of Colombian patients with non-melanoma skin cancer. Materials and Methods: One hundred and fifteen patients with non-melanoma skin cancer were included. Exons 5-8 were amplified and analyzed by PCR-High Resolution Melting and Sanger sequencing. Results: Fifty-seven patients with basal cell carcinomas and 58 with squamous cell carcinomas were studied. 16% of patients with basal cell carcinoma and 26% of patients with squamous cell carcinoma had mutations in the TP53 gene. The most frequent mutations were substitutions, while three patients had deletions. The most frequent mutation was p.R158G. Conclusion: The analysis showed that Colombian individuals with non-melanoma skin cancer have genetic TP53 variants different from those reported as recurrent for this disease.


2015 ◽  
Vol 130 (S1) ◽  
pp. S26-S31 ◽  
Author(s):  
R F Coombe ◽  
A K Lam ◽  
J O'Neill

AbstractBackground:Parotid gland tumours are complex neoplasms with a broad histological range. The parotid gland is also a common site of face and scalp skin cancer metastases.Method:Parotidectomies performed by ENT department in the Gold Coast health district from 2006 to 2013.Results:A total of 158 specimens were examined. Of these, 53.80 per cent were benign and 46.20 per cent were malignant. Pleomorphic adenoma was the most common tumour (29.11 per cent), followed by cutaneous squamous cell carcinoma (23.42 per cent) and Warthin's tumour (12.03 per cent).Conclusion:Metastatic squamous cell carcinoma accounted for a large proportion of parotid masses in our case series, reflecting the high prevalence of non-melanoma skin cancer in Australia. Primary parotid neoplasms had similar incidence rates to other studies.


Author(s):  
HARSHIT SHAH

NMSC (Non-melanoma skin cancer) is the most commonly occurring malignancy in Caucasians. Out of all diagnosed NMSC cases, 95% of the cases are of basal cell carcinoma and squamous cell carcinoma. The therapeutic approaches to cure or ultimately rescue the skin area affected by NMSC include surgical methods, photodynamic therapy, radiation therapy, immunotherapy, and chemotherapy. This article aims to provide a brief overview of the preliminary mechanism of action, clinical studies, advantages, and disadvantages of currently available treatment modalities.


Author(s):  
Bushra Mohammed Ali ◽  
Hiwa Abas Ahmed

Objectives are to identify the frequency of non-melanoma skin cancer cases were registered at Hiwa hospital and to find out the association between cases and controls with their sociodemographic status and risk factors. A case control approach was used, by retrospective chart review of all non-melanoma skin cancer cases presented between 1st of January 2015 till 31st of December 2016 at Sulaimani Hiwa hospital from which 70 cases conducted   and 70 controls from Baxshen hospital. Data entered to Microsoft excel, analysed by SPSS V 21. Chi-square test was employed to assess the association between different variables, P value of 0.05 or less considered as statistical significant This study included 70 cases and 70 controls were age and gender matched,  most of the cases were in between age 56-70 years old, illiterate 39(55.7%),  jobless 26(37.1%), from urban area 45 (64.3%) , married 65 (92.9%). had sufficient income and barely sufficient. About (64%) of cases had squamous cell carcinoma and (36%) had basal cell carcinoma. Most of the cases had family history of skin cancer (11.4%), and 44 (62.9%) of cases had a history of more than 4 hours exposure to sun in a day and 36 (51.4%) of cases were with normal BMI. Most of the cases 32 (45.7%) with type (O) blood group, not smoking cigarette 51 (72.9%) and not drinking alcohol 69 (98.6%). This study showed a statistical significant association between non-melanoma skin cancer with level of education (P value =0.002), family history (P value = 0.02), time of exposure to sun light (P value of < 0.001) and BMI (p value = 0.001).  Skin cancer and cancer percentage were in increase pattern especially non-melanoma skin cancer, most of non-melanoma skin cancer cases were squamous cell carcinoma, with a significant association with level of education, income status, time of exposure to sun light, family history and BMI


Sign in / Sign up

Export Citation Format

Share Document