Background Factors Affecting Visual Acuity at Initial Visit in Eyes with Central Retinal Vein Occlusion: Multicenter Study in Japan

Purpose: To determine the baseline characteristics of patients with central retinal vein occlusion (CRVO) that were significantly associated with the best-corrected visual acuity (BCVA) at the initial examination. Methods: This was a retrospective multicenter study using the medical records registered in 17 ophthalmological institutions in Japan. Patients with untreated CRVO (≥20-years-of-age) who were initially examined between January 2013 and December 2017 were studied. The patients’ baseline factors that were significantly associated with the BCVA at the initial examination were determined by univariate and multivariate linear regression analyses. Results: Data from 517 eyes of 517 patients were analyzed. Univariate analyses showed that an older age (r = 0.194, p < 0.001) and the right eye (r = −0.103, p < 0.019) were significantly associated with poorer BCVA at the initial visit. Multivariate analyses also showed that an older age (β = 0.191, p < 0.001) and the right eye (β = −0.089, p = 0.041) were significantly associated with poorer BCVA at the initial visit. Conclusions: The results indicate that an older age, a known strong factor, and the right eye were significantly associated with poorer BCVA at the initial visit to the hospital. These results suggest that functional and/or anatomical differences between the right and left eyes may be involved in these results.

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Background factors affecting visual acuity at initial visit in eyes with central retinal vein occlusion: multicenter study in Japan

10.21203/rs.3.rs-815373/v1 ◽

2021 ◽

Author(s):

Mineo Kondo ◽

Hidetaka Noma ◽

Masahiko Shimura ◽

Masahiko Sugimoto ◽

Yoshitsugu Matsui ◽

...

Keyword(s):

Visual Acuity ◽

Logistic Regression ◽

Multicenter Study ◽

Older Age ◽

Initial Visit ◽

Regression Analyses ◽

Initial Examination ◽

Vein Occlusion ◽

The Right ◽

Central Retinal Vein

Abstract This retrospective multicenter study was designed to determine the baseline characteristics of patients in Japan with central retinal vein occlusion (CRVO) that were significantly associated with best-corrected visual acuity (BCVA) at the initial examination. The patients’ baseline factors that were significantly associated with the BCVA at the initial examination were determined by univariate, multivariate, and logistic regression analyses. Data from 517 eyes of 517 patients (mean age, 69.9 ± 12.2 years; men, 57.3%) were analyzed. Univariate analyses showed that an older age (r=0.194, P<0.001) and the right eye (r=-0.103, P<0.019) were significantly associated with poorer BCVA at the initial visit. Multivariate analyses showed that an older age (β=0.191, P<0.001) and the right eye (β=-0.089, P=0.041) were also significantly associated with poorer BCVA at the initial visit. In addition, logistic regression analyses showed that these two factors were also significantly related to the BCVAs poorer than 1.0 logMAR units (0.1 decimal BCVA) at the initial visit. Results indicate that an older age, a known strong factor, and the right eye were significantly associated with poorer BCVA at the initial visit. These results suggest that functional and/or anatomical differences between the right and left eyes may be involved in these results.

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Efficacy and Safety of an Aflibercept Treat-and-Extend Regimen in Treatment-Naïve Patients with Macular Oedema Secondary to Central Retinal Vein Occlusion (CRVO): A Prospective 12-Month, Single-Arm, Multicentre Trial

Journal of Ophthalmology ◽

10.1155/2018/8310350 ◽

2018 ◽

Vol 2018 ◽

pp. 1-7

Author(s):

Jose Garcia-Arumi ◽

Francisco Gómez-Ulla ◽

Navea Amparo ◽

Enrique Cervera ◽

Alex Fonollosa ◽

...

Keyword(s):

Visual Acuity ◽

Retinal Vein Occlusion ◽

Central Retinal Vein Occlusion ◽

Macular Oedema ◽

Efficacy And Safety ◽

Foveal Thickness ◽

Treat And Extend ◽

Vein Occlusion ◽

Treatment Naïve ◽

Central Retinal Vein

Objectives. To evaluate efficacy and safety of an aflibercept treat-and-extend (TAE) regimen in patients with macular oedema (MO) secondary to central retinal vein occlusion (CRVO). Design, Setting, and Patients. Phase IV, prospective, open-label, single-arm trial in 11 Spanish hospitals. Treatment-naïve patients with <6 month diagnosis of MO secondary to CRVO and best-corrected visual acuity (BCVA) of 73-24 ETDRS letters were included between 23 January 2015 and 17 March 2016. Intervention. Intravitreal aflibercept 2 mg monthly (3 months) followed by proactive individualized dosing. Main Outcomes. Mean change in BCVA after 12 months. Results. 24 eyes (24 patients) were included; mean (SD) age: 62.8 (15.0) years; 54.2% male; median (IQR) time since diagnosis: 7.6 (3.0, 15.2) days. Mean BCVA scores significantly improved between baseline (56.0 (16.5)) and Month 12 (74.1 (17.6)); mean (95% CI) change: 14.8 (8.2, 21.4); P=0.0001. Twelve (50.0%) patients gained ≥15 ETDRS letters. Foveal thickness improved between baseline (mean: 569.4 (216.8) µm) and Month 12 (mean 257.4 (48.4) µm); P<0.0001. At Month 12, 8.3% patients had MO. The mean (SD) number of injections: 8.3 (3.0). No treatment-related AEs were reported. Five (20.8%) patients experienced ocular AEs. Two nonocular serious AEs were reported. Conclusions. An aflibercept TAE regimen improves visual acuity in patients with MO secondary to CRVO over 12 months with good tolerability.

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Comment on “Correlation between macular ganglion cell-inner plexiform layer thickness and visual acuity after resolution of the macular edema secondary to central retinal vein occlusion”

International Journal of Ophthalmology ◽

10.18240/ijo.2019.04.29 ◽

2019 ◽

Vol 11 (4) ◽

Keyword(s):

Visual Acuity ◽

Ganglion Cell ◽

Macular Edema ◽

Layer Thickness ◽

Retinal Vein Occlusion ◽

Central Retinal Vein Occlusion ◽

Plexiform Layer ◽

Inner Plexiform Layer ◽

Vein Occlusion ◽

Central Retinal Vein

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Detection of Multi-Class Retinal Diseases Using Artificial Intelligence: An Expeditious Learning Using Deep CNN with Minimal Data

Biomedical & Pharmacology Journal ◽

10.13005/bpj/1788 ◽

2019 ◽

Vol 12 (3) ◽

pp. 1577-1586 ◽

Cited By ~ 2

Author(s):

Karthikeyan S. ◽

Sanjay Kumar P. ◽

R J Madhusudan Madhusudan ◽

S K Sundaramoorthy Sundaramoorthy ◽

P K Krishnan Namboori3

Keyword(s):

Real Time ◽

Retinal Vein Occlusion ◽

Central Retinal Vein Occlusion ◽

Research Work ◽

Diagnostic Strategy ◽

Fundus Images ◽

Vein Occlusion ◽

Deep Cnn ◽

The Right ◽

Central Retinal Vein

The health-related complications such as diabetes, macular degeneration, inflammatory conditions, ageing and fungal infections may cause damages to the retina and the macula of the eye, leading to permanent vision loss. The major diseases associated with retina are Arteriosclerotic retinopathy (AR), Central retinal vein occlusion (CRVO), Branch retinal artery occlusion (BRAO), Coat's disease (CD) and Hemi-Central Retinal Vein Occlusion (HRVO). The symptomatic variations among these disorders are relatively confusing so that a systematic diagnostic strategy is difficult to set in. Therefore, an early detection device is required that is capable of differentiating the various ophthalmic complications and thereby helping in providing the right treatment to the patient at the right time. In this research work, 'Deep Convolution Neural Networks (Deep CNN) based machine learning approach has been used for the detection of the twelve major retinal complications from the minimal set of fundus images. The model was further cross-validated with real-time fundus images. The model is found to be superior in its efficiency, specificity and ability to minimize the misclassification. The “multi-class retinal disease” model on further cross-validation with real-time fundus image of the gave an accuracy of 95.63 %, validation accuracy of 92.99 % and F1 score of 91.96 %. The multi-class model is found to be a theranostic clinical support system for the ophthalmologist for diagnosing different kinds of retinal problems, especially BRAO, BRVO, CRAO, CD, DR, HRVO, HP, HR, and CN.

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Changes in visual acuity after intravitreal ranibizumab injections in patients with ischemic and non-ischemic central retinal vein occlusion

Acta Ophthalmologica ◽

10.1111/j.1755-3768.2010.286.x ◽

2010 ◽

Vol 88 ◽

pp. 0-0

Author(s):

L MOUSTAKA ◽

G AMARIOTAKIS ◽

E PARIKAKIS ◽

D KARAGIANNIS ◽

A STRATOS ◽

...

Keyword(s):

Visual Acuity ◽

Retinal Vein Occlusion ◽

Central Retinal Vein Occlusion ◽

Intravitreal Ranibizumab ◽

Vein Occlusion ◽

Central Retinal Vein

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Frosted Branch Angiitis Secondary to Familial Mediterranean Fever Resembling Central Retinal Vein Occlusion

Case Reports in Ophthalmological Medicine ◽

10.1155/2016/2916027 ◽

2016 ◽

Vol 2016 ◽

pp. 1-4 ◽

Cited By ~ 1

Author(s):

Serdar Ozates ◽

Pınar Çakar Ozdal ◽

Mehmet Yasin Teke

Keyword(s):

Visual Acuity ◽

Familial Mediterranean Fever ◽

Retinal Vein Occlusion ◽

Central Retinal Vein Occlusion ◽

Vision Loss ◽

Retinal Vasculitis ◽

Frosted Branch Angiitis ◽

Vein Occlusion ◽

Mediterranean Fever ◽

Central Retinal Vein

Purpose. To report a case of unilateral frosted branch angiitis (FBA) resembling central retinal vein occlusion associated with Familial Mediterranean Fever (FMF). Case Report. A 32-year-old woman presented with progressive, painless vision loss in her left eye lasting for 2 days. She was clinically diagnosed with FMF 2 months ago. The best-corrected visual acuity (BCVA) was 20/20 in her right eye and there was light perception in the left. Ophthalmologic examination revealed severe retinal vasculitis showing clinical features of FBA in the left eye. 64 mg/day oral methylprednisolone was started. A significant improvement in retinal vasculitis was observed in two weeks. However, BCVA did not increase significantly due to subhyaloid premacular hemorrhage. Argon laser posterior hyaloidotomy was performed. One week after hyaloidotomy, visual acuity improved to 20/20 and intravitreal hemorrhage disappeared. Four months after the first attack, FBA recurred. Oral methylprednisolone dosage was increased to 64 mg/day and combined with azathioprine 150 mg. At the end of 12-month follow-up, the BCVA was 20/25 and development of epiretinal membrane was observed in the left eye. Conclusions. Frosted branch angiitis may occur with gene abnormalities as an underlying condition. Our case showed that FMF might be a causative disease.

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Intravitreal Steroid Injections in Macular Edema due to Central Retinal Vein Occlusion

Güncel Retina Dergisi (Current Retina Journal) ◽

10.37783/crj-0136 ◽

2019 ◽

pp. 38-44

Keyword(s):

Visual Acuity ◽

Macular Edema ◽

Retinal Vein Occlusion ◽

Central Retinal Vein Occlusion ◽

Side Effect ◽

Lamina Cribrosa ◽

Initial Application ◽

Vein Occlusion ◽

Intravitreal Dexamethasone ◽

Central Retinal Vein

Retinal vein occlusion is the most common retinal vascular disease after diabetic retinopathy. An occlusion that affects the entire retinal venous system at the level of the lamina cribrosa is called central retinal vein occlusion (CRVO). One of the major complications that threaten visual acuity in CRVO patients is macular edema. Intravitreal dexamethasone implant is widely used in the treatment of macular edema. Efficacy has been shown in terms of short-term edema resolution and increased visual acuity. It seems that the effect on the macula decreases on average in the third month. It is a good option for patients who need to reduce the number of visits. There is no additional side effect except an increase in the incidence of cataracts with recurrent injections. Increasing of intraocular pressure appears to be a tolerable side effect. Their activities are reduced when they are done every six months or when the initial application period is long. Intravitreal steroid treatment is an effective alternative for macular edema secondary to CRVO.

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Central retinal vein occlusion: A patient with systemic sclerosis

Vojnosanitetski pregled ◽

10.2298/vsp141028073k ◽

2016 ◽

Vol 73 (9) ◽

pp. 868-872

Author(s):

Jelena Karadzic ◽

Aleksandra Radosavljevic ◽

Igor Kovacevic

Keyword(s):

Visual Acuity ◽

Systemic Sclerosis ◽

Macular Edema ◽

Retinal Vein Occlusion ◽

Central Retinal Vein Occlusion ◽

Case Reports ◽

Immunosuppressive Treatment ◽

Central Vein ◽

Vein Occlusion ◽

Central Retinal Vein

Introduction. Scleroderma (systemic sclerosis) is a severe chronic connective tissue disease, which results in involvement of numerous internal organs. Changes in the eye are the consequences of organ-specific manifestations of scleroderma or adverse effects of immunosuppressive treatment applied. Case report. We reported a 42-year-old woman with systemic sclerosis and acute deterioration of vision in the left eye, with visual acuity 0.9. After thorough clinical examination, including fluorescein angiography and optical coherence tomography, the diagnosis of nonischemic central retinal vein occlusion was made. Further biochemical, rheumatological and immunological investigation, apart from inactive systemic sclerosis, showed normal findings. Therefore, the cause of central retinal vein occlusion could only be attributed to the microvascular changes in systemic sclerosis. After three months, visual acuity deteriorated to 0.6 due to the development of cystoid macular edema. The patient received intravitreal injection of bevacizumab and after a single dose visual acuity improved to 0.9. After a 6- month follow-up, macular edema resolved and visual acuity stabilized. Conclusion. According to our knowledge and current data from the literature, central retinal vein occlusion is a rare vision threatening manifestation of scleroderma. There are only few published case reports on central vein occlusion in scleroderma patients. Examination of the ocular fundus is recommended for evaluation of vascular disease in patients with systemic sclerosis.

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