scholarly journals Correlation between Preoperative Serum Levels of Calcium, Phosphate, and Intact Parathyroid Hormone and Radiological Outcomes in Spinal Interbody Fusion among End-Stage Renal Disease Patients

2021 ◽  
Vol 10 (22) ◽  
pp. 5447
Author(s):  
Ting-Yu Shih ◽  
Yun-Che Wu ◽  
Sheng-Chieh Tseng ◽  
Kun-Hui Chen ◽  
Chien-Chou Pan ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
End Stage Renal Disease ◽  
Interbody Fusion ◽  
Serum Levels ◽  
Screw Loosening ◽  
Fusion Surgery ◽  
Preoperative Serum ◽  
Cage Subsidence ◽  
Stage Renal Disease ◽  
End Stage

Spinal fusion surgery for end-stage renal disease (ESRD) patients is a clinical challenge. This study aimed to investigate whether postoperative radiological outcomes are related to preoperative serum calcium, phosphate, or intact parathyroid hormone (iPTH) levels in patients with ESRD who underwent spinal interbody fusion surgery. This study included 62-consecutive patients with ESRD who underwent anterior cervical discectomy and fusion (ACDF) or transforaminal lumbar interbody fusion (TLIF) surgery for symptomatic spinal disorder. The most recent preoperative serum calcium, phosphate, and iPTH levels were recorded, and the postoperative radiographic outcomes were assessed. A significant correlation was found between the occurrence of cage subsidence and higher blood phosphate, calcium–phosphate product (Ca × P), and iPTH levels in the TLIF group. The occurrence of pedicle screw loosening was related to higher blood phosphate and Ca × P product in the TLIF group. However, no correlation was found between the fusion grades and the serum levels in either the TLIF or ACDF groups. These results indicated that higher preoperative serum phosphate and Ca × P product are risk factors for both cage subsidence and screw loosening in patients with ESRD who underwent TLIF surgery. Higher iPTH levels are also a possible risk factor for cage subsidence.

scholarly journals CUT OFF VALUE OF PROCALCITONIN IN END STAGE RENAL DISEASE PATIENTS WITHOUT INFECTION

2021 ◽  
Vol 5 (02) ◽  
Author(s):  
Naila Asif ◽  
Samina Shamim ◽  
Shafqat Waqar Khanzada ◽  
Muhammad Rizwan
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Serum Levels ◽  
Acute Phase Reactant ◽  
Normal Serum ◽  
Maintenance Hemodialysis ◽  
Maintenance Haemodialysis ◽  
Reactive Protein ◽  
Stage Renal Disease ◽  
End Stage

OBJECTIVE: To determine cut off value of procalciton (PCT) in aseptic end stage renal disease patients undergoing haemodialysis. BACKGROUND: Haemodialysisis considered as a proinflammatory state and therefore associated with release of inflammatory cytokines and acute phase reactant proteins. The conventional laboratory markers (C-reactive protein, erythrocyte sedimentation rate) are efficient tools for the diagnosis of infection in patients with normal kidney functions. However they can be nonspecifically elevated in patients on haemodialysis and only reflect inflammatory response not associated with infection. PCT is considered a very important biomarker in differentiating infections from inflammation. The study was undertaken to evaluate normal serum levels of PCT in patients undergoing HD.PATIENTS AND METHOD: The study included 82 end-stage renal failure patients without evidence of systemic or localized infection undergoing maintenance haemodialysis. RESULTS: In our study, the PCT concentrations showed a mean of .622ng/ml in patients on maintenance hemodialysis without signs of infection. CONCLUSION:The study suggests that serum PCT at a cutoff value of .62ng/ml should be considered normal in aseptic haemodialysis patients. KEYWORDS: Procalcitonin, haemodialysis, sepsis

Evaluation of the Role of Gabapentin and/or Omega-3 in Uremic Pruritus for Patients Undergoing Hemodialysis

2018 ◽  
Vol 9 (SPL1) ◽  
Author(s):  
Sinan Forat Hussein ◽  
Kadhim Ali Kadhim ◽  
Ali JassimAl Sultani ◽  
Saad Abdulrahman Hussain
Keyword(s):  
Renal Disease ◽  
Fish Oil ◽  
End Stage Renal Disease ◽  
Serum Levels ◽  
Efficacy And Safety ◽  
Omega 3 ◽  
Uremic Pruritus ◽  
Stage Renal Disease ◽  
End Stage

Uremic pruritus is chronic itching that occurs in patients with advanced or end-stage renal disease. It is one of common symptoms in patients with end-stage renal disease with approximately 60–90% of patients on hemodialysis (HD) suffering from this problem. This study was designed to evaluate the efficacy and safety of prescribing Gabapentin or Omega-3 alone or in combination for relieving uremic pruritus in Iraqi patients undergoing hemodialysis. The results showed that all the three involved regimens (gabapentin,omega-3,and the combination of both drugs) had significantly reduced the pruritus score. Furthermore,the combination was significantly superior to other regimens in reducing pruritus score,while no significant effect was observed by all the regimens on interleukin-6 or on parathyroid hormone serum levels. In Conclusion Gabapentin 100mg plus 1000mg omega-3 based fish oil capsules containing 120mg is superior to gabapentin 100mg capsule or 1g of omega-3 based fish oil capsule containing 120mg docosahexaenoic acid and 180mg ecosapentaenoic acid (each alone),in reducing pruritus score in a sample of Iraqi patients.

scholarly journals Serum Levels of 1,5-Anhydroglucitol and Risk of Incident End-Stage Renal Disease

2017 ◽  
Vol 186 (8) ◽  
pp. 952-960 ◽  
Author(s):  
Casey M Rebholz ◽  
Morgan E Grams ◽  
Yuan Chen ◽  
Alden L Gross ◽  
Yingying Sang ◽  
...  
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Serum Levels ◽  
Stage Renal Disease ◽  
End Stage

Influence of CAPD and Residual Diuresis on the Serum Levels of Alpha-1-Microglobulin in End-Stage Renal Disease

Nephron ◽  
1989 ◽  
Vol 51 (3) ◽  
pp. 367-369 ◽  
Author(s):  
M.H. Weber ◽  
P. Reetze ◽  
F. Neumann ◽  
G. Warneke ◽  
F. Scheler
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Serum Levels ◽  
Stage Renal Disease ◽  
End Stage ◽  
Residual Diuresis

scholarly journals Parathyroid Hormone Status in Patients with End Stage Renal Disease on Maintenance Haemodialysis

2014 ◽  
Vol 4 (1) ◽  
pp. 13-17
Author(s):  
SM Sajjad ◽  
YA Zaman ◽  
MA Rahim ◽  
A Mahmuda ◽  
WMM Haque ◽  
...  
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Calcium Phosphate ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Maintenance Haemodialysis ◽  
Stage Renal Disease ◽  
End Stage ◽  
Esrd Patients ◽  
Pth Level

Objective: To evaluate parathyroid hormone (PTH) status among end stage renal disease (ESRD) patients on maintenance haemodialysis (MHD). Methodology: This descriptive cross-sectional study was done in the Department of Nephrology, BIRDEM General Hospital, Dhaka, from April to September 2011. Results: A total of 50 patients were included in this study with a 3:2 male predominance. Mean age was 54.6 (range 34-76) years. Mean duration of ESRD was 3.73 years. All the patients were diabetic and other common co-morbidities were hypertension (76%), dyslipidaemia (56%), ischaemic heart disease (48%) and stroke (12%). They were receiving calcium (72%), vitamin D (40%), both calcium and vitamin D (38%) supplementation and 20% were not on any medication for treatment of chronic kidney disease mineral bone disorder (CKD-MBD). Mean pre-dialysis values of urea and creatinine were 30.28 mg/dl and 8.67 mg/dl respectively. Mean (± SD) serum level of calcium, phosphate and PTH were 8.32 (±1.26) mg/dl, 4.42 (±1.54) mg/dl and 125.45±117.71 pg/ml respectively. In 76% of the study subjects, PTH level was above normal. Significant difference (P=<0.05) in PTH levels was observed among patients with and without any medication for prevention of CKD-MBD but the levels were within the acceptable range. Serum calcium level in the study subjects had significant positive relationship with serum PTH level. It was also observed that PTH level had significant negative relationship with phosphate level. Conclusion: PTH level was higher in ESRD patients on MHD specially those who were not on any medication than those who took calcium, vitamin D or both but it was still within the acceptable reference range. In such patients, serum calcium, phosphate and PTH levels should be monitored periodically. DOI: http://dx.doi.org/10.3329/birdem.v4i1.18547 Birdem Med J 2014; 4(1): 13-17

scholarly journals Estimation of Serum Vitamin D2, Growth Hormone, Alkaline Phosphatase and Calcium Phosphate Product in Patients with End Stage Renal Disease

2021 ◽  
Vol 9 (01) ◽  
pp. 61-65
Author(s):  
Santosh Chaudhary ◽  
Narayan Gautam ◽  
Manoj Karki ◽  
Sunkeshari Deshar ◽  
Archana Jayan ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
End Stage Renal Disease ◽  
Hypovitaminosis D ◽  
Vitamin D2 ◽  
Hypertension Status ◽  
Significant Difference ◽  
Phosphate Product ◽  
Stage Renal Disease ◽  
End Stage ◽  
Esrd Patients

INTRODUCTION The chronic kidney disease (CKD) patient's calcium phosphate product, alkaline phosphatase (ALP), vitamin-D2  and human growth hormone (hGH) are altered under haemodialysis. This study aimed to evaluate these biochemical variables in conjunction with haemoglobin and blood pressure to find out their association in End Stage Renal Disease (ESRD) patients. MATERIAL AND METHODS This cross-sectional study comprised of 104 patients with ESRD undergoing haemodialysis. The estimated glomerular filtration rate (eGFR) was calculated by Cockcroft-Gault (CG) equation and calcium, phosphorus, ALP were measured by fully automated analyzer whereas vitamin-D2  and hGH were measured by sandwich and competitive enzyme linked immune sorbent assay (ELISA) techniques. RESULTS The mean age of patients was 53.12 ±16.37 years comprising 68% male. The hypovitaminosis D was 57.7% deficiency and 23.1% insufficiency states whereas hGH insufficiency was 22.1%. The calcium phosphate product was found to be increased in only 39.9% cases. The increased ALP level was observed in 64.4% cases. There was statistically significant association between hGH and Hb status (p=0.03). The significant difference in mean sodium and Ca×P of ESRD cases was observed with hypertension status (p=0.03 and p=0.01) respectively. Moreover, the significant difference in mean eGFR and hGH was observed with haemoglobin status (p=0.0001and p=0.01) respectively. CONCLUSION Increased level of ALP and hypovitaminosis-D was very common in ESRD patients undergoing dialysis with less prevalence of hGH insufficiency and calcium phosphate product increment. The anaemia and hypertension status can be pre-existing condition with ESRD which are cumbersome to control if not monitor in these patients.

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