scholarly journals Biguanide Pharmaceutical Formulations and the Applications of Bile Acid-Based Nano Delivery in Chronic Medical Conditions

2022 ◽  
Vol 23 (2) ◽  
pp. 836
Author(s):  
Melissa Jones ◽  
Corina Mihaela Ionescu ◽  
Daniel Walker ◽  
Susbin Raj Wagle ◽  
Bozica Kovacevic ◽  
...  

Biguanides, particularly the widely prescribed drug metformin, have been marketed for many decades and have well-established absorption profiles. They are commonly administered via the oral route and, despite variation in oral uptake, remain commonly prescribed for diabetes mellitus, typically type 2. Studies over the last decade have focused on the design and development of advanced oral delivery dosage forms using bio nano technologies and novel drug carrier systems. Such studies have demonstrated significantly enhanced delivery and safety of biguanides using nanocapsules. Enhanced delivery and safety have widened the potential applications of biguanides not only in diabetes but also in other disorders. Hence, this review aimed to explore biguanides’ pharmacokinetics, pharmacodynamics, and pharmaceutical applications in diabetes, as well as in other disorders.

1999 ◽  
Vol 185 (1) ◽  
pp. 103-111 ◽  
Author(s):  
Claudia Valenta ◽  
Emil Nowack ◽  
Andreas Bernkop-Schnürch

Nanoscale ◽  
2014 ◽  
Vol 6 (5) ◽  
pp. 2759-2767 ◽  
Author(s):  
Xubo Lin ◽  
Tingting Bai ◽  
Yi Y. Zuo ◽  
Ning Gu

Understanding the interactions between nanoparticles and pulmonary surfactant can help promote the nanoparticle-based respiratory drug carrier systems.


Author(s):  
Rohit Rajendra Bhosale ◽  
Hosahalli Veerabhadrappa Gangadharappa ◽  
Devegowda Vishakante Gowda ◽  
Riyaz Ali Mahafez Ali Osmani ◽  
Rudra Vaghela ◽  
...  

2012 ◽  
Vol 188 ◽  
pp. 1-14 ◽  
Author(s):  
Chau Chun Beh ◽  
Raffaella Mammucari ◽  
Neil R. Foster

Author(s):  
Abraham Domb ◽  
Neeraj Kumar ◽  
Tzviel Sheskin ◽  
Alfonso Bentolila ◽  
Joram Slager ◽  
...  

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