scholarly journals The Role of Mitochondrial DNA Mutations in Cardiovascular Diseases

2022 ◽  
Vol 23 (2) ◽  
pp. 952
Author(s):  
Siarhei A. Dabravolski ◽  
Victoria A. Khotina ◽  
Vasily N. Sukhorukov ◽  
Vladislav A. Kalmykov ◽  
Liudmila M. Mikhaleva ◽  
...  

Cardiovascular diseases (CVD) are one of the leading causes of morbidity and mortality worldwide. mtDNA (mitochondrial DNA) mutations are known to participate in the development and progression of some CVD. Moreover, specific types of mitochondria-mediated CVD have been discovered, such as MIEH (maternally inherited essential hypertension) and maternally inherited CHD (coronary heart disease). Maternally inherited mitochondrial CVD is caused by certain mutations in the mtDNA, which encode structural mitochondrial proteins and mitochondrial tRNA. In this review, we focus on recently identified mtDNA mutations associated with CVD (coronary artery disease and hypertension). Additionally, new data suggest the role of mtDNA mutations in Brugada syndrome and ischemic stroke, which before were considered only as a result of mutations in nuclear genes. Moreover, we discuss the molecular mechanisms of mtDNA involvement in the development of the disease.

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Anna M. Czarnecka ◽  
Ewa Bartnik

Mitochondrial DNA mutations and polymorphisms have been the focus of intensive investigations for well over a decade in an attempt to understand how they affect fundamental processes such as cancer and aging. Initial interest in mutations occurring in mitochondrial DNA of cancer cells diminished when most were found to be the same mutations which occurred during the evolution of human mitochondrial haplogroups. However, increasingly correlations are being found between various mitochondrial haplogroups and susceptibility to cancer or diseases in some cases and successful aging in others.


2013 ◽  
Vol 51 (7-8) ◽  
pp. 588-602 ◽  
Author(s):  
Yu Ding ◽  
Jianhang Leng ◽  
Fan Fan ◽  
Bohou Xia ◽  
Pan Xu

2011 ◽  
Vol 35 ◽  
pp. S92
Author(s):  
A. de Vries ◽  
M. Zwaan ◽  
B. Beverloo ◽  
I. de Coo ◽  
G. Schoonderwoerd ◽  
...  

2008 ◽  
Vol 1777 ◽  
pp. S77-S78 ◽  
Author(s):  
Praturi Gopalakrishna ◽  
Periyasamy Govindaraj ◽  
Ayyasamy Vanniarajan ◽  
Rampalli Viswa Chandra ◽  
Aileni Amarendra Reddy ◽  
...  

2007 ◽  
Vol 226 (1-2) ◽  
pp. 185-193 ◽  
Author(s):  
Tatsuya Yamasoba ◽  
Shinichi Someya ◽  
Chikako Yamada ◽  
Richard Weindruch ◽  
Tomas A. Prolla ◽  
...  

Biomolecules ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. 377 ◽  
Author(s):  
Aleksandrina Volobueva ◽  
Andrey Grechko ◽  
Shaw-Fang Yet ◽  
Igor Sobenin ◽  
Alexander Orekhov

Atherosclerosis-related cardiovascular diseases remain the leading cause of morbidity and mortality, and the search for novel diagnostic and therapeutic methods is ongoing. Mitochondrial DNA (mtDNA) mutations associated with atherosclerosis represent one of the less explored aspects of the disease pathogenesis that may bring some interesting opportunities for establishing novel molecular markers and, possibly, new points of therapeutic intervention. Recent studies have identified a number of mtDNA mutations, for which the heteroplasmy level was positively or negatively associated with atherosclerosis, including the disease at its early, subclinical stages. In this review, we summarize the results of these studies, providing a list of human mtDNA mutations potentially involved in atherosclerosis. The molecular mechanisms underlying such involvement remain to be elucidated, although it is likely that some of them may be responsible for the increased oxidative stress, which plays an important role in atherosclerosis.


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