scholarly journals Theranostic Platforms Based on Silica and Magnetic Nanoparticles Containing Quinacrine, Chitosan, Fluorophores, and Quantum Dots

2022 ◽  
Vol 23 (2) ◽  
pp. 932
Author(s):  
Dmitry V. Korolev ◽  
Galina A. Shulmeyster ◽  
Natalia V. Evreinova ◽  
Maria S. Syrovatkina ◽  
Maria S. Istomina ◽  
...  

In this paper, we describe the synthesis of multilayer nanoparticles as a platform for the diagnosis and treatment of ischemic injuries. The platform is based on magnetite (MNP) and silica (SNP) nanoparticles, while quinacrine is used as an anti-ischemic agent. The synthesis includes the surface modification of nanoparticles with (3-glycidyloxypropyl)trimethoxysilane (GPMS), the immobilization of quinacrine, and the formation of a chitosan coating, which is used to fix the fluorophore indocyanine green (ICG) and colloidal quantum dots AgInS2/ZnS (CQDs), which serve as secondary radiation sources. The potential theranostic platform was studied in laboratory animals.

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Min-Jae Choi ◽  
F. Pelayo García de Arquer ◽  
Andrew H. Proppe ◽  
Ali Seifitokaldani ◽  
Jongmin Choi ◽  
...  

AbstractControl over carrier type and doping levels in semiconductor materials is key for optoelectronic applications. In colloidal quantum dots (CQDs), these properties can be tuned by surface chemistry modification, but this has so far been accomplished at the expense of reduced surface passivation and compromised colloidal solubility; this has precluded the realization of advanced architectures such as CQD bulk homojunction solids. Here we introduce a cascade surface modification scheme that overcomes these limitations. This strategy provides control over doping and solubility and enables n-type and p-type CQD inks that are fully miscible in the same solvent with complete surface passivation. This enables the realization of homogeneous CQD bulk homojunction films that exhibit a 1.5 times increase in carrier diffusion length compared with the previous best CQD films. As a result, we demonstrate the highest power conversion efficiency (13.3%) reported among CQD solar cells.


2018 ◽  
Vol 17 (1) ◽  
pp. 74-82 ◽  
Author(s):  
M. S. Istomina ◽  
E. I. Pochkaeva ◽  
D. L. Sonin ◽  
N. A. Pechnikova ◽  
V. N. Postnov ◽  
...  

The research is devoted to the investigating of the possibility of using colloidal quantum dots, covered by various layers and nanoparticles of chitosan labelled with indocyanin green for fluorescence imaging in vitro and in vivo. Pure quantum dots and dots in the shell synthesized from 3-aminopropyltriethoxysilane and in the shell of albumin were investigated. Research using fluorescence Visualizer IVIS Lumina LT Series III (Perkin Elmer, USA) was conducted. The possibility of using quantum dots for in vitro diagnostics, and chitosan nanoparticles - in vitro and in vivo was presented.


Author(s):  
Lishuang Wang ◽  
Ying Lv ◽  
Jie Lin ◽  
Jialong Zhao ◽  
Xingyuan Liu ◽  
...  

For quantum dots light-emitting diodes (QLEDs), typical colloidal quantum dots (QDs) are usually composed of a core/shell heterostructure which is covered with organic ligands as surface passivated materials to confine...


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