scholarly journals The Role of Vitamin D in Diabetic Nephropathy: A Translational Approach

2022 ◽  
Vol 23 (2) ◽  
pp. 807
Author(s):  
Charlotte Delrue ◽  
Reinhart Speeckaert ◽  
Joris R. Delanghe ◽  
Marijn M. Speeckaert

According to several animal and human studies, vitamin D appears to play a significant role in the development of diabetic nephropathy. However, the possible renoprotective effect of vitamin D and its influence on the reversal of already existing renal damage remains doubtful. At this moment, there are a few hypotheses concerning the underlying molecular and genetic mechanisms including the link between vitamin D and inflammation, oxidative stress, and extracellular matrix accumulation. The present review aims to investigate the potential role of vitamin D in the development of diabetic kidney disease from a translational approach.

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Jorge Rojas-Rivera ◽  
Alberto Ortiz ◽  
Jesus Egido

Drugs targeting the renin-angiotensin-aldosterone system (RAAS) are the mainstay of therapy to retard the progression of proteinuric chronic kidney disease (CKD) such as diabetic nephropathy. However, diabetic nephropathy is still the first cause of end-stage renal disease. New drugs targeted to the pathogenesis and mechanisms of progression of these diseases beyond RAAS inhibition are needed. There is solid experimental evidence of a key role of oxidative stress and its interrelation with inflammation on renal damage. However, randomized and well-powered trials on these agents in CKD are scarce. We now review the biological bases of oxidative stress and its role in kidney diseases, with focus on diabetic nephropathy, as well as the role of the Keap1-Nrf2 pathway and recent clinical trials targeting this pathway with bardoxolone methyl.


2010 ◽  
Vol 23 (2) ◽  
pp. 190-200 ◽  
Author(s):  
Marta Krenz-Niedbała ◽  
Elżbieta A. Puch ◽  
Krzysztof Kościński

Nutrients ◽  
2011 ◽  
Vol 3 (12) ◽  
pp. 1023-1041 ◽  
Author(s):  
Louise O’Mahony ◽  
Magdalena Stepien ◽  
Michael J. Gibney ◽  
Anne P. Nugent ◽  
Lorraine Brennan

Sign in / Sign up

Export Citation Format

Share Document